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Volumn 14, Issue 1, 2015, Pages 48-66

3-Chloropropane-1,2-diol (3-MCPD) in Soy Sauce: A Review on the Formation, Reduction, and Detection of This Potential Carcinogen

Author keywords

2 diol (3 MCPD); 3 monochloropropane 1; Acid HVP soy sauce; Carcinogen; Heat process contaminants

Indexed keywords

2-DIOL (3-MCPD); 3-CHLOROPROPANE-1 ,2-DIOL; 3-MONOCHLOROPROPANE-1; CARCINOGENIC COMPOUNDS; HEAT PROCESS; LABORATORY ANIMALS; SENSORY PROPERTIES; SOY SAUCE;

EID: 84916221038     PISSN: None     EISSN: 15414337     Source Type: Journal    
DOI: 10.1111/1541-4337.12120     Document Type: Article
Times cited : (76)

References (140)
  • 1
    • 33745413425 scopus 로고    scopus 로고
    • Rapid and simple determination of chloropropanols (3-MCPD and 1,3-DCP) in food products using isotope dilution GC-MS
    • Abu-El-Haj S, Bogusz MJ, Ibrahim Z, Hassan H, Al Tufail M. 2007. Rapid and simple determination of chloropropanols (3-MCPD and 1, 3-DCP) in food products using isotope dilution GC-MS. Food Control 18:81-90.
    • (2007) Food Control , vol.18 , pp. 81-90
    • Abu-El-Haj, S.1    Bogusz, M.J.2    Ibrahim, Z.3    Hassan, H.4    Al Tufail, M.5
  • 2
    • 84916243478 scopus 로고    scopus 로고
    • Supported liquid extraction: SLE cartridges and plates Accessed 2014 Sep 23.
    • Agilent Technologies. 2014. Supported liquid extraction: SLE cartridges and plates. Available from: http://www.chem.agilent.com/en-US/products-services/Columns-Sample-Preparation/Sample-Preparation/Supported-Liquid-Extraction/SLE-Cartridges-and-Plates/Pages/default.aspx. Accessed 2014 Sep 23.
    • (2014)
  • 3
    • 84916226830 scopus 로고
    • Anon.. Bestimmung von 3-Chlor-1, 2-Propandiol (3-MCPD) in Speisewürzen (Eiweißhydrolysate). Amtliche Sammlung von Untersuchungsverfahren nach § 35 LMBG. L 52.02-1.
    • Anon. 1995. Bestimmung von 3-Chlor-1, 2-Propandiol (3-MCPD) in Speisewürzen (Eiweißhydrolysate). Amtliche Sammlung von Untersuchungsverfahren nach § 35 LMBG. L 52.02-1.
    • (1995)
  • 4
    • 84916206213 scopus 로고    scopus 로고
    • Determination of 3-chloro-1,2-propanediol in foods and food ingredients, gas chromatography/mass spectrometric detection. AOAC Official Method 2000.01. AOAC Intl. 48.1.06.
    • AOAC. 2002. Determination of 3-chloro-1, 2-propanediol in foods and food ingredients, gas chromatography/mass spectrometric detection. AOAC Official Method 2000.01. AOAC Intl. 48.1.06.
    • (2002)
  • 6
    • 84916218215 scopus 로고    scopus 로고
    • Comparison between 3-MCPD and its palmitic esters in a 90-day toxicological study. Scientific report submitted to EFSA, CFP/EFSA/CONTAM/2009/01.
    • Barocelli E, Corradi A, Mutti A, Petronini P. 2011. Comparison between 3-MCPD and its palmitic esters in a 90-day toxicological study. Scientific report submitted to EFSA, CFP/EFSA/CONTAM/2009/01.
    • (2011)
    • Barocelli, E.1    Corradi, A.2    Mutti, A.3    Petronini, P.4
  • 7
    • 84988347025 scopus 로고    scopus 로고
    • Cyclohexanone/sulfonated polymer catalyst: a new simple derivatizing procedure for GC-MS determination of 2- and 3-monochloropropanediols
    • Becalski A, Zhao T, Sit D. 2013. Cyclohexanone/sulfonated polymer catalyst: a new simple derivatizing procedure for GC-MS determination of 2- and 3-monochloropropanediols. Food Energy Secur 2:157-65.
    • (2013) Food Energy Secur , vol.2 , pp. 157-165
    • Becalski, A.1    Zhao, T.2    Sit, D.3
  • 8
    • 4744350029 scopus 로고    scopus 로고
    • Biodegradation of 3-chloro-1,2-propanediol with Saccharomyces cerevisiae
    • Bel-Rhlid R, Talmon JP, Fay LB, Juillerat MA. 2004. Biodegradation of 3-chloro-1, 2-propanediol with Saccharomyces cerevisiae. J Agr Food Chem 52:6165-9.
    • (2004) J Agr Food Chem , vol.52 , pp. 6165-6169
    • Bel-Rhlid, R.1    Talmon, J.P.2    Fay, L.B.3    Juillerat, M.A.4
  • 9
    • 0030668768 scopus 로고    scopus 로고
    • Determination of 1,3-dichloro-2-propanol and 3-chloro-1,2-propanediol in papers treated with polyamidoamine-epichlorohydrin wet-strength resins by gas chromatography-mass spectrometry using selective ion monitoring
    • Bodén L, Lundgren M, Stensiö K-E, Gorzynski M. 1997. Determination of 1, 3-dichloro-2-propanol and 3-chloro-1, 2-propanediol in papers treated with polyamidoamine-epichlorohydrin wet-strength resins by gas chromatography-mass spectrometry using selective ion monitoring. J Chromatogr A 788:195-203.
    • (1997) J Chromatogr A , vol.788 , pp. 195-203
    • Bodén, L.1    Lundgren, M.2    Stensiö, K.-E.3    Gorzynski, M.4
  • 10
    • 84916216221 scopus 로고
    • inventors.. Process for preparing amino acids. U.S. Patent 2657232 A.
    • Borkenhagen LK, inventors. 1953. Process for preparing amino acids. U.S. Patent 2657232 A.
    • (1953)
    • Borkenhagen, L.K.1
  • 11
    • 77953899406 scopus 로고    scopus 로고
    • Enzymatic removal of 3-monochloro-1,2-propanediol (3-MCPD) and its ester from oils
    • Bornscheuer UT, Hesseler M. 2010. Enzymatic removal of 3-monochloro-1, 2-propanediol (3-MCPD) and its ester from oils. Eur J Lipid Sci Technol 112: 552-6.
    • (2010) Eur J Lipid Sci Technol , vol.112 , pp. 552-556
    • Bornscheuer, U.T.1    Hesseler, M.2
  • 12
    • 17444411964 scopus 로고    scopus 로고
    • Influence of dough ingredients on 3-chloropropane-1,2-diol (3-MCPD) formation in toast
    • Breitling-Utzmann CM, Hrenn H, Haase NU, Unbehend GM. 2005. Influence of dough ingredients on 3-chloropropane-1, 2-diol (3-MCPD) formation in toast. Food Addit Contam 22:97-103.
    • (2005) Food Addit Contam , vol.22 , pp. 97-103
    • Breitling-Utzmann, C.M.1    Hrenn, H.2    Haase, N.U.3    Unbehend, G.M.4
  • 13
    • 0035293505 scopus 로고    scopus 로고
    • Determination of 3-chloro-1,2-propanediol in foods and food ingredients by gas chromatography with mass spectrometric detection: collaborative study
    • Brereton P, Kelly J, Crews C, Honour S, Wood R, Davies A. 2001. Determination of 3-chloro-1, 2-propanediol in foods and food ingredients by gas chromatography with mass spectrometric detection: collaborative study. J AOAC Int 84:455-65.
    • (2001) J AOAC Int , vol.84 , pp. 455-465
    • Brereton, P.1    Kelly, J.2    Crews, C.3    Honour, S.4    Wood, R.5    Davies, A.6
  • 14
    • 84916206496 scopus 로고    scopus 로고
    • Maximum levels for various chemical contaminants in foods
    • Accessed 2014 May 5.
    • Canadian Standards. 2012. Maximum levels for various chemical contaminants in foods. Available from: http://www.hc-sc.gc.ca/fn-an/securit/chem-chim/contaminants-guidelines-directives-eng.php#share. Accessed 2014 May 5.
