Synthesis, anticonvulsant activity, and structure-activity relationships of sodium channel blocking 3-aminopyrroles

Journal of Medicinal Chemistry

Volumn 41, Issue 1, 1998, Pages 63-73

  Unverferth, Klaus ^a   Engel, Jürgen ^a   Höfgen, Norbert ^a   Rostock, Angelika ^a   Günther, Ralf ^b   Lankau, Hans Joachim ^c   Menzer, Manfred ^a   Rolfs, Andreas ^a   Liebscher, Jürgen ^a   Müller, Birgit ^a   Hofmann, Hans Jörg ^a  

^a ASTA MEDICA AG   (Germany)

^b HUMBOLDT UNIVERSITY   (Germany)

^c UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

3 AMINOPYRROLE DERIVATIVE; 4 (4 BROMOPHENYL) 3 MORPHOLINOPYRROLE 2 CARBOXYLIC ACID METHYL ESTER; ACETOPHENONE; ANTICONVULSIVE AGENT; CARBAMAZEPINE; DEZINAMIDE; FELBAMATE; GLYCINE DERIVATIVE; LAMOTRIGINE; PHENYTOIN; REMACEMIDE; RUFINAMIDE; SODIUM CHANNEL; UNCLASSIFIED DRUG; VINPOCETINE; ZONISAMIDE;

ANIMAL CELL; ANIMAL TISSUE; ANTICONVULSANT ACTIVITY; ARTICLE; FREQUENCY MODULATION; MALE; MOTOR PERFORMANCE; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT; SEIZURE; SODIUM TRANSPORT; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTICONVULSANTS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROSHOCK; INDICATORS AND REAGENTS; MALE; MICE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MOTOR ACTIVITY; NEUROTOXINS; PENTYLENETETRAZOLE; PYRROLES; RATS; RATS, SPRAGUE-DAWLEY; SEIZURES; SODIUM CHANNEL BLOCKERS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 14444270343     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm970327j     Document Type: Article

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