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Volumn 38, Issue 1, 2014, Pages 111-120

A randomized placebo-controlled pilot trial of omega-3 fatty acids and alpha lipoic acid in Alzheimer's disease

Author keywords

Alpha lipoic acid; Alzheimer's disease; clinical trial; omega 3 fatty acids

Indexed keywords

DOCOSAHEXAENOIC ACID; ICOSAPENTAENOIC ACID; ISOPROSTANE DERIVATIVE; OMEGA 3 FATTY ACID; THIOCTIC ACID;

EID: 84887224886     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-130722     Document Type: Article
Times cited : (230)

References (36)
  • 1
    • 0037042299 scopus 로고    scopus 로고
    • Alzheimer's disease
    • Cummings JL, Cole G (2002) Alzheimer's disease. JAMA 287, 2335-2338.
    • (2002) JAMA , vol.287 , pp. 2335-2338
    • Cummings, J.L.1    Cole, G.2
  • 2
    • 70349237729 scopus 로고    scopus 로고
    • Therapeutic potential of n-3 polyunsaturated fatty acids in disease
    • Fetterman JW, Zdanowicz MM (2009) Therapeutic potential of n-3 polyunsaturated fatty acids in disease. Am J Health Sys 66, 1169-1179.
    • (2009) Am J Health Sys , vol.66 , pp. 1169-1179
    • Fetterman, J.W.1    Zdanowicz, M.M.2
  • 3
    • 77951173605 scopus 로고    scopus 로고
    • Omega-3 fatty acids: Potentialroleinthe managementofearly Alzheimer's disease
    • Jicha GA, Markesbery WR (2010) Omega-3 fatty acids: Potentialroleinthe managementofearly Alzheimer's disease. Clin Invest Aging 5, 45-61.
    • (2010) Clin Invest Aging , vol.5 , pp. 45-61
    • Jicha, G.A.1    Markesbery, W.R.2
  • 4
    • 69549138351 scopus 로고    scopus 로고
    • Are all n-3 polyunsaturated fatty acids created equal?
    • Anderson BM, Ma DW (2009) Are all n-3 polyunsaturated fatty acids created equal? Lipid Health Dis 8, 33.
    • (2009) Lipid Health Dis , vol.8 , pp. 33
    • Anderson, B.M.1    Ma, D.W.2
  • 8
    • 69949104384 scopus 로고    scopus 로고
    • Alpha-lipoic acid as a dietary supplement: Molecular mechanisms and therapeutic benefit
    • Shay KP, Moreau RF, Smith EJ, Smith AR, Hagen TM (2009) Alpha-lipoic acid as a dietary supplement: Molecular mechanisms and therapeutic benefit. Biochim Biophys Acta 10, 1149-1160.
    • (2009) Biochim Biophys Acta , vol.10 , pp. 1149-1160
    • Shay, K.P.1    Moreau, R.F.2    Smith, E.J.3    Smith, A.R.4    Hagen, T.M.5
  • 9
    • 0000197851 scopus 로고    scopus 로고
    • Alpha-lipoic acid: A metabolic antioxidant and potential redox modulator of transcription
    • Packer L, Roy S, Sen CK (1997) Alpha-lipoic acid: A metabolic antioxidant and potential redox modulator of transcription. Adv Pharmacol 38, 79-101.
    • (1997) Adv Pharmacol , vol.38 , pp. 79-101
    • Packer, L.1    Roy, S.2    Sen, C.K.3
  • 10
    • 0037012016 scopus 로고    scopus 로고
    • Alpha-lipoic acid modulates NF-κB activity in human monocytic cells by direct interaction with DNA
    • DOI 10.1016/S0531-5565(01)00207-8, PII S0531556501002078
    • Lee HA, Hughes DA (2002) Alpha-lipoic acid modulates NF-kappaB activity in human monocytic cells by direct interaction with DNA. Exp Gerontol 37, 401-410. (Pubitemid 34073558)
    • (2002) Experimental Gerontology , vol.37 , Issue.2-3 , pp. 401-410
    • Lee, H.A.1    Hughes, D.A.2
  • 11
    • 20444434019 scopus 로고    scopus 로고
    • 2-isoprostane formation in elderly men
    • DOI 10.1016/j.atherosclerosis.2004.11.026, PII S0021915005002212
    • Helmersson J, Larsson A, Vessby B, Basu S (2005) Active smoking and a history of smoking are associated with enhances prostaglandin F (2 alpha), interleukin 6 and F2 isoprostane formation in elderly men. Atheroslcerosis 181, 201-207. (Pubitemid 40812327)
    • (2005) Atherosclerosis , vol.181 , Issue.1 , pp. 201-207
    • Helmersson, J.1    Larsson, A.2    Vessby, B.3    Basu, S.4
  • 12
    • 0025151982 scopus 로고
    • Placental transfer of essential fatty acids in humans: Venous-arterial difference for docosahexaenoic acid in fetal umbilical erythrocytes
    • Ruyle M, Connor WE, Anderson GJ, Lowensohn RI (1990) Placental transfer of essential fatty acids in humans: Venous-arterial difference for docosahexaenoic acid in fetal umbilical erythrocytes. Proc Natl Acad Sci USA 87, 7902-7906.
