Design, synthesis, and biological evaluation of hydrazone incorporated 1,2,4-triazines as anticonvulsant agents

Archiv der Pharmazie

Volumn 347, Issue 12, 2014, Pages 958-968

  Amir, Mohammed ^a   Ali, Israr ^a   Hassan, Mohd Zaheen ^a   Mulakayala, Naveen ^b  

^a HAMDARD UNIVERSITY   (India)

^b UNIVERSITY OF HYDERABAD   (India)

Author keywords

Anticonvulsant; CNS depression; GABA; Hydrazone; Triazine

Indexed keywords

1,2,4 TRIAZINE DERIVATIVE; 4 [[2 [5 (3 CHLOROBENZYL) 3 PHENYL 1,2,4 TRIAZINE 6 YL]HYDRAZONO]METHYL] N,N DIMETHYLANILINE; 4 [[2 [5 (4 CHLOROBENZYL) 3 PHENYL 1,2,4 TRIAZINE 6 YL]HYDRAZONO]METHYL] N,N DIMETHYLANILINE; 5 (3 CHLOROBENZYL) 3 PHENYL 6 [2 (1 PARA TOLYLETHYLIDENE)HYDRAZINYL] 1,2,4 TRIAZINE; 5 (3 CHLOROBENZYL) 6 [2 (2 CHLOROBENZYLIDENE)HYDRAZINYL] 3 PHENYL 1,2,4 TRIAZINE; 5 (3 CHLOROBENZYL) 6 [2 (4 METHOXYBENZYLIDENE)HYDRAZINYL] 3 PHENYL 1,2,4 TRIAZINE; 5 (3 CHLOROBENZYL) 6 [2 [1 (4 BROMOPHENYL)ETHYLIDENE]HYDRAZINYL] 3 PHENYL 1,2,4 TRIAZINE; 5 (3 CHLOROBENZYL) 6 [2 [1 (4 CHLOROPHENYL)ETHYLIDENE]HYDRAZINYL] 3 PHENYL 1,2,4 TRIAZINE; 5 (4 CHLOROBENZYL) 3 PHENYL 6 [2 (1 PARA TOLYLETHYLIDENE)HYDRAZINYL] 1,2,4 TRIAZINE; 5 (4 CHLOROBENZYL) 6 [2 (2 CHLOROBENZYLIDENE)HYDRAZINYL] 3 PHENYL 1,2,4 TRIAZINE; 5 (4 CHLOROBENZYL) 6 [2 (4 METHOXYBENZYLIDENE)HYDRAZINYL] 3 PHENYL 1,2,4 TRIAZINE; 5 (4 CHLOROBENZYL) 6 [2 [1 (4 BROMOPHENYL)ETHYLIDENE]HYDRAZINYL] 3 PHENYL 1,2,4 TRIAZINE; 5 (4 CHLOROBENZYL) 6 [2 [1 (4 CHLOROPHENYL)ETHYLIDENE]HYDRAZINYL] 3 PHENYL 1,2,4 TRIAZINE; 5 BENZYL 3 PHENYL 6 [2 (1 PARA TOLYLETHYLIDENE)HYDRAZINYL] 1,2,4 TRIAZINE; 5 BENZYL 6 [2 (2 CHLOROBENZYLIDENE)HYDRAZINYL] 3 PHENYL 1,2,4 TRIAZINE; 5 BENZYL 6 [2 (4 METHOXYBENZYLIDENE)HYDRAZINYL] 3 PHENYL 1,2,4 TRIAZINE; 5 BENZYL 6 [2 (4 N,N DIMETHYLAMINOBENZYLIDENE)HYDRAZINYL] 3 PHENYL 1,2,4 TRIAZINE; 5 BENZYL 6 [2 (BENZYLIDENE)HYDRAZINYL] 3 PHENYL 1,2,4 TRIAZINE; 5 BENZYL 6 [2 [1 (4 BROMOPHENYL)ETHYLIDENE]HYDRAZINYL] 3 PHENYL 1,2,4 TRIAZINE; 5 BENZYL 6 [2 [1 (4 CHLOROPHENYL)ETHYLIDENE]HYDRAZINYL] 3 PHENYL 1,2,4 TRIAZINE; 6 (2 BENZYLIDENEHYDRAZINYL) 5 (3 CHLOROBENZYL) 3 PHENYL 1,2,4 TRIAZINE; 6 (2 BENZYLIDENEHYDRAZINYL) 5 (4 CHLOROBENZYL) 3 PHENYL 1,2,4 TRIAZINE; ANTICONVULSIVE AGENT; CARBAMAZEPINE; CENTRAL DEPRESSANT AGENT; HYDRAZONE DERIVATIVE; LAMOTRIGINE; PHENYTOIN; REMACEMIDE; UNCLASSIFIED DRUG;

4 AMINOBUTYRIC ACID BRAIN LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; CONFERENCE PAPER; CONTROLLED STUDY; DRUG DESIGN; DRUG SYNTHESIS; ELECTROSHOCK SEIZURE; EPILEPSY; FEMALE; MALE; MOLECULAR DOCKING; MOUSE; NONHUMAN; PENTYLENETETRAZOLE-INDUCED SEIZURE; PHARMACOPHORE;

EID: 84914689006     PISSN: 03656233     EISSN: 15214184     Source Type: Journal    
DOI: 10.1002/ardp.201400045     Document Type: Conference Paper

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