Synthesis and biological evaluation of phenanthrenes as cytotoxic agents with pharmacophore modeling and ChemGPS-NP prediction as topo II inhibitors

PLoS ONE

Volumn 7, Issue 5, 2012, Pages

  Lee, Chia Lin ^a,b   Lin, Ying Ting ^c   Chang, Fang Rong ^c,d   Chen, Guan Yu ^b   Backlund, Anders ^e   Yang, Juan Chang ^c   Chen, Shu Li ^c   Wu, Yang Chang ^a,b,c  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^c KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^d KAOHSIUNG MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^e UPPSALA UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

1,4,5,6,7 PENTAMETHOXYPHENANTHRENE; 1,4,5,7 TETRAMETHOXYPHENANTHRENE; 3,3,5,7 TETRAMETHOXY 2,3 DIHYDRO 1,4 PHENANTHRENEQUINONE; 3,5,6,7 TETRAMETHOXY 1,4 PHENANTHRENEQUINONE; 3,5,6,7,1',5',6',7' OCTAMETHOXY [8,8']BI 1,4,5',6' PHENANTHRENEQUINONE; 3,5,6,7,3',5',6',7' NONAMETHOXY 2,3 DIHYDRO[8,8']BI 1,4,1',4' PHENANTHRENEQUINONE; 3,5,6,7,3',5',6',7' OCTAMETHOXY [8,8']BI 1,4,1',4' PHENANTHRENEQUINONE; 3,5,7 TRIMETHOXY 1,4 PHENANTHRENEQUINONE; 4 HYDROXY 1,5,7 TRIMETHOXYPHENANTHRENE; 5 ACETOXY 3,6,7 DIMETHOXY 1,4 PHENANTHRENEQUINONE; 5 ACETOXY 3,6,7 TRIMETHOXY 1,4 PHENANTHRENEQUINONE; 5 HYDROXY 1,4,6,7 TETRAMETHOXYPHENANTHRENE; 5 HYDROXY 1,4,7 TRIMETHOXYPHENANTHRENE; 5 HYDROXY 3,6,7 TRIMETHOXY 1,4 PHENANTHRENEQUINONE; 5 HYDROXY 3,7 TRIMETHOXY 1,4 PHENANTHRENEQUINONE; 5,6 DIHYDROXY 1,4,7 TRIMETHOXYPHENANTHRENE; 5,6,7 TRIMETHOXY 1,4 PHENANTHRENEQUINONE; 5,6,7,5',6',7' HEXAMETHOXY [8,8']BI 1,4 PHENANTHRENEQUINONE; 5,7 DIMETHOXY 1,4 PHENANTHRENEQUINONE; CALANQUINONE A; CYTOTOXIC AGENT; DENBINOBIN; DNA TOPOISOMERASE (ATP HYDROLYSING); DOXORUBICIN; GYRASE INHIBITOR; PHENANTHRENE DERIVATIVE; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT;

ARTICLE; BREAST CANCER; CANCER CELL CULTURE; DEMETHYLATION; DRUG ACETYLATION; DRUG CYTOTOXICITY; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; LIVER CANCER; LUNG CANCER; LUNG FIBROBLAST; MOUTH CANCER; PHARMACOPHORE; PREDICTION; STRUCTURE ACTIVITY RELATION; BIOLOGY; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; METABOLISM; SYNTHESIS; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CHEMISTRY TECHNIQUES, SYNTHETIC; COMPUTATIONAL BIOLOGY; DNA TOPOISOMERASES, TYPE II; HUMANS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PHENANTHRENES; STRUCTURE-ACTIVITY RELATIONSHIP; TOPOISOMERASE II INHIBITORS;

EID: 84861546500     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0037897     Document Type: Article

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