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Volumn 42, Issue 6, 2014, Pages 1506-1511

Lipid-based patterning of the immunological synapse

Author keywords

Actin; Cell polarity; Microtubule; Protein kinase C (PKC); Signal transduction; T cell

Indexed keywords

DIACYLGLYCEROL; F ACTIN; INOSITOL PHOSPHATE; LIPID;

EID: 84911903337     PISSN: 03005127     EISSN: 14708752     Source Type: Journal    
DOI: 10.1042/BST20140191     Document Type: Review
Times cited : (11)

References (61)
  • 1
    • 79952201000 scopus 로고    scopus 로고
    • Understanding the structure and function of the immunological synapse
    • CrossRef PubMed
    • Dustin, M.L., Chakraborty, A.K. and Shaw, A.S. (2010) Understanding the structure and function of the immunological synapse. Cold Spring Harb. Perspect. Biol. 2, a002311 CrossRef PubMed
    • (2010) Cold Spring Harb. Perspect. Biol. , vol.2 , pp. a002311
    • Dustin, M.L.1    Chakraborty, A.K.2    Shaw, A.S.3
  • 2
    • 44049096985 scopus 로고    scopus 로고
    • T cell activation and the cytoskeleton: You can't have one without the other
    • CrossRef PubMed
    • Gomez, T.S. and Billadeau, D.D. (2008) T cell activation and the cytoskeleton: you can't have one without the other. Adv. Immunol. 97, 1-64 CrossRef PubMed
    • (2008) Adv. Immunol. , vol.97 , pp. 1-64
    • Gomez, T.S.1    Billadeau, D.D.2
  • 3
    • 84885354654 scopus 로고    scopus 로고
    • From lipid second messengers to molecular motors: Microtubule-organizing center reorientation
    • CrossRef PubMed
    • Huse, M., Le Floc'h, A. and Liu, X. (2013) From lipid second messengers to molecular motors: microtubule-organizing center reorientation in cells. Immunol. Rev. 256, 95-106 CrossRef PubMed
    • (2013) Rftxt Cells. Immunol. Rev. , vol.256 , pp. 95-106
    • Huse, M.1    Le Floc'h, A.2    Liu, X.3
  • 4
    • 84863229197 scopus 로고    scopus 로고
    • Actin retrograde flow and actomyosin II arc contraction drive receptor cluster dynamics at the immunological synapse in Jurkat T cells
    • CrossRef PubMed
    • Yi, J., Wu, X.S., Crites, T. and Hammer, 3rd, J.A. (2012) Actin retrograde flow and actomyosin II arc contraction drive receptor cluster dynamics at the immunological synapse in Jurkat T cells. Mol. Biol. Cell 23, 834-852 CrossRef PubMed
    • (2012) Mol. Biol. Cell , vol.23 , pp. 834-852
    • Yi, J.1    Wu, X.S.2    Crites, T.3    Hammer, J.A.4
  • 5
    • 27544441784 scopus 로고    scopus 로고
    • Actin and agonist MHC-peptide complex-dependent T cell receptor microclusters as scaffolds for signaling
    • CrossRef PubMed
    • Campi, G., Varma, R. and Dustin, M.L. (2005) Actin and agonist MHC-peptide complex-dependent T cell receptor microclusters as scaffolds for signaling. J. Exp. Med. 202, 1031-1036 CrossRef PubMed
    • (2005) J. Exp. Med. , vol.202 , pp. 1031-1036
    • Campi, G.1    Varma, R.2    Dustin, M.L.3
  • 6
    • 77951688912 scopus 로고    scopus 로고
    • Essential role of ubiquitin and TSG101 protein in formation and function of the central supramolecular activation cluster
    • CrossRef PubMed
    • Vardhana, S., Choudhuri, K., Varma, R. and Dustin, M.L. (2010) Essential role of ubiquitin and TSG101 protein in formation and function of the central supramolecular activation cluster. Immunity 32, 531-540 CrossRef PubMed
    • (2010) Immunity , vol.32 , pp. 531-540
    • Vardhana, S.1    Choudhuri, K.2    Varma, R.3    Dustin, M.L.4
  • 7
    • 33746011209 scopus 로고    scopus 로고
    • T cell receptor-proximal signals are sustained in peripheral microclusters and terminated in the central supramolecular activation cluster
