Notch dimerization is required for leukemogenesis and T-cell development

Genes and Development

Volumn 24, Issue 21, 2010, Pages 2395-2407

  Liu, Hudan ^a,b   Chi, Anthony W S ^b   Arnett, Kelly L ^c,d   Chiang, Mark Y ^a,b   Xu, Lanwei ^a,b   Shestova, Olga ^a,b   Wang, Hongfang ^c   Li, Yue Ming ^e   Bhandoola, Avinash ^b   Aster, Jon C ^c   Blacklow, Stephen C ^c,d   Pear, Warren S ^a,b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d DANA FARBER CANCER INSTITUTE   (United States)

^e MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

c Myc; Leukemia; Lymphocyte; Notch; T ALL; Transcription

Indexed keywords

INTERLEUKIN 2 RECEPTOR ALPHA; NOTCH RECEPTOR; NOTCH1 RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BINDING SITE; CELL FATE; CELL GROWTH; CELL MATURATION; CELL TRANSFORMATION; DIMERIZATION; GENE; HEY1 GENE; HUMAN; HUMAN CELL; LEUKEMIA CELL; LEUKEMOGENESIS; MOUSE; NONHUMAN; ONCOGENE C MYC; PRIORITY JOURNAL; PROTEIN EXPRESSION; PTALPHA GENE; PTCA GENE; SENSITIVITY ANALYSIS; T LYMPHOCYTE;

ANIMALS; BASE SEQUENCE; BINDING SITES; CELL LINE, TUMOR; CELL PROLIFERATION; CELLS, CULTURED; FLOW CYTOMETRY; LEUKEMIA; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; MODELS, MOLECULAR; PRECURSOR T-CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS C-MYC; RECEPTOR, NOTCH1; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEQUENCE HOMOLOGY, NUCLEIC ACID; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; TRANSCRIPTION, GENETIC;

EID: 78049421614     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.1975210     Document Type: Article

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