Effect of formononetin on mechanical properties and chemical composition of bones in rats with ovariectomy-induced osteoporosis

Evidence-based Complementary and Alternative Medicine

Volumn 2013, Issue , 2013, Pages

  Kaczmarczyk Sedlak, Ilona ^a   Wojnar, Weronika ^a   Zych, Maria ^a   Ozimina Kamińska, Ewa ^a   Taranowicz, Joanna ^a   Siwek, Agata ^a  

^a MEDICAL UNIVERSITY OF SILESIA   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; ESTRADIOL; FORMONONETIN; ORGANIC COMPOUND; PHOSPHORUS;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY MASS; BONE; BONE LENGTH; BONE MINERAL; CHEMICAL COMPOSITION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG EFFECT; FEMALE; FRACTURE; NONHUMAN; OSTEOPOROSIS; OVARIECTOMY; PRIORITY JOURNAL; RAT; THYMUS; UTERUS WEIGHT; WATER CONTENT; YOUNG MODULUS;

EID: 84878726694     PISSN: 1741427X     EISSN: 17414288     Source Type: Journal    
DOI: 10.1155/2013/457052     Document Type: Article

References (56)

1. Ardakani F. E., Mirmohamadi S. J., Osteoporosis and oral bone resorption: a review. Journal of Oral and Maxillofacial Surgery 2009 8 2 121 126
2. Khurana J. S., Fitzpatrick L. A., Khurana J. S., Osteoporosis and metabolic bone disease. Bone Pathology 2009 New Jersey, NJ, USA Humana Press 217 237
3. Gallagher J. C., Sai A. J., Molecular biology of bone remodeling: implications for new therapeutic targets for osteoporosis. Maturitas 2010 65 4 301 307 2-s2.0-77649183118 10.1016/j.maturitas.2010.01.002
4. Seeman E., Estrogen, androgen, and the pathogenesis of bone fragility in women and men. Current Osteoporosis Reports 2004 2 3 90 96 2-s2.0-23944475651
5. Bowring C. E., Francis R. M., National Osteoporosis Society's Position statement on hormone replacement therapy in the prevention and treatment of osteoporosis. Menopause International 2011 17 2 63 65 2-s2.0-79959435269 10.1258/mi.2011.011012
6. Rossouw J. E., Anderson G. L., Prentice R. L., LaCroix A. Z., Kooperberg C., Stefanick M. L., Jackson R. D., Beresford S. A. A., Howard B. V., Johnson K. C., Kotchen J. M., Ockene J., Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the women's health initiative randomized controlled trial. Journal of the American Medical Association 2002 288 3 321 333 2-s2.0-0037125379 (Pubitemid 34761611)
7. Zhu H. M., Qin L., Garnero P., Genant H. K., Zhang G., Dai K., Yao X., Gu G., Hao Y., Li Z., Zhao Y., Li W., Yang J., Zhao X., Shi D., Fuerst T., Lu Y., Li H., Zhang X., Li C., Zhao J., Wu Q., Zhao S. J., The first multicenter and randomized clinical trial of herbal Fufang for treatment of postmenopausal osteoporosis. Osteoporosis International 2012 23 1317 1327
8. Atkinson C., Compston J. E., Day N. E., Dowsett M., Bingham S. A., The effects of phytoestrogen isoflavones on bone density in women: a double-blind, randomized, placebo-controlled trial1-3. American Journal of Clinical Nutrition 2004 79 2 326 333 2-s2.0-1342328575 (Pubitemid 41095988)
9. Cederroth C. R., Nef S., Soy, phytoestrogens and metabolism: a review. Molecular and Cellular Endocrinology 2009 304 1-2 30 42 2-s2.0-67349280310 10.1016/j.mce.2009.02.027
10. Khoja K. K., Shafi G., Hasan T. N., Syed N. A., Al-Khalifa A. S., Al-Assaf A. H., Alshatwi A. A., Fenugreek, a naturally occurring edible spice, kills MCF-7 human breast cancer cells via an apoptotic pathway. Asian Pacific Journal of Cancer Prevention 2011 12 3299 3304
