메뉴 건너뛰기




Volumn 53, Issue 3, 2014, Pages 169-180

Silibinin inhibits prostate cancer cells- and RANKL-induced osteoclastogenesis by targeting NFATc1, NF-κB, and AP-1 activation in RAW264.7 cells

Author keywords

NFATc1; Osteoclastogenesis; Prostate cancer; RANK ligand; Silibinin

Indexed keywords

NFATC1; OSTEOCLASTOGENESIS; PROSTATE CANCER; RANK LIGAND; SILIBININ;

EID: 84894279317     PISSN: 08991987     EISSN: 10982744     Source Type: Journal    
DOI: 10.1002/mc.21959     Document Type: Article
Times cited : (48)

References (59)
  • 1
    • 0038721560 scopus 로고    scopus 로고
    • Phenotypic heterogeneity of end-stage prostate carcinoma metastatic to bone
    • Roudier MP, True LD, Higano CS, et al. Phenotypic heterogeneity of end-stage prostate carcinoma metastatic to bone. Hum Pathol 2003; 34:646-653.
    • (2003) Hum Pathol , vol.34 , pp. 646-653
    • Roudier, M.P.1    True, L.D.2    Higano, C.S.3
  • 2
    • 41849083088 scopus 로고    scopus 로고
    • Targeting the receptor activator of nuclear factor-kappaB (RANK) ligand in prostate cancer bone metastases
    • Saad F, Markus R, Goessl C. Targeting the receptor activator of nuclear factor-kappaB (RANK) ligand in prostate cancer bone metastases. BJU Int 2008; 101:1071-1075.
    • (2008) BJU Int , vol.101 , pp. 1071-1075
    • Saad, F.1    Markus, R.2    Goessl, C.3
  • 4
    • 57349101056 scopus 로고    scopus 로고
    • Osteotropic cancers: From primary tumor to bone
    • Buijs JT, van der Pluijm G. Osteotropic cancers: From primary tumor to bone. Cancer Lett 2009; 273:177-193.
    • (2009) Cancer Lett , vol.273 , pp. 177-193
    • Buijs, J.T.1    van der Pluijm, G.2
  • 5
    • 69249206543 scopus 로고    scopus 로고
    • The critical role of the bone microenvironment in cancer metastases
    • Casimiro S, Guise TA, Chirgwin J. The critical role of the bone microenvironment in cancer metastases. Mol Cell Endocrinol 2009; 310:71-81.
    • (2009) Mol Cell Endocrinol , vol.310 , pp. 71-81
    • Casimiro, S.1    Guise, T.A.2    Chirgwin, J.3
  • 6
    • 69249244442 scopus 로고    scopus 로고
    • Molecular mechanisms of metastasis in prostate cancer
    • Clarke NW, Hart CA, Brown MD. Molecular mechanisms of metastasis in prostate cancer. Asian J Androl 2009; 11:57-67.
    • (2009) Asian J Androl , vol.11 , pp. 57-67
    • Clarke, N.W.1    Hart, C.A.2    Brown, M.D.3
  • 7
    • 67849134912 scopus 로고    scopus 로고
    • Multidisciplinary approach to the treatment of bone metastases: Osteo-Oncology Center, a new organizational model
    • Ibrahim T, Flamini E, Fabbri L, et al. Multidisciplinary approach to the treatment of bone metastases: Osteo-Oncology Center, a new organizational model. Tumori 2009; 95:291-297.
    • (2009) Tumori , vol.95 , pp. 291-297
    • Ibrahim, T.1    Flamini, E.2    Fabbri, L.3
  • 8
    • 0034284970 scopus 로고    scopus 로고
    • Bone resorption by osteoclasts
    • Teitelbaum SL. Bone resorption by osteoclasts. Science 2000; 289:1504-1508.
    • (2000) Science , vol.289 , pp. 1504-1508
    • Teitelbaum, S.L.1
  • 9
    • 33846031926 scopus 로고    scopus 로고
    • The molecular understanding of osteoclast differentiation
    • Asagiri M, Takayanagi H. The molecular understanding of osteoclast differentiation. Bone 2007; 40:251-264.
    • (2007) Bone , vol.40 , pp. 251-264
    • Asagiri, M.1    Takayanagi, H.2
  • 10
    • 84857852442 scopus 로고    scopus 로고
    • Denosumab for the management of bone disease in patients with solid tumors
    • Body JJ. Denosumab for the management of bone disease in patients with solid tumors. Expert Rev Anticancer Ther 2012; 12:307-322.
