Molecular dynamics using atomic-resolution structure reveal structural fluctuations that may lead to polymerization of human Cu-Zn superoxide dismutase

Proceedings of the National Academy of Sciences of the United States of America

Volumn 104, Issue 24, 2007, Pages 10040-10044

  Strange, Richard W ^a   Yong, Chin W ^a   Smith, William ^a   Hasnain, S Samar ^a  

^a DARESBURY LABORATORY   (United Kingdom)

Author keywords

Amyotrophic lateral sclerosis; Motor neuron disease; Protein misfolding

Indexed keywords

COPPER ZINC SUPEROXIDE DISMUTASE; APOENZYME; BIOPOLYMER; COPPER; SUPEROXIDE DISMUTASE; ZINC;

AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; ENZYME STRUCTURE; FAMILIAL DISEASE; GENE MUTATION; HUMAN; MOLECULAR DYNAMICS; MOTOR NEURON DISEASE; POLYMERIZATION; PRIORITY JOURNAL; PROTEIN FOLDING; BINDING SITE; CHEMICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; COMPUTER SIMULATION; DIMERIZATION; ELECTRICITY; ENZYME STABILITY; GENETICS; METABOLISM; MUTATION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN SECONDARY STRUCTURE; X RAY CRYSTALLOGRAPHY; X RAY DIFFRACTION;

AMYOTROPHIC LATERAL SCLEROSIS; APOENZYMES; BINDING SITES; BIOPOLYMERS; COMPUTER SIMULATION; COPPER; CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; ELECTROSTATICS; ENZYME STABILITY; HUMANS; MODELS, CHEMICAL; MODELS, MOLECULAR; MUTATION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN STRUCTURE, SECONDARY; SUPEROXIDE DISMUTASE; X-RAY DIFFRACTION; ZINC;

EID: 34547165170     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0703857104     Document Type: Article

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