11. Kuhnle G. G. C., Vogiatzoglou A., Ward H. A., Khaw K. T., Dietary phytoestrogens and health-a population study. Proceedings of the Nutrition Society 2011 70 OCE4, article E254
12. Sehmisch S., Erren M., Kolios L., Tezval M., Seidlova-Wuttke D., Wuttke W., Stuermer K. M., Stuermer E. K., Effects of isoflavones equol and genistein on bone quality in a rat osteopenia model. Phytotherapy Research 2010 24 supplement 2 S168 S174 2-s2.0-77953881925 10.1002/ptr.3060
13. Ha H., Lee H. Y., Lee J. H., Jung D., Choi J., Song K. Y., Jung H. J., Choi J. S., Chang S. I., Kim C., Formononetin prevents ovariectomy-induced bone loss in rats. Archives of Pharmacal Research 2010 33 4 625 632 2-s2.0-77954518605 10.1007/s12272-010-0418-8
14. Wu J. H., Li Q., Wu M. Y., Guo D. J., Chen H. L., Chen S. L., Seto S. W., Au A. L. S., Poon C. C. W., Leung G. P. H., Lee S. M. Y., Kwan Y. W., Chan S. W., Formononetin, an isoflavone, relaxes rat isolated aorta through endothelium-dependent and endothelium-independent pathways. Journal of Nutritional Biochemistry 2010 21 7 613 620 2-s2.0-77953812949 10.1016/j.jnutbio.2009.03.010
15. Huh J. E., Seo D. M., Baek Y. H., Choi D. Y., Park D. S., Lee J. D., Biphasic positive effect of formononetin on metabolic activity of human normal and osteoarthritic subchondral osteoblasts. International Immunopharmacology 2010 10 4 500 507 2-s2.0-77949652721 10.1016/j.intimp.2010.01.012
16. Lauwaet T., Andersen Y., van de Ven L., Eckmann L., Gillin F. D., Rapid detachment of Giardia lamblia trophozoites as a mechanism of antimicrobial action of the isoflavone formononetin. Journal of Antimicrobial Chemotherapy 2010 65 3 531 534 2-s2.0-77950314506 10.1093/jac/dkp501
17. Auyeung K. K. W., Ko J. K. S., Novel herbal flavonoids promote apoptosis but differentially induce cell cycle arrest in human colon cancer cell. Investigational New Drugs 2010 28 1 1 13 2-s2.0-74149085539 10.1007/s10637-008- 9207-3 (Pubitemid 46274648)
18. He X., Blount J. W., Ge S., Tang Y., Dixon R. A., A genomic approach to isoflavone biosynthesis in kudzu (Pueraria lobata). Planta 2011 233 4 843 855 2-s2.0-79953052392 10.1007/s00425-010-1344-1
19. Kuhnle G. G. C., Dell'Aquila C., Runswick S. A., Bingham S. A., Variability of phytoestrogen content in foods from different sources. Food Chemistry 2009 113 4 1184 1187 2-s2.0-56049128140 10.1016/j.foodchem.2008.08.004
20. Mu H., Bai Y. H., Wang S. T., Zhu Z. M., Zhang Y. W., Research on antioxidant effects and estrogenic effect of formononetin from Trifolium pratense (red clover). Phytomedicine 2009 16 4 314 319 2-s2.0-62549107554 10.1016/j.phymed.2008.07.005
21. Zhou T., Shun M., Zhou L., Yang H., Zhong K., Zhang X., Zhang H., Fan D., Chui D., Formononetin could increase soluble-APP α secretion by up-regulating ADAM10 level. Molecular Neurodegeneration 2012 7 supplement 1, article O10
22. Huh J. E., Kwon N. H., Baek Y. H., Lee J. D., Choi D. Y., Jingushi S., Kim K. I., Park D. S., Formononetin promotes early fracture healing through stimulating angiogenesis by up-regulating VEGFR-2/Flk-1 in a rat fracture model. International Immunopharmacology 2009 9 12 1357 1365 2-s2.0-70349553828 10.1016/j.intimp.2009.08.003
