Persistently enhanced sensitivity of pancreatic islets from ob/ob mice to PKC-stimulated insulin secretion

American Journal of Physiology - Endocrinology and Metabolism

Volumn 272, Issue 2 35-2, 1997, Pages

  Chen, Neng Guin ^a   Romsos, Dale R ^a  

^a Michigan State University   (United States)

Author keywords

acetylcholine; Ca2+ channel agonist BAY K 8644; cultured islets; protein kinase C agonist phorbol 12 myristate 13 acetate

Indexed keywords

1,4 DIHYDRO 2,6 DIMETHYL 5 NITRO 4 [2 (TRIFLUOROMETHYL)PHENYL] 3 PYRIDINECARBOXYLIC ACID METHYL ESTER; CALCIUM CHANNEL; INSULIN; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE C;

ANIMAL CELL; ARTICLE; CHANNEL GATING; CONTROLLED STUDY; FEMALE; HYPERINSULINEMIA; INSULIN RELEASE; MOUSE; NONHUMAN; PANCREAS ISLET CELL; PRIORITY JOURNAL;

EID: 0031001932     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.1997.272.2.e304     Document Type: Article

References (23)

1. Akita, Y., S. Ohno, Y. Konno, A. Yano, and K. Suzuki. Expression and properties of two distinct classes of the phorbol ester receptor family, four conventional protein kinase C types, and a novel protein kinase C. J. Biol. Chem. 265: 354-362, 1990.
2. Atef, N., C. Brule, M. Bihoreau, and A. Ktorza. Enhanced insulin secretory response to acetylcholine by perifused pancreas of 5-day-old preobese Zucker rats. Endocrinology 129: 2219-2224, 1991.
3. Chen, H., O. Charlat, L. A. Tartaglia, E. A. Woolf, X. Weng, S. J. Ellis, N. D. Lakey, J. Culpepper, K. J. Moore, R. E. Breitbart, G. M. Duyk, R. I. Tepper, and J. P. Morgenstern. Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice. Cell 84: 491-495, 1996.
4. Chen, N.-G., and D. R. Romsos. Enhanced sensitivity of pancreatic islets from preobese 2-week-old 06/06 mice to neurohormonal stimulation of insulin secretion. Endocrinology 136: 505-511, 1995.
5. Flatt, P. R., C. J. Bailey, P.-O. Berggren, L. Herberg, and S. K. Swanston-Flatt. Defective insulin secretion in diabetes and insulinoma. In: Nutrient Regulation of Insulin Secretion, edited by P. R. Flatt. London: Portland, 1992, p. 341-406.
6. Fournier, L., N. Begin-Heick, J. F. Whitefield, and J.-L. Schwartz. Comparison of the properties of the ATP-sensitive K channels of pancreatic B-cells of lean and obese (06/06) C57BL/6J mice. J. Membr. Biol. 129: 267-276, 1992.
7. Gao, Z.-Y., P. Gilon, and J. C. Henquin. The role of protein kinase-C in signal transduction through vasopressin and acetylcholine receptors in pancreatic β-cells from normal mouse. Endocrinology 135: 191-199, 1994.
8. Hayek, A. Insulin release in long-term culture from isolated islets of obese and lean Zucker rats. Horm. Metab. Res. 12: 85-86, 1980.
9. Henquin, J. C., W. Schmeer, M. Henquin, and H. P. Meissner. Effects of a calcium channel agonist on the electrical, ionic and secretory events in mouse pancreatic B-cells. Biochem. Biophys. Res. Commun. 131: 980-986, 1985.
10. Kekow, J., K. Ulrichs, W. Muller-Ruchholtz, and W. L. Gross. Measurement of rat insulin-ELISA with increased sensitivity, high accuracy and greater practicability than established radioimmunoassay. Diabetes 37: 321-326, 1988.
11. Kieffer, T. J., R. S. Heller, and J. F. Habener. Leptin receptors expressed on pancreatic β-cells. Biochem. Biophys. Res. Commun. 224: 522-527, 1996.
12. Labarca, C., and K. Paigen. A simple, rapid and sensitive DNA assay procedure. Anal. Biochem. 102: 344-352, 1980.
13. Lacy, P. E., and M. Kostianovsky. Method for the isolation of intact islets of Langerhans from the rat pancreas. Diabetes 16: 35-39, 1967.
14. Persaud, S. J., P. M. Jones, and S. L. Howell. The role of protein kinase C in insulin secretion. In: Nutrient Regulation of Insulin Secretion, edited by P. R. Flatt. London: Portland, 1992, p. 247-269.
15. 2+ and cyclic AMP in addition to inhibiting protein kinase C in rat islets of Langerhans. Mol. Cell. Endocrinol. 94: 55-60, 1993.
16. Persaud, S. J., P. M. Jones, D. Sugen, and S. L. Howell. The role of protein kinase C in cholinergic stimulation of insulin secretion from rat islets of Langerhans. Biochem. J. 264: 753-758, 1989.
17. 2+, cAMP and phospholipid-derived messengers in coupling mechanisms of insulin secretion. Physiol. Rev. 67: 1185-1248, 1987.
18. Sokal, R. R., and F. J. Rohlf. Biometry: The Principles and Practice of Statistics in Biological Research. New York: Freeman, 1981, p. 394-395.
19. Tartaglia, L. A., M. Dembski, X. Weng, N. Deng, J. Culpepper, R. Devos, G. J. Richards, L. A. Campfield, F. T. Clark, J. Deeds, C. Muir, S. Sanker, A. Moriarty, K. J. Moore, J. S. Smutko, G. G. Mays, E. A. Woolf, C. A. Monroe, and R. I. Tepper. Identification and expression cloning of a leptin receptor, Ob-R. Cell 83: 1263-1271, 1995.
20. Tassava, T. M., T. Okuda, and D. R. Romsos. Insulin secretion from 06/06 mouse pancreatic islets: effects of neurotransmitters. Am. J. Physiol. 262 (Endocrinol. Metab. 25): E338-E343, 1992.
21. 2+, cAMP and diacylglycerol. Mol. Cell. Endocrinol. 70: 119-137, 1990.
22. Zawalich, W. S., K. C. Zawalich, and G. G. Kelley. Regulation of insulin release by phospholipase C activation in mouse islets: differential effects of glucose and neurohumoral stimulation. Endocrinology 136: 4903-4909, 1995.
23. Zhang, Y., R. Proenca, M. Maffei, M. Barone, L. Leopold, and J. M. Friedman. Positional cloning of the mouse obese gene and its human homologue. Nature Lond. 372: 425-432, 1994.