메뉴 건너뛰기




Volumn 61, Issue 41, 2013, Pages 9955-9960

Toxic mechanisms of 3-monochloropropane-1,2-diol on progesterone production in R2C rat Leydig cells

Author keywords

3 MCPD; cAMP; early apoptosis; mitochondrial membrane potential; progesterone; R2C cells

Indexed keywords

3-MCPD; CAMP; CONCENTRATION-DEPENDENT; HYDROXYSTEROID DEHYDROGENASE; MITOCHONDRIAL MEMBRANE POTENTIAL; PROGESTERONE; REPRODUCTIVE FUNCTION; STEROIDOGENIC ACUTE REGULATORY PROTEINS;

EID: 84886882313     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/jf400809r     Document Type: Article
Times cited : (30)

References (40)
  • 3
    • 85115358605 scopus 로고    scopus 로고
    • Chloropropanols and their esters in cereal products
    • Hamlet, C. G.; Sadd, P. A. Chloropropanols and their esters in cereal products Czech J. Food Sci. 2004, 22, 259-262
    • (2004) Czech J. Food Sci. , vol.22 , pp. 259-262
    • Hamlet, C.G.1    Sadd, P.A.2
  • 5
    • 0035055455 scopus 로고    scopus 로고
    • The effects of domestic cooking on the levels of 3-monochloropropanediol in foods
    • Crews, C.; Brereton, P.; Davies, A. The effects of domestic cooking on the levels of 3-monochloropropanediol in foods Food Addit. Contam. 2001, 18, 271-280
    • (2001) Food Addit. Contam. , vol.18 , pp. 271-280
    • Crews, C.1    Brereton, P.2    Davies, A.3
  • 6
    • 0036325264 scopus 로고    scopus 로고
    • Occurrence of 3-chloro-propane-1,2-diol (3-MCPD) and related compounds in foods: A review
    • Hamlet, C. G.; Sadd, P. A.; Crews, C.; Velišek, J.; Baxter, D. E. Occurrence of 3-chloro-propane-1,2-diol (3-MCPD) and related compounds in foods: a review Food Addit. Contam. 2002, 19, 619-631
    • (2002) Food Addit. Contam. , vol.19 , pp. 619-631
    • Hamlet, C.G.1    Sadd, P.A.2    Crews, C.3    Velišek, J.4    Baxter, D.E.5
  • 8
    • 0016805633 scopus 로고
    • The entry of α-chlorohydrin into body fluids of male rats and its effect upon incorporation of glycerol into lipids
    • Edwards, E. N.; Jones, A. R.; Waites, G. M. H. The entry of α-chlorohydrin into body fluids of male rats and its effect upon incorporation of glycerol into lipids J. Reprod. Fertil. 1975, 43, 225-232
    • (1975) J. Reprod. Fertil. , vol.43 , pp. 225-232
    • Edwards, E.N.1    Jones, A.R.2    Waites, G.M.H.3
  • 9
    • 77953752600 scopus 로고    scopus 로고
    • Novel biomarkers of 3-chloro-1,2-propanediol exposure by ultra performance liquid chromatography/mass spectrometry based metabonomic analysis of rat urine
    • Li, Y.; Liu, S.; Wang, C.; Li, K.; Shan, Y.-J.; Wang, X.-J.; Sun, C.-H. Novel biomarkers of 3-chloro-1,2-propanediol exposure by ultra performance liquid chromatography/mass spectrometry based metabonomic analysis of rat urine Chem. Res. Toxicol. 2010, 23, 1012-1017
    • (2010) Chem. Res. Toxicol. , vol.23 , pp. 1012-1017
    • Li, Y.1    Liu, S.2    Wang, C.3    Li, K.4    Shan, Y.-J.5    Wang, X.-J.6    Sun, C.-H.7
  • 10
    • 34547310548 scopus 로고    scopus 로고
    • Setting maximum levels for certain contaminants in foodstuffs
    • EC
    • EC Setting maximum levels for certain contaminants in foodstuffs Off. J. Eur. Communities 2001, 5-24
    • (2001) Off. J. Eur. Communities , pp. 5-24
  • 11
    • 54549105470 scopus 로고    scopus 로고
    • 3-MCPD-esters in edible fats and oils-A new and worldwide problem
    • Weißhaar, R. 3-MCPD-esters in edible fats and oils-A new and worldwide problem Eur. J. Lipid Sci. Technol. 2008, 110, 671-672
    • (2008) Eur. J. Lipid Sci. Technol. , vol.110 , pp. 671-672
    • Weißhaar, R.1
  • 12