23. Zhang S., Tang X., Tian J., Li C., Zhang G., Jiang W., Zhang Z., Cardioprotective effect of sulphonated formononetin on acute myocardial infarction in rats. Basic and Clinical Pharmacology and Toxicology 2011 108 6 390 395 2-s2.0-79955956352 10.1111/j.1742-7843.2011.00676.x
24. Chen J., Zeng J., Xin M., Huang W., Chen X., Formononetin induces cell cycle arrest of human breast cancer cells via IGF1/PI3K/Akt pathways in vitro and in vivo. Hormone and Metabolic Research 2011 43 10 681 686
25. Kanadaswami C., Lee L. T., Lee P. P. H., Hwang J. J., Ke F. C., Huang Y. T., Lee M. T., The antitumor activities of flavonoids. In Vivo 2005 19 5 895 910 2-s2.0-23044455268 (Pubitemid 41065151)
26. Xing D. X., Liu X. L., Xue C. K., Huang Q., Liu Z. G., Xiong L., The estrogenic effect of formononetin and its effect on the expression of rats' atrium estrogen receptors Journal of Chinese Medicine Materials 2010 33 9 1445 1449
27. Kalu D. N., The ovariectomized rat model of postmenopausal bone loss. Bone and Mineral 1991 15 3 175 191 2-s2.0-0026068145 10.1016/0169-6009(91)90124- I
28. Folwarczna J., Nowińska B., Śliwiński L., Pytlik M., Cegieła U., Betka A., Fenoterol did not enhance glucocorticoid-induced skeletal changes in male rats. Acta Biochimica Polonica 2011 58 3 313 319
29. Stürmer E. K., Seidlová-Wuttke D., Sehmisch S., Rack T., Wille J., Frosch K. H., Wuttke W., Stürmer K. M., Standardized bending and breaking test for the normal and osteoporotic metaphyseal tibias of the rat: effect of estradiol, testosterone, and raloxifene. Journal of Bone and Mineral Research 2006 21 1 89 96 2-s2.0-29644439883 10.1359/JBMR.050913 (Pubitemid 43023230)
30. Kaczmarczyk-Sedlak I., Janiec W., Pytlik M., Śliwiński L., Folwarczna J., Cegieła U., Nowińska B., Barnaś M., Effect of administration of etidronate and retinol on bone mechanical properties in ovariectomized rats. Pharmacological Reports 2005 57 2 203 211 2-s2.0-20344385963 (Pubitemid 40778711)
31. Wang Z. L., Sun J. Y., Wang D. N., Xie Y. H., Wang S. W., Zhao W. M., Pharmacological studies of the large-scaled purified genistein from Huaijiao (Sophora japonica-Leguminosae) on anti-osteoporosis. Phytomedicine 2006 13 9-10 718 723 2-s2.0-33750524252 10.1016/j.phymed.2005.09.005 (Pubitemid 44666393)
32. Bitto A., Burnett B. P., Polito F., Marini H., Levy R. M., Armbruster M. A., Minutoli L., Di Stefano V., Irrera N., Antoci S., Granese R., Squadrito F., Altavilla D., Effects of genistein aglycone in osteoporotic, ovariectomized rats: a comparison with alendronate, raloxifene and oestradiol. British Journal of Pharmacology 2008 155 6 896 905 2-s2.0-57349120714 10.1038/bjp.2008.305
33. Miao Q., Li J. G., Miao S., Hu N., Zhang J., Zhang S., Xie Y. H., Wang J. B., Wang S. W., The bone-protective effect of genistein in the animal model of bilateral ovariectomy: roles of phytoestrogens and PTH/PTHR1 against post-menopausal osteoporosis. International Journal of Molecular Science 2012 13 56 70
34. Morabito N., Crisafulli A., Vergara C., Gaudio A., Lasco A., Frisina N., D'Anna R., Corrado F., Pizzoleo M. A., Cincotta M., Altavilla D., Ientile R., Squadrito F., Effects of genistein and hormone-replacement therapy on bone loss in early postmenopausal women: a randomized double-blind placebo-controlled study. Journal of Bone and Mineral Research 2002 17 10 1904 1912