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 7902-7906
    • Ruyle, M.1    Connor, W.E.2    Anderson, G.J.3    Lowensohn, R.I.4
  • 13
    • 0030768236 scopus 로고    scopus 로고
    • The pharmacology of the antioxidant lipoic acid
    • Biewenga GP, Haenen GR, Bast A (1997) The pharmacology of the antioxidant lipoic acid. Gen Pharmacol 29, 315-331.
    • (1997) Gen Pharmacol , vol.29 , pp. 315-331
    • Biewenga, G.P.1    Haenen, G.R.2    Bast, A.3
  • 15
    • 0033105976 scopus 로고    scopus 로고
    • 2- isoprostanes using gas chromatography-mass spectrometry
    • DOI 10.1006/abio.1998.3037
    • Mori TA, Croft KD, Puddey IB, Beilin LJ (1999) Animproved method for the measurement of urinary and plasma F2-isoprostanes using gas chromatography-mass spectrometry. Anal Biochem 268, 117-125. (Pubitemid 29115518)
    • (1999) Analytical Biochemistry , vol.268 , Issue.1 , pp. 117-125
    • Mori, T.A.1    Croft, K.D.2    Puddey, I.B.3    Beilin, L.J.4
  • 16
    • 0034802664 scopus 로고    scopus 로고
    • 2α metabolite excretion rate and day to day variation in healthy humans
    • DOI 10.1054/plef.2001.0295
    • Helmersson J, Basu S (2001) F (2)-isoprostane and prostaglandin F (2 alpha) metabolite excretion rate and day to day variation in healthy humans. Prostaglandins Leukot Essent Fatty Acids 65, 99-102. (Pubitemid 32928143)
    • (2001) Prostaglandins Leukotrienes and Essential Fatty Acids , vol.65 , Issue.2 , pp. 99-102
    • Helmersson, J.1    Basu, S.2
  • 17
    • 0016823810 scopus 로고
    • "mini-mental state". A practical method for grading the cognitive state of patients for the clinician
    • Folstein M, Folstein SE, McHugh PR (1975) "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12, 189-198.
    • (1975) J Psychiatr Res , vol.12 , pp. 189-198
    • Folstein, M.1    Folstein, S.E.2    McHugh, P.R.3
  • 18
    • 0021520020 scopus 로고
    • A new rating scale for Alzheimer's disease
    • Rosen WG, Mohs RC, Davis KL (1984) A new rating scale for Alzheimer's disease. Am J Psychiatry 141, 1356-1364.
    • (1984) Am J Psychiatry , vol.141 , pp. 1356-1364
    • Rosen, W.G.1    Mohs, R.C.2    Davis, K.L.3
  • 19
    • 0030771116 scopus 로고    scopus 로고
    • An inventory to assess activities of daily living for clinical trials in Alzheimer's disease. The Alzheimer's Disease Cooperative Study
    • Galasko D, Bennett D, Sano M, Ernesto C, Thomas R, Grund-man M, Ferris S (1997) An inventory to assess activities of daily living for clinical trials in Alzheimer's disease. The Alzheimer's Disease Cooperative Study. Alzheimer Dis Assoc Disord 11 (S2), S33-S39.
    • (1997) Alzheimer Dis Assoc Disord , vol.11 , Issue.S2
    • Galasko, D.1    Bennett, D.2    Sano, M.3    Ernesto, C.4    Thomas, R.5    Grund-Man, M.6    Ferris, S.7
  • 20
    • 0036084541 scopus 로고    scopus 로고
    • Antioxidant strategies for Alzheimer's disease
    • DOI 10.1079/PNS2002146
    • Grundman M, Delaney P (2002) Antioxidant strategies for Alzheimer's disease. Proc Nutr Soc 61, 191-202. (Pubitemid 34665793)
    • (2002) Proceedings of the Nutrition Society , vol.61 , Issue.2 , pp. 191-202
    • Grundman, M.1    Delaney, P.2
  • 21
    • 0032238783 scopus 로고    scopus 로고
    • 2-isoprostanes in Alzheimer's disease: Evidence for enhanced lipid peroxidation in vivo
    • Pratico D, MY Lee V, Trojanowski JQ, Rokach J, Fitzgerald GA (1998) Increased F2-isoprostanes in Alzheimer's disease: Evidence for enhanced lipid peroxidationin vivo. FASEB J 12, 1777-1783. (Pubitemid 28553673)
    • (1998) FASEB Journal , vol.12 , Issue.15 , pp. 1777-1783
    • Pratico, D.1    Lee, V.M.-Y.2    Trojanowski, J.Q.3    Rokach, J.4    Fitzgerald, G.A.5
  • 23
    • 33845442944 scopus 로고    scopus 로고
    • Chronic dietary α-lipoic acid reduces deficits in hippocampal memory of aged Tg2576 mice
    • DOI 10.1016/j.neurobiolaging.2005.12.014, PII S0197458005004537
    • Quinn JF, Bussiere JR, Hammond RS, Montine TJ, Henson E, Jones RE, Stackman RW Jr (2007) Chronic dietary alpha-lipoic acid reduces deficits in hippocampal memory of aged Tg2576 mice. Neurobiol Aging 28, 213-225. (Pubitemid 44894634)
