Phosphorylation of the guanine-nucleotide-exchange factor CalDAG-GEFI by protein kinase a regulates Ca2+-dependent activation of platelet Rap1b GTPase

Biochemical Journal

Volumn 453, Issue 1, 2013, Pages 115-123

  Guidetti, Gianni Francesco ^a   Manganaro, Daria ^a   Consonni, Alessandra ^a   Canobbio, Ilaria ^a   Balduini, Cesare ^a   Torti, Mauro ^a  

^a UNIVERSITY OF PAVIA   (Italy)

Author keywords

Calcium and diacylglycerol regulated guanine nucleotide exchange factor I (CaLDAG GEFI); cAMP; Platelet; Platelet inhibition; Protein phosphorylation; Rap1b; Signal transduction

Indexed keywords

CALCIUM; CALCIUM AND DIACYLGLYCEROL REGULATED GUANINE NUCLEOTIDE EXCHANGE FACTOR I; CYCLIC AMP DEPENDENT PROTEIN KINASE; FORSKOLIN; GUANINE NUCLEOTIDE EXCHANGE FACTOR; GUANOSINE TRIPHOSPHATASE; UNCLASSIFIED DRUG;

ARTICLE; EMBRYO; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MUTANT; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION;

ANIMALS; BLOOD PLATELETS; CALCIMYCIN; CALCIUM; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DNA-BINDING PROTEINS; FORSKOLIN; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HEK293 CELLS; HUMANS; ISOQUINOLINES; PHOSPHORYLATION; PLATELET ACTIVATION; RAP GTP-BINDING PROTEINS; RATS; SULFONAMIDES;

EID: 84879027082     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20130131     Document Type: Article

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