    • 79952609936 scopus 로고    scopus 로고
    • Fatty acid esters of chloropropanols and related com-pounds in food: Toxicological aspects
    • Schilter, B.; Scholz, G.; Seefelder, W. Fatty acid esters of chloropropanols and related com-pounds in food: Toxicological aspects Eur. J. Lipid Sci. Technol. 2011, 113, 309-313
    • (2011) Eur. J. Lipid Sci. Technol. , vol.113 , pp. 309-313
    • Schilter, B.1    Scholz, G.2    Seefelder, W.3
  • 13
    • 79957996832 scopus 로고    scopus 로고
    • Simultaneous determination and differentiation of glycidyl esters and 3-monochloropropane-1,2-diol (MCPD) esters in different foodstuffs by GC-MS
    • Küsters, M.; Bimber, U.; Reeser, S.; Gallitzendörfer, R.; Gerhartz, M. Simultaneous determination and differentiation of glycidyl esters and 3-monochloropropane-1,2-diol (MCPD) esters in different foodstuffs by GC-MS J. Agric. Food Chem. 2011, 59, 6263-6270
    • (2011) J. Agric. Food Chem. , vol.59 , pp. 6263-6270
    • Küsters, M.1    Bimber, U.2    Reeser, S.3    Gallitzendörfer, R.4    Gerhartz, M.5
  • 14
    • 77953142518 scopus 로고    scopus 로고
    • Rapid and simple micromethod for the simultaneous determination of 3-MCPD and 3-MCPD esters in different foodstuffs
    • Küsters, M.; Bimber, U.; Ossenbrüggen, A.; Reeser, S.; Gallitzendörfer, R.; Gerhartz, M. Rapid and simple micromethod for the simultaneous determination of 3-MCPD and 3-MCPD esters in different foodstuffs J. Agric. Food Chem. 2010, 58, 6570-6577
    • (2010) J. Agric. Food Chem. , vol.58 , pp. 6570-6577
    • Küsters, M.1    Bimber, U.2    Ossenbrüggen, A.3    Reeser, S.4    Gallitzendörfer, R.5    Gerhartz, M.6
  • 15
    • 79952612785 scopus 로고    scopus 로고
    • Formation and occurrence of esters of 3-chloropropane-1,2-diol (3-CPD) in foods: What we know and what we assume
    • Hamlet, C. G.; Asuncion, L.; Velíšek, J.; Doležal, M.; Zelinková, Z.; Crews, C. Formation and occurrence of esters of 3-chloropropane-1,2-diol (3-CPD) in foods: What we know and what we assume Eur. J. Lipid Sci. Technol. 2011, 113, 279-303
    • (2011) Eur. J. Lipid Sci. Technol. , vol.113 , pp. 279-303
    • Hamlet, C.G.1    Asuncion, L.2    Velíšek, J.3    Doležal, M.4    Zelinková, Z.5    Crews, C.6
  • 16
    • 0015296962 scopus 로고
    • Reversible infertility in male swine fed α-chlorohydrin
    • Johnson, L. A.; Pursel, V. G. Reversible infertility in male swine fed α-chlorohydrin J. Anim. Sci. 1972, 34, 241-244
    • (1972) J. Anim. Sci. , vol.34 , pp. 241-244
    • Johnson, L.A.1    Pursel, V.G.2
  • 18
    • 0022591877 scopus 로고
    • Non-steroidal interference with male fertility
    • Vickery, B. H. Non-steroidal interference with male fertility Adv. Contracept. 1986, 2, 1-30
    • (1986) Adv. Contracept. , vol.2 , pp. 1-30
    • Vickery, B.H.1
  • 19
    • 84865189098 scopus 로고    scopus 로고
    • (S)- α-chlorohydrin inhibits protein tyrosine phosphorylation through blocking cyclic AMP - Protein kinase A pathway in spermatozoa
    • Zhang, H.; Yu, H.; Wang, X.; Zheng, W.; Yang, B.; Pi, J.; He, G.; Qu, W. (S)- α-chlorohydrin inhibits protein tyrosine phosphorylation through blocking cyclic AMP-protein kinase A pathway in spermatozoa PLoS One 2012, 7, e43004
    • (2012) PLoS One , vol.7 , pp. 43004
    • Zhang, H.1    Yu, H.2    Wang, X.3    Zheng, W.4    Yang, B.5    Pi, J.6    He, G.7    Qu, W.8
  • 20
    • 84870908972 scopus 로고    scopus 로고
    • Comparison between 3-MCPD and its palmitic esters in a 90-day toxicological study