    • CrossRef PubMed
    • Varma, R., Campi, G., Yokosuka, T., Saito, T. and Dustin, M.L. (2006) T cell receptor-proximal signals are sustained in peripheral microclusters and terminated in the central supramolecular activation cluster. Immunity 25, 117-127 CrossRef PubMed
    • (2006) Immunity , vol.25 , pp. 117-127
    • Varma, R.1    Campi, G.2    Yokosuka, T.3    Saito, T.4    Dustin, M.L.5
  • 8
    • 52649128664 scopus 로고    scopus 로고
    • Shouts, whispers, and the kiss of death: Directional secretion in T cells
    • CrossRef PubMed
    • Huse, M., Quann, E.J. and Davis, M.M. (2008) Shouts, whispers, and the kiss of death: directional secretion in T cells. Nat. Immunol. 9, 1105-1111 CrossRef PubMed
    • (2008) Nat. Immunol. , vol.9 , pp. 1105-1111
    • Huse, M.1    Quann, E.J.2    Davis, M.M.3
  • 9
    • 38449096740 scopus 로고    scopus 로고
    • Secretory mechanisms in cell-mediated cytotoxicity
    • CrossRef PubMed
    • Stinchcombe, J.C. and Griffiths, G.M. (2007) Secretory mechanisms in cell-mediated cytotoxicity. Annu. Rev. Cell Dev. Biol. 23, 495-517 CrossRef PubMed
    • (2007) Annu. Rev. Cell Dev. Biol. , vol.23 , pp. 495-517
    • Stinchcombe, J.C.1    Griffiths, G.M.2
  • 10
    • 42649127027 scopus 로고    scopus 로고
    • The actin cytoskeleton in T cell activation
    • CrossRef PubMed
    • Burkhardt, J.K., Carrizosa, E. and Shaffer, M.H. (2008) The actin cytoskeleton in T cell activation. Annu. Rev. Immunol. 26, 233-259 CrossRef PubMed
    • (2008) Annu. Rev. Immunol. , vol.26 , pp. 233-259
    • Burkhardt, J.K.1    Carrizosa, E.2    Shaffer, M.H.3
  • 11
    • 0033083257 scopus 로고    scopus 로고
    • TCR, LFA-1, and CD28 play unique and complementary roles in signaling T cell cytoskeletal reorganization
    • PubMed
    • Sedwick, C.E., Morgan, M.M., Jusino, L., Cannon, J.L., Miller, J. and Burkhardt, J.K. (1999) TCR, LFA-1, and CD28 play unique and complementary roles in signaling T cell cytoskeletal reorganization. J. Immunol. 162, 1367-1375 PubMed
    • (1999) J. Immunol. , vol.162 , pp. 1367-1375
    • Sedwick, C.E.1    Morgan, M.M.2    Jusino, L.3    Cannon, J.L.4    Miller, J.5    Burkhardt, J.K.6
  • 13
    • 34447647655 scopus 로고    scopus 로고
    • Spatial and temporal dynamics of T cell receptor signaling with a photoactivatable agonist
    • CrossRef PubMed
    • Huse, M., Klein, L.O., Girvin, A.T., Faraj, J.M., Li, Q.J., Kuhns, M.S. and Davis, M.M. (2007) Spatial and temporal dynamics of T cell receptor signaling with a photoactivatable agonist. Immunity 27, 76-88 CrossRef PubMed
    • (2007) Immunity , vol.27 , pp. 76-88
    • Huse, M.1    Klein, L.O.2    Girvin, A.T.3    Faraj, J.M.4    Li, Q.J.5    Kuhns, M.S.6    Davis, M.M.7
  • 14
    • 0038445896 scopus 로고    scopus 로고
    • Linker for activation of T cells, ζ -associated protein-70, and Src homology 2 domain-containing leukocyte protein-76 are required for TCR-induced microtubule-organizing center polarization
    • CrossRef PubMed
    • Kuhne, M.R., Lin, J., Yablonski, D., Mollenauer, M.N., Ehrlich, L.I., Huppa, J., Davis, M.M. and Weiss, A. (2003) Linker for activation of T cells, ζ -associated protein-70, and Src homology 2 domain-containing leukocyte protein-76 are required for TCR-induced microtubule-organizing center polarization. J. Immunol. 171, 860-866 CrossRef PubMed
    • (2003) J. Immunol. , vol.171 , pp. 860-866
    • Kuhne, M.R.1    Lin, J.2    Yablonski, D.3    Mollenauer, M.N.4    Ehrlich, L.I.5    Huppa, J.6    Davis, M.M.7    Weiss, A.8