35. Marini H., Minutoli L., Polito F., Bitto A., Altavilla D., Atteritano M., Gaudio A., Mazzaferro S., Frisina A., Frisina N., Lubrano C., Bonaiuto M., D'Anna R., Cannata M. L., Corrado F., Adamo E. B., Wilson S., Squadrito F., Effects of the phytoestrogen genistein on bone metabolism in osteopenic postmenopausal women: a randomized trial. Annals of Internal Medicine 2007 146 12 839 847 2-s2.0-34347383831 (Pubitemid 351650484)
36. Zhang X., Shu X. O., Li H., Yang G., Li Q., Gao Y. T., Zheng W., Prospective cohort study of soy food consumption and risk of bone fracture among postmenopausal women. Archives of Internal Medicine 2005 165 16 1890 1895 2-s2.0-25144490031 10.1001/archinte.165.16.1890 (Pubitemid 41352084)
37. Pru J. K., The bone-promoting actions of formononetin in established osteopenia. Menopause 2012 19 8 843 844
38. Tyagi A. M., Srivastava K., Singh A. K., Kumar A., Changkija B., Pandey R., Lahiri S., Nagar G. K., Yadav D. K., Maurya R., Trivedi R., Singh D., Formononetin reverses established osteopenia in adult ovariectomized rats. Menopause 2012 19 8 856 863
39. Delmas P. D., Bjarnason N. H., Mitlak B. H., Ravoux A. C., Shah A. S., Huster W. J., Draper M., Christiansen C., Effects of raloxifene on bone mineral density, serum cholesterol concentrations, and uterine endometrium in postmenopausal women. The New England Journal of Medicine 1997 337 23 1641 1647 2-s2.0-0030664688 10.1056/NEJM199712043372301 (Pubitemid 27510100)
40. Cauley J. A., Norton L., Lippman M. E., Eckert S., Krueger K. A., Purdie D. W., Farrerons J., Karasik A., Mellstrom D., Ng K. W., Stepan J. J., Powles T. J., Morrow M., Costa A., Silfen S. L., Walls E. L., Schmitt H., Muchmore D. B., Jordan V. C., Continued breast cancer risk reduction in postmenopausal women treated with raloxifene: 4-year results from the MORE trial. Breast Cancer Research and Treatment 2001 65 2 125 134 2-s2.0-0035120523 10.1023/A: 1006478317173 (Pubitemid 32193616)
41. Johnell O., Scheele W. H., Lu Y., Reginster J. Y., Need A. G., Seeman E., Additive effects of raloxifene and alendronate on bone density and biochemical markers of bone remodeling in postmenopausal women with osteoporosis. Journal of Clinical Endocrinology and Metabolism 2002 87 3 985 992 2-s2.0-0036963450 10.1210/jc.87.3.985 (Pubitemid 36121052)
42. Gautam A. K., Bhargavan B., Tyagi A. M., Srivastava K., Yadav D. K., Kumar M., Singh A., Mishra J. S., Singh A. B., Sanyal S., Maurya R., Manickavasagam L., Singh S. P., Wahajuddin W., Jain G. K., Chattopadhyay N., Singh D., Differential effects of formononetin and cladrin on osteoblast function, peak bone mass achievement and bioavailability in rats. Journal of Nutritional Biochemistry 2011 22 4 318 327 2-s2.0-78651239360 10.1016/j.jnutbio.2010.02.010
43. Ruppel M. E., Miller L. M., Burr D. B., The effect of the microscopic and nanoscale structure on bone fragility. Osteoporosis International 2008 19 9 1251 1265 2-s2.0-49549090015 10.1007/s00198-008-0579-1
44. Anumula S., Wehrli S. L., Magland J., Wright A. C., Wehrli F. W., Ultra-short echo-time MRI detects changes in bone mineralization and water content in OVX rat bone in response to alendronate treatment. Bone 2010 46 5 1391 1399 2-s2.0-77951256738 10.1016/j.bone.2010.01.372