    • (2012) Expert Rev Anticancer Ther , vol.12 , pp. 307-322
    • Body, J.J.1
  • 11
    • 79952360832 scopus 로고    scopus 로고
    • Denosumab versus zoledronic acid for treatment of bone metastases in men with castration-resistant prostate cancer: A randomised, double-blind study
    • Fizazi K, Carducci M, Smith M, et al. Denosumab versus zoledronic acid for treatment of bone metastases in men with castration-resistant prostate cancer: A randomised, double-blind study. Lancet 2011; 377:813-822.
    • (2011) Lancet , vol.377 , pp. 813-822
    • Fizazi, K.1    Carducci, M.2    Smith, M.3
  • 12
    • 0036675220 scopus 로고    scopus 로고
    • Metastasis to bone: Causes, consequences and therapeutic opportunities
    • Mundy GR. Metastasis to bone: Causes, consequences and therapeutic opportunities. Nat Rev Cancer 2002; 2:584-593.
    • (2002) Nat Rev Cancer , vol.2 , pp. 584-593
    • Mundy, G.R.1
  • 13
    • 0038706164 scopus 로고    scopus 로고
    • Signal transduction by receptor activator of nuclear factor kappa B in osteoclasts
    • Lee ZH, Kim HH. Signal transduction by receptor activator of nuclear factor kappa B in osteoclasts. Biochem Biophys Res Commun 2003; 305:211-214.
    • (2003) Biochem Biophys Res Commun , vol.305 , pp. 211-214
    • Lee, Z.H.1    Kim, H.H.2
  • 14
    • 23044485912 scopus 로고    scopus 로고
    • RANKing intracellular signaling in osteoclasts
    • Feng X. RANKing intracellular signaling in osteoclasts. IUBMB Life 2005; 57:389-395.
    • (2005) IUBMB Life , vol.57 , pp. 389-395
    • Feng, X.1
  • 16
    • 33846519345 scopus 로고    scopus 로고
    • Hepatoprotective herbal drug, silymarin from experimental pharmacology to clinical medicine
    • Pradhan SC, Girish C. Hepatoprotective herbal drug, silymarin from experimental pharmacology to clinical medicine. Indian J Med Res 2006; 124:491-504.
    • (2006) Indian J Med Res , vol.124 , pp. 491-504
    • Pradhan, S.C.1    Girish, C.2
  • 17
    • 33244472101 scopus 로고    scopus 로고
    • Silymarin and silibinin cause G1 and G2-M cell cycle arrest via distinct circuitries in human prostate cancer PC3 cells: A comparison of flavanone silibinin with flavanolignan mixture silymarin
    • Deep G, Singh RP, Agarwal C, Kroll DJ, Agarwal R. Silymarin and silibinin cause G1 and G2-M cell cycle arrest via distinct circuitries in human prostate cancer PC3 cells: A comparison of flavanone silibinin with flavanolignan mixture silymarin. Oncogene 2006; 25:1053-1069.
    • (2006) Oncogene , vol.25 , pp. 1053-1069
    • Deep, G.1    Singh, R.P.2    Agarwal, C.3    Kroll, D.J.4    Agarwal, R.5
  • 18
    • 59449097284 scopus 로고    scopus 로고
    • Silibinin suppresses growth of human prostate carcinoma PC-3 orthotopic xenograft via activation of extracellular signal-regulated kinase 1/2 and inhibition of signal transducers and activators of transcription signaling
    • Singh RP, Raina K, Deep G, Chan D, Agarwal R. Silibinin suppresses growth of human prostate carcinoma PC-3 orthotopic xenograft via activation of extracellular signal-regulated kinase 1/2 and inhibition of signal transducers and activators of transcription signaling. Clin Cancer Res 2009; 15:613-621.
    • (2009) Clin Cancer Res , vol.15 , pp. 613-621
    • Singh, R.P.1    Raina, K.2    Deep, G.3    Chan, D.4    Agarwal, R.5
  • 19
    • 53049106036 scopus 로고    scopus 로고
    • Stage-specific inhibitory effects and associated mechanisms of silibinin on tumor progression and metastasis in transgenic adenocarcinoma of the mouse prostate model
    • Raina K, Rajamanickam S, Singh RP, Deep G, Chittezhath M, Agarwal R. Stage-specific inhibitory effects and associated mechanisms of silibinin on tumor progression and metastasis in transgenic adenocarcinoma of the mouse prostate model. Cancer Res 2008; 68:6822-6830.
