Menthone aryl acid hydrazones: A new class of anticonvulsants

Medicinal Chemistry

Volumn 7, Issue 1, 2011, Pages 56-61

  Jain, Jainendra ^a   Kumar, Y ^b   Sinha, Reema ^a   Kumar, Rajeev ^a   Stables, James ^c  

^a Ram Eesh Institute of Vocational & Technical Education   (India)

^b ITS Paramedical College (Pharmacy)   (India)

^c NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

Author keywords

( ) 3 menthone; Anticonvulsant; Aryl acid hydrazone; MES; Minimal clonic seizure; Protective index (pI); ScPTZ

Indexed keywords

4 CHLORO N (2 ISOPROPYL 5 METHYLCYCLOHEXYLIDENE)BENZOHYDRAZIDE; ANTICONVULSIVE AGENT; HYDRAZONE DERIVATIVE; MENTHONE; SEMICARBAZIDE DERIVATIVE; THIOSEMICARBAZIDE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; CLONIC SEIZURE; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG SAFETY; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTRIC SHOCK; MALE; MOTOR DYSFUNCTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; REACTION ANALYSIS;

ANIMALS; ANTICONVULSANTS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROSHOCK; HYDRAZONES; INJECTIONS, INTRAPERITONEAL; MALE; MENTHOL; MICE; MOLECULAR STRUCTURE; MOTOR ACTIVITY; PENTYLENETETRAZOLE; RATS; RATS, SPRAGUE-DAWLEY; ROTAROD PERFORMANCE TEST; SEIZURES; SEMICARBAZIDES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 78751505395     PISSN: 15734064     EISSN: None     Source Type: Journal    
DOI: 10.2174/157340611794072689     Document Type: Article

References (17)

1. Wasterlain, C.; Siegel, G.; Albers, R. W.; Molinoff, P. Basic Neurochemistry. Molecular, Cellular and Medical Aspects: Raven Press: New York, 1989.
2. Porter, R. J.; Rogawski, M. A. New Antiepileptic drugs: from serendipity to rational discovery. Epilepsia, 1992, 33, S1-S6.
3. Davis, H. L.; Johnson, D. D.; Crawford, R. D. Epileptiform seizures in domestic fowl. IX. Implications of the absence of anticonvulsant activity of ethosuximide in a pharmacological model of epilepsy. Can. J. Physiol. Pharmacol., 1978, 56, 310-315.
4. Eadie, M. J., Tyrer, J. H. Anticonvulsant Therapy, Pharmacological Basis and Practice: Churchill Livingstone: London, 1989.
5. Yogeeswari, P.; Sriram, D.; Veena, V.; Kavya, R.; Rakhra, K.; Mehta, S.; Raghvendran, J. V.; Thirumurugan, R.; Stables, J. P. Synthesis of aryl semicarbazones as potential anticonvulsant agents. Biomed. Pharmacother., 2005, 59, 51-55.
6. Dimmock, J. R.; Pandeya, S. N.; Quail, J. W.; Pugazhenthi, U.; Allen, T. M.; Kao, G. Y.; Bulzarini, J.; De, Clercq, E. Evaluation of the semicarbazones, thiosemicarbazones and biscarbohydrazones of some aryl alicyclic ketones for anticonvulsant and other biological properties. Eur. J. Med. Chem., 1995, 30, 303-314.
7. Jain, Jainendra.; Kumar, Y.; Stables, James.; Sinha, Reema. Menthone semicarbazides and thiosemicarbazides as anticonvulsant agents. Med. Chem., 2010, 6, 44-50.
8. Pandeya, S.N.; Aggarwal, N.; Jain, J.S. Evaluation of semicarbazones for anticonvulsant and sedative hypnotic properties. Pharmazie, 1999, 54, 300-303.
9. Souza, M. F.; Santos, F. A.; Sidrim J. J. C. Antinociceptive, Anticonvulsant and antibacterial effects of the essential oil from flower heads of Egletes Viscosa L. Phytother. Res., 1998, 12, 28-31.
10. Stanislaw, L.; Jonna, K.; Bozena, F.; Jolanta, H.; Grazyna, W. Stereochemistry of terpene derivatives. Part 2: Synthesis of new chiral amino acids with potential neuroactivity. Tetrahedron: Asymmetry, 2000, 11, 1295-1302.
11. Jain, J. S.; Srivastava, R. S.; Aggrawal, N.; Sinha, R. Synthesis and evaluation of Schiff bases for anticonvulsant and behavioral depressant properties. Central Nerv. Syst. Agents Med. Chem., 2007, 7, 200-204.
12. Mishra, V.; Pandeya, S. N. Analgesic activity and hypnosis potentiation effect of (±) 3-menthone semicarbazone and thiosemicarbazone derivatives. Acta Pharm., 2001, 51, 83-88.
13. Mishra, V.; Pandeya, S. N.; Pannecouque, C.; Witvrouw, M.; De, Clercq. E. Anti HIV activity of thiosemicarbazone and semicarbazone derivatives of (±) 3-menthone. Arch. Pharm. Pharm. Med. Chem., 2002, 5, 183-186.
14. Cui, X. S.; Chen, J.; Chai, K. Y.; Lee. J. S.; Quan. Z. S. Synthesis and anticonvulsant evaluation of 3-substituted-4-(4-hexyloxyphenyl)- 4H-1,2,4-triazoles. Med. Chem. Res., 2009, 18, 49-58.
15. Krall, R. I.; Penry, J. K.; White, B. G.; Kupferberg, H. J.; Swinyard, E. A. Antiepileptic drug development. II: Anticonvulsant drug screening. Epilepsia, 1978, 19, 409-428.
16. Loscher, W.; Schimdt, D. Strategies in antiepileptic drug development: Is rational drug design superior to random screening and structural variation. Epilepsy Res., 1994, 17, 95-134.
17. Siddiqui, N.; Rana, A.; Khan, S. A.; Bhat, M. A.; Haque, S. E. Synthesis of benzothiazole semicarbazones as novel anticonvulsants- The role of hydrophobic domain. Bioorg. Med. Chem. Lett., 2007, 17, 4178-4182.