Formononetin attenuates osteoclastogenesis via suppressing the RANKL-induced activation of NF-κB, c-Fos, and nuclear factor of activated T-cells cytoplasmic 1 signaling pathway

Journal of Natural Products

Volumn 77, Issue 11, 2014, Pages 2423-2431

  Huh, Jeong Eun ^a   Lee, Wong In ^a   Kang, Jung Won ^a   Nam, Dongwoo ^a   Choi, Do Young ^a   Park, Dong Suk ^b   Lee, Sang Hoon ^a   Lee, Jae Dong ^a  

^a Kyung Hee University   (South Korea)

^b Kyung Hee University College of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

FORMONONETIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; MONOCYTE CHEMOTACTIC PROTEIN 1; NUCLEAR FACTOR OF ACTIVATED T CELL CYTOPLASMIC 1; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPROTEGERIN; PROTEIN C FOS; PROTEIN KINASE B; RANTES; SMALL INTERFERING RNA; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR NFAT; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ISOFLAVONE DERIVATIVE; PHYTOESTROGEN;

ANIMAL CELL; ARTICLE; BONE MARROW DERIVED MACROPHAGE; ENZYME ACTIVATION; MOUSE; NONHUMAN; OSTEOBLAST; OSTEOCLAST; OSTEOCLASTOGENESIS; OSTEOLYSIS; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; WESTERN BLOTTING; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; MACROPHAGE; METABOLISM;

CHEMOKINE CCL2; INTERLEUKIN-6; ISOFLAVONES; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MACROPHAGES; MITOGEN-ACTIVATED PROTEIN KINASES; MOLECULAR STRUCTURE; NF-KAPPA B; OSTEOBLASTS; OSTEOCLASTS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHYTOESTROGENS; PROTO-ONCOGENE PROTEINS C-FOS; RANK LIGAND; SIGNAL TRANSDUCTION;

EID: 84913582426     PISSN: 01633864     EISSN: 15206025     Source Type: Journal    
DOI: 10.1021/np500417d     Document Type: Article

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