    • (2012)
  • 15
    • 0003954817 scopus 로고    scopus 로고
    • 4th ed. United States: McGraw-Hill Higher Education.
    • Carey FA. 2000. Organic chemistry. 4th ed. United States: McGraw-Hill Higher Education.
    • (2000) Organic chemistry
    • Carey, F.A.1
  • 16
    • 14244260036 scopus 로고    scopus 로고
    • Survey on 3-monochloro-1, 2-propandiol (3-MCPD) contents of soy sauce products during fiscal year 2002 in Taiwan
    • Cheng W-C, Chen H-C, Lin Y-P, Lee H-F, Chang P-C, Chou S-S. 2004. Survey on 3-monochloro-1, 2-propandiol (3-MCPD) contents of soy sauce products during fiscal year 2002 in Taiwan. J Food Drug Anal 12:336-41.
    • (2004) J Food Drug Anal , vol.12 , pp. 336-341
    • Cheng, W.-C.1    Chen, H.-C.2    Lin, Y.-P.3    Lee, H.-F.4    Chang, P.-C.5    Chou, S.-S.6
  • 20
    • 0037023338 scopus 로고    scopus 로고
    • Sensitive method for the determination of 1,3-dichloropropan-2-ol and 3-chloropropane-1,2-diol in soy sauce by capillary gas chromatography with mass spectrometric detection
    • Chung WC, Hui KY, Cheng SC. 2002. Sensitive method for the determination of 1, 3-dichloropropan-2-ol and 3-chloropropane-1, 2-diol in soy sauce by capillary gas chromatography with mass spectrometric detection. J Chromatogr A 952:185-92.
    • (2002) J Chromatogr A , vol.952 , pp. 185-192
    • Chung, W.C.1    Hui, K.Y.2    Cheng, S.C.3
  • 22
    • 0026241219 scopus 로고
    • Mechanism of formation of chloropropanols present in protein hydrolysates
    • Collier PD, Cromie DDO, Davies AP. 1991. Mechanism of formation of chloropropanols present in protein hydrolysates. J AOAC 68:785-90
    • (1991) J AOAC , vol.68 , pp. 785-790
    • Collier, P.D.1    Cromie, D.D.O.2    Davies, A.P.3
  • 23
    • 84916221198 scopus 로고    scopus 로고
    • Setting maximum levels for certain contaminants in foodstuffs, Commission regulation (EC) Nr 466/2001. Official Journal of the European Communities, L77/1 -13.
    • Commission Regulation. 2001. Setting maximum levels for certain contaminants in foodstuffs, Commission regulation (EC) Nr 466/2001. Official Journal of the European Communities, L77/1 -13.
    • (2001)
  • 25
    • 12144291095 scopus 로고    scopus 로고
    • Development of an analytical method for 3-monochloropropane-1,2-diol in soy sauce using 4-heptanone as derivatizing agent
    • Dayrit FM, Niñonuevo MR. 2004. Development of an analytical method for 3-monochloropropane-1, 2-diol in soy sauce using 4-heptanone as derivatizing agent. Food Addit Contam 21:204-9.
    • (2004) Food Addit Contam , vol.21 , pp. 204-209
    • Dayrit, F.M.1    Niñonuevo, M.R.2
  • 26
    • 33645447112 scopus 로고    scopus 로고
    • Determination of free and bound 3-chloropropane-1,2-diol by gas chromatography with mass spectrometric detection using deuterated 3-chloropropane-1,2-diol as internal standard
    • Divinová V, Svejkovská B, Doležal M, Velíšek J. 2004. Determination of free and bound 3-chloropropane-1, 2-diol by gas chromatography with mass spectrometric detection using deuterated 3-chloropropane-1, 2-diol as internal standard. Czech J Food Sci 22:182-9.
    • (2004) Czech J Food Sci , vol.22 , pp. 182-189
    • Divinová, V.1    Svejkovská, B.2    Doležal, M.3    Velíšek, J.4
  • 27
    • 84916242908 scopus 로고    scopus 로고
    • European agency for the evaluation of medicinal products, oelxalic acid. Summary report EMEA/MRL/891/03-FINAL. Accessed 2014 May 5.
    • EAEMP. 2004. European agency for the evaluation of medicinal products, oelxalic acid. Summary report EMEA/MRL/891/03-FINAL. Available from: http://www.emea.eu.int/pdfs/vet/mrls/o89103en.pdf. Accessed 2014 May 5.
    • (2004)
  • 28
    • 33751358979 scopus 로고    scopus 로고
    • Evaluation of the genotoxic potential of 3-monochloropropane-1, 2-diol (3-MCPD) and its metabolites, glycidol and beta-chlorolactic acid, using the single cell gel/comet assay
    • El Ramy R, Ould Elhkim M, Lezmi S, Poul JM. 2007. Evaluation of the genotoxic potential of 3-monochloropropane-1, 2-diol (3-MCPD) and its metabolites, glycidol and beta-chlorolactic acid, using the single cell gel/comet assay. Food and Chemical 45:41-8.
    • (2007) Food and Chemical , vol.45 , pp. 41-48
    • El Ramy, R.1    Ould Elhkim, M.2    Lezmi, S.3    Poul, J.M.4
  • 29
    • 84916237564 scopus 로고    scopus 로고
    • Registration review: conventional cases schedule: 2012-2015. Accessed 2014 July 22.
    • EPA. 2013. Registration review: conventional cases schedule: 2012-2015. Available from: www.epa.gov/oppsrrd1/registration_review/fy12-fy15-conventional-sched.pdf. Accessed 2014 July 22.
    • (2013)
  • 30
    • 0015415229 scopus 로고
    • Detection of chemical mutagens by the dominant lethal assay in the mouse
    • Epstein SS, Arnold E, Andrea J, Bass W, Bishop Y. 1972. Detection of chemical mutagens by the dominant lethal assay in the mouse. Toxicol Appl Pharm 23:288-325.
    • (1972) Toxicol Appl Pharm , vol.23 , pp. 288-325
    • Epstein, S.S.1    Arnold, E.2    Andrea, J.3    Bass, W.4    Bishop, Y.5
  • 31
    • 84916215114 scopus 로고
    • Alpha-chlorohydrin (Epibloc®): a toxicant-sterilant as an alternative in rodent control. Proceedings of the Tenth Vertebrate Pest Conference. February 23, 1982, Univ. of Nebraska-Lincoln.
    • Ericsson RJ. 1982. Alpha-chlorohydrin (Epibloc®): a toxicant-sterilant as an alternative in rodent control. Proceedings of the Tenth Vertebrate Pest Conference. February 23, 1982, Univ. of Nebraska-Lincoln.
    • (1982)
    • Ericsson, R.J.1
  • 32
    • 84916221530 scopus 로고    scopus 로고
    • Report of experts participating in task 3.2.9, collection and collation of data on levels of 3-monochloropropanediol (3-MCPD) and related substances in foodstuffs. Directorate-General Health and Consumer Protection, Brussels. Accessed 2014 May 5.
    • European Commission. 2004. Report of experts participating in task 3.2.9, collection and collation of data on levels of 3-monochloropropanediol (3-MCPD) and related substances in foodstuffs. Directorate-General Health and Consumer Protection, Brussels. Available from: http://ec.europa.eu/food/food/chemicalsafety/contaminants/scoop_3-2-9_final_report_chloropropanols_en.pdf. Accessed 2014 May 5.
    • (2004)
  • 33
    • 84916205471 scopus 로고    scopus 로고
    • Nr 1881/2006 of 19 September 2006 setting maximum levels for certain contaminants in foodstuffs. Off J Eur Union, 9. Accessed 2014 July 3.
    • European Commission. 2006. Nr 1881/2006 of 19 September 2006 setting maximum levels for certain contaminants in foodstuffs. Off J Eur Union, 9. Available from: http://eur-lex.europa.eu/legal-content/EN/TXT/?uri=uriserv:OJ.L_.2006.364.01.0005.01.ENG. Accessed 2014 July 3.
    • (2006)
  • 34
    • 84916199856 scopus 로고    scopus 로고
    • Foodstuffs-determination of 3-monochloropropane-1,2-diol by GC/MS. Report Nr. EN 14573:2004. Berlin, Germany: Beuth Verlag.
    • European Standard. 2005. Foodstuffs-determination of 3-monochloropropane-1, 2-diol by GC/MS. Report Nr. EN 14573:2004. Berlin, Germany: Beuth Verlag.
