Procyanidin B2 inhibits NLRP3 inflammasome activation in human vascular endothelial cells

Biochemical Pharmacology

Volumn 92, Issue 4, 2014, Pages 599-606

  Yang, Haixia ^a,b   Xiao, Lei ^a   Yuan, Yue ^a   Luo, Xiaoqin ^a   Jiang, Manli ^a   Ni, Jiahua ^a   Wang, Nanping ^a,c  

^a XI'AN JIAOTONG UNIVERSITY   (China)

^b Therapeutic Vaccines Engineering Center of Shaanxi Province   (China)

^c PEKING UNIVERSITY   (China)

Author keywords

AP 1; NLRP3 inflammasome; Procyanidin B2; ROS

Indexed keywords

ANTIINFLAMMATORY AGENT; CRYOPYRIN; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; LIPOPOLYSACCHARIDE; PROCYANIDIN B2; PROCYANIDIN DERIVATIVE; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR AP 1; UNCLASSIFIED DRUG; BIFLAVONOID; CARRIER PROTEIN; CATECHIN; INFLAMMASOME; NLRP3 PROTEIN, HUMAN; PRIMER DNA; PROANTHOCYANIDIN; PROTEIN C JUN;

ANTIINFLAMMATORY ACTIVITY; ARTHRITIS; ARTICLE; ATHEROSCLEROSIS; CONTROLLED STUDY; CYTOKINE RELEASE; DIABETES MELLITUS; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; PATHOGENESIS; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; TRANSCRIPTION INITIATION SITE; UMBILICAL VEIN ENDOTHELIAL CELL; CYTOLOGY; DRUG EFFECTS; GENE SILENCING; GENETICS; METABOLISM; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; VASCULAR ENDOTHELIUM;

BASE SEQUENCE; BIFLAVONOIDS; CARRIER PROTEINS; CATECHIN; DNA PRIMERS; ENDOTHELIUM, VASCULAR; GENE KNOCKDOWN TECHNIQUES; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; INFLAMMASOMES; POLYMERASE CHAIN REACTION; PROANTHOCYANIDINS; PROTO-ONCOGENE PROTEINS C-JUN;

EID: 84912082241     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2014.10.001     Document Type: Article

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