Effect of hyperglycaemia on muscarinic M3 receptor expression and secretory sensitivity to cholinergic receptor activation in islets

Diabetes, Obesity and Metabolism

Volumn 16, Issue 10, 2014, Pages 947-956

  Hauge Evans, A C ^a   Reers, C ^a   Kerby, A ^a   Franklin, Z ^a   Amisten, S ^a   King, A J ^a   Hassan, Z ^a   Vilches Flores, A ^a,b   Tippu, Z ^a   Persaud, S J ^a   Jones, P M ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

Author keywords

Encapsulated islets; Hyperglycaemia; Insulin secretion; Muscarinic M3 receptors; Ob ob mouse model; Parasympathetic regulation

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; 2 [1 (3 DIMETHYLAMINOPROPYL) 5 METHOXY 1H INDOL 3 YL] 3 (1H INDOL 3 YL)MALEIMIDE; ALGINIC ACID; BETA 2 ADRENERGIC RECEPTOR; CALCIUM SENSING RECEPTOR; CARBACHOL; CHOLINERGIC RECEPTOR; GLUCOSE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; INSULIN; MESSENGER RNA; MUSCARINIC M3 RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN P85; MUSCARINIC AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GENOTYPE; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN TISSUE; HYPERGLYCEMIA; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; INSULIN RELEASE; MALE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET; PHENOTYPE; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RADIOIMMUNOASSAY; RECEPTOR DOWN REGULATION; STREPTOZOTOCIN-INDUCED DIABETES MELLITUS; AGONISTS; ANIMAL; EXPERIMENTAL DIABETES MELLITUS; METABOLISM; MOUSE MUTANT; SECRETION (PROCESS);

ANIMALS; DIABETES MELLITUS, EXPERIMENTAL; GLUCOSE; HYPERGLYCEMIA; INSULIN; ISLETS OF LANGERHANS; MALE; MICE; MICE, OBESE; MUSCARINIC AGONISTS; PHOSPHATIDYLINOSITOL 3-KINASES; RECEPTOR, MUSCARINIC M3;

EID: 84912083730     PISSN: 14628902     EISSN: 14631326     Source Type: Journal    
DOI: 10.1111/dom.12301     Document Type: Article

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