    • (2005)
  • 35
    • 84916219743 scopus 로고    scopus 로고
    • Discussion paper on chloropropanols derived from the manufacture of acid-HVP and the heat processing of food. Proc 1st Session of Codex Committee on Contaminants in Foods. Beijing, China
    • FAO, WHO. 2007. Discussion paper on chloropropanols derived from the manufacture of acid-HVP and the heat processing of food. Proc 1st Session of Codex Committee on Contaminants in Foods. Beijing, China. p 16-20.
    • (2007) , pp. 16-20
  • 36
    • 84916221256 scopus 로고    scopus 로고
    • Reduction of 3-monochloropropane-1, 2-diol (3-MCPD) during the production of acid-hydrolyzed vegetable protein (Acid-HVPs) and products that contain acid-HVPs
    • Rome: World Health Organization
    • FAO. 2012. Reduction of 3-monochloropropane-1, 2-diol (3-MCPD) during the production of acid-hydrolyzed vegetable protein (Acid-HVPs) and products that contain acid-HVPs. In: Prevention and reduction of food and feed contamination. Rome: World Health Organization. p 148-54.
    • (2012) Prevention and reduction of food and feed contamination , pp. 148-154
  • 37
    • 84916241083 scopus 로고    scopus 로고
    • Accessed 2014 May 5.
    • FAOSTAT. 2011. Available from: http://faostat.fao.org/site/535/default.aspx#ancor. Accessed 2014 May 5.
    • (2011)
  • 38
    • 84916202778 scopus 로고    scopus 로고
    • CPG Sec 500.500 guidance levels for 3-MCPD (3-chloro-1,2-propanediol) in acid-hydrolyzed protein and Asian-style sauces Accessed 2014 May 5.
    • FDA. 2008. CPG Sec 500.500 guidance levels for 3-MCPD (3-chloro-1, 2-propanediol) in acid-hydrolyzed protein and Asian-style sauces. Available from: http://www.fda.gov/ICECI/ComplianceManuals/CompliancePolicyGuidanceManual/ucm074419.htm. Accessed 2014 May 5.
    • (2008)
  • 39
    • 84916244436 scopus 로고    scopus 로고
    • 3-MCPD: measurement of unscheduled DNA synthesis in rat liver using an in vitro/in vivo procedure.. York: Convance Laboratories Ltd.
    • Fellows M. 2000. 3-MCPD: measurement of unscheduled DNA synthesis in rat liver using an in vitro/in vivo procedure. Report nr. 1863/1-D5140. York: Convance Laboratories Ltd.
    • (2000)
    • Fellows, M.1
  • 40
    • 84916208841 scopus 로고
    • inventor.. Using sulfuric acid and specific conditions. U.S. 4874893 A.
    • Flork M, inventor. 1989. Using sulfuric acid and specific conditions. U.S. 4874893 A.
    • (1989)
    • Flork, M.1
  • 41
    • 84916227566 scopus 로고
    • Issue Nr. 149, New Zealand Gazette Office Accessed 2014 May 5.
    • Food Standards Australia New Zealand Act. 1991. Issue Nr. 149, New Zealand Gazette Office. Available from: https://www.dia.govt.nz//Pubforms.nsf/NZGZT/NZGazette149Nov01.pdf/$file/NZGazette149Nov01.pdf. Accessed 2014 May 5.
    • (1991)
  • 42
    • 0345404350 scopus 로고    scopus 로고
    • The vicinal chloroalcohols 1,3-dichloro-2-propanol (DC2P), 3-chloro-1,2-propanediol (3CPD) and 2-chloro-1,3-propanediol (2CPD) are not genotoxic in vivo in the wing spot test of Drosophila melanogaster
    • Frei H, Wurgler FE. 1997. The vicinal chloroalcohols 1, 3-dichloro-2-propanol (DC2P), 3-chloro-1, 2-propanediol (3CPD) and 2-chloro-1, 3-propanediol (2CPD) are not genotoxic in vivo in the wing spot test of Drosophila melanogaster. Mutat Res 394:59-68.
    • (1997) Mutat Res , vol.394 , pp. 59-68
    • Frei, H.1    Wurgler, F.E.2
  • 43
    • 22244459634 scopus 로고    scopus 로고
    • Technical Report Series Nr. 15. October 2003. Accessed May 5, 2014.
    • FSANZ. 2003. Chloropropanols in food, an analysis of the public health risk. Technical Report Series Nr. 15. October 2003. Available from: http://www.foodstandards.gov.au/publications/documents/Chloropropanol%20Report%20(no%20appendices)-%2011%20Sep%2003b-2.pdf. Accessed May 5, 2014.
    • (2003) Chloropropanols in food, an analysis of the public health risk
  • 44
    • 80053177586 scopus 로고    scopus 로고
    • Combined solid-phase extraction and gas chromatography-mass spectrometry used for determination of chloropropanols in water
    • Gonzalez P, Racamonde I, Carro AM, Lorenzo RA. 2011. Combined solid-phase extraction and gas chromatography-mass spectrometry used for determination of chloropropanols in water. J Sep Sci 34:2697-704.
    • (2011) J Sep Sci , vol.34 , pp. 2697-2704
    • Gonzalez, P.1    Racamonde, I.2    Carro, A.M.3    Lorenzo, R.A.4
  • 45
    • 84916212046 scopus 로고
    • In vitro mammalian cell HPRT-test with 3-chloro-1,2-propanol. In: Unpublished report Nr. G91/3 from Fraunhofer-Institute für Toxicologie und Aerosolforschung, Hannover, Germany.
    • Gorlitz BD. 1991. In vitro mammalian cell HPRT-test with 3-chloro-1, 2-propanol. In: Unpublished report Nr. G91/3 from Fraunhofer-Institute für Toxicologie und Aerosolforschung, Hannover, Germany.
    • (1991)
    • Gorlitz, B.D.1
  • 46
    • 84873792261 scopus 로고
    • Protein hydrolysates; flavor ingredients for foods
    • Hall LA. 1946. Protein hydrolysates; flavor ingredients for foods. Food Ind 18:4808-16.
    • (1946) Food Ind , vol.18 , pp. 4808-4816
    • Hall, L.A.1
  • 48
    • 0030984136 scopus 로고    scopus 로고
    • Determination of the chloropropanols, 3-Chloro-1,2-propandiol and 2-Chloro-1,3-propandiol, in hydrolysed vegetable proteins and seasonings by gas chromatography/ion trap tandem mass spectrometry
    • Hamlet CG, Sutton PG. 1997. Determination of the chloropropanols, 3-Chloro-1, 2-propandiol and 2-Chloro-1, 3-propandiol, in hydrolysed vegetable proteins and seasonings by gas chromatography/ion trap tandem mass spectrometry. Rapid Commun Mass Sp 11:1417-24.
    • (1997) Rapid Commun Mass Sp , vol.11 , pp. 1417-1424
    • Hamlet, C.G.1    Sutton, P.G.2
  • 49
    • 1542581492 scopus 로고    scopus 로고
    • Influence of composition, moisture, pH and temperature on the formation and decay kinetics of monochloropropanediols in wheat flour dough
    • Hamlet CG, Sadd PA, Gray DA. 2003. Influence of composition, moisture, pH and temperature on the formation and decay kinetics of monochloropropanediols in wheat flour dough. Eur Food Res Technol 216:122-28.
    • (2003) Eur Food Res Technol , vol.216 , pp. 122-128
    • Hamlet, C.G.1    Sadd, P.A.2    Gray, D.A.3
  • 50
    • 84916225871 scopus 로고
    • An assessment of the mutagenic potential of 1,3-dichloro-2-propanol, 3-chloro-1,2-propanediol and a cocktail of chloropropanols using the mouse lymohoma TK locus assay. Unpublished report nr. ULR 130 ABC/861423, Huntingdon Research Centre, England.
    • Henderson L, Bosworth H, Ransome S, Banks S, Brabbs C, Tinner A. 1987. An assessment of the mutagenic potential of 1, 3-dichloro-2-propanol, 3-chloro-1, 2-propanediol and a cocktail of chloropropanols using the mouse lymohoma TK locus assay. Unpublished report nr. ULR 130 ABC/861423, Huntingdon Research Centre, England.