    • Barocelli, E.; Corradi, A.; Mutti, A.; Petronini, P. G. Comparison between 3-MCPD and its palmitic esters in a 90-day toxicological study EFSA 2011, 1-131
    • (2011) EFSA , pp. 1-131
    • Barocelli, E.1    Corradi, A.2    Mutti, A.3    Petronini, P.G.4
  • 22
    • 33749585599 scopus 로고    scopus 로고
    • The steroid hormone biosynthesis pathway as a target for endocrine-disrupting chemicals
    • Sanderson, J. T. The steroid hormone biosynthesis pathway as a target for endocrine-disrupting chemicals Toxicol. Sci. 2006, 94, 3-21
    • (2006) Toxicol. Sci. , vol.94 , pp. 3-21
    • Sanderson, J.T.1
  • 23
    • 79961028123 scopus 로고    scopus 로고
    • Effect of 2,2′,4,4′-tetrahydroxybenzophenone (BP2) on steroidogenesis in testicular Leydig cells
    • Kim, Y.; Ryu, J. C.; Choi, H. S.; Lee, K. Effect of 2,2′,4, 4′-tetrahydroxybenzophenone (BP2) on steroidogenesis in testicular Leydig cells Toxicology 2011, 288, 18-26
    • (2011) Toxicology , vol.288 , pp. 18-26
    • Kim, Y.1    Ryu, J.C.2    Choi, H.S.3    Lee, K.4
  • 24
    • 9444242160 scopus 로고    scopus 로고
    • Regulation of steroidogenesis and steroidogenic acute regulatory protein in R2C cells by DAX-1 (dosage-sensitive sex reversal, adrenal hypoplasia congenita, critical region on the X chromosome, gene-1)
    • Jo, Y.; Stocco, D. M. Regulation of steroidogenesis and steroidogenic acute regulatory protein in R2C cells by DAX-1 (dosage-sensitive sex reversal, adrenal hypoplasia congenita, critical region on the X chromosome, gene-1) Endocrinology 2004, 145, 5629-5637
    • (2004) Endocrinology , vol.145 , pp. 5629-5637
    • Jo, Y.1    Stocco, D.M.2
  • 25
    • 0028230014 scopus 로고
    • Inhibitory action of peritoneal macrophages on progesterone secretion from co-cultured rat gran-ulosa cells
    • Shakil, T.; Whitehead, S. A. Inhibitory action of peritoneal macrophages on progesterone secretion from co-cultured rat gran-ulosa cells Biol. Reprod. 1994, 50, 1183-1189
    • (1994) Biol. Reprod. , vol.50 , pp. 1183-1189
    • Shakil, T.1    Whitehead, S.A.2
  • 26
    • 65749107985 scopus 로고    scopus 로고
    • Artesunate induced morphological and mechanical changes of Jurkat cell studied by AFM
    • Cai, X.; Gao, S.; Cai, J.; Wu, Y.; Deng, H. Artesunate induced morphological and mechanical changes of Jurkat cell studied by AFM Scanning 2009, 31, 83-89
    • (2009) Scanning , vol.31 , pp. 83-89
    • Cai, X.1    Gao, S.2    Cai, J.3    Wu, Y.4    Deng, H.5
  • 28
    • 34247143380 scopus 로고    scopus 로고
    • Phthalate ester toxicity in Leydig cells: Developmental timing and dosage considerations
    • Ge, R.-S.; Chen, G.-R.; Tanrikut, C.; Hardy, M.-P. Phthalate ester toxicity in Leydig cells: Developmental timing and dosage considerations Reprod. Toxicol. 2007, 23, 366-373
    • (2007) Reprod. Toxicol. , vol.23 , pp. 366-373
    • Ge, R.-S.1    Chen, G.-R.2    Tanrikut, C.3    Hardy, M.-P.4
  • 30
    • 79960697168 scopus 로고    scopus 로고
    • Dihydrolipoamide dehydrogenase and cAMP are associated with cadmium-mediated Leydig cell damage
    • Zhang, Q.; Zou, P.; Zhan, H.; Zhang, M.; Zhang, L.; Ge, R.-S.; Huang, Y.-D. Dihydrolipoamide dehydrogenase and cAMP are associated with cadmium-mediated Leydig cell damage Toxicol. Lett. 2011, 205, 183-189
    • (2011) Toxicol. Lett. , vol.205 , pp. 183-189
    • Zhang, Q.1    Zou, P.2    Zhan, H.3    Zhang, M.4    Zhang, L.5    Ge, R.-S.6    Huang, Y.-D.7
  • 31
    • 34247586570 scopus 로고    scopus 로고
    • A bioluminescent-based, HTS-compatible assay to monitor G-protein-coupled receptor modulation of cellular cyclic AMP
