Comprehensive tracking of host cell proteins during monoclonal antibody purifications using mass spectrometry

mAbs

Volumn 6, Issue 3, 2014, Pages 659-670

  Zhang, Qingchun ^a   Goetze, Andrew M ^a   Cui, Huanchun ^a   Wylie, Jenna ^a   Trimble, Steve ^b   Hewig, Art ^a   Flynn, Gregory C ^a  

^a AMGEN INC   (United States)

^b AMGEN INC   (United States)

Author keywords

Antibody; Host cell proteins; Mass spectrometry; Monoclonal

Indexed keywords

ACTIN CYTOPLASMIC 1; ALANINE TRANSFER RNA LIGASE; ALPHA ENOLASE; ALPHA TUBULIN; CALRETICULIN; CELL PROTEIN; CHAPERONIN CONTAINING TCP1 GAMMA; CLUSTERIN; ELONGATION FACTOR 1ALPHA; ELONGATION FACTOR 2; ENDOPLASMIN; GALECTIN 3 BINDING PROTEIN; GLUCOSE REGULATED PROTEIN; GLUTATHIONE TRANSFERASE; GLUTATHIONE TRANSFERASE P; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; HEAT SHOCK PROTEIN 90; HEAT SHOCK PROTEIN 90 BETA; HOST CELL PROTEIN; HYPOXIA UPREGULATED PROTEIN 1; LAMININ BETA 1; LAMININ GAMMA1; MONOCLONAL ANTIBODY; PEROXIREDOXIN 1; PHOSPHOLIPID TRANSFER PROTEIN; PROTEIN A; PYRUVATE KINASE; T COMPLEX PROTEIN 1 DELTA; TRANSKETOLASE; UNCLASSIFIED DRUG; UNINDEXED DRUG; ACTIN; CULTURE MEDIUM; PROTEIN; RECOMBINANT PROTEIN; STAPHYLOCOCCUS PROTEIN A;

ANIMAL CELL; ARTICLE; CATION EXCHANGE; CELL CULTURE; CELL TRACKING; CHO CELL LINE; CONTROLLED STUDY; CULTURE MEDIUM; DRUG PURIFICATION; FEMALE; GEL ELECTROPHORESIS; GENETIC VARIABILITY; HOST CELL; ION EXCHANGE CHROMATOGRAPHY; LARGE SCALE PRODUCTION; LIMIT OF QUANTITATION; MASS SPECTROMETRY; NONHUMAN; PROTEIN ANALYSIS; PROTEIN PURIFICATION; VIRUS INACTIVATION; ANIMAL; BIOSYNTHESIS; BIOTECHNOLOGY; CHEMISTRY; CRICETULUS; DRUG CONTAMINATION; GENETICS; HAMSTER; ISOLATION AND PURIFICATION; LIQUID CHROMATOGRAPHY; PREVENTION AND CONTROL; PROCEDURES;

ACTINS; ANIMALS; ANTIBODIES, MONOCLONAL; BIOTECHNOLOGY; CHO CELLS; CHROMATOGRAPHY, LIQUID; CLUSTERIN; CRICETINAE; CRICETULUS; CULTURE MEDIA; DRUG CONTAMINATION; MASS SPECTROMETRY; PROTEINS; RECOMBINANT PROTEINS; STAPHYLOCOCCAL PROTEIN A;

EID: 84899740805     PISSN: 19420862     EISSN: 19420870     Source Type: Journal    
DOI: 10.4161/mabs.28120     Document Type: Article

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