Calcium binding to gatekeeper residues flanking aggregation-prone segments underlies non-fibrillar amyloid traits in superoxide dismutase 1 (SOD1)

Biochimica et Biophysica Acta - Proteins and Proteomics

Volumn 1854, Issue 2, 2015, Pages 118-126

  Estácio, Sílvia G ^a,b   Leal, Sónia S ^c   Cristóvão, Joana S ^c   Faísca, Patrícia F N ^a,b   Gomes, Cláudio M ^c  

^a Centro de Fisica da Materia Condensada   (Portugal)

^b UNIVERSITY OF LISBON   (Portugal)

^c INSTITUTO DE TECNOLOGIA QUÍMICA E BIOLÓGICA   (Portugal)

Author keywords

Electrostatic interaction; Gatekeeping residue; Isothermal titration calorimetry; Molecular dynamics; Protein aggregation; Protein dynamics

Indexed keywords

AMYLOID; AMYLOID PROTEIN; CALCIUM ION; COPPER ZINC SUPEROXIDE DISMUTASE; OLIGOMER; ZINC BINDING PROTEIN; CALCIUM; PROTEIN BINDING; SUPEROXIDE DISMUTASE;

AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; BETA SHEET; BINDING AFFINITY; BINDING SITE; CALCIUM BINDING; CONTROLLED STUDY; ENTROPY; EXPERIMENTAL STUDY; ISOTHERMAL TITRATION CALORIMETRY; MOLECULAR DYNAMICS; PH; PROTEIN AGGREGATION; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; REGULATORY MECHANISM; SIMULATION; STATIC ELECTRICITY; CHEMISTRY; GENETICS; HUMAN; METABOLISM; MOTONEURON; MUTATION; PATHOLOGY; PROTEIN SECONDARY STRUCTURE; PROTEINOSIS;

PYRONIA TITHONUS;

AMYOTROPHIC LATERAL SCLEROSIS; CALCIUM; ENTROPY; HUMANS; MOLECULAR DYNAMICS SIMULATION; MOTOR NEURONS; MUTATION; PROTEIN AGGREGATION, PATHOLOGICAL; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; SUPEROXIDE DISMUTASE;

EID: 84915749799     PISSN: 15709639     EISSN: 18781454     Source Type: Journal    
DOI: 10.1016/j.bbapap.2014.11.005     Document Type: Article

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