The phosphatidylinositol 3-Kinase, p38, and extracellular signal-regulated kinase pathways are involved in osteoclast differentiation

Bone

Volumn 30, Issue 1, 2002, Pages 71-77

  Lee, S E ^a,c   Woo, K M ^e   Kim, S Y ^d   Kim, H M ^f   Kwack, K ^g   Lee, Z H ^a,b,c   Kim, H H ^a,b,c,d  

^a National Research Laboratory for Bone Metabolism South Korea   (South Korea)

^b Research Center for Proteineous Materials   (South Korea)

^c Wonkwang Dental Research Institute   (South Korea)

^d Chosun University   (South Korea)

^e Gangneung Wonju National University   (South Korea)

^f School of Dentistry   (South Korea)

^g Immunomodulation Research Center   (South Korea)

Author keywords

Akt; ERK; Osteoclast; p38; PI 3 kinase; TRAP

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; MITOGEN ACTIVATED PROTEIN KINASE 1; OSTEOCLAST DIFFERENTIATION FACTOR; PHOSPHATIDYLINOSITOL; PHOSPHATIDYLINOSITOL 3 KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BONE MARROW; BONE MARROW CELL; CELL DIFFERENTIATION; COCULTURE; CONTROLLED STUDY; GENE EXPRESSION REGULATION; MOUSE; NONHUMAN; OSTEOBLAST; OSTEOCLAST; OSTEOLYSIS; SIGNAL TRANSDUCTION; STEM CELL;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; CARRIER PROTEINS; CELL DIFFERENTIATION; CELL LINE; CHROMONES; COCULTURE TECHNIQUES; ENZYME INHIBITORS; FLAVONOIDS; HUMANS; IMIDAZOLES; MACROPHAGE COLONY-STIMULATING FACTOR; MAP KINASE KINASE 1; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED ICR; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; MORPHOLINES; OSTEOBLASTS; OSTEOCLASTS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; PYRIDINES; RANK LIGAND; RECEPTOR ACTIVATOR OF NUCLEAR FACTOR-KAPPA B; SIGNAL TRANSDUCTION; STEM CELLS;

EID: 0036138694     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/S8756-3282(01)00657-3     Document Type: Article

References (37)

1. A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function
2. c-Src is required for stimulation of gelsolin-associated phosphatidylinositol 3-kinase
3. Osteopontin stimulates gelsolin-associated phosphoinositide levels and phosphatidylinositol triphosphate-hydroxyl kinase
4. Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells
5. PI3K; downstream AKTion blocks apoptosis
6. Evidence for a functional association between phosphatidylinositol 3-kinase and c-src in the spreading response of osteoclasts to colony-stimulating factor-1
7. Ras controls growth, survival and differentiation in the Drosophila eye by different thresholds of MAP kinase activity
8. Wortmannin, a potent inhibitor of phosphatidylinositol 3-kinase, inhibits osteoclastic bone resorption in vitro
9. CSF-1 signal transduction
10. Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand
11. Specific activation of the p38 mitogen-activated protein kinase signaling pathway and induction of neurite outgrowth in PC12 cells by bone morphogenetic protein-2
12. Phosphatidylinositol 3-kinase inhibitors block differentiation of skeletal muscle cells
13. Receptor activator of NF-kappaB recruits multiple TRAF family adaptors and activates c-Jun N-terminal kinase
14. Growth factor receptor-bound protein 2 SH2/SH3 domain binding to CD28 and its role in co-signaling
15. Tumor necrosis factor alpha stimulates osteoclast differentiation by a mechanism independent of the ODF/RANKL-RANK interaction
16. OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis
17. Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation
18. Phosphatidylinositol 3-kinase association with the osteoclast cytoskeleton, and its involvement in osteoclast attachment and spreading
19. Activation of c-Jun N-terminal kinase and activator protein 1 by receptor activator of NF-κB
20. RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolism
21. Involvement of p38 mitogen-activated protein kinase signaling pathway in osteoclastogenesis mediated by receptor activator of NF-kappa B ligand (RANKL)
22. RANK is the essential signaling receptor for osteoclast differentiation factor in osteoclastogenesis
23. Wortmannin, a specific inhibitor of phosphatidylinositol-3 kinase, blocks osteoclastic bone resorption
24. Wortmannin inhibits spreading and chemotaxis of rat osteoclasts in vitro
25. Mitogen-activated protein kinases; specific messages from ubiquitous messengers
26. Osteoprotegerin; a novel secreted protein involved in the regulation of bone density
27. Mitogen-activated protein kinase cascades and regulation of gene expression
28. 3 in osteoclast differentiation and function
29. Modulation of osteoclast differentiation
30. Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families
31. Identification and characterization of the new osteoclast progenitor with macrophage phenotypes being able to differentiate into mature osteoclasts
32. Bone resorption by osteoclasts
33. Cellular signaling; pivoting around PDK-1
34. Origin of osteoclasts; mature monocytes and macrophages are capable of differentiating into osteoclasts under a suitable microenvironment prepared by bone marrow-derived stromal cells
35. TRANCE, a TNF family member, activates Akt/PKB through a signaling complex involving TRAF6 and c-Src
36. TRANCE is a novel ligand of the tumor necrosis factor receptor family that activates c-Jun N-terminal kinase in T cells
37. Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and identical to TRANCE-RANKL