    • (2007) Neurobiology of Aging , vol.28 , Issue.2 , pp. 213-225
    • Quinn, J.F.1    Bussiere, J.R.2    Hammond, R.S.3    Montine, T.J.4    Henson, E.5    Jones, R.E.6    Stackman Jr., R.W.7
  • 24
    • 77949673613 scopus 로고    scopus 로고
    • DHA may prevent age-related dementia
    • Cole GM, Frautschy SA (2010) DHA may prevent age-related dementia. J Nutr 140, 869-874.
    • (2010) J Nutr , vol.140 , pp. 869-874
    • Cole, G.M.1    Frautschy, S.A.2
  • 25
    • 0034986275 scopus 로고    scopus 로고
    • Alpha-lipoic acid as a new treatment option for Azheimer type dementia
    • DOI 10.1016/S0167-4943(01)00104-2, PII S0167494301001042
    • Hager K, Marahrens A, Kenklies M, Riederer P, Münch G (2001) Alpha-lipoic acid as a new treatment option for Azheimer type dementia. Arch Gerontol Geriatr 32, 275-282. (Pubitemid 32505692)
    • (2001) Archives of Gerontology and Geriatrics , vol.32 , Issue.3 , pp. 275-282
    • Hager, K.1    Marahrens, A.2    Kenklies, M.3    Riederer, P.4    Munch, G.5
  • 26
    • 38449099641 scopus 로고    scopus 로고
    • Alpha-lipoic acid as a new treatment option for Alzheimer's disease-A 48 months follow-up analysis
    • Hager K, Kenklies M, McAfoose J, Engel J, Münch G (2007) Alpha-lipoic acid as a new treatment option for Alzheimer's disease-a 48 months follow-up analysis. J Neural Transm Suppl 72, 189-193.
    • (2007) J Neural Transm Suppl , vol.72 , pp. 189-193
    • Hager, K.1    Kenklies, M.2    McAfoose, J.3    Engel, J.4    Münch, G.5
  • 27
    • 39049190910 scopus 로고    scopus 로고
    • Improvement of insulin sensitivity in patients with type 2 diabetes mellitus after oral administration of alpha-lipoic acid
    • Kamenova P (2006) Improvement of insulin sensitivity in patients with type 2 diabetes mellitus after oral administration of alpha-lipoic acid. Hormones 5, 251-258.
    • (2006) Hormones , vol.5 , pp. 251-258
    • Kamenova, P.1
  • 29
    • 79953896769 scopus 로고    scopus 로고
    • Lipoic acid stimulates cAMP production via G protein-coupled receptor-dependent and-independent mechanisms
    • Salinthone S, Schillace RV, Tsang C, Regan JW, Bourdette DN, Carr DW (2011) Lipoic acid stimulates cAMP production via G protein-coupled receptor-dependent and-independent mechanisms. J Nutr Biochem 22, 681-690.
    • (2011) J Nutr Biochem , vol.22 , pp. 681-690
    • Salinthone, S.1    Schillace, R.V.2    Tsang, C.3    Regan, J.W.4    Bourdette, D.N.5    Carr, D.W.6
  • 31
    • 84859039093 scopus 로고    scopus 로고
    • Effects of n-3 PUFA supplementation on plasma soluble adhesion molecules: A meta-analysis of randomized controlled trials
    • Yang Y, Lu N, Chen D, Meng L, Zheng Y, Hui R (2012) Effects of n-3 PUFA supplementation on plasma soluble adhesion molecules: A meta-analysis of randomized controlled trials. Am J Clin Nutr 95, 972-980.
    • (2012) Am J Clin Nutr , vol.95 , pp. 972-980
    • Yang, Y.1    Lu, N.2    Chen, D.3    Meng, L.4    Zheng, Y.5    Hui, R.6
  • 34
    • 84860847063 scopus 로고    scopus 로고
    • Similarities and differences between the effects of EPA and DHA on markers of atherosclerosis in humans subjects
    • Kelley DS, Adkins Y (2012) Similarities and differences between the effects of EPA and DHA on markers of atherosclerosis in humans subjects. Proc Nutr Soc 71, 322-331.
    • (2012) Proc Nutr Soc , vol.71 , pp. 322-331
    • Kelley, D.S.1    Adkins, Y.2
  • 35
    • 40549113353 scopus 로고    scopus 로고
    • Nutritional biomarkers in Alzheimer's disease: The association between carotenoids, n-3 fatty acids, and dementia severity
    • Wang W, Shinto L, Connor WE, Quinn JF (2008) Nutritional biomarkers in Alzheimer's disease: The association between carotenoids, n-3 fatty acids, and dementia severity. J Alzheimers Dis 13, 31-38. (Pubitemid 351365625)
    • (2008) Journal of Alzheimer's Disease , vol.13 , Issue.1 , pp. 31-38
    • Wang, W.1    Shinto, L.2    Connor, W.E.3    Quinn, J.F.4


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