    • (1987)
    • Henderson, L.1    Bosworth, H.2    Ransome, S.3    Banks, S.4    Brabbs, C.5    Tinner, A.6
  • 51
    • 84880017318 scopus 로고    scopus 로고
    • A novel approach of periodate oxidation coupled with HPLC-FLD for the quantitative determination of 3-chloro-1,2-propanediol in water and vegetable oil
    • Hu Z, Cheng P, Guo M, Zhang W, Qi Y. 2013. A novel approach of periodate oxidation coupled with HPLC-FLD for the quantitative determination of 3-chloro-1, 2-propanediol in water and vegetable oil. J Agr Food Chem 61:6614-21.
    • (2013) J Agr Food Chem , vol.61 , pp. 6614-6621
    • Hu, Z.1    Cheng, P.2    Guo, M.3    Zhang, W.4    Qi, Y.5
  • 52
    • 0033566998 scopus 로고    scopus 로고
    • High-performance liquid chromatographic-fluorescent method to determine chloroacetaldehyde, a neurotoxic metabolite of the anticancer drug ifosfamide, in plasma and in liver microsomal incubations
    • Huang Z, Waxman DJ. 1999. High-performance liquid chromatographic-fluorescent method to determine chloroacetaldehyde, a neurotoxic metabolite of the anticancer drug ifosfamide, in plasma and in liver microsomal incubations. Anal Biochem 273:117-25.
    • (1999) Anal Biochem , vol.273 , pp. 117-125
    • Huang, Z.1    Waxman, D.J.2
  • 53
    • 28444460389 scopus 로고    scopus 로고
    • Determination of 3-chloropropane-1,2-diol in liquid hydrolyzed vegetable proteins and soy sauce by solid-phase micro extraction and gas chromatography/mass spectrometry
    • Huang M, Jiang G, He B, Liu J, Zhou Q, Fu W, Wu Y. 2005. Determination of 3-chloropropane-1, 2-diol in liquid hydrolyzed vegetable proteins and soy sauce by solid-phase micro extraction and gas chromatography/mass spectrometry. Anal Sci 21:1343-7.
    • (2005) Anal Sci , vol.21 , pp. 1343-1347
    • Huang, M.1    Jiang, G.2    He, B.3    Liu, J.4    Zhou, Q.5    Fu, W.6    Wu, Y.7
  • 54
    • 84916233954 scopus 로고    scopus 로고
    • Studies on formation of 3-monochloropropanediols in the models consisted of monoolein, sodium chloride and water. International Conference on Frontiers of Energy, Environmental Materials and Civil Engineering, 21-22 November 2013. Shanghai, China: DEStech Publications.
    • Huang MQ, Wu JH, Sun PP, Sun BG, Zhang JL. 2013. Studies on formation of 3-monochloropropanediols in the models consisted of monoolein, sodium chloride and water. International Conference on Frontiers of Energy, Environmental Materials and Civil Engineering, 21-22 November 2013. Shanghai, China: DEStech Publications.
    • (2013)
    • Huang, M.Q.1    Wu, J.H.2    Sun, P.P.3    Sun, B.G.4    Zhang, J.L.5
  • 55
    • 84916243405 scopus 로고    scopus 로고
    • th International Congress of Nutrition. September 2013, Spain.
    • th International Congress of Nutrition. September 2013, Spain.
    • (2013)
    • Huo, J.1    Sun, J.2    Chen, J.3
  • 56
    • 84916197711 scopus 로고
    • IARC monographs on the evaluation of carcinogenic risks to humans: some industrial chemicals. International Agency for Research on Cancer, Vol. 60, France.
    • IARC. 1994. IARC monographs on the evaluation of carcinogenic risks to humans: some industrial chemicals. International Agency for Research on Cancer, Vol. 60, France.
    • (1994)
  • 57
    • 84901700146 scopus 로고    scopus 로고
    • Some chemicals present in industrial and consumer products, food and drinking water. International Agency for Research on Cancer, Vol. 101, France.
    • IARC. 2013. Some chemicals present in industrial and consumer products, food and drinking water. International Agency for Research on Cancer, Vol. 101, France.
    • (2013)
  • 58
    • 84916240074 scopus 로고    scopus 로고
    • Agents classified by the IARC monographs, Volumes 1-109 Accessed 2014 May 5.
    • IARC. 2014. Agents classified by the IARC monographs, Volumes 1-109. Available from: http://monographs.iarc.fr/ENG/Classification/Classificat-ionsGroupOrder.pdf. Accessed 2014 May 5. p. 15.
    • (2014) , pp. 15
  • 59
    • 84916206407 scopus 로고    scopus 로고
    • Guidance for industry SIC (R2) dose selection for carcinogenicity studies Accessed 2014 May 5.
    • ICH. 2008. Guidance for industry SIC (R2) dose selection for carcinogenicity studies. Available from: http://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/ucm074-919.pdf. Accessed 2014 May 5.
    • (2008)
  • 60
    • 84916207372 scopus 로고
    • Evaluation of 3-chloro-1,2-propanediol (3-MCPD) in the bone marrow and colonic micronucleus test in mice. Unpublished report nr 1265, p 1-57, Nestec Ltd, Research Centre.
    • Jaccaud E, Aeschbacher H. 1989. Evaluation of 3-chloro-1, 2-propanediol (3-MCPD) in the bone marrow and colonic micronucleus test in mice. Unpublished report nr 1265, p 1-57, Nestec Ltd, Research Centre.
    • (1989)
    • Jaccaud, E.1    Aeschbacher, H.2
  • 61
    • 84916230603 scopus 로고    scopus 로고
    • 1,3-dichloro-2-propanol. Safety evaluation of certain food additives and contaminants. In: WHO food addit ser 48. Prepared by the fifty-seventh meeting of the Joint FAO/WHO Expert Committee on Food Additives (JECFA). Geneva, Switzerland.
    • JECFA. 2002. 1, 3-dichloro-2-propanol. Safety evaluation of certain food additives and contaminants. In: WHO food addit ser 48. Prepared by the fifty-seventh meeting of the Joint FAO/WHO Expert Committee on Food Additives (JECFA). Geneva, Switzerland.
    • (2002)
  • 62
    • 77957819919 scopus 로고    scopus 로고
    • Carcinogenicity study of 3-monochloropropane-1,2-diol (3-MCPD) administered by drinking water to B6C3F1 mice showed no carcinogenic potential
    • Jeong J, Han BS, Cho WS, Choi M, Ha CS, Lee BS, Kim YB, Son WC, Kim CY. 2010. Carcinogenicity study of 3-monochloropropane-1, 2-diol (3-MCPD) administered by drinking water to B6C3F1 mice showed no carcinogenic potential. Arch Toxicol 84:719-29.
    • (2010) Arch Toxicol , vol.84 , pp. 719-729
    • Jeong, J.1    Han, B.S.2    Cho, W.S.3    Choi, M.4    Ha, C.S.5    Lee, B.S.6    Kim, Y.B.7    Son, W.C.8    Kim, C.Y.9
  • 63
    • 0016609929 scopus 로고
    • The metabolism of 3-chloro-, 3-bromo- and 3-iodopropan-1,2-diol in rats and mice
    • Jones AR. 1975. The metabolism of 3-chloro-, 3-bromo- and 3-iodopropan-1, 2-diol in rats and mice. Xenobiotica 5:155-65.
    • (1975) Xenobiotica , vol.5 , pp. 155-165
    • Jones, A.R.1
  • 64
    • 0020876229 scopus 로고
    • Antifertility actions of alpha-chlorohydrin in the male
    • Jones AR. 1983. Antifertility actions of alpha-chlorohydrin in the male. Aust J Biol Sci 36:333-50.
    • (1983) Aust J Biol Sci , vol.36 , pp. 333-350
    • Jones, A.R.1
  • 65
    • 0018578175 scopus 로고
    • Epoxides as obligatory intermediated in the metabolism of α-halohydrins
    • Jones AR, Fakhouri. 1979. Epoxides as obligatory intermediated in the metabolism of α-halohydrins. Xenobiotica 9:595-9.
    • (1979) Xenobiotica , vol.9 , pp. 595-599
    • Jones, A.R.1    Fakhouri2
  • 66
    • 0017275778 scopus 로고
    • Antifertility and dominant lethal mutation studies in male rats with dl-alpha-chlorohydrin and an amino-analogue
    • Jones P, Jackson H. 1976. Antifertility and dominant lethal mutation studies in male rats with dl-alpha-chlorohydrin and an amino-analogue. Contraception 13:639-46.