    • Kumar, M.; Hsiao, K.; Vidugiriene, J.; Goueli, S. A. A bioluminescent-based, HTS-compatible assay to monitor G-protein-coupled receptor modulation of cellular cyclic AMP Assay Drug Dev. Technol. 2007, 5, 237-246
    • (2007) Assay Drug Dev. Technol. , vol.5 , pp. 237-246
    • Kumar, M.1    Hsiao, K.2    Vidugiriene, J.3    Goueli, S.A.4
  • 33
    • 0032980459 scopus 로고    scopus 로고
    • A re-appraisal of the post-testicular action and toxicity of chlorinated antifertility compounds
    • Jones, A. R.; Cooper, T. G. A re-appraisal of the post-testicular action and toxicity of chlorinated antifertility compounds Int. J. Androl. 1999, 22, 130-138
    • (1999) Int. J. Androl. , vol.22 , pp. 130-138
    • Jones, A.R.1    Cooper, T.G.2
  • 34
    • 0035672719 scopus 로고    scopus 로고
    • Steroidogenic acute regulatory protein: An update on its regulation and mechanism of action
    • Christenson, L. K.; Strauss, J. F., III Steroidogenic acute regulatory protein: An update on its regulation and mechanism of action Arch. Med. Res. 2001, 32, 576-586
    • (2001) Arch. Med. Res. , vol.32 , pp. 576-586
    • Christenson, L.K.1    Strauss III, J.F.2
  • 36
    • 84859520018 scopus 로고    scopus 로고
    • Assessment of DNA damage caused by locally produced hydroxyapatite-silica nanocomposite using Comet assay on human lung fibroblast cell line
    • Musa, M.; Kannan, T. P.; Ab Rahman, I. Assessment of DNA damage caused by locally produced hydroxyapatite-silica nanocomposite using Comet assay on human lung fibroblast cell line Mol. Cell. Toxicol. 2012, 8, 53-60
    • (2012) Mol. Cell. Toxicol. , vol.8 , pp. 53-60
    • Musa, M.1    Kannan, T.P.2    Ab Rahman, I.3
  • 37
    • 0031792920 scopus 로고    scopus 로고
    • Reactive oxygen species and oxidative DNA damage
    • Hemnani, T.; Parihar, M. S. Reactive oxygen species and oxidative DNA damage Indian J. Physiol. Pharmacol. 1998, 42, 440-452
    • (1998) Indian J. Physiol. Pharmacol. , vol.42 , pp. 440-452
    • Hemnani, T.1    Parihar, M.S.2
  • 38
    • 0037661090 scopus 로고    scopus 로고
    • Reactive oxygen disrupts mitochondria in MA-10 tumor Leydig Cells and inhibits steroidogenic acute regulatory (StAR) protein and steroidogenesis
    • Diemer, T.; Allen, J. A.; Hales, K. H.; Hales, D. B. Reactive oxygen disrupts mitochondria in MA-10 tumor Leydig Cells and inhibits steroidogenic acute regulatory (StAR) protein and steroidogenesis Endocrinology 2003, 144, 2882-28914
    • (2003) Endocrinology , vol.144 , pp. 2882-28914
    • Diemer, T.1    Allen, J.A.2    Hales, K.H.3    Hales, D.B.4
  • 39
    • 33751358979 scopus 로고    scopus 로고
    • Evaluation of the genotoxic potential of 3-monochloropropane-1,2-diol (3-MCPD) and its metabolites, glycidol and β-chlorolactic acid, using the single cell gel/comet assay
    • El Ramy, R.; Ould Elhkim, M.; Lezmi, S.; Poul, J. M. Evaluation of the genotoxic potential of 3-monochloropropane-1,2-diol (3-MCPD) and its metabolites, glycidol and β-chlorolactic acid, using the single cell gel/comet assay Food Chem. Toxicol. 2007, 45, 41-48
    • (2007) Food Chem. Toxicol. , vol.45 , pp. 41-48
    • El Ramy, R.1    Ould Elhkim, M.2    Lezmi, S.3    Poul, J.M.4
  • 40
    • 33747884339 scopus 로고    scopus 로고
    • DNA damage-induced cell death by apoptosis
    • Wynand, P. R.; Bernd, K. DNA damage-induced cell death by apoptosis Trends Mol. Med. 2006, 12, 440-450
    • (2006) Trends Mol. Med. , vol.12 , pp. 440-450
    • Wynand, P.R.1    Bernd, K.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.