  • 15
    • 0032559586 scopus 로고    scopus 로고
    • Cytoskeletal polarization of T cells is regulated by an immunoreceptor tyrosine-based activation motif-dependent mechanism
    • CrossRef PubMed
    • Lowin-Kropf, B., Shapiro, V.S. and Weiss, A. (1998) Cytoskeletal polarization of T cells is regulated by an immunoreceptor tyrosine-based activation motif-dependent mechanism. J. Cell Biol. 140, 861-871 CrossRef PubMed
    • (1998) J. Cell Biol. , vol.140 , pp. 861-871
    • Lowin-Kropf, B.1    Shapiro, V.S.2    Weiss, A.3
  • 16
    • 67349243386 scopus 로고    scopus 로고
    • Localized diacylglycerol drives the polarization of the microtubule-organizing center in T cells
    • CrossRef PubMed
    • Quann, E.J., Merino, E., Furuta, T. and Huse, M. (2009) Localized diacylglycerol drives the polarization of the microtubule-organizing center in T cells. Nat. Immunol. 10, 627-635 CrossRef PubMed
    • (2009) Nat. Immunol. , vol.10 , pp. 627-635
    • Quann, E.J.1    Merino, E.2    Furuta, T.3    Huse, M.4
  • 17
    • 33646560593 scopus 로고    scopus 로고
    • Diacylglycerol and protein kinase D localization during T lymphocyte activation
    • CrossRef PubMed
    • Spitaler, M., Emslie, E., Wood, C.D. and Cantrell, D. (2006) Diacylglycerol and protein kinase D localization during T lymphocyte activation. Immunity 24, 535-546 CrossRef PubMed
    • (2006) Immunity , vol.24 , pp. 535-546
    • Spitaler, M.1    Emslie, E.2    Wood, C.D.3    Cantrell, D.4
  • 18
    • 0022362235 scopus 로고
    • The reorientation of the Golgi apparatus and the microtubule-organizing center in the cytotoxic effector cell is a prerequisite in the lysis of bound target cells
    • PubMed
    • Kupfer, A., Dennert, G. and Singer, S.J. (1985) The reorientation of the Golgi apparatus and the microtubule-organizing center in the cytotoxic effector cell is a prerequisite in the lysis of bound target cells. J. Mol. Cell. Immunol. 2, 37-49 PubMed
    • (1985) J. Mol. Cell. Immunol. , vol.2 , pp. 37-49
    • Kupfer, A.1    Dennert, G.2    Singer, S.J.3
  • 19
    • 27844539756 scopus 로고    scopus 로고
    • Protein kinase C and the regulation of the actin cytoskeleton
    • CrossRef PubMed
    • Larsson, C. (2006) Protein kinase C and the regulation of the actin cytoskeleton. Cell. Signal. 18, 276-284 CrossRef PubMed
    • (2006) Cell. Signal. , vol.18 , pp. 276-284
    • Larsson, C.1
  • 20
    • 34250692040 scopus 로고    scopus 로고
    • Protein kinase C theta (PKCtheta): A key player in T cell life and death
    • CrossRef PubMed
    • Hayashi, K. and Altman, A. (2007) Protein kinase C theta (PKCtheta): a key player in T cell life and death. Pharmacol. Res. 55, 537-544 CrossRef PubMed
    • (2007) Pharmacol. Res. , vol.55 , pp. 537-544
    • Hayashi, K.1    Altman, A.2
  • 21
    • 33947097707 scopus 로고    scopus 로고
    • Selective function of PKC-θ in T cells
    • PubMed
    • Manicassamy, S., Gupta, S. and Sun, Z. (2006) Selective function of PKC-θ in T cells. Cell. Mol. Immunol. 3, 263-270 PubMed
    • (2006) Cell. Mol. Immunol. , vol.3 , pp. 263-270
    • Manicassamy, S.1    Gupta, S.2    Sun, Z.3
  • 22
    • 0031012266 scopus 로고    scopus 로고
    • Selective modulation of protein kinase C-θ during T-cell activation
    • CrossRef PubMed
    • Monks, C.R., Kupfer, H., Tamir, I., Barlow, A. and Kupfer, A. (1997) Selective modulation of protein kinase C-θ during T-cell activation. Nature 385, 83-86 CrossRef PubMed
    • (1997) Nature , vol.385 , pp. 83-86
