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Volumn 7, Issue 6, 2014, Pages 837-846

Lipoic acid and lipoic acid analogs in cancer metabolism and chemotherapy

Author keywords

cancer metabolism; chemotherapy; lipoate; lipoate analogs; lipoic acid; lipoic acid analogs; tumor mitochondria; two compartment metabolism

Indexed keywords

LIPOIC ACID DERIVATIVE; THIOCTIC ACID; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT;

EID: 84911924137     PISSN: 17512433     EISSN: 17512441     Source Type: Journal    
DOI: 10.1586/17512433.2014.966816     Document Type: Review
Times cited : (42)

References (61)
  • 1
    • 0002908647 scopus 로고
    • Crystalline lipoic acid A. Catalytic agent associated with pyruvate dehydrogenase
    • Reed LJ, Crystalline Lipoic Acid A. Catalytic Agent Associated with Pyruvate Dehydrogenase. Science 1951;114(2952): 93-4
    • (1951) Science , vol.114 , Issue.2952 , pp. 93-94
    • Reed, L.J.1
  • 2
    • 0035914303 scopus 로고    scopus 로고
    • A trail of research from lipoic acid to alpha-keto acid dehydrogenase complexes
    • Reed LJ. A trail of research from lipoic acid to alpha-keto acid dehydrogenase complexes. J Biol Chem 2001;276(42):38329-36
    • (2001) J Biol Chem , vol.276 , Issue.42 , pp. 38329-38336
    • Reed, L.J.1
  • 4
    • 84887224886 scopus 로고    scopus 로고
    • A randomized placebo-controlled pilot trial of omega-3 fatty acids and alpha lipoic acid in Alzheimer's disease
    • Shinto L, Quinn J, Montine T, et al. A randomized placebo-controlled pilot trial of omega-3 fatty acids and alpha lipoic acid in Alzheimer's disease. J Alzheimers Dis 2014;38(1):111-20
    • (2014) J Alzheimers Dis , vol.38 , Issue.1 , pp. 111-120
    • Shinto, L.1    Quinn, J.2    Montine, T.3
  • 6
    • 0002741844 scopus 로고
    • Effect of a-lipoic acid on vitamin C and vitamin e deficiencies
    • Rosenberg HR, Culik R. Effect of a-lipoic acid on vitamin C and vitamin E deficiencies. Arch Biochem Biophys 1959; 80(1):86-93
    • (1959) Arch Biochem Biophys , vol.80 , Issue.1 , pp. 86-93
    • Rosenberg, H.R.1    Culik, R.2
  • 7
    • 0029031443 scopus 로고
    • Thioctic (lipoic) acid: A therapeutic metal-chelating antioxidant?
    • Ou P, Tritschler HJ, Wolff SP. Thioctic (lipoic) acid: a therapeutic metal-chelating antioxidant? Biochem Pharmacol 1995; 50(1):123-6
    • (1995) Biochem Pharmacol , vol.50 , Issue.1 , pp. 123-126
    • Ou, P.1    Tritschler, H.J.2    Wolff, S.P.3
  • 8
    • 0030696877 scopus 로고    scopus 로고
    • Lipoic acid increases de novo synthesis of cellular glutathione by improving cystine utilization
    • Han D, Handelman G, Marcocci L, et al. Lipoic acid increases de novo synthesis of cellular glutathione by improving cystine utilization. BioFactors 1997;6(3):321-38
    • (1997) BioFactors , vol.6 , Issue.3 , pp. 321-338
    • Han, D.1    Handelman, G.2    Marcocci, L.3
  • 9
    • 69949104384 scopus 로고    scopus 로고
    • Alpha-lipoic acid as a dietary supplement: Molecular mechanisms and therapeutic potential
    • Shay KP, Moreau RF, Smith EJ, et al. Alpha-lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potential. Biochim Biophys Acta 2009; 1790(10):1149-60