    • (2008) Cancer Res , vol.68 , pp. 6822-6830
    • Raina, K.1    Rajamanickam, S.2    Singh, R.P.3    Deep, G.4    Chittezhath, M.5    Agarwal, R.6
  • 20
    • 59449085306 scopus 로고    scopus 로고
    • Silibinin inhibits established prostate tumor growth, progression, invasion, and metastasis and suppresses tumor angiogenesis and epithelial-mesenchymal transition in transgenic adenocarcinoma of the mouse prostate model mice
    • Singh RP, Raina K, Sharma G, Agarwal R. Silibinin inhibits established prostate tumor growth, progression, invasion, and metastasis and suppresses tumor angiogenesis and epithelial-mesenchymal transition in transgenic adenocarcinoma of the mouse prostate model mice. Clin Cancer Res 2008; 14:7773-7780.
    • (2008) Clin Cancer Res , vol.14 , pp. 7773-7780
    • Singh, R.P.1    Raina, K.2    Sharma, G.3    Agarwal, R.4
  • 21
    • 33845899681 scopus 로고    scopus 로고
    • A phase I and pharmacokinetic study of silybin-phytosome in prostate cancer patients
    • Flaig TW, Gustafson DL, Su LJ, et al. A phase I and pharmacokinetic study of silybin-phytosome in prostate cancer patients. Invest New Drugs 2007; 25:139-146.
    • (2007) Invest New Drugs , vol.25 , pp. 139-146
    • Flaig, T.W.1    Gustafson, D.L.2    Su, L.J.3
  • 22
    • 77952317006 scopus 로고    scopus 로고
    • A study of high-dose oral silybin-phytosome followed by prostatectomy in patients with localized prostate cancer
    • Flaig TW, Glode M, Gustafson D, et al. A study of high-dose oral silybin-phytosome followed by prostatectomy in patients with localized prostate cancer. Prostate 2010; 70:848-855.
    • (2010) Prostate , vol.70 , pp. 848-855
    • Flaig, T.W.1    Glode, M.2    Gustafson, D.3
  • 23
    • 0024360602 scopus 로고
    • Rapid test for in vivo stability and DNA binding of mutated octamer binding proteins with 'mini-extracts' prepared from transfected cells
    • Muller MM, Schreiber E, Schaffner W, Matthias P. Rapid test for in vivo stability and DNA binding of mutated octamer binding proteins with 'mini-extracts' prepared from transfected cells. Nucleic Acids Res 1989; 17:6420.
    • (1989) Nucleic Acids Res , vol.17 , pp. 6420
    • Muller, M.M.1    Schreiber, E.2    Schaffner, W.3    Matthias, P.4
  • 24
    • 0031921546 scopus 로고    scopus 로고
    • Anticarcinogenic effect of a flavonoid antioxidant, silymarin, in human breast cancer cells MDA-MB 468: Induction of G1 arrest through an increase in Cip1/p21 concomitant with a decrease in kinase activity of cyclin-dependent kinases and associated cyclins
    • Zi X, Feyes DK, Agarwal R. Anticarcinogenic effect of a flavonoid antioxidant, silymarin, in human breast cancer cells MDA-MB 468: Induction of G1 arrest through an increase in Cip1/p21 concomitant with a decrease in kinase activity of cyclin-dependent kinases and associated cyclins. Clin Cancer Res 1998; 4:1055-1064.
    • (1998) Clin Cancer Res , vol.4 , pp. 1055-1064
    • Zi, X.1    Feyes, D.K.2    Agarwal, R.3
  • 25
    • 68849113912 scopus 로고    scopus 로고
    • Silibinin suppresses growth and induces apoptotic death of human colorectal carcinoma LoVo cells in culture and tumor xenograft
    • Kaur M, Velmurugan B, Tyagi A, et al. Silibinin suppresses growth and induces apoptotic death of human colorectal carcinoma LoVo cells in culture and tumor xenograft. Mol Cancer Ther 2009; 8:2366-2374.
