Transition metal-free direct C-H functionalization of quinones and naphthoquinones with diaryliodonium salts: Synthesis of aryl naphthoquinones as β-secretase inhibitors

Journal of Organic Chemistry

Volumn 79, Issue 18, 2014, Pages 8607-8613

  Wang, Dawei ^a   Ge, Bingyang ^a   Li, Liang ^a   Shan, Jie ^a   Ding, Yuqiang ^a  

^a JIANGNAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

KETONES; SALTS; TRANSITION METALS;

C-H FUNCTIONALIZATION; DIARYLIODONIUM SALTS; FUNCTIONALIZATIONS; NAPHTHOQUINONES; NOVEL LIGANDS; RADICAL MECHANISM; RADICAL TRAPPING; SECRETASES;

TRANSITION METAL COMPOUNDS;

2 (3 METHOXYPHENYL)[1,4]BENZOQUINONE; 2 (3,5 DIMETHYLPHENYL)[1,4]BENZOQUINONE; 2 (4 BROMOPHENYL)[1,4]BENZOQUINONE; 2 (4 ETHOXYPHENYL)[1,4]BENZOQUINONE; 2 (4 ETHOXYPHENYL)[1,4]NAPHTHOQUINONE; 2 (4 ETHYLPHENYL)[1,4]NAPHTHOQUINONE; 2 (4 IODOPHENYL)[1,4]BENZOQUINONE; 2 (4 ISOPROPYLPHENYL)[1,4]BENZOQUINONE; 2 (4 ISOPROPYLPHENYL)[1,4]NAPHTHOQUINONE; 2 (4 METHOXYPHENYL)[1,4]BENZOQUINONE; 2 (4 METHOXYPHENYL)[1,4]NAPHTHOQUINONE; 2 (4 TERT BUTYLPHENYL)[1,4]BENZOQUINONE; 2 (4 TERT BUTYLPHENYL)[1,4]NAPHTHOQUINONE; 2 BIPHENYL 4 YL[1,4]BENZOQUINONE; 2 BIPHENYL 4 YL[1,4]NAPHTHOQUINONE; 2 M TOLYLCYCLOHEXA 2,5 DIENE 1,4 DIONE; 2 M TOLYL[1,4]NAPHTHOQUINONE; 2 NAPHTHALEN 2 YL[1,4]BENZOQUINONE; 2 O TOLYL[1,4]BENZOQUINONE; 2 O TOLYL[1,4]NAPHTHOQUINONE; 2 PARA TOLYL[1,4]BENZOQUINONE; 2 PARA TOLYL[1,4]NAPHTHOQUINONE; 2 PHENYL[1,4]NAPHTHOQUINONE; 3 (3,6 DIOXOCYCLOHEXA 1,4 DIENYL)BENZONITRILE; BETA SECRETASE INHIBITOR; INORGANIC SALT; NAPHTHOQUINONE; QUINONE DERIVATIVE; TRANSITION ELEMENT; UNCLASSIFIED DRUG; UNINDEXED DRUG; CATION; METAL; SECRETASE;

ARTICLE; ARYLATION; CONTROLLED STUDY; COVALENT BOND; DRUG SYNTHESIS; ORGANIC CHEMISTRY; STEREOSPECIFICITY; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; SYNTHESIS;

AMYLOID PRECURSOR PROTEIN SECRETASES; METALS; MOLECULAR STRUCTURE; NAPHTHOQUINONES; ONIUM COMPOUNDS; QUINONES; TRANSITION ELEMENTS;

EID: 84911904916     PISSN: 00223263     EISSN: 15206904     Source Type: Journal    
DOI: 10.1021/jo501467v     Document Type: Article

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