Cancer metabolism, stemness and tumor recurrence : MCT1 and MCT4 are functional biomarkers of metabolic symbiosis in head and neck cancer

Cell Cycle

Volumn 12, Issue 9, 2013, Pages 1371-1384

  Curry, Joseph M ^a   Tuluc, Madalina ^a   Whitaker Menezes, Diana ^b   Ames, Julie A ^a   Anantharaman, Archana ^a   Butera, Aileen ^a   Leiby, Benjamin ^a   Cognetti, David M ^a   Sotgia, Federica ^b,c   Lisanti, Michael P ^b,c   Martinez Outschoorn, Ubaldo E ^b  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

^c UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Glycolysis; Head and neck cancer; MCT1; MCT4; Metabolic symbiosis; Mitochondria; Monocarboxylate transporters (MCT); Oxidative stress; OXPHOS; Stem cells; TOMM20; Tumor recurrence; Tumor stroma

Indexed keywords

BIOLOGICAL MARKER; CYTOCHROME C OXIDASE; KETONE BODY; KI 67 ANTIGEN; LACTATE DEHYDROGENASE; LACTIC ACID; METFORMIN; MONOCARBOXYLATE TRANSPORTER 1; CARRIER PROTEIN; CELL SURFACE RECEPTOR; COTRANSPORTER; MONOCARBOXYLATE TRANSPORT PROTEIN 1; MONOCARBOXYLATE TRANSPORTER; MUSCLE PROTEIN; SLC16A4 PROTEIN, HUMAN; TOMM20 PROTEIN, HUMAN; TUMOR MARKER;

ADULT; AEROBIC METABOLISM; AGED; ARTICLE; CANCER CELL; CANCER PROGNOSIS; CANCER STAGING; CELL DIFFERENTIATION; CELL POPULATION; CELL PROLIFERATION; COHORT ANALYSIS; CORRELATION ANALYSIS; ENERGY METABOLISM; ENZYME ACTIVITY; FEMALE; FIBROBLAST; GLYCOLYSIS; HEAD AND NECK SQUAMOUS CELL CARCINOMA; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPOPHARYNX CARCINOMA; IMMUNOHISTOCHEMISTRY; LARYNX CARCINOMA; MAJOR CLINICAL STUDY; MALE; MITOCHONDRIAL RESPIRATION; MOUTH SQUAMOUS CELL CARCINOMA; OROPHARYNX CARCINOMA; OXIDATIVE PHOSPHORYLATION; OXIDATIVE STRESS; PARACRINE SIGNALING; PROTEIN EXPRESSION; STROMA CELL; SYMBIOSIS; TUMOR RECURRENCE; CANCER STEM CELL; EPITHELIUM CELL; HEAD AND NECK TUMOR; KAPLAN MEIER METHOD; METABOLISM; MIDDLE AGED; MITOCHONDRION; PATHOLOGY; VERY ELDERLY;

AGED; AGED, 80 AND OVER; CELL DIFFERENTIATION; CELL PROLIFERATION; EPITHELIAL CELLS; FEMALE; FIBROBLASTS; GLYCOLYSIS; HEAD AND NECK NEOPLASMS; HUMANS; KAPLAN-MEIER ESTIMATE; KETONE BODIES; LACTIC ACID; MALE; MEMBRANE TRANSPORT PROTEINS; MIDDLE AGED; MITOCHONDRIA; MONOCARBOXYLIC ACID TRANSPORTERS; MUSCLE PROTEINS; NEOPLASM RECURRENCE, LOCAL; NEOPLASM STAGING; NEOPLASTIC STEM CELLS; OXIDATIVE PHOSPHORYLATION; OXIDATIVE STRESS; RECEPTORS, CELL SURFACE; SYMPORTERS; TUMOR MARKERS, BIOLOGICAL;

EID: 84877150506     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.24092     Document Type: Article

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