    • (2009) Mol Cancer Ther , vol.8 , pp. 2366-2374
    • Kaur, M.1    Velmurugan, B.2    Tyagi, A.3
  • 26
    • 0344827261 scopus 로고    scopus 로고
    • Silibinin upregulates the expression of cyclin-dependent kinase inhibitors and causes cell cycle arrest and apoptosis in human colon carcinoma HT-29 cells
    • Agarwal C, Singh RP, Dhanalakshmi S, et al. Silibinin upregulates the expression of cyclin-dependent kinase inhibitors and causes cell cycle arrest and apoptosis in human colon carcinoma HT-29 cells. Oncogene 2003; 22:8271-8282.
    • (2003) Oncogene , vol.22 , pp. 8271-8282
    • Agarwal, C.1    Singh, R.P.2    Dhanalakshmi, S.3
  • 27
    • 46249129317 scopus 로고    scopus 로고
    • Isosilybin B causes androgen receptor degradation in human prostate carcinoma cells via PI3K-Akt-Mdm2-mediated pathway
    • Deep G, Oberlies NH, Kroll DJ, Agarwal R. Isosilybin B causes androgen receptor degradation in human prostate carcinoma cells via PI3K-Akt-Mdm2-mediated pathway. Oncogene 2008; 27:3986-3998.
    • (2008) Oncogene , vol.27 , pp. 3986-3998
    • Deep, G.1    Oberlies, N.H.2    Kroll, D.J.3    Agarwal, R.4
  • 28
    • 33745112128 scopus 로고    scopus 로고
    • Silibinin inhibits UVB- and epidermal growth factor-induced mitogenic and cell survival signaling involving activator protein-1 and nuclear factor-kappaB in mouse epidermal JB6 cells
    • Singh RP, Dhanalakshmi S, Mohan S, Agarwal C, Agarwal R. Silibinin inhibits UVB- and epidermal growth factor-induced mitogenic and cell survival signaling involving activator protein-1 and nuclear factor-kappaB in mouse epidermal JB6 cells. Mol Cancer Ther 2006; 5:1145-1153.
    • (2006) Mol Cancer Ther , vol.5 , pp. 1145-1153
    • Singh, R.P.1    Dhanalakshmi, S.2    Mohan, S.3    Agarwal, C.4    Agarwal, R.5
  • 29
    • 57349142011 scopus 로고    scopus 로고
    • Isosilibinin inhibits advanced human prostate cancer growth in athymic nude mice: Comparison with silymarin and silibinin
    • Deep G, Raina K, Singh RP, Oberlies NH, Kroll DJ, Agarwal R. Isosilibinin inhibits advanced human prostate cancer growth in athymic nude mice: Comparison with silymarin and silibinin. Int J Cancer 2008; 123:2750-2758.
    • (2008) Int J Cancer , vol.123 , pp. 2750-2758
    • Deep, G.1    Raina, K.2    Singh, R.P.3    Oberlies, N.H.4    Kroll, D.J.5    Agarwal, R.6
  • 30
    • 84055177046 scopus 로고    scopus 로고
    • Osteoblastogenesis and osteoprotection enhanced by flavonolignan silibinin in osteoblasts and osteoclasts
    • Kim JL, Kang SW, Kang MK, et al. Osteoblastogenesis and osteoprotection enhanced by flavonolignan silibinin in osteoblasts and osteoclasts. J Cell Biochem 2012; 113:247-259.
    • (2012) J Cell Biochem , vol.113 , pp. 247-259
    • Kim, J.L.1    Kang, S.W.2    Kang, M.K.3
  • 31
    • 73349124125 scopus 로고    scopus 로고
    • GM-CSF and IL-4 induce dendritic cell differentiation and disrupt osteoclastogenesis through M-CSF receptor shedding by up-regulation of TNF-alpha converting enzyme (TACE)
    • Hiasa M, Abe M, Nakano A, et al. GM-CSF and IL-4 induce dendritic cell differentiation and disrupt osteoclastogenesis through M-CSF receptor shedding by up-regulation of TNF-alpha converting enzyme (TACE). Blood 2009; 114:4517-4526.
    • (2009) Blood , vol.114 , pp. 4517-4526
    • Hiasa, M.1    Abe, M.2    Nakano, A.3
  • 32
    • 79952699649 scopus 로고    scopus 로고
    • RANKL-independent human osteoclast formation with APRIL, BAFF, NGF, IGF I and IGF II
    • Hemingway F, Taylor R, Knowles HJ, Athanasou NA. RANKL-independent human osteoclast formation with APRIL, BAFF, NGF, IGF I and IGF II. Bone 2011; 48:938-944.
