Structures of γ-Aminobutyric Acid (GABA) Aminotransferase, a Pyridoxal 5′-Phosphate, and [2Fe-2S] Cluster-containing Enzyme, Complexed with γ-Ethynyl-GABA and with the Antiepilepsy Drug Vigabatrin

Journal of Biological Chemistry

Volumn 279, Issue 1, 2004, Pages 363-373

  Storici, Paola ^a,e   De Biase, Daniela ^b   Bossa, Francesco ^b   Bruno, Stefano ^c   Mozzarelli, Andrea ^c   Peneff, Caroline ^a   Silverman, Richard B ^d   Schirmer, Tilman ^a  

^a UNIVERSITY OF BASEL   (Switzerland)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c UNIVERSITY OF PARMA   (Italy)

^d NORTHWESTERN UNIVERSITY   (United States)

^e PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABSORPTION; BRAIN; CRYSTAL STRUCTURE; DRUG PRODUCTS; ENZYME INHIBITION; SPECTROPHOTOMETRY;

ANTIEPILEPSY DRUGS;

BIOCHEMISTRY;

4 AMINOBUTYRATE AMINOTRANSFERASE; 4 AMINOBUTYRIC ACID DERIVATIVE; DIMER; GAMMA ETHYNYL 4 AMINOBUTYRIC ACID; IRON; PYRIDOXAL 5 PHOSPHATE; SULFUR; UNCLASSIFIED DRUG; VIGABATRIN;

ARTICLE; COMPLEX FORMATION; COVALENT BOND; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; DRUG MECHANISM; ENZYME ACTIVE SITE; ENZYME INACTIVATION; ENZYME STRUCTURE; PRIORITY JOURNAL; STRUCTURE ANALYSIS;

SUS SCROFA;

EID: 0347052772     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M305884200     Document Type: Article

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