45. Kaczmarczyk-Sedlak I., Folwarczna J., Trzeciak H. I., Thalidomide affects the skeletal system of ovariectomized rats. Pharmacological Reports 2009 61 3 529 538 2-s2.0-67651146485
46. Folwarczna J., Zych M., Burczyk J., Trzeciak H., Trzeciak H. I., Effects of natural phenolic acids on the skeletal system of ovariectomized rats. Planta Medica 2009 75 15 1567 1572 2-s2.0-73949090685 10.1055/s-0029-1185904
47. Cegieła U., Folwarczna J., Pytlik M., Zgórka G., Effects of extracts from Trifolium medium L. and Trifolium pratense L. on development of estrogen deficiency-induced osteoporosis in rats. Evidence-Based Complementary and Alternative Medicine 2012 2012 11 921684 10.1155/2012/921684
48. Turner C. H., Bone strength: current concepts. Annals of the New York Academy of Sciences 2006 1068 1 429 446 2-s2.0-33744750875 10.1196/annals.1346. 039 (Pubitemid 43824172)
49. Muthusami S., Ramachandran I., Muthusamy B., Vasudevan G., Prabhu V., Subramaniam V., Jagadeesan A., Narasimhan S., Ovariectomy induces oxidative stress and impairs bone antioxidant system in adult rats. Clinica Chimica Acta 2005 360 1-2 81 86 2-s2.0-24044460427 10.1016/j.cccn.2005.04.014 (Pubitemid 41225396)
50. Lean J. M., Davies J. T., Fuller K., Jagger C. J., Kirstein B., Partington G. A., Urry Z. L., Chambers T. J., A crucial role for thiol antioxidants in estrogen-deficiency bone loss. Journal of Clinical Investigation 2003 112 6 915 923 2-s2.0-0142186681 10.1172/JCI200318859 (Pubitemid 38063749)
51. Lee N. K., Choi Y. G., Baik J. Y., Han S. Y., Jeong D. W., Bae Y. S., Kim N., Lee S. Y., A crucial role for reactive oxygen species in RANKL-induced osteoclast differentiation. Blood 2005 106 3 852 859 2-s2.0-22144457305 10.1182/blood-2004-09-3662 (Pubitemid 41076424)
52. Muhammad N., Luke D. A., Shuida A. N., Mohamed N., Soelaimana I. N., Two different isomers of vitamin e prevent bone loss in postmenopausal osteoporosis rat model. Evidence-Based Complementary and Alternative Medicine 2012 2012 7 161527 10.1155/2012/161527
53. Rachoń D., Vortherms T., Seidlová-Wuttke D., Menche A., Wuttke W., Uterotropic effects of dietary equol administration in ovariectomized Sprague-Dawley rats. Climacteric 2007 10 5 416 426 2-s2.0-34548634189 10.1080/13697130701624757 (Pubitemid 47402937)
54. Rachoń D., Menche A., Vortherms T., Seidlová-Wuttke D., Wuttke W., Effects of dietary equol administration on the mammary gland in ovariectomized Sprague-Dawley rats. Menopause 2008 15 2 340 345 2-s2.0-40449104394 10.1097/gme.0b013e318093df58 (Pubitemid 351354997)
55. Ward H. A., Kuhnle G. G. C., Mulligan A. A., Lentjes M. A. H., Luben R. N., Khaw K. T., Breast, colorectal, and prostate cancer risk in the European Prospective Investigation into Cancer and Nutrition-Norfolk in relation to phytoestrogen intake derived from an improved database. American Journal of Clinical Nutrition 2010 91 2 440 448 2-s2.0-75649104669 10.3945/ajcn.2009.28282
56. Leclercq G., de Cremoux P., This P., Jacquot Y., Lack of sufficient information on the specificity and selectivity of commercial phytoestrogens preparations for therapeutic purposes. Maturitas 2011 68 1 56 64 2-s2.0-78650589344 10.1016/j.maturitas.2010.10.003