Formononetin-induced apoptosis by activation of Ras/p38 mitogen-activated protein kinase in estrogen receptor-positive human breast cancer cells

Hormone and Metabolic Research

Volumn 44, Issue 13, 2012, Pages 943-948

  Chen, J ^a   Sun, L ^a  

^a GUILIN MEDICAL UNIVERSITY   (China)

Author keywords

apoptosis; breast cancer; formononetin; MAPK; p38

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; FORMONONETIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN BAX; PROTEIN BCL 2; RAF PROTEIN; RAS PROTEIN; STRESS ACTIVATED PROTEIN KINASE;

ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CANCER CELL CULTURE; CELL PROLIFERATION; CELL STRAIN MCF 7; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; ESTROGEN RECEPTOR POSITIVE BREAST CANCER; HUMAN; HUMAN CELL; IN VITRO STUDY; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; FEMALE; HUMANS; ISOFLAVONES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHYTOESTROGENS; PROTO-ONCOGENE PROTEINS C-BCL-2; RAS PROTEINS; RECEPTORS, ESTROGEN;

TRIFOLIUM PRATENSE;

EID: 84871249427     PISSN: 00185043     EISSN: 14394286     Source Type: Journal    
DOI: 10.1055/s-0032-1321818     Document Type: Article

References (26)

1. Hilakivi-Clarke L., Wang C., Kalil M., Riggins R., Pestell R. G. Nutritional modulation of the cell cycle and breast cancer. Endocr Relat Cancer: 2004; 11 603 622
2. Hall J. M., Couse J. F., Korach K. S. The multifaceted mechanisms of estradiol and estrogen receptor signaling. J Biol Chem: 2001; 276 36869 36872
3. Kim K. H., Moriarty K., Bender J. R. Vascular cell signaling by membrane estrogen receptors. Steroids: 2008; 73 864 869
4. Fatih Y. Phytoestrogens in Functional Foods. Taylor & Francis Ltd: 2005; 5 210 211
5. Jin S., Zhang Q. Y., Kang X. M., Wang J. X., Zhao W. H. Daidzein induces MCF-7 breast cancer cell apoptosis via the mitochondrial pathway. Ann Oncol: 2010; 21 263 268
6. Adlercreutz H. Phyto-oestrogens and cancer. Lancet Oncol: 2002; 3 364 373
7. Hsieh C. Y., Santell R. C., Haslam S. Z., Helferich W. G. Estrogenic effects of genistein on the growth of estrogen receptor-positive human breast cancer (MCF-7) cells in vitro and in vivo. Cancer Res: 1998; 58 3833 3838
8. Messina M. J., Loprinzi C. L. Soy for breast cancer survivors: a critical review of the literature. J Nutr: 2001; 131 3095S 3108S
9. Clinton D. A., Kimberly F. A., Young H. J., Goeppinger T. S., Doerge D. R., Helferich W. G. Soy processing influences growth of estrogen-dependent breast cancer tumors. Carcinogenesis: 2004; 25 1649 1657
10. Chen J., Liu L., Hou R., Shao Z., Wu Y., Chen X., Zhou L. Calycosin promotes proliferation of estrogen receptor-positive cells via estrogen receptors and ERK1/2 activation in vitro and in vivo. Cancer Lett: 2011; 308 144 151
11. Ye Y., Hou R., Chen J., Mo L., Zhang J., Huang Y., Mo Z. Formononetin-induced Apoptosis of Human Prostate Cancer Cells Through ERK1/2 Mitogen-activated Protein Kinase Inactivation. Horm Metab Res: 2012; 44 263 267
12. Chen J., Zeng J., Xin M., Huang W., Chen X. Formononetin induces cell cycle arrest of human breast cancer cells via IGF1/PI3K/Akt pathways in vitro and in vivo. Horm Metab Res: 2011; 43 681 686
13. Tang J. Y., Li S., Li Z. H., Zhang Z. J., Hu G., Cheang L. C., Alex D., Hoi M. P., Kwan Y. W., Chan S. W., Leung G. P., Lee S. M. Calycosin promotes angiogenesis involving estrogen receptor and mitogen-activated protein kinase (MAPK) signaling pathway in zebrafish and HUVEC. PLoS One: 2010; 5 e11822
14. Byers S., Park M., Sommers C., Seslar S. Breast carcinoma: a collective disorder. Breast Cancer Res Treat: 1994; 31 203 215
15. Driggers P. H., Segars J. H. Estrogen action and cytoplasmic signaling pathways. Part II: the role of growth factors and phosphorylation in estrogen signaling. Trends Endocrinol Metab: 2002; 13 422 427
16. Segars J. H., Driggers P. H. Estrogen action and cytoplasmic signaling cascades. Part I: membrane-associated signaling complexes. Trends Endocrinol Metab: 2002; 13 349 354
17. Levin E. R. Integration of the extranuclear and nuclear actions of estrogen. Mol Endocrinol: 2005; 19 1951 1959
18. Di X., Yu L., Moore A. B., Castro L., Zheng X., Hermon T., Dixon D. A low concentration of genistein induces estrogen receptor-alpha and insulin-like growth factor-I receptor interactions and proliferation in uterine leiomyoma cells. Hum Reprod: 2008; 23 1873 1883
19. Lau W. S., Chen W. F., Chan R. Y., Guo D. A., Wong M. S. Mitogen-activated protein kinase (MAPK) pathway mediates the oestrogen-like activities of ginsenoside Rg1 in human breast cancer (MCF-7) cells. Br J Pharmacol: 2009; 156 1136 1146
20. Bapat S., Verkleij A., Post J. A. Peroxynitrite activates mitogen-activated protein kinase (MAPK) via a MEK-independent pathway: a role for protein kinase C. FEBS Lett: 2001; 499 21 26
21. Chen L., Mayer J. A., Krisko T. I., Speers C. W., Wang T., Hilsenbeck S. G., Brown P. H. Inhibition of the p38 Kinase Suppresses the Proliferation of Human ER-Negative Breast Cancer Cells. Cancer Res: 2009; 69 8853 8861
22. Wang X. S., Diener K., Manthey C. L., Wang S., Rosenzweig B., Bray J., Delaney J., Cole C. N., Chan-Hui P. Y., Mantlo N., Lichenstein H. S., Zukowski M., Yao Z. Molecular cloning and characterization of a novel p38 mitogen-activated protein kinase. J Biol Chem: 1997; 272 23668 23674
23. Kumar S., McDonnell P. C., Gum R. J., Hand A. T., Lee J. C., Young P. R. Novel homologues of CSBP/p38 MAP kinase: activation, substrate specificity and sensitivity to inhibition by pyridinyl imidazoles. Biochem Biophys Res Commun: 1997; 235 533 538
24. Kim B. J., Ryu S. W., Song B. J. JNK- and p38 kinasemediated phosphorylation of Bax leads to its activation and mitochondrial translocation and to apoptosis of human hepatoma HepG2 cells. J Biol Chem: 2006; 281 21256 21265
25. Fister S., Günthert A. R., Aicher B., Paulini K. W., Emons G., Gründker C. GnRH-II antagonists induce apoptosis in human endometrial, ovarian, and breast cancer cells via activation of stress-induced MAPKs p38 and JNK and proapoptotic protein Bax. Cancer Res: 2009; 69 6473 6481
26. Yuan Z. Q., Feldman R. I., Sussman G. E., Coppola D., Nicosia S. V., Cheng J. Q. AKT2 inhibition of cisplatin-induced JNK/p38 and Bax activation by phosphorylation of ASK1: implication of AKT2 in chemoresistance. J Biol Chem: 2003; 278 23432 23440