    • (2009) Biochim Biophys Acta , vol.1790 , Issue.10 , pp. 1149-1160
    • Shay, K.P.1    Moreau, R.F.2    Smith, E.J.3
  • 10
    • 0000561914 scopus 로고
    • A-Ketoglutaric Dehydrogenase VIII Isolation and some properties of a flavoprotein component
    • Searls RL, Sanadi DR. a-Ketoglutaric Dehydrogenase VIII. Isolation and some properties of a flavoprotein component. J Biol Chem 1960;235(8):2485-91
    • (1960) J Biol Chem , vol.235 , Issue.8 , pp. 2485-2491
    • Searls, R.L.1    Sanadi, D.R.2
  • 11
    • 0014139748 scopus 로고
    • The standard redox potential of cysteine-cystine from the thiol-disulphide exchange reaction with glutathione and lipoic acid
    • Jocelyn PC. The standard redox potential of cysteine-cystine from the thiol-disulphide exchange reaction with glutathione and lipoic acid. Eur J Biochem 1967;2(3): 327-31
    • (1967) Eur J Biochem , vol.2 , Issue.3 , pp. 327-331
    • Jocelyn, P.C.1
  • 12
    • 0032571329 scopus 로고    scopus 로고
    • Cloning and functional expression of a cDNA encoding a mammalian sodium-dependent vitamin transporter mediating the uptake of pantothenate, biotin, and lipoate
    • Prasad PD, Wang H, Kekuda R, et al. Cloning and functional expression of a cDNA encoding a mammalian sodium-dependent vitamin transporter mediating the uptake of pantothenate, biotin, and lipoate. J Biol Chem 1998; 273(13):7501-6
    • (1998) J Biol Chem , vol.273 , Issue.13 , pp. 7501-7506
    • Prasad, P.D.1    Wang, H.2    Kekuda, R.3
  • 13
    • 34447336400 scopus 로고    scopus 로고
    • Transepithelial transport of alpha-lipoic acid across human intestinal Caco-2 cell monolayers
    • Takaishi N, Yoshida K, Satsu H, Shimizu M. Transepithelial transport of alpha-lipoic acid across human intestinal Caco-2 cell monolayers. J Agri Food Chem 2007;55(13):5253-9
    • (2007) J Agri Food Chem , vol.55 , Issue.13 , pp. 5253-5259
    • Takaishi, N.1    Yoshida, K.2    Satsu, H.3    Shimizu, M.4
  • 14
    • 0036628732 scopus 로고    scopus 로고
    • Uptake, recycling, and antioxidant actions of alpha-lipoic acid in endothelial cells
    • Jones W, Li X, Qu Z-C, et al. Uptake, recycling, and antioxidant actions of alpha-lipoic acid in endothelial cells. Free Radic Biol Med 2002;33(1):83-93
    • (2002) Free Radic Biol Med , vol.33 , Issue.1 , pp. 83-93
    • Jones, W.1    Li, X.2    Qu, Z.-C.3
  • 15
    • 33845713183 scopus 로고    scopus 로고
    • Lipoic acid as a novel treatment for Alzheimer's disease and related dementias
    • Holmquist L, Stuchbury G, Berbaum K, et al. Lipoic acid as a novel treatment for Alzheimer's disease and related dementias. Pharm Ther 2007;113(1):154-64
    • (2007) Pharm Ther , vol.113 , Issue.1 , pp. 154-164
    • Holmquist, L.1    Stuchbury, G.2    Berbaum, K.3
  • 16
    • 8644274038 scopus 로고    scopus 로고
    • R-lipoic acid inhibits mammalian pyruvate dehydrogenase kinase
    • Korotchkina LG, Sidhu S, Patel MS. R-lipoic acid inhibits mammalian pyruvate dehydrogenase kinase. Free Radic Res 2004; 38(10):1083-92
    • (2004) Free Radic Res , vol.38 , Issue.10 , pp. 1083-1092
    • Korotchkina, L.G.1    Sidhu, S.2    Patel, M.S.3
  • 17
    • 0036408866 scopus 로고    scopus 로고