    • (2011) Bone , vol.48 , pp. 938-944
    • Hemingway, F.1    Taylor, R.2    Knowles, H.J.3    Athanasou, N.A.4
  • 33
    • 68149163293 scopus 로고    scopus 로고
    • The mechanism of osteoclast differentiation induced by IL-1
    • Kim JH, Jin HM, Kim K, et al. The mechanism of osteoclast differentiation induced by IL-1. J Immunol 2009; 183:1862-1870.
    • (2009) J Immunol , vol.183 , pp. 1862-1870
    • Kim, J.H.1    Jin, H.M.2    Kim, K.3
  • 34
    • 70349607938 scopus 로고    scopus 로고
    • Silibinin inhibits osteoclast differentiation mediated by TNF family members
    • Kim JH, Kim K, Jin HM, et al. Silibinin inhibits osteoclast differentiation mediated by TNF family members. Mol Cells 2009; 28:201-207.
    • (2009) Mol Cells , vol.28 , pp. 201-207
    • Kim, J.H.1    Kim, K.2    Jin, H.M.3
  • 35
    • 18744366041 scopus 로고    scopus 로고
    • Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts
    • Takayanagi H, Kim S, Koga T, et al. Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts. Dev Cell 2002; 3:889-901.
    • (2002) Dev Cell , vol.3 , pp. 889-901
    • Takayanagi, H.1    Kim, S.2    Koga, T.3
  • 37
    • 25444444351 scopus 로고    scopus 로고
    • Contribution of nuclear factor of activated T cells c1 to the transcriptional control of immunoreceptor osteoclast-associated receptor but not triggering receptor expressed by myeloid cells-2 during osteoclastogenesis
    • Kim Y, Sato K, Asagiri M, Morita I, Soma K, Takayanagi H. Contribution of nuclear factor of activated T cells c1 to the transcriptional control of immunoreceptor osteoclast-associated receptor but not triggering receptor expressed by myeloid cells-2 during osteoclastogenesis. J Biol Chem 2005; 280:32905-32913.
    • (2005) J Biol Chem , vol.280 , pp. 32905-32913
    • Kim, Y.1    Sato, K.2    Asagiri, M.3    Morita, I.4    Soma, K.5    Takayanagi, H.6
  • 38
    • 0034613188 scopus 로고    scopus 로고
    • Involvement of p38 mitogen-activated protein kinase signaling pathway in osteoclastogenesis mediated by receptor activator of NF-kappa B ligand (RANKL)
    • Matsumoto M, Sudo T, Saito T, Osada H, Tsujimoto M. Involvement of p38 mitogen-activated protein kinase signaling pathway in osteoclastogenesis mediated by receptor activator of NF-kappa B ligand (RANKL). J Biol Chem 2000; 275:31155-31161.
    • (2000) J Biol Chem , vol.275 , pp. 31155-31161
    • Matsumoto, M.1    Sudo, T.2    Saito, T.3    Osada, H.4    Tsujimoto, M.5
  • 39
    • 77956643639 scopus 로고    scopus 로고
    • Osteomimicry: How tumor cells try to deceive the bone
    • Rucci N, Teti A. Osteomimicry: How tumor cells try to deceive the bone. Front Biosci (Schol Ed) 2010; 2:907-915.
    • (2010) Front Biosci (Schol Ed) , vol.2 , pp. 907-915
    • Rucci, N.1    Teti, A.2
  • 42
    • 78649962502 scopus 로고    scopus 로고
    • Optimizing clinical benefits of bisphosphonates in cancer patients with bone metastases
    • Aapro M, Saad F, Costa L. Optimizing clinical benefits of bisphosphonates in cancer patients with bone metastases. Oncologist 2010; 15:1147-1158.
    • (2010) Oncologist , vol.15 , pp. 1147-1158
    • Aapro, M.1    Saad, F.2    Costa, L.3
  • 43
    • 84855516339 scopus 로고    scopus 로고
    • Denosumab and bone-metastasis-free survival in men with castration-resistant prostate cancer: Results of a phase 3, randomised, placebo-controlled trial
    • Smith MR, Saad F, Coleman R, et al. Denosumab and bone-metastasis-free survival in men with castration-resistant prostate cancer: Results of a phase 3, randomised, placebo-controlled trial. Lancet 2012; 379:39-46.
