Triazole incorporated thiazoles as a new class of anticonvulsants: Design, synthesis and in vivo screening

European Journal of Medicinal Chemistry

Volumn 45, Issue 4, 2010, Pages 1536-1543

  Siddiqui, Nadeem ^a   Ahsan, Waquar ^a  

^a HAMDARD UNIVERSITY   (India)

Author keywords

Anticonvulsants; Distance mapping; Neurotoxicity; Thiazoles; Triazoles

Indexed keywords

3 [4 (4 BROMOPHENYL) 1,3 THIAZOL 2 YLAMINO] 4 (2 METHOXYPHENYL) 4,5 DIHYDRO 1H 1,2,4 TRIAZOLE 5 THIONE; 3 [4 (4 BROMOPHENYL) 1,3 THIAZOL 2 YLAMINO] 4 (2 METHYLPHENYL) 4,5 DIHYDRO 1H 1,2,4 TRIAZOLE 5 THIONE; 3 [4 (4 BROMOPHENYL) 1,3 THIAZOL 2 YLAMINO] 4 (4 METHOXYPHENYL) 4,5 DIHYDRO 1H 1,2,4 TRIAZOLE 5 THIONE; 3 [4 (4 BROMOPHENYL) 1,3 THIAZOL 2 YLAMINO] 4 (4 METHYLPHENYL) 4,5 DIHYDRO 1H 1,2,4 TRIAZOLE 5 THIONE; 3 [4 (4 BROMOPHENYL) 1,3 THIAZOL 2 YLAMINO] 4 PHENYL 4,5 DIHYDRO 1H 1,2,4 TRIAZOLE 5 THIONE; 3 [4 (4 CHLOROPHENYL) 1,3 THIAZOL 2 YLAMINO] 4 (2 METHOXYPHENYL) 4,5 DIHYDRO 1H 1,2,4 TRIAZOLE 5 THIONE; 3 [4 (4 CHLOROPHENYL) 1,3 THIAZOL 2 YLAMINO] 4 (2 METHYLPHENYL) 4,5 DIHYDRO 1H 1,2,4 TRIAZOLE 5 THIONE; 3 [4 (4 CHLOROPHENYL) 1,3 THIAZOL 2 YLAMINO] 4 (4 METHOXYPHENYL) 4,5 DIHYDRO 1H 1,2,4 TRIAZOLE 5 THIONE; 3 [4 (4 CHLOROPHENYL) 1,3 THIAZOL 2 YLAMINO] 4 (4 METHYLPHENYL) 4,5 DIHYDRO 1H 1,2,4 TRIAZOLE 5 THIONE; 3 [4 (4 CHLOROPHENYL) 1,3 THIAZOL 2 YLAMINO] 4 PHENYL 4,5 DIHYDRO 1H 1,2,4 TRIAZOLE 5 THIONE; 3 [4 (4 NITROPHENYL) 1,3 THIAZOL 2 YLAMINO] 4 PHENYL 4,5 DIHYDRO 1H 1,2,4 TRIAZOLE 5 THIONE; 4 (2 METHOXYPHENYL) 3 (4 PHENYL 1,3 THIAZOL 2 YLAMINO) 4,5 DIHYDRO 1H 1,2,4 TRIAZOLE 5 THIONE; 4 (2 METHOXYPHENYL) 3 [4 (4 NITROPHENYL) 1,3 THIAZOL 2 YLAMINO] 4,5 DIHYDRO 1H 1,2,4 TRIAZOLE 5 THIONE; 4 (2 METHYLPHENYL) 3 (4 PHENYL 1,3 THIAZOL 2 YLAMINO) 4,5 DIHYDRO 1H 1,2,4 TRIAZOLE 5 THIONE; 4 (2 METHYLPHENYL) 3 [4 (4 NITROPHENYL) 1,3 THIAZOL 2 YLAMINO] 4,5 DIHYDRO 1H 1,2,4 TRIAZOLE 5 THIONE; 4 (4 METHOXYPHENYL) 3 (4 PHENYL 1,3 THIAZOL 2 YLAMINO) 4,5 DIHYDRO 1H 1,2,4 TRIAZOLE 5 THIONE; 4 (4 METHOXYPHENYL) 3 [4 (4 NITROPHENYL) 1,3 THIAZOL 2 YLAMINO] 4,5 DIHYDRO 1H 1,2,4 TRIAZOLE 5 THIONE; 4 (4 METHYLPHENYL) 3 (4 PHENYL 1,3 THIAZOL 2 YLAMINO) 4,5 DIHYDRO 1H 1,2,4 TRIAZOLE 5 THIONE; 4 (4 METHYLPHENYL) 3 [4 (4 NITROPHENYL) 1,3 THIAZOL 2 YLAMINO] 4,5 DIHYDRO 1H 1,2,4 TRIAZOLE 5 THIONE; 4 PHENYL 3 (4 PHENYL 1,3 THIAZOL 2 YLAMINO) 4,5 DIHYDRO 1H 1,2,4 TRIAZOLE 5 THIONE; 4,5 DIHYDRO 1H 1,2,4 TRIAZOLE 5 THIONE DERIVATIVE; ANTICONVULSIVE AGENT; CARBAMAZEPINE; LAMOTRIGINE; PHENOBARBITAL; PHENYTOIN; THIAZOLE DERIVATIVE; TRIAZOLE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VALPROIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG DESIGN; DRUG SAFETY; DRUG SCREENING; DRUG SYNTHESIS; ELECTRIC SHOCK; FEMALE; LETHAL DOSE; MALE; MOUSE; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PHARMACOPHORE; PHYSICAL CHEMISTRY; SEIZURE; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTICONVULSANTS; DRUG DESIGN; ELECTROCONVULSIVE THERAPY; LETHAL DOSE 50; MICE; TRIAZOLES;

EID: 77349097539     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2009.12.062     Document Type: Article

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