    • Inactivation of the 2-oxo acid dehydrogenase complexes upon generation of intrinsic radical species
    • Bunik VI, Sievers C. Inactivation of the 2-oxo acid dehydrogenase complexes upon generation of intrinsic radical species. Eur J Biochem 2002;269(20):5004-15
    • (2002) Eur J Biochem , vol.269 , Issue.20 , pp. 5004-5015
    • Bunik, V.I.1    Sievers, C.2
  • 18
    • 0037352050 scopus 로고    scopus 로고
    • 2-Oxo acid dehydrogenase complexes in redox regulation Role of the lipoate residues and thioredoxin
    • Bunik VI. 2-Oxo acid dehydrogenase complexes in redox regulation. Role of the lipoate residues and thioredoxin. Eur J Biochem 2003;270(6):1036-42
    • (2003) Eur J Biochem , vol.270 , Issue.6 , pp. 1036-1042
    • Bunik, V.I.1
  • 19
    • 37849043898 scopus 로고    scopus 로고
    • Reversible inhibition of alpha-ketoglutarate dehydrogenase by hydrogen peroxide: Glutathionylation and protection of lipoic acid
    • Applegate MAB, Humphries KM, Szweda LI. Reversible inhibition of alpha-ketoglutarate dehydrogenase by hydrogen peroxide: glutathionylation and protection of lipoic acid. Biochemistry 2008;47(1):473-8
    • (2008) Biochemistry , vol.47 , Issue.1 , pp. 473-478
    • Applegate, M.A.B.1    Humphries, K.M.2    Szweda, L.I.3
  • 20
    • 4544359913 scopus 로고    scopus 로고
    • Mitochondrial alpha-ketoglutarate dehydrogenase complex generates reactive oxygen species
    • Starkov AA, Fiskum G, Chinopoulos C, et al. Mitochondrial alpha-ketoglutarate dehydrogenase complex generates reactive oxygen species. J Neurosci 2004;24(36): 7779-88
    • (2004) J Neurosci , vol.24 , Issue.36 , pp. 7779-7788
    • Starkov, A.A.1    Fiskum, G.2    Chinopoulos, C.3
  • 21
    • 4544226082 scopus 로고    scopus 로고
    • Generation of reactive oxygen species in the reaction catalyzed by alpha-ketoglutarate dehydrogenase
    • Tretter L, Adam-Vizi V. Generation of reactive oxygen species in the reaction catalyzed by alpha-ketoglutarate dehydrogenase. J Neurosci 2004;24(36): 7771-8
    • (2004) J Neurosci , vol.24 , Issue.36 , pp. 7771-7778
    • Tretter, L.1    Adam-Vizi, V.2
  • 22
    • 0024586535 scopus 로고
    • Supramolecular organization of tricarboxylic acid cycle enzymes
    • Lyubarev AE, Kurganov BI. Supramolecular organization of tricarboxylic acid cycle enzymes. Bio Sys 1989;22(2):91-102
    • (1989) Bio Sys , vol.22 , Issue.2 , pp. 91-102
    • Lyubarev, A.E.1    Kurganov, B.I.2
  • 23
    • 78650103059 scopus 로고    scopus 로고
    • A-Ketoglutarate dehydrogenase: A mitochondrial redox sensor
    • Mclain AL, Szweda PA, Szweda LI. a-Ketoglutarate dehydrogenase: a mitochondrial redox sensor. Free Radic Res 2011;45(1):29-36
    • (2011) Free Radic Res , vol.45 , Issue.1 , pp. 29-36
    • McLain, A.L.1    Szweda, P.A.2    Szweda, L.I.3
  • 24
    • 0030768236 scopus 로고    scopus 로고
    • The pharmacology of the antioxidant lipoic acid
    • Biewenga GP, Haenen G, Bast A. The pharmacology of the antioxidant lipoic acid. Gen Pharmacol 1997;29(3):315-31
    • (1997) Gen Pharmacol , vol.29 , Issue.3 , pp. 315-331
    • Biewenga, G.P.1    Haenen, G.2    Bast, A.3
  • 25
    • 33847349283 scopus 로고    scopus 로고
    • Reactive oxygen species: A breath of life or death?