    • (2012) Lancet , vol.379 , pp. 39-46
    • Smith, M.R.1    Saad, F.2    Coleman, R.3
  • 44
    • 77957598340 scopus 로고    scopus 로고
    • Antimetastatic efficacy of silibinin: Molecular mechanisms and therapeutic potential against cancer
    • Deep G, Agarwal R. Antimetastatic efficacy of silibinin: Molecular mechanisms and therapeutic potential against cancer. Cancer Metastasis Rev 2010; 29:447-463.
    • (2010) Cancer Metastasis Rev , vol.29 , pp. 447-463
    • Deep, G.1    Agarwal, R.2
  • 45
    • 80051505318 scopus 로고    scopus 로고
    • Role of E-cadherin in antimigratory and antiinvasive efficacy of silibinin in prostate cancer cells
    • Deep G, Gangar SC, Agarwal C, Agarwal R. Role of E-cadherin in antimigratory and antiinvasive efficacy of silibinin in prostate cancer cells. Cancer Prev Res (Phila) 2011; 4:1222-1232.
    • (2011) Cancer Prev Res (Phila) , vol.4 , pp. 1222-1232
    • Deep, G.1    Gangar, S.C.2    Agarwal, C.3    Agarwal, R.4
  • 46
    • 62349117597 scopus 로고    scopus 로고
    • Growth inhibition and regression of lung tumors by silibinin: Modulation of angiogenesis by macrophage-associated cytokines and nuclear factor-kappaB and signal transducers and activators of transcription 3
    • Tyagi A, Singh RP, Ramasamy K, et al. Growth inhibition and regression of lung tumors by silibinin: Modulation of angiogenesis by macrophage-associated cytokines and nuclear factor-kappaB and signal transducers and activators of transcription 3. Cancer Prev Res (PhilaPa) 2009; 2:74-83.
    • (2009) Cancer Prev Res (PhilaPa) , vol.2 , pp. 74-83
    • Tyagi, A.1    Singh, R.P.2    Ramasamy, K.3
  • 47
    • 80054833809 scopus 로고    scopus 로고
    • TNFalpha inhibits the development of osteoclasts through osteoblast-derived GM-CSF
    • Atanga E, Dolder S, Dauwalder T, Wetterwald A, Hofstetter W. TNFalpha inhibits the development of osteoclasts through osteoblast-derived GM-CSF. Bone 2011; 49:1090-1100.
    • (2011) Bone , vol.49 , pp. 1090-1100
    • Atanga, E.1    Dolder, S.2    Dauwalder, T.3    Wetterwald, A.4    Hofstetter, W.5
  • 48
    • 77956281340 scopus 로고    scopus 로고
    • The role of RANKL and MMP-9 in the bone resorption caused by ameloblastoma
    • Qian Y, Huang HZ. The role of RANKL and MMP-9 in the bone resorption caused by ameloblastoma. J Oral Pathol Med 2010; 39:592-598.
    • (2010) J Oral Pathol Med , vol.39 , pp. 592-598
    • Qian, Y.1    Huang, H.Z.2
  • 49
    • 79953310334 scopus 로고    scopus 로고
    • Adiponectin inhibits osteoclastogenesis and bone resorption via APPL1-mediated suppression of Akt1
    • Tu Q, Zhang J, Dong LQ, et al. Adiponectin inhibits osteoclastogenesis and bone resorption via APPL1-mediated suppression of Akt1. J Biol Chem 2011; 286:12542-12553.
    • (2011) J Biol Chem , vol.286 , pp. 12542-12553
    • Tu, Q.1    Zhang, J.2    Dong, L.Q.3
  • 50
    • 18044394024 scopus 로고    scopus 로고
    • Adiponectin increases bone mass by suppressing osteoclast and activating osteoblast
    • Oshima K, Nampei A, Matsuda M, et al. Adiponectin increases bone mass by suppressing osteoclast and activating osteoblast. Biochem Biophys Res Commun 2005; 331:520-526.
