Assessing the effect of loop mutations in the folding space of β2microglobulin with molecular dynamics simulations

International Journal of Molecular Sciences

Volumn 14, Issue 9, 2013, Pages 17256-17278

  Estácio, Sílvia G ^a   Shakhnovich, Eugene I ^b   Faísca, Patrícia F N ^a  

^a UNIVERSITY OF LISBON   (Portugal)

^b HARVARD UNIVERSITY   (United States)

Author keywords

Dialysis related amyloidosis; Discrete molecular dynamics; Folding pathways; Intermediate states; Molten globule; Principal component analysis

Indexed keywords

AMYLOID; BETA 2 MICROGLOBULIN; CYSTEINE;

ACIDITY; AMYLOIDOSIS; ARTICLE; CONTROLLED STUDY; DISULFIDE BOND; HUMAN; HYDROPHOBICITY; IN VITRO STUDY; LOOP MUTATION; MOLECULAR DYNAMICS; MUTATION; PKA; PRINCIPAL COMPONENT ANALYSIS; PROTEIN AGGREGATION; PROTEIN FOLDING; SIMULATION; THERMODYNAMICS; THERMOSTABILITY;

BETA 2-MICROGLOBULIN; HUMANS; MOLECULAR DYNAMICS SIMULATION; MUTATION; PROTEIN STRUCTURE, SECONDARY;

EID: 84883486569     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms140917256     Document Type: Article

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