Synthesis and evaluation of Hsp90 inhibitors that contain the 1,4-naphthoquinone scaffold

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 2, 2009, Pages 634-640

  Kyle Hadden, M ^a   Hill, Stephanie A ^a   Davenport, Jason ^b   Matts, Robert L ^b   Blagg, Brian S J ^a  

^a UNIVERSITY OF KANSAS   (United States)

^b OKLAHOMA STATE UNIVERSITY   (United States)

Author keywords

Anti proliferation; Cancer; High throughput screening; Hsp90; MCF 7; Naphthoquinone

Indexed keywords

1,4 NAPHTHOQUINONE DERIVATIVE; 2 AMINO 3 CHLORO 1,4 NAPHTHOQUINONE; 2 AMINO 3 PHENYLNAPHTHALENE 1,4 DIONE; 3',6 DIMETHOXY N [3 (4 METHOXYPHENYL) 1,4 DIOXO 1,4 DIHYDRONAPHTHALEN 2 YL]BIPHENYL 3 CARBOXAMIDE; HEAT SHOCK PROTEIN 90; HEAT SHOCK PROTEIN 90 INHIBITOR; N (1,4 DIOXO 3 PHENYL 1,4 DIHYDRONAPHTHALEN 2 YL)ACETAMIDE; N (1,4 DIOXO 3 PHENYL 1,4 DIHYDRONAPHTHALEN 2 YL)BENZAMIDE; SCAFFOLD PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG SCREENING; DRUG SYNTHESIS; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IC 50; PROTEIN DEGRADATION; STRUCTURE ACTIVITY RELATION;

CELL LINE, TUMOR; CELL PROLIFERATION; ENZYME INHIBITORS; HSP90 HEAT-SHOCK PROTEINS; HUMANS; INHIBITORY CONCENTRATION 50; NAPHTHOQUINONES; RECEPTOR, ERBB-2; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 58749114540     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.11.064     Document Type: Article

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