    • Fruehauf JP, Meyskens FL. Reactive oxygen species: a breath of life or death? Clin Cancer Res 2007;13(3):789-94
    • (2007) Clin Cancer Res , vol.13 , Issue.3 , pp. 789-794
    • Fruehauf, J.P.1    Meyskens, F.L.2
  • 26
    • 84911946560 scopus 로고    scopus 로고
    • Cancer metabolism: A nexus of matter, energy and reactive oxygen species
    • In: Kanner S, editor Springer; New York, NY, USA
    • Bingham P, Stuart SD, Zachar Z. Cancer metabolism: a nexus of matter, energy and reactive oxygen species. In: Kanner S, editor. Tumor metabolom targeting and drug development. Springer; New York, NY, USA: 2014. p. 7-27
    • (2014) Tumor Metabolom Targeting and Drug Development , pp. 7-27
    • Bingham, P.1    Stuart, S.D.2    Zachar, Z.3
  • 27
    • 0037362060 scopus 로고    scopus 로고
    • Alpha-lipoic acid induces p27(Kip)- dependent cell cycle arrest in non-transformed cell lines and apoptosis in tumor cell lines
    • Van de Mark K, Chen JS, Steliou K, et al. alpha-lipoic acid induces p27(Kip)- dependent cell cycle arrest in non-transformed cell lines and apoptosis in tumor cell lines. J Cell Physiol 2003;194(3): 325-40
    • (2003) J Cell Physiol , vol.194 , Issue.3 , pp. 325-340
    • Van De Mark, K.1    Chen, J.S.2    Steliou, K.3
  • 28
    • 84860721634 scopus 로고    scopus 로고
    • Alpha lipoic acid selectively inhibits proliferation and adhesion to fibronectin of v-H-ras-transformed 3Y1 cells
    • Yamasaki M, Iwase M, Kawano K, et al. Alpha lipoic acid selectively inhibits proliferation and adhesion to fibronectin of v-H-ras-transformed 3Y1 cells. J Clin Biochem Nutr 2012;50(3):234-40
    • (2012) J Clin Biochem Nutr , vol.50 , Issue.3 , pp. 234-240
    • Yamasaki, M.1    Iwase, M.2    Kawano, K.3
  • 29
    • 43549122067 scopus 로고    scopus 로고
    • Alpha-lipoic acid induces apoptosis in hepatoma cells via the PTEN/Akt pathway
    • Shi DY, Liu HL, Stern JS, et al. Alpha-lipoic acid induces apoptosis in hepatoma cells via the PTEN/Akt pathway. FEBS Lett 2008;582(12):1667-71
    • (2008) FEBS Lett , vol.582 , Issue.12 , pp. 1667-1671
    • Shi, D.Y.1    Liu, H.L.2    Stern, J.S.3
  • 30
    • 77954906454 scopus 로고    scopus 로고
    • Alpha-Lipoic acid reduces matrix metalloproteinase activity in MDA-MB-231 human breast cancer cells
    • Lee HS, Na MH, Kim WK. alpha-Lipoic acid reduces matrix metalloproteinase activity in MDA-MB-231 human breast cancer cells. Nutr Res 2010;30(6):403-9
    • (2010) Nutr Res , vol.30 , Issue.6 , pp. 403-409
    • Lee, H.S.1    Na, M.H.2    Kim, W.K.3
  • 31
    • 84867847230 scopus 로고    scopus 로고
    • Alpha-lipoic acid induces sodium iodide symporter expression in TPC-1 thyroid cancer cell line
    • Choi HJ, Kim TY, Ruiz-Llorente S, et al. Alpha-lipoic acid induces sodium iodide symporter expression in TPC-1 thyroid cancer cell line. Nucl Med Biol 2012;39(8): 1275-80
    • (2012) Nucl Med Biol , vol.39 , Issue.8 , pp. 1275-1280
    • Choi, H.J.1    Kim, T.Y.2    Ruiz-Llorente, S.3
  • 32
    • 18044392727 scopus 로고    scopus 로고
    • Alpha-lipoic acid induces apoptosis in human colon cancer cells by increasing mitochondrial respiration with a concomitant O-2(-.)-generation
