Evicting hitchhiker antigens from purified antibodies

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 877, Issue 14-15, 2009, Pages 1543-1552

  Luhrs, Keith A ^a   Harris, Debra A ^a   Summers, Scott ^b   Parseghian, Missag H ^a  

^a Peregrine Pharmaceuticals Inc   (United States)

^b Avid Bioservices Inc   (United States)

Author keywords

Affinity chromatography; Antibody purification; Commercial scale purification; Hitchhiker antigens; Host cell proteins

Indexed keywords

ANTIBODY PURIFICATION; CELL LINES; CELLULAR STRUCTURES; CHROMATIN IMMUNOPRECIPITATION; COMMERCIAL-SCALE PURIFICATION; CULTURE SUPERNATANT; DNA COMPLEXES; HITCHHIKER ANTIGENS; HOST CELL PROTEINS; MANUFACTURING PLANTS; MOBILE PHASE; PRODUCTION YIELDS; PROTEIN A; PROTEIN A CHROMATOGRAPHIES; VIRAL PARTICLES;

AFFINITY CHROMATOGRAPHY; AMINES; ANTIGENS; BIOASSAY; BIOCHIPS; CHROMATOGRAPHIC ANALYSIS; COLUMN CHROMATOGRAPHY; DNA; GENES; IONIC STRENGTH; MONOCLONAL ANTIBODIES; NUCLEIC ACIDS; ORGANIC COMPOUNDS; PROTEINS; PURIFICATION; SODIUM; SODIUM CHLORIDE;

CELL CULTURE;

ANTIGEN; DNA; ENDOTOXIN; HISTONE ANTIBODY; HITCHIKER ANTIGEN; MONOCLONAL ANTIBODY; PROTEIN A; SODIUM CHLORIDE; UNCLASSIFIED DRUG;

ANTIGEN ANTIBODY COMPLEX; ANTIGEN DETECTION; ANTIGEN EXPRESSION; ARTICLE; BINDING AFFINITY; BIOREACTOR; CELL STRUCTURE; CHROMATIN IMMUNOPRECIPITATION; DNA HISTONE INTERACTION; EPITOPE MAPPING; HUMAN; HUMAN CELL; IONIC STRENGTH; PRION; PRIORITY JOURNAL; PROTEIN PURIFICATION; VIRUS PARTICLE;

ANTIBODIES; ANTIGENS; CHROMATOGRAPHY, AFFINITY; DNA; HISTONES; HUMANS;

EID: 65249126931     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2009.03.042     Document Type: Article

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