    • (1976) Contraception , vol.13 , pp. 639-646
    • Jones, P.1    Jackson, H.2
  • 67
    • 36949059454 scopus 로고
    • Antifertility effects and metabolism of alpha and epi-chlorhydrins in the rat
    • Jones AR, Davies P, Edwards K, Jackson H. 1969. Antifertility effects and metabolism of alpha and epi-chlorhydrins in the rat. Nature 224:83.
    • (1969) Nature , vol.224 , pp. 83
    • Jones, A.R.1    Davies, P.2    Edwards, K.3    Jackson, H.4
  • 68
    • 0018075609 scopus 로고
    • The oxidative metabolism of alpha-chlorohydrin in the male rat and the formation of spermatocoeles
    • Jones AR, Milton DH, Murcott C. 1978. The oxidative metabolism of alpha-chlorohydrin in the male rat and the formation of spermatocoeles. Xenobiotica 8:573-82.
    • (1978) Xenobiotica , vol.8 , pp. 573-582
    • Jones, A.R.1    Milton, D.H.2    Murcott, C.3
  • 69
    • 0019475496 scopus 로고
    • The renal toxicity of some halogenated derivatives of propane in the rat
    • Jones AR, Porter K, Stevenson D. 1981. The renal toxicity of some halogenated derivatives of propane in the rat. Naturwissenschaften 68:98-9.
    • (1981) Naturwissenschaften , vol.68 , pp. 98-99
    • Jones, A.R.1    Porter, K.2    Stevenson, D.3
  • 70
    • 0026777898 scopus 로고
    • Determination of 3-chloropropanediol and related dioxolanes by gas chromatography
    • Kissa E. 1992. Determination of 3-chloropropanediol and related dioxolanes by gas chromatography. J Chromatogr A 605:134-8.
    • (1992) J Chromatogr A , vol.605 , pp. 134-138
    • Kissa, E.1
  • 71
    • 34548227087 scopus 로고    scopus 로고
    • Nachweis und Bestimmung von 3-Monochlorpropan-1,2-diol (3-MCPD) mit GC-MS/MS
    • Kuballa T, Ruge W. 2003. Nachweis und Bestimmung von 3-Monochlorpropan-1, 2-diol (3-MCPD) mit GC-MS/MS. Lebensmittelchem 57:57-8.
    • (2003) Lebensmittelchem , vol.57 , pp. 57-58
    • Kuballa, T.1    Ruge, W.2
  • 72
    • 84916205086 scopus 로고    scopus 로고
    • Laws of Malaysia..Malaysia food act 1983 and regulations 1985. The Commissioner of Law Revision. Malaysia.
    • Laws of Malaysia. 2012.Malaysia food act 1983 and regulations 1985. The Commissioner of Law Revision. Malaysia.
    • (2012)
  • 73
    • 5144233027 scopus 로고    scopus 로고
    • Evaluation of the potential immunotoxicity of 3-monochloro-1, 2-propanediol in Balb/c mice: I. Effect on antibody forming cell, mitogen-stimulated lymphocyte proliferation, splenic subset, and natural killer cell activity
    • Lee JK, Byun JA, Park SH, Kim HS, Park JH, Eom JH, Oh HY. 2004. Evaluation of the potential immunotoxicity of 3-monochloro-1, 2-propanediol in Balb/c mice: I. Effect on antibody forming cell, mitogen-stimulated lymphocyte proliferation, splenic subset, and natural killer cell activity. Toxicology 204:1-11.
    • (2004) Toxicology , vol.204 , pp. 1-11
    • Lee, J.K.1    Byun, J.A.2    Park, S.H.3    Kim, H.S.4    Park, J.H.5    Eom, J.H.6    Oh, H.Y.7
  • 74
    • 19944408331 scopus 로고    scopus 로고
    • Evaluation of the potential immunotoxicity of 3-monochloro-1, 2-propanediol in Balb/c mice: II. Effect on thymic subset, delayed-type hypersensitivity, mixed-lymphocyte reaction, and peritoneal macrophage activity
    • Lee JK, Byun JA, Park SH, Choi HJ, Kim HS, Oh HY. 2005a. Evaluation of the potential immunotoxicity of 3-monochloro-1, 2-propanediol in Balb/c mice: II. Effect on thymic subset, delayed-type hypersensitivity, mixed-lymphocyte reaction, and peritoneal macrophage activity. Toxicology 211:187-196.
    • (2005) Toxicology , vol.211 , pp. 187-196
    • Lee, J.K.1    Byun, J.A.2    Park, S.H.3    Choi, H.J.4    Kim, H.S.5    Oh, H.Y.6
  • 75
    • 17144388595 scopus 로고    scopus 로고
    • Immunotoxic effect of β-chlorolactic acid on murine splenocyte and peritoneal macrophage function in vitro
    • Lee JK, Ryu MH, Byun JA. 2005b. Immunotoxic effect of β-chlorolactic acid on murine splenocyte and peritoneal macrophage function in vitro. Toxicology 210:175-87.
    • (2005) Toxicology , vol.210 , pp. 175-187
    • Lee, J.K.1    Ryu, M.H.2    Byun, J.A.3
  • 76
    • 34247544970 scopus 로고    scopus 로고
    • Determination of 1,3-dichloro-2-propanol and 3-chloro-1,2-propandiol in soy sauce by headspace derivatization solid-phase microextraction combined with gas chromatography-mass spectrometry
    • Lee MR, Chiu TC, Dou J. 2007. Determination of 1, 3-dichloro-2-propanol and 3-chloro-1, 2-propandiol in soy sauce by headspace derivatization solid-phase microextraction combined with gas chromatography-mass spectrometry. Anal Chim Acta 591:167-72.
    • (2007) Anal Chim Acta , vol.591 , pp. 167-172
    • Lee, M.R.1    Chiu, T.C.2    Dou, J.3
  • 77
    • 84860208698 scopus 로고    scopus 로고
    • Moesin is a biomarker for the assessment of genotoxic carcinogens in mouse lymphoma
    • Lee Y, Choi I-K, Sheen Y, Park S, Kwon H. 2012. Moesin is a biomarker for the assessment of genotoxic carcinogens in mouse lymphoma. Mol Cells 33:203-10.
    • (2012) Mol Cells , vol.33 , pp. 203-210
    • Lee, Y.1    Choi, I.-K.2    Sheen, Y.3    Park, S.4    Kwon, H.5
  • 78
    • 41849097766 scopus 로고    scopus 로고
    • Determination of 3-MCPD by GC-MS/MS with PTV-LV injector used for a survey of Spanish foodstuffs
    • Leon N, Yusa V, Pardo O, Pastor A. 2008. Determination of 3-MCPD by GC-MS/MS with PTV-LV injector used for a survey of Spanish foodstuffs. Talanta 75:824-31.
    • (2008) Talanta , vol.75 , pp. 824-831
    • Leon, N.1    Yusa, V.2    Pardo, O.3    Pastor, A.4
  • 79
    • 0142075298 scopus 로고    scopus 로고
    • Molecular sensing of 3-chloro-1,2-propanediol by molecular imprinting
    • Leung MKP, Chiu BKW, Lam MHW. 2003. Molecular sensing of 3-chloro-1, 2-propanediol by molecular imprinting. Analytica Chimica Acta 491:15-25.
    • (2003) Analytica Chimica Acta , vol.491 , pp. 15-25
    • Leung, M.K.P.1    Chiu, B.K.W.2    Lam, M.H.W.3
  • 81
    • 77953752600 scopus 로고    scopus 로고
    • Novel biomarkers of 3-chloro-1,2-propanediol exposure by ultra-performance liquid chromatography/mass spectrometry based metabonomic analysis of rat urine
    • Li Y, Liu S, Wang C, Li K, Shan YJ, Wang XJ, Sun CH. 2010. Novel biomarkers of 3-chloro-1, 2-propanediol exposure by ultra-performance liquid chromatography/mass spectrometry based metabonomic analysis of rat urine. Chem Res Toxicol 23:1012-7.
    • (2010) Chem Res Toxicol , vol.23 , pp. 1012-1017
    • Li, Y.1    Liu, S.2    Wang, C.3    Li, K.4    Shan, Y.J.5    Wang, X.J.6    Sun, C.H.7
  • 82
    • 0029162369 scopus 로고
    • Industrial production of soy sauce
    • Luh BS. 1995. Industrial production of soy sauce. J Ind Microbiol 14:467-71.