    • Wenzel U, Nickel A, Daniel H. Alpha-lipoic acid induces apoptosis in human colon cancer cells by increasing mitochondrial respiration with a concomitant O-2(-.)-generation. Apoptosis 2005;10(2):359-68
    • (2005) Apoptosis , vol.10 , Issue.2 , pp. 359-368
    • Wenzel, U.1    Nickel, A.2    Daniel, H.3
  • 33
    • 33845726964 scopus 로고    scopus 로고
    • Increased ROS generation and p53 activation in alpha-lipoic acid-induced apoptosis of hepatoma cells
    • Simbula G, Columbano A, Ledda-Columbano GM, et al. Increased ROS generation and p53 activation in alpha-lipoic acid-induced apoptosis of hepatoma cells. Apoptosis 2007;12(1): 113-23
    • (2007) Apoptosis , vol.12 , Issue.1 , pp. 113-123
    • Simbula, G.1    Columbano, A.2    Ledda-Columbano, G.M.3
  • 34
    • 77953812337 scopus 로고    scopus 로고
    • The natural antioxidant alpha-lipoic acid induces p27(Kip1)-dependent cell cycle arrest and apoptosis in MCF-7 human breast cancer cells
    • Dozio E, Ruscica M, Passafaro L, et al. The natural antioxidant alpha-lipoic acid induces p27(Kip1)-dependent cell cycle arrest and apoptosis in MCF-7 human breast cancer cells. Eur J Pharmacol 2010;641(1):29-34
    • (2010) Eur J Pharmacol , vol.641 , Issue.1 , pp. 29-34
    • Dozio, E.1    Ruscica, M.2    Passafaro, L.3
  • 35
    • 33751180574 scopus 로고    scopus 로고
    • Reactive oxygen species mediate caspase activation and apoptosis induced by lipoic acid in human lung epithelial cancer cells through Bcl-2 down-regulation
    • Moungjaroen J, Nimmannit U, Callery PS, et al. Reactive oxygen species mediate caspase activation and apoptosis induced by lipoic acid in human lung epithelial cancer cells through Bcl-2 down-regulation. J Pharmacol Exp Ther 2006;319(3):1062-9
    • (2006) J Pharmacol Exp Ther , vol.319 , Issue.3 , pp. 1062-1069
    • Moungjaroen, J.1    Nimmannit, U.2    Callery, P.S.3
  • 36
    • 33748529374 scopus 로고    scopus 로고
    • Alpha-lipoic acid modulates ovarian surface epithelial cell growth
    • Vig-Varga E, Benson EA, Limbil TL, et al. Alpha-lipoic acid modulates ovarian surface epithelial cell growth. Gynecol Oncol 2006; 103(1):45-52
    • (2006) Gynecol Oncol , vol.103 , Issue.1 , pp. 45-52
    • Vig-Varga, E.1    Benson, E.A.2    Limbil, T.L.3
  • 37
    • 54049130826 scopus 로고    scopus 로고
    • Control of cellular redox status and upregulation of quinone reductase NQO1 via Nrf2 activation by alpha-lipoic acid in human leukemia HL-60 cells
    • Elangovan S, Hsieh TC. Control of cellular redox status and upregulation of quinone reductase NQO1 via Nrf2 activation by alpha-lipoic acid in human leukemia HL-60 cells. Int J Oncol 2008;33(4):833-8
    • (2008) Int J Oncol , vol.33 , Issue.4 , pp. 833-838
    • Elangovan, S.1    Hsieh, T.C.2
  • 38
    • 80052228524 scopus 로고    scopus 로고
    • Effects of Lipoic Acid, Caffeic Acid and a Synthesized Lipoyl-Caffeic Conjugate on Human Hepatoma Cell Lines
    • Guerriero E, Sorice A, Capone F, et al. Effects of Lipoic Acid, Caffeic Acid and a Synthesized Lipoyl-Caffeic Conjugate on Human Hepatoma Cell Lines. Molecules 2011;16(8):6365-77
    • (2011) Molecules , vol.16 , Issue.8 , pp. 6365-6377
    • Guerriero, E.1    Sorice, A.2    Capone, F.3
  • 39
    • 84870672248 scopus 로고    scopus 로고
    • Lipoic acid inhibits cell proliferation of tumor cells in vitro and in vivo
