A novel approach to monitor clearance of host cell proteins associated with monoclonal antibodies

Biotechnology Progress

Volumn 30, Issue 5, 2014, Pages 1114-1124

  Aboulaich, Nabila ^a   Chung, Wai Keen ^a   Thompson, Jenny Heidbrink ^a   Larkin, Christopher ^a   Robbins, David ^a   Zhu, Min ^a  

^a MEDIMMUNE   (United States)

Author keywords

Host cell protein clearance; Host cell protein impurities; MAb process development; Protein protein interaction; Proteomics

Indexed keywords

AFFINITY CHROMATOGRAPHY; CYTOLOGY; DISSOCIATION; MASS SPECTROMETRY; MONOCLONAL ANTIBODIES; PROTEOMICS; PURIFICATION; STABILITY;

COMPREHENSIVE COMPARISONS; ENZYME LINKED IMMUNOSORBENT ASSAY; HOST CELL PROTEIN; MONOCLONAL ANTIBODIES (MABS); PROCESS DEVELOPMENT; PROTEIN A CHROMATOGRAPHY; PROTEIN-PROTEIN INTERACTIONS; STRUCTURAL STABILITIES;

CELLS;

IMMOBILIZED ANTIBODY; MONOCLONAL ANTIBODY; PROTEIN; PROTEIN BINDING;

AFFINITY CHROMATOGRAPHY; ANIMAL; CHEMISTRY; CHO CELL LINE; CLASSIFICATION; CRICETULUS; ENZYME LINKED IMMUNOSORBENT ASSAY; HAMSTER; METABOLISM; METHODOLOGY; PH; PROCEDURES; PROTEOMICS;

ANIMALS; ANTIBODIES, IMMOBILIZED; ANTIBODIES, MONOCLONAL; CHO CELLS; CHROMATOGRAPHY, AFFINITY; CRICETINAE; CRICETULUS; ENZYME-LINKED IMMUNOSORBENT ASSAY; HYDROGEN-ION CONCENTRATION; PROTEIN BINDING; PROTEINS; PROTEOMICS; RESEARCH DESIGN;

EID: 84914179287     PISSN: 87567938     EISSN: 15206033     Source Type: Journal    
DOI: 10.1002/btpr.1948     Document Type: Article

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