The natural flavonoid galangin inhibits osteoclastic bone destruction and osteoclastogenesis by suppressing NF-κB in collagen-induced arthritis and bone marrow-derived macrophages

European Journal of Pharmacology

Volumn 698, Issue 1-3, 2013, Pages 57-66

  Huh, Jeong Eun ^a   Jung, In Tae ^a   Choi, Junyoung ^a   Baek, Yong Hyeon ^b   Lee, Jae Dong ^a   Park, Dong Suk ^b   Choi, Do Young ^a  

^a Kyung Hee University   (South Korea)

^b Kyung Hee University College of Medicine   (South Korea)

Author keywords

Bone destruction; Galangin; NF B; Osteoclastogenesis; RANKL

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; COLLAGEN; GALANGIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 17; INTERLEUKIN 1BETA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPROTEGERIN; PROTEIN C JUN; PROTEIN KINASE B; SMALL INTERFERING RNA; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTHRITIS; ARTHROPATHY; ARTICLE; BONE DESTRUCTION; BONE EROSION; BONE MARROW; C JUN GENE; CHONDROPATHY; COCULTURE; CONTROLLED STUDY; DISEASE COURSE; DISEASE SEVERITY; DRUG DOSE COMPARISON; DRUG MECHANISM; DRUG SAFETY; ENZYME SPECIFICITY; FEMALE; GENE; GENETIC TRANSFECTION; HISTOPATHOLOGY; HYPERPLASIA; JOINT SWELLING; MACROPHAGE; MALE; NFATC1 GENE; NONHUMAN; ONCOGENE C FOS; OSTEOBLAST; OSTEOCLASTOGENESIS; PANNUS; PAW EDEMA; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS INHIBITION; RAT; SIGNAL TRANSDUCTION; SYNOVIAL HYPERPLASIA; SYNOVITIS; TREATMENT DURATION; WESTERN BLOTTING;

ANIMALS; ARTHRITIS, EXPERIMENTAL; BIOLOGICAL AGENTS; BIOLOGICAL MARKERS; BONE AND BONES; BONE MARROW CELLS; CELL DIFFERENTIATION; COCULTURE TECHNIQUES; CYTOKINES; FEMALE; FLAVONOIDS; HUMANS; I-KAPPA B KINASE; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MACROPHAGES; MALE; MICE; NF-KAPPA B; OSTEOBLASTS; OSTEOCLASTS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; RANK LIGAND; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84871929030     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2012.08.013     Document Type: Article

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