    • Monks, C.R.1    Kupfer, H.2    Tamir, I.3    Barlow, A.4    Kupfer, A.5
  • 23
    • 77349122303 scopus 로고    scopus 로고
    • Protein kinase C: Poised to signal
    • CrossRef PubMed
    • Newton, A.C. (2010) Protein kinase C: poised to signal. Am. J. Physiol. Endocrinol. Metab. 298, E395-E402 CrossRef PubMed
    • (2010) Am. J. Physiol. Endocrinol. Metab. , vol.298 , pp. E395-E402
    • Newton, A.C.1
  • 24
    • 79959376445 scopus 로고    scopus 로고
    • A cascade of protein kinase C isozymes promotes cytoskeletal polarization in T cells
    • CrossRef PubMed
    • Quann, E.J., Liu, X., Altan-Bonnet, G. and Huse, M. (2011) A cascade of protein kinase C isozymes promotes cytoskeletal polarization in T cells. Nat. Immunol. 12, 647-654 CrossRef PubMed
    • (2011) Nat. Immunol. , vol.12 , pp. 647-654
    • Quann, E.J.1    Liu, X.2    Altan-Bonnet, G.3    Huse, M.4
  • 25
    • 84899681547 scopus 로고    scopus 로고
    • The variable hinge region of novel PKCs determines localization to distinct regions of the immunological synapse
    • CrossRef PubMed
    • Basu, R., Chen, Y., Quann, E.J. and Huse, M. (2014) The variable hinge region of novel PKCs determines localization to distinct regions of the immunological synapse. PLoS ONE 9, e95531 CrossRef PubMed
    • (2014) PLoS ONE , vol.9 , pp. e95531
    • Basu, R.1    Chen, Y.2    Quann, E.J.3    Huse, M.4
  • 26
    • 80054895503 scopus 로고    scopus 로고
    • A motif in the V3 domain of the kinase PKC-theta determines its localization in the immunological synapse and functions in T cells via association with CD28
    • CrossRef PubMed
    • Kong, K.F., Yokosuka, T., Canonigo-Balancio, A.J., Isakov, N., Saito, T. and Altman, A. (2011) A motif in the V3 domain of the kinase PKC-theta determines its localization in the immunological synapse and functions in T cells via association with CD28. Nat. Immunol. 12, 1105-1112 CrossRef PubMed
    • (2011) Nat. Immunol. , vol.12 , pp. 1105-1112
    • Kong, K.F.1    Yokosuka, T.2    Canonigo-Balancio, A.J.3    Isakov, N.4    Saito, T.5    Altman, A.6
  • 27
    • 80052843195 scopus 로고    scopus 로고
    • An active kinase domain is required for retention of PKCθ at the T cell immunological synapse
    • CrossRef PubMed
    • Cartwright, N.G., Kashyap, A.K. and Schaefer, B.C. (2011) An active kinase domain is required for retention of PKCθ at the T cell immunological synapse. Mol. Biol. Cell 22, 3491-3497 CrossRef PubMed
    • (2011) Mol. Biol. Cell , vol.22 , pp. 3491-3497
    • Cartwright, N.G.1    Kashyap, A.K.2    Schaefer, B.C.3
  • 28
    • 84868548033 scopus 로고    scopus 로고
    • Protein kinase C-θ clustering at immunological synapses amplifies effector responses in NK cells
    • CrossRef PubMed
    • Merino, E., Abeyweera, T.P., Firth, M.A., Zawislak, C.L., Basu, R., Liu, X., Sun, J.C. and Huse, M. (2012) Protein kinase C-θ clustering at immunological synapses amplifies effector responses in NK cells. J. Immunol. 189, 4859-4869 CrossRef PubMed
    • (2012) J. Immunol. , vol.189 , pp. 4859-4869
    • Merino, E.1    Abeyweera, T.P.2    Firth, M.A.3    Zawislak, C.L.4    Basu, R.5    Liu, X.6    Sun, J.C.7    Huse, M.8
  • 30
    • 10344253279 scopus 로고    scopus 로고
    • Protein kinase C? Is dispensable for TCR/CD3-signaling
    • CrossRef PubMed
    • Gruber, T., Thuille, N., Hermann-Kleiter, N., Leitges, M. and Baier, G. (2005) Protein kinase C? is dispensable for TCR/CD3-signaling. Mol. Immunol. 42, 305-310 CrossRef PubMed
    • (2005) Mol. Immunol. , vol.42 , pp. 305-310
    • Gruber, T.1    Thuille, N.2    Hermann-Kleiter, N.3    Leitges, M.4    Baier, G.5