    • (1995) J Ind Microbiol , vol.14 , pp. 467-471
    • Luh, B.S.1
  • 84
    • 0033638808 scopus 로고    scopus 로고
    • 3-monochloropropane-1, 2-diol (3-MCPD) in soy sauces and similar products available from retail outlets in the UK
    • Macarthur R, Crews C, Davies A, Brereton P, Hough P, Harvey D. 2000. 3-monochloropropane-1, 2-diol (3-MCPD) in soy sauces and similar products available from retail outlets in the UK. Food Addit Contam 17:903-6.
    • (2000) Food Addit Contam , vol.17 , pp. 903-906
    • Macarthur, R.1    Crews, C.2    Davies, A.3    Brereton, P.4    Hough, P.5    Harvey, D.6
  • 85
    • 84916227506 scopus 로고    scopus 로고
    • Survey of chloropropanols in soy sauce: imported food monitoring. Accessed 2014 May 5.
    • MAF. 2011. Survey of chloropropanols in soy sauce: imported food monitoring. Available from: http://www.foodsafety.govt.nz/elibrary/industry/soy-sauce-survey-report2011.pdf. Accessed 2014 May 5.
    • (2011)
  • 86
    • 0042467316 scopus 로고
    • Quantitative estimate of mutagenicity of tris-[1,3-dichloro-2 propyl]-phosphate (TCPP) and its possible metabolites in Salmonella
    • Majeska J, Matheson DW. 1983. Quantitative estimate of mutagenicity of tris-[1, 3-dichloro-2 propyl]-phosphate (TCPP) and its possible metabolites in Salmonella. Environ Mol Mutagen 5:478.
    • (1983) Environ Mol Mutagen , vol.5 , pp. 478
    • Majeska, J.1    Matheson, D.W.2
  • 87
    • 84916202701 scopus 로고    scopus 로고
    • 3-MCPD: induction of micronuclei in bone-marrow of treated rats. Unpublished Report Nr 1863/2-D5140, Covance Laboratories.
    • Marshall RM. 2000. 3-MCPD: induction of micronuclei in bone-marrow of treated rats. Unpublished Report Nr 1863/2-D5140, Covance Laboratories.
    • (2000)
    • Marshall, R.M.1
  • 89
    • 0033989787 scopus 로고    scopus 로고
    • Determination of halogenated mono-alcohols and diols in water by gas chromatography with electron-capture detection
    • Matthew BM, Anastasio C. 2000. Determination of halogenated mono-alcohols and diols in water by gas chromatography with electron-capture detection. J Chromatogr A 866:65-77.
    • (2000) J Chromatogr A , vol.866 , pp. 65-77
    • Matthew, B.M.1    Anastasio, C.2
  • 90
    • 84916239484 scopus 로고
    • In Vitro sister chromatid exchange assay in mammalian Cells. Unpublished report Nr. 91/4 CM, Fraunhofer- Institute für Toxicologie und Aerosolforschung, Hannover, Germany.
    • May C. 1991. In Vitro sister chromatid exchange assay in mammalian Cells. Unpublished report Nr. 91/4 CM, Fraunhofer- Institute für Toxicologie und Aerosolforschung, Hannover, Germany.
    • (1991)
    • May, C.1
  • 91
    • 0032503009 scopus 로고    scopus 로고
    • Sensitive method for the determination of 3-chloropropane-1,2-diol and 2-chloropropane-1,3-diol by capillary gas chromatography with mass spectrometric detection
    • Meierhans DC, Bruehlmann S, Meili J, Taeschler C. 1998. Sensitive method for the determination of 3-chloropropane-1, 2-diol and 2-chloropropane-1, 3-diol by capillary gas chromatography with mass spectrometric detection. J Chromatogr A 802:325-33.
    • (1998) J Chromatogr A , vol.802 , pp. 325-333
    • Meierhans, D.C.1    Bruehlmann, S.2    Meili, J.3    Taeschler, C.4
  • 92
    • 84916212774 scopus 로고    scopus 로고
    • Merck Milipore.. Liquid-liquid extraction. Accessed 2014 Sep 23.
    • Merck Milipore. 2014. Liquid-liquid extraction. Available from: http://www.emdmillipore.com/MY/en/products/analytics-sample-prep/chromatography-for-analysis/sample-preparation-for-chromatography/liquid-liquid-extraction/QpGb.qB._b0AAAE_Hg93.Lxj, nav?CategoryName=000000260002c8f800010023&CategoryDomainName=Merck-MerckMillipore#Benefits. Accessed 2014 Sep 23.
    • (2014)
  • 93
    • 34547852044 scopus 로고    scopus 로고
    • Energy metabolism and sperm function
    • Miki K. 2007. Energy metabolism and sperm function. Soc Reprod Fertil Suppl 65:309-25.
    • (2007) Soc Reprod Fertil Suppl , vol.65 , pp. 309-325
    • Miki, K.1
  • 94
    • 3242759921 scopus 로고    scopus 로고
    • Glycolysis plays a major role for adenosine triphosphate supplementation in mouse sperm flagellar movement
    • Mukai C, Okuno M. 2004. Glycolysis plays a major role for adenosine triphosphate supplementation in mouse sperm flagellar movement. Biol Reprod 71:540-7.
    • (2004) Biol Reprod , vol.71 , pp. 540-547
    • Mukai, C.1    Okuno, M.2
  • 95
    • 84916212097 scopus 로고    scopus 로고
    • Acid hydrolyzed vegetable protein seasoning. SB10338-2000, File Nr. 7296-2000. Accessed 2014 May 5.
    • National Standard of the People's Republic of China. 2000. Acid hydrolyzed vegetable protein seasoning. SB10338-2000, File Nr. 7296-2000. Available from: http://down.gb99.cn:8080/gb1309/sb/20040514_sb10338-2000.rar. Accessed 2014 May 5.
    • (2000)
  • 97
    • 84916207940 scopus 로고    scopus 로고
    • 1,3-dichloro-2-propanol [CAS no. 96-23-1]: review of toxicological literature. National Toxicology Program, Research Triangle Park, NC.
    • NTP. 2005. 1, 3-dichloro-2-propanol [CAS no. 96-23-1]: review of toxicological literature. National Toxicology Program, Research Triangle Park, NC.
    • (2005)
  • 98
    • 0242574924 scopus 로고    scopus 로고
    • Survey of chloropropanols in soy sauces and related products
    • Nyman PJ, Diachenko GW, Perfetti GA. 2003. Survey of chloropropanols in soy sauces and related products. Food Addit Contam 20:909-15.
    • (2003) Food Addit Contam , vol.20 , pp. 909-915
    • Nyman, P.J.1    Diachenko, G.W.2    Perfetti, G.A.3
  • 99
    • 84916242755 scopus 로고    scopus 로고
    • Test no. 451: carcinogenicity studies Accessed 2014 May 5.
    • OECD. 2008. Test no. 451: carcinogenicity studies. Available from: http://www.oecd.org/chemicalsafety/testing/41753121.pdf. Accessed 2014 May 5.
    • (2008)
  • 100
    • 84916240872 scopus 로고    scopus 로고
    • Guidance document 116 on the conduct and design of chronic toxicity and carcinogenicity studies, supporting test guidelines 451, 452, and 453 (2nd ed.)Accessed 2014 May 5.
    • OECD. 2012. Guidance document 116 on the conduct and design of chronic toxicity and carcinogenicity studies, supporting test guidelines 451, 452, and 453 (2nd ed.). Available from: http://search.oecd.org/officialdocuments/displaydocumentpdf/?cote=ENV/JM/MONO(2011)47&doclanguage=en. Accessed 2014 May 5.
    • (2012)
  • 101
    • 84916233201 scopus 로고    scopus 로고
    • 3-monochloropropane-1,2-diol (3-MCPD; α-chlorohydrin). California Environmental Protection Agency Accessed 2014 May 5.
    • OEHHA. 2010a. 3-monochloropropane-1, 2-diol (3-MCPD; α-chlorohydrin). California Environmental Protection Agency. Available from: http://www.oehha.ca.gov/Prop65/hazard_ident/pdf_zip/123mcpd.pdf. Accessed 2014 May 5.
    • (2010)
  • 102
    • 84916241804 scopus 로고    scopus 로고
    • 1,3-dichloro-2-propanol (1,3-DCP; α, gamma;-dichlorohydrin). California Environmental Protection Agency. Accessed 2014 Sep 18.