    • Feuerecker BS, Pirsig C, Seidl M, et al. Lipoic acid inhibits cell proliferation of tumor cells in vitro and in vivo. Cancer Biol Ther 2012;14:1425-35
    • (2012) Cancer Biol Ther , vol.14 , pp. 1425-1435
    • Feuerecker, B.S.1    Pirsig, C.2    Seidl, M.3
  • 40
    • 84862332140 scopus 로고    scopus 로고
    • Alpha-lipoic acid controls tumor growth and modulates hepatic redox state in ehrlich-ascites-carcinoma-bearing mice
    • Al Abdan M. Alpha-lipoic acid controls tumor growth and modulates hepatic redox state in ehrlich-ascites-carcinoma-bearing mice. Sci World J 2012;doi; 10.1100/2012/ 509838
    • (2012) Sci World J
    • Al Abdan, M.1
  • 41
    • 77950841021 scopus 로고    scopus 로고
    • A combination of alpha lipoic acid and calcium hydroxycitrate is efficient against mouse cancer models: Preliminary results
    • Schwartz LM, Abolhassani A, Guais E, et al. A combination of alpha lipoic acid and calcium hydroxycitrate is efficient against mouse cancer models: preliminary results. Oncol Rep 2010;23(5):1407-16
    • (2010) Oncol Rep , vol.23 , Issue.5 , pp. 1407-1416
    • Schwartz, L.M.1    Abolhassani, A.2    Guais, E.3
  • 42
    • 77949402381 scopus 로고    scopus 로고
    • Revisiting the ALA/N (alpha-lipoic acid/ low-dose naltrexone) protocol for people with metastatic and nonmetastatic pancreatic cancer: A report of 3 new cases
    • Berkson BM, Rubin DM, Berkson AJ. Revisiting the ALA/N (alpha-lipoic acid/ low-dose naltrexone) protocol for people with metastatic and nonmetastatic pancreatic cancer: a report of 3 new cases. Integr Cancer Ther 2009;8(4):416-22
    • (2009) Integr Cancer Ther , vol.8 , Issue.4 , pp. 416-422
    • Berkson, B.M.1    Rubin, D.M.2    Berkson, A.J.3
  • 43
    • 84897062309 scopus 로고    scopus 로고
    • Metabolic Treatment of Cancer: Intermediate Results of a Prospective Case Series
    • Schwartz LL, Buhler P, Icard H, et al. Metabolic Treatment of Cancer: intermediate Results of a Prospective Case Series. Anticancer Res 2014;34(2):973-80
    • (2014) Anticancer Res , vol.34 , Issue.2 , pp. 973-980
    • Schwartz, L.L.1    Buhler, P.2    Icard, H.3
  • 44
    • 78650727185 scopus 로고    scopus 로고
    • Lipoic acid: Energy metabolism and redox regulation of transcription and cell signaling
    • Packer L, Cadenas E. Lipoic acid: energy metabolism and redox regulation of transcription and cell signaling. J Clin Biochem Nutr 2011;48(1):26-32
    • (2011) J Clin Biochem Nutr , vol.48 , Issue.1 , pp. 26-32
    • Packer, L.1    Cadenas, E.2
  • 45
    • 85006768050 scopus 로고
    • The metabolism of tumors in the body
    • Warburg O, Wind F, Negelein E. The metabolism of tumors in the body. J Gen Physiol 1927;8(6):519-30
    • (1927) J Gen Physiol , vol.8 , Issue.6 , pp. 519-530
    • Warburg, O.1    Wind, F.2    Negelein, E.3
  • 46
  • 47
    • 85015483678 scopus 로고    scopus 로고
    • The pyruvate dehydrogenase complex in cancer: Implications for the transformed state and cancer chemotherapy
    • In: Canuto R, editor. Available from
    • Bingham PM, Zachar Z. The Pyruvate Dehydrogenase Complex in Cancer: Implications for the Transformed State and Cancer Chemotherapy. In: Canuto R, editor. Dehydrogenases. InTech; 2012.p. 41-62; Available from: http://dx.doi.org/ 10.5772/48582