    • (2005) Biochem Biophys Res Commun , vol.331 , pp. 520-526
    • Oshima, K.1    Nampei, A.2    Matsuda, M.3
  • 52
    • 23844509510 scopus 로고    scopus 로고
    • Interferon-alpha and -beta differentially regulate osteoclastogenesis: Role of differential induction of chemokine CXCL11 expression
    • Coelho LF, Magno de Freitas Almeida G, Mennechet FJ, Blangy A, Uze G. Interferon-alpha and -beta differentially regulate osteoclastogenesis: Role of differential induction of chemokine CXCL11 expression. Proc Natl Acad Sci USA 2005; 102:11917-11922.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 11917-11922
    • Coelho, L.F.1    Magno de Freitas Almeida, G.2    Mennechet, F.J.3    Blangy, A.4    Uze, G.5
  • 53
    • 79955095546 scopus 로고    scopus 로고
    • Purification and identification of lactoperoxidase in milk basic proteins as an inhibitor of osteoclastogenesis
    • Morita Y, Ono A, Serizawa A, et al. Purification and identification of lactoperoxidase in milk basic proteins as an inhibitor of osteoclastogenesis. J Dairy Sci 2011; 94:2270-2279.
    • (2011) J Dairy Sci , vol.94 , pp. 2270-2279
    • Morita, Y.1    Ono, A.2    Serizawa, A.3
  • 54
    • 82555197779 scopus 로고    scopus 로고
    • Positive regulators of osteoclastogenesis and bone resorption in rheumatoid arthritis
    • Braun T, Zwerina J. Positive regulators of osteoclastogenesis and bone resorption in rheumatoid arthritis. Arthritis Res Ther 2011; 13:235.
    • (2011) Arthritis Res Ther , vol.13 , pp. 235
    • Braun, T.1    Zwerina, J.2
  • 55
    • 33749370406 scopus 로고    scopus 로고
    • Hepatocyte growth factor can substitute for M-CSF to support osteoclastogenesis
    • Adamopoulos IE, Xia Z, Lau YS, Athanasou NA. Hepatocyte growth factor can substitute for M-CSF to support osteoclastogenesis. Biochem Biophys Res Commun 2006; 350:478-483.
    • (2006) Biochem Biophys Res Commun , vol.350 , pp. 478-483
    • Adamopoulos, I.E.1    Xia, Z.2    Lau, Y.S.3    Athanasou, N.A.4
  • 56
    • 75149134683 scopus 로고    scopus 로고
    • Titanium induced production of chemokines CCL17/TARC and CCL22/MDC in human osteoclasts and osteoblasts
    • Cadosch D, Gautschi OP, Chan E, Simmen HP, Filgueira L. Titanium induced production of chemokines CCL17/TARC and CCL22/MDC in human osteoclasts and osteoblasts. J Biomed Mater Res A 2010; 92:475-483.
    • (2010) J Biomed Mater Res A , vol.92 , pp. 475-483
    • Cadosch, D.1    Gautschi, O.P.2    Chan, E.3    Simmen, H.P.4    Filgueira, L.5
  • 57
    • 0032212144 scopus 로고    scopus 로고
    • Osteoclast-mediated bone resorption is stimulated during short-term administration of granulocyte colony-stimulating factor but is not responsible for hematopoietic progenitor cell mobilization
    • Takamatsu Y, Simmons PJ, Moore RJ, Morris HA, To LB, Levesque JP. Osteoclast-mediated bone resorption is stimulated during short-term administration of granulocyte colony-stimulating factor but is not responsible for hematopoietic progenitor cell mobilization. Blood 1998; 92:3465-3473.
    • (1998) Blood , vol.92 , pp. 3465-3473
    • Takamatsu, Y.1    Simmons, P.J.2    Moore, R.J.3    Morris, H.A.4    To, L.B.5    Levesque, J.P.6
  • 58
    • 0034707671 scopus 로고    scopus 로고
    • Reciprocal role of ERK and NF-kappaB pathways in survival and activation of osteoclasts
    • Miyazaki T, Katagiri H, Kanegae Y, et al. Reciprocal role of ERK and NF-kappaB pathways in survival and activation of osteoclasts. J Cell Biol 2000; 148:333-342.
    • (2000) J Cell Biol , vol.148 , pp. 333-342
    • Miyazaki, T.1    Katagiri, H.2    Kanegae, Y.3
  • 59
    • 37249090188 scopus 로고    scopus 로고
    • The role of NFAT in osteoclast formation
    • Takayanagi H. The role of NFAT in osteoclast formation. Ann NY Acad Sci 2007; 1116:227-237.
    • (2007) Ann NY Acad Sci , vol.1116 , pp. 227-237
    • Takayanagi, H.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.