    • OEHHA. 2010b. 1, 3-dichloro-2-propanol (1, 3-DCP; α, γ-dichlorohydrin). California Environmental Protection Agency. Available from: http://www.oehha.ca.gov/Prop65/hazard_ident/pdf_zip/13dcp.pdf. Accessed 2014 Sep 18.
    • (2010)
  • 104
    • 0020063241 scopus 로고
    • The Hela DNA-synthesis inhibition test as a rapid screen for mutagenic carcinogens
    • Painter RB, Howard R. 1982. The Hela DNA-synthesis inhibition test as a rapid screen for mutagenic carcinogens. Mutat Res 92:427-37.
    • (1982) Mutat Res , vol.92 , pp. 427-437
    • Painter, R.B.1    Howard, R.2
  • 105
    • 79958858656 scopus 로고    scopus 로고
    • State of the art manufacturing of protein hydrolysates
    • In: Pasupuleti VK, Demain AL, editors.. New York: Springer.
    • Pasupuleti VK, Braun S. 2010. State of the art manufacturing of protein hydrolysates. In: Pasupuleti VK, Demain AL, editors. Protein hydrolysates in biotechnology. New York: Springer. p 11-32.
    • (2010) Protein hydrolysates in biotechnology , pp. 11-32
    • Pasupuleti, V.K.1    Braun, S.2
  • 106
    • 0024292607 scopus 로고
    • Determination of residue epichlohydrin and 3-chloropropanediol in water by gas chromatography with electron capture detection
    • Pesselman RL, Feit MJ. 1988. Determination of residue epichlohydrin and 3-chloropropanediol in water by gas chromatography with electron capture detection. J Chromatogr 439:448-52.
    • (1988) J Chromatogr , vol.439 , pp. 448-452
    • Pesselman, R.L.1    Feit, M.J.2
  • 107
    • 0025120563 scopus 로고
    • Malignant transformation of mouse M2-fibroblasts by glycerol chlorohydrines contained in protein hydrolysates and commercial food
    • Piasecki A, Ruge A, Marquardt H. 1990. Malignant transformation of mouse M2-fibroblasts by glycerol chlorohydrines contained in protein hydrolysates and commercial food. Arzneimittel-Forsch 40:1054-5.
    • (1990) Arzneimittel-Forsch , vol.40 , pp. 1054-1055
    • Piasecki, A.1    Ruge, A.2    Marquardt, H.3
  • 108
    • 0025738021 scopus 로고
    • Determination of 3-chloropropane-1,2-diol in liquid hydrolyzed vegetable proteins by capillary gas chromatography with flame ionization detection
    • Plantinga WJ, Van Toorn WG, Stegen GHD. 1991. Determination of 3-chloropropane-1, 2-diol in liquid hydrolyzed vegetable proteins by capillary gas chromatography with flame ionization detection. J Chromatogr A 555:311-4.
    • (1991) J Chromatogr A , vol.555 , pp. 311-314
    • Plantinga, W.J.1    Van Toorn, W.G.2    Stegen, G.H.D.3
  • 109
    • 80052314293 scopus 로고    scopus 로고
    • Determination of chloropropanols in foods by one-step extraction and derivatization using pressurized liquid extraction and gas chromatography-mass spectrometry
    • Racamonde I, Gonzalez P, Lorenzo RA, Carro AM. 2011. Determination of chloropropanols in foods by one-step extraction and derivatization using pressurized liquid extraction and gas chromatography-mass spectrometry. J Chromatogr A 1218:6878-83.
    • (2011) J Chromatogr A , vol.1218 , pp. 6878-6883
    • Racamonde, I.1    Gonzalez, P.2    Lorenzo, R.A.3    Carro, A.M.4
  • 110
    • 84916206936 scopus 로고    scopus 로고
    • FSA Project: C03017, 18, 19. Accessed 2014 May 5.
    • Reece P. 2005. The origin and formation of 3-MCPD in foods and food ingredients. FSA Project: C03017, 18, 19. Available from: http://www.foodbase.org.uk//admintools/reportdocuments/43_84_FINAL_REPORT.pdf. Accessed 2014 May 5.
    • (2005)
    • Reece, P.1
  • 111
    • 79957667183 scopus 로고    scopus 로고
    • Changes in food flavor due to processing
    • 2nd ed. Boca Raton, Fla.: CRC Press.
    • Reineccius M. 2006. Changes in food flavor due to processing. In: Flavor chemistry and technology. 2nd ed. Boca Raton, Fla.: CRC Press. p 261-94.
    • (2006) Flavor chemistry and technology , pp. 261-294
    • Reineccius, M.1
  • 112
    • 31344470660 scopus 로고    scopus 로고
    • -1 level: application to a wide range of foods
    • -1 level: application to a wide range of foods. Food Addit Contam 22:1189-97.
    • (2005) Food Addit Contam , vol.22 , pp. 1189-1197
    • Rétho, C.1    Blanchard, F.2
  • 113
    • 3843146380 scopus 로고    scopus 로고
    • Model studies on the formation of monochloropropanediols in the presence of lipase
    • Robert MC, Oberson JM, Stadler RH. 2004. Model studies on the formation of monochloropropanediols in the presence of lipase. J Agric Food Chem 52:5102-8.
    • (2004) J Agric Food Chem , vol.52 , pp. 5102-5108
    • Robert, M.C.1    Oberson, J.M.2    Stadler, R.H.3
  • 114
    • 0023044335 scopus 로고
    • Gas-liquid chromatography of 3-chloropropanediol
    • Rodman LE, Ross RD. 1986. Gas-liquid chromatography of 3-chloropropanediol. J Chromatogr A 369:97-103.
    • (1986) J Chromatogr A , vol.369 , pp. 97-103
    • Rodman, L.E.1    Ross, R.D.2
  • 116
    • 84916222350 scopus 로고    scopus 로고
    • Safety evaluation of certain additives and contaminants, 3-chloro-1,2-propanediol. In: WHO food additives series 48, 57th meeting of the joint FAO/WHO, Rome.
    • Schlatter J, Baars AJ, DiNovi M, Lawrie S, Lorentzen R. 2002. Safety evaluation of certain additives and contaminants, 3-chloro-1, 2-propanediol. In: WHO food additives series 48, 57th meeting of the joint FAO/WHO, Rome.
    • (2002)
    • Schlatter, J.1    Baars, A.J.2    DiNovi, M.3    Lawrie, S.4    Lorentzen, R.5
  • 117
    • 84916225980 scopus 로고    scopus 로고
    • 22 Sauces withdrawn: foreign products found to contain excessive cancer-causing chemical. The New Straits Times, Malaysia. Available from: http://www.aboutsafety.com/article.cfm?id=1061. Accessed 2014 May 5.
    • Sennyah P. 2001. 22 Sauces withdrawn: foreign products found to contain excessive cancer-causing chemical. The New Straits Times, Malaysia. Available from: http://www.aboutsafety.com/article.cfm?id=1061. Accessed 2014 May 5.
    • (2001)
    • Sennyah, P.1
  • 118
    • 0020041638 scopus 로고
    • Mutagenicity of glycerol chlorohydrines and of their esters with higher fatty acids present in protein hydrolysates
    • Silhankova L, Smid F, Cerna M, Davidek J, Velisek J. 1982. Mutagenicity of glycerol chlorohydrines and of their esters with higher fatty acids present in protein hydrolysates. Mutat Res 103:77-81.
    • (1982) Mutat Res , vol.103 , pp. 77-81
    • Silhankova, L.1    Smid, F.2    Cerna, M.3    Davidek, J.4    Velisek, J.5
  • 119
    • 33644661050 scopus 로고    scopus 로고
    • The diagnostic role of urinary N-acetyl-beta-D-glucosaminidase (NAG) activity in the detection of renal tubular impairment
    • Skalova S. 2005. The diagnostic role of urinary N-acetyl-beta-D-glucosaminidase (NAG) activity in the detection of renal tubular impairment. Acta Med (Hradec Kralove) 48:75-80.
    • (2005) Acta Med (Hradec Kralove) , vol.48 , pp. 75-80
    • Skalova, S.1
  • 120
    • 0027322011 scopus 로고
    • Determination of 3-chloropropane-1, 2-diol in hydrolysed vegetable proteins by capillary gas chromatography with electrolytic conductivity detection
    • Spyres G. 1993. Determination of 3-chloropropane-1, 2-diol in hydrolysed vegetable proteins by capillary gas chromatography with electrolytic conductivity detection. J Chromatogr A 638:71-4.