    • (2012) Dehydrogenases. InTech , pp. 41-62
    • Bingham, P.M.1    Zachar, Z.2
  • 48
    • 84858604270 scopus 로고    scopus 로고
    • Metabolic reprogramming: A cancer hallmark even warburg did not anticipate
    • Ward PS, Thompson CB. Metabolic reprogramming: a cancer hallmark even warburg did not anticipate. Cancer Cell 2012;21(3):297-308
    • (2012) Cancer Cell , vol.21 , Issue.3 , pp. 297-308
    • Ward, P.S.1    Thompson, C.B.2
  • 49
    • 0022891340 scopus 로고
    • Tumors - Wounds that do not heal - Similarities between tumor stroma generation and wound-healing
    • Dvorak HF. Tumors - wounds that do not heal - similarities between tumor stroma generation and wound-healing. N Engl J Med 1986;315(26):1650-9
    • (1986) N Engl J Med , vol.315 , Issue.26 , pp. 1650-1659
    • Dvorak, H.F.1
  • 50
    • 62549151252 scopus 로고    scopus 로고
    • Why are tumour blood vessels abnormal and why is it important to know?
    • Nagy JA, Chang SH, Dvorak AM, et al. Why are tumour blood vessels abnormal and why is it important to know? Br J Cancer 2009;100(6):865-9
    • (2009) Br J Cancer , vol.100 , Issue.6 , pp. 865-869
    • Nagy, J.A.1    Chang, S.H.2    Dvorak, A.M.3
  • 51
    • 84855434874 scopus 로고    scopus 로고
    • Caveolin-1 and cancer metabolism in the tumor microenvironment: Markers, models, and mechanisms
    • Sotgia F, Martinez-Outschoorn UE, Ubaldo E, et al. Caveolin-1 and cancer metabolism in the tumor microenvironment: markers, models, and mechanisms. Ann Rev Pathol 2012;7(7): 423-67
    • (2012) Ann Rev Pathol , vol.7 , Issue.7 , pp. 423-467
    • Sotgia, F.1    Martinez-Outschoorn, U.E.2    Ubaldo, E.3
  • 52
    • 84055225365 scopus 로고    scopus 로고
    • Warburg meets autophagy: Cancer-associated fibroblasts accelerate tumor growth and metastasis via oxidative stress, mitophagy, and aerobic glycolysis
    • Pavlides S, Vera I, Gandara R, et al. Warburg meets autophagy: cancer-associated fibroblasts accelerate tumor growth and metastasis via oxidative stress, mitophagy, and aerobic glycolysis. Antioxid Redox Signal 2012;16(11):1264-84
    • (2012) Antioxid Redox Signal , vol.16 , Issue.11 , pp. 1264-1284
    • Pavlides, S.1    Vera, I.2    Gandara, R.3
  • 53
    • 84877150506 scopus 로고    scopus 로고
    • Cancer metabolism, stemness and tumor recurrence: MCT1 and MCT4 are functional biomarkers of metabolic symbiosis in head and neck cancer
    • Curry JM, Tuluc M, Whitaker-Menezes D, et al. Cancer metabolism, stemness and tumor recurrence: MCT1 and MCT4 are functional biomarkers of metabolic symbiosis in head and neck cancer. Cell Cycle 2013;12(9):1371-84
    • (2013) Cell Cycle , vol.12 , Issue.9 , pp. 1371-1384
    • Curry, J.M.1    Tuluc, M.2    Whitaker-Menezes, D.3
  • 54
    • 84897544161 scopus 로고    scopus 로고
    • Catabolic cancer-associated fibroblasts transfer energy and biomass to anabolic cancer cells, fueling tumor growth
    • Martinez-Outschoorn UE, Lisanti MP, Sotgia F. Catabolic cancer-associated fibroblasts transfer energy and biomass to anabolic cancer cells, fueling tumor growth. Semin Cancer Biol 2014;2014:25:47-60
    • (2014) Semin Cancer Biol , vol.2014 , Issue.25 , pp. 47-60
    • Martinez-Outschoorn, U.E.1    Lisanti, M.P.2    Sotgia, F.3