    • (1993) J Chromatogr A , vol.638 , pp. 71-74
    • Spyres, G.1
  • 121
    • 0021323831 scopus 로고
    • The action of (R)-and (S)-α-chlorohydrin and their metabolites on the metabolism of boar sperm
    • Stevenson D, Jones A. 1984. The action of (R)-and (S)-α-chlorohydrin and their metabolites on the metabolism of boar sperm. Int J Androl 7:79-86.
    • (1984) Int J Androl , vol.7 , pp. 79-86
    • Stevenson, D.1    Jones, A.2
  • 122
    • 0018729397 scopus 로고
    • Mutagenicity of halogenated and oxygenated three-carbon compounds
    • Stolzenberg SJ, Hine CH. 1979. Mutagenicity of halogenated and oxygenated three-carbon compounds. J Toxicol Env Health 5:1149-58.
    • (1979) J Toxicol Env Health , vol.5 , pp. 1149-1158
    • Stolzenberg, S.J.1    Hine, C.H.2
  • 123
    • 0019278925 scopus 로고
    • Mutagenicity of 2- and 3-carbon halogenated compounds in the Salmonella/mammalian-microsome test
    • Stolzenberg SJ, Hine CH. 1980. Mutagenicity of 2- and 3-carbon halogenated compounds in the Salmonella/mammalian-microsome test. Environ Mol Mutagen 2:59-66.
    • (1980) Environ Mol Mutagen , vol.2 , pp. 59-66
    • Stolzenberg, S.J.1    Hine, C.H.2
  • 124
    • 84886882313 scopus 로고    scopus 로고
    • Toxic mechanisms of 3-monochloropropane-1,2-diol on progesterone production in R2C rat Leydig cells
    • Sun J, Bai S, Bai W, Zou F, Zhang L, Su Z, Zhang Q, Ou S, Huang Y. 2013. Toxic mechanisms of 3-monochloropropane-1, 2-diol on progesterone production in R2C rat Leydig cells. J Agr Food Chem 61:9955-60.
    • (2013) J Agr Food Chem , vol.61 , pp. 9955-9960
    • Sun, J.1    Bai, S.2    Bai, W.3    Zou, F.4    Zhang, L.5    Su, Z.6    Zhang, Q.7    Ou, S.8    Huang, Y.9
  • 125
    • 84916198674 scopus 로고
    • Carcinogenicity study on 3-monochloro propane-1, 2-diol (3-MCPD) administered in drinking water to Fischer 344 rats. Report Nr. RE-SR93003 submitted to WHO by Nestec Ltd., Research & Development, Switzerland.
    • Sunahara G, Perrin I, Marchessini M. 1993. Carcinogenicity study on 3-monochloro propane-1, 2-diol (3-MCPD) administered in drinking water to Fischer 344 rats. Report Nr. RE-SR93003 submitted to WHO by Nestec Ltd., Research & Development, Switzerland.
    • (1993)
    • Sunahara, G.1    Perrin, I.2    Marchessini, M.3
  • 126
    • 84916210434 scopus 로고    scopus 로고
    • Global trade dispute brewing over soy sauce. The Taipei Times, Taiwan. Accessed 2014 May 5.
    • Tokyo AP. 2004. Global trade dispute brewing over soy sauce. The Taipei Times, Taiwan. Available from: http://www.taipeitimes.com/News/worldbiz/archives/2004/09/27/2003204609. Accessed 2014 May 5.
    • (2004)
    • Tokyo, A.P.1
  • 128
    • 0000098355 scopus 로고
    • Degradation of epichlorohydrin and halohydrins by bacterial cultures isolated from freshwater sediment
    • Van Den Wijngaard AJ, Janssen DB, Witholt B. 1989. Degradation of epichlorohydrin and halohydrins by bacterial cultures isolated from freshwater sediment. J Gen Microbiol 135:2199-208.
    • (1989) J Gen Microbiol , vol.135 , pp. 2199-2208
    • Van Den Wijngaard, A.J.1    Janssen, D.B.2    Witholt, B.3
  • 131
    • 32744476889 scopus 로고    scopus 로고
    • 3-chloropropane-1,2-diol in models simulating processed foods: precursors and agents causing its decomposition
    • Velisek J, Calta P, Crews C, Hasnip S, Dolezal M. 2003. 3-chloropropane-1, 2-diol in models simulating processed foods: precursors and agents causing its decomposition. Czech J Food Sci 21:153-61.
    • (2003) Czech J Food Sci , vol.21 , pp. 153-161
    • Velisek, J.1    Calta, P.2    Crews, C.3    Hasnip, S.4    Dolezal, M.5
  • 132
    • 84916242703 scopus 로고    scopus 로고
    • A survey of chloropropanols (3-MCPD and 1,3-DCP) in soy sauces and similar products from Brazil
    • Vicente E, Arisseto AP, Monteiro V, Furlani RPZ, Toledo MCF. 2011. A survey of chloropropanols (3-MCPD and 1, 3-DCP) in soy sauces and similar products from Brazil. Toxicol Lett 205:S145-6.
    • (2011) Toxicol Lett , vol.205 , pp. S145-S146
    • Vicente, E.1    Arisseto, A.P.2    Monteiro, V.3    Furlani, R.P.Z.4    Toledo, M.C.F.5
  • 134
    • 77953593985 scopus 로고    scopus 로고
    • Fatty acid ester of glycidol in refined fats and oil
    • Weisshaar R, Perz R. 2010. Fatty acid ester of glycidol in refined fats and oil. Eur J Lipid Sci Technol 112:158-65.
    • (2010) Eur J Lipid Sci Technol , vol.112 , pp. 158-165
    • Weisshaar, R.1    Perz, R.2
  • 135
    • 27844547637 scopus 로고    scopus 로고
    • 3-Monochloropropane-1,2-diol (3-MCPD) in soy and oyster sauces: occurrence and dietary intake assessment
    • Wong KO, Cheong YH, Seah HL. 2006. 3-Monochloropropane-1, 2-diol (3-MCPD) in soy and oyster sauces: occurrence and dietary intake assessment. Food Control 17:408-13.
    • (2006) Food Control , vol.17 , pp. 408-413
    • Wong, K.O.1    Cheong, Y.H.2    Seah, H.L.3
  • 136
    • 84916241250 scopus 로고    scopus 로고
    • Committee on sanitary and phytosanitary measures. Report G/SPS/GEN/204/Rev.2.
    • WTO. 2002. Committee on sanitary and phytosanitary measures. Report G/SPS/GEN/204/Rev.2.
    • (2002)
  • 137
    • 33746255969 scopus 로고    scopus 로고
    • Determination of 3-chloro-1,2-propanediol in soy sauces by capillary electrophoresis with electrochemical detection
    • Xing X, Cao Y. 2007. Determination of 3-chloro-1, 2-propanediol in soy sauces by capillary electrophoresis with electrochemical detection. Food Control 18:167-72.
    • (2007) Food Control , vol.18 , pp. 167-172
    • Xing, X.1    Cao, Y.2
  • 138
    • 84872326122 scopus 로고    scopus 로고
    • Properties and biotechnological applications of halohydrin dehalogenase: current state and future perspectives
    • You ZH, Liu ZQ, Zheng YG. 2013. Properties and biotechnological applications of halohydrin dehalogenase: current state and future perspectives. Appl Microbial Biotechnol 97:9-21
    • (2013) Appl Microbial Biotechnol , vol.97 , pp. 9-21
    • You, Z.H.1    Liu, Z.Q.2    Zheng, Y.G.3
  • 140
    • 84865189098 scopus 로고    scopus 로고
    • (S)-α-chlorohydrin inhibits protein tyrosine phosphorylation through blocking cyclic AMP - protein kinase A pathway in spermatozoa
    • Zhang H, Yu H, Wang X, Zheng W, Yang B, Pi J, He G, Qu W. 2012. (S)-α-chlorohydrin inhibits protein tyrosine phosphorylation through blocking cyclic AMP - protein kinase A pathway in spermatozoa. PLoS One 7:e43004.
    • (2012) PLoS One , vol.7 , pp. e43004
    • Zhang, H.1    Yu, H.2    Wang, X.3    Zheng, W.4    Yang, B.5    Pi, J.6    He, G.7    Qu, W.8


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