  • 55
    • 0346158376 scopus 로고    scopus 로고
    • Regulation of pyruvate dehydrogenase complex activity by reversible phosphorylation
    • Holness MJ, Sugden MC. Regulation of pyruvate dehydrogenase complex activity by reversible phosphorylation. Biochem Soc Trans 2003;31(6):1143-51
    • (2003) Biochem Soc Trans , vol.31 , Issue.6 , pp. 1143-1151
    • Holness, M.J.1    Sugden, M.C.2
  • 56
    • 80052845698 scopus 로고    scopus 로고
    • Overexpression of pyruvate dehydrogenase kinase 3 increases drug resistance and early recurrence in colon cancer
    • Lu CW, Lin SC, Chien CW, et al. Overexpression of pyruvate dehydrogenase kinase 3 increases drug resistance and early recurrence in colon cancer. Am J Pathol 2011;179(3):1405-14
    • (2011) Am J Pathol , vol.179 , Issue.3 , pp. 1405-1414
    • Lu, C.W.1    Lin, S.C.2    Chien, C.W.3
  • 57
    • 33644614520 scopus 로고    scopus 로고
    • HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia
    • Kim JW, Tchernyshyov I, Semenza GL, et al. HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia. Cell Metab 2006;3(3):177-85
    • (2006) Cell Metab , vol.3 , Issue.3 , pp. 177-185
    • Kim, J.W.1    Tchernyshyov, I.2    Semenza, G.L.3
  • 58
    • 33644622570 scopus 로고    scopus 로고
    • HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption
    • Papandreou I, Cairns RA, Fontana L, et al. HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption. Cell Metab 2006;3(3): 187-97
    • (2006) Cell Metab , vol.3 , Issue.3 , pp. 187-197
    • Papandreou, I.1    Cairns, R.A.2    Fontana, L.3
  • 59
    • 84910095664 scopus 로고    scopus 로고
    • A strategically designed small molecule attacks alpha-ketoglutarate dehydrogenase in tumor cells through a redox process
    • Available from
    • Stuart SD, Schauble A, Gupta S, et al. A strategically designed small molecule attacks alpha-ketoglutarate dehydrogenase in tumor cells through a redox process. Cancer Metabol 2014.2:4. Available from: www. cancerandmetabolism.com/content/2/1/4
    • (2014) Cancer Metabol , vol.2 , pp. 4
    • Stuart, S.D.1    Schauble, A.2    Gupta, S.3
  • 60
    • 80755133485 scopus 로고    scopus 로고
    • Non-redox-active lipoatederivates disrupt cancer cell mitochondrial metabolism and are potent anticancer agents in vivo
    • Zachar Z, Marecek J, Maturo C, et al. Non-redox-active lipoatederivates disrupt cancer cell mitochondrial metabolism and are potent anticancer agents in vivo. J Mol Med 2011;89(11):1137-48
    • (2011) J Mol Med , vol.89 , Issue.11 , pp. 1137-1148
    • Zachar, Z.1    Marecek, J.2    Maturo, C.3
  • 61
    • 84910088129 scopus 로고    scopus 로고
    • A phase i study of the first-in-class anti-mitochondrial metabolism agent, CPI-613, in patients with advanced hematologic malignancies
    • pii: clincanres.1019. PMID: 25165100. [Epub ahead of print]
    • Pardee TS, Lee K, Luddy J, et al. A phase I study of the first-in-class anti-mitochondrial metabolism agent, CPI-613, in patients with advanced hematologic malignancies. Clin Cancer Res 2014;pii: clincanres.1019. PMID: 25165100. [Epub ahead of print]
    • (2014) Clin Cancer Res
    • Pardee, T.S.1    Lee, K.2    Luddy, J.3


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