  • 31
    • 84880381626 scopus 로고    scopus 로고
    • Diacylglycerol promotes centrosome polarization in T cells via reciprocal localization of dynein and myosin II
    • CrossRef PubMed
    • Liu, X., Kapoor, T.M., Chen, J.K. and Huse, M. (2013) Diacylglycerol promotes centrosome polarization in T cells via reciprocal localization of dynein and myosin II. Proc. Natl. Acad. Sci. U.S.A. 110, 11976-11981 CrossRef PubMed
    • (2013) Proc. Natl. Acad. Sci. U.S.A. , vol.110 , pp. 11976-11981
    • Liu, X.1    Kapoor, T.M.2    Chen, J.K.3    Huse, M.4
  • 32
    • 70450228589 scopus 로고    scopus 로고
    • Regulators of the cytoplasmic dynein motor
    • CrossRef PubMed
    • Kardon, J.R. and Vale, R.D. (2009) Regulators of the cytoplasmic dynein motor. Nat. Rev. Mol. Cell Biol. 10, 854-865 CrossRef PubMed
    • (2009) Nat. Rev. Mol. Cell Biol. , vol.10 , pp. 854-865
    • Kardon, J.R.1    Vale, R.D.2
  • 33
    • 70350454867 scopus 로고    scopus 로고
    • Non-muscle myosin II takes centre stage in cell adhesion and migration
    • CrossRef PubMed
    • Vicente-Manzanares, M., Ma, X., Adelstein, R.S. and Horwitz, A.R. (2009) Non-muscle myosin II takes centre stage in cell adhesion and migration. Nat. Rev. Mol. Cell Biol. 10, 778-790 CrossRef PubMed
    • (2009) Nat. Rev. Mol. Cell Biol. , vol.10 , pp. 778-790
    • Vicente-Manzanares, M.1    Ma, X.2    Adelstein, R.S.3    Horwitz, A.R.4
  • 34
    • 33749037156 scopus 로고    scopus 로고
    • The ARP2/3 complex: An actin nucleator comes of age
    • CrossRef PubMed
    • Goley, E.D. and Welch, M.D. (2006) The ARP2/3 complex: an actin nucleator comes of age. Nat. Rev. Mol. Cell Biol. 7, 713-726 CrossRef PubMed
    • (2006) Nat. Rev. Mol. Cell Biol. , vol.7 , pp. 713-726
    • Goley, E.D.1    Welch, M.D.2
  • 35
    • 76549123909 scopus 로고    scopus 로고
    • Generation of branched actin networks: Assembly and regulation of the N-WASP and WAVE molecular machines
    • CrossRef PubMed
    • Derivery, E. and Gautreau, A. (2010) Generation of branched actin networks: assembly and regulation of the N-WASP and WAVE molecular machines. BioEssays 32, 119-131 CrossRef PubMed
    • (2010) BioEssays , vol.32 , pp. 119-131
    • Derivery, E.1    Gautreau, A.2
  • 36
    • 84885339434 scopus 로고    scopus 로고
    • Wiskott-Aldrich syndrome protein: Dynamic regulation of actin homeostasis: From activation through function and signal termination in T lymphocytes
    • CrossRef PubMed
    • Matalon, O., Reicher, B. and Barda-Saad, M. (2013) Wiskott-Aldrich syndrome protein: dynamic regulation of actin homeostasis: from activation through function and signal termination in T lymphocytes. Immunol. Rev. 256, 10-29 CrossRef PubMed
    • (2013) Immunol. Rev. , vol.256 , pp. 10-29
    • Matalon, O.1    Reicher, B.2    Barda-Saad, M.3
  • 37
    • 30044446991 scopus 로고    scopus 로고
    • The WAVE2 complex regulates actin cytoskeletal reorganization and CRAC-mediated calcium entry during T cell activation
    • CrossRef PubMed
    • Nolz, J.C., Gomez, T.S., Zhu, P., Li, S., Medeiros, R.B., Shimizu, Y., Burkhardt, J.K., Freedman, B.D. and Billadeau, D.D. (2006) The WAVE2 complex regulates actin cytoskeletal reorganization and CRAC-mediated calcium entry during T cell activation. Curr. Biol. 16, 24-34 CrossRef PubMed
    • (2006) Curr. Biol. , vol.16 , pp. 24-34
    • Nolz, J.C.1    Gomez, T.S.2    Zhu, P.3    Li, S.4    Medeiros, R.B.5    Shimizu, Y.6    Burkhardt, J.K.7    Freedman, B.D.8    Billadeau, D.D.9
  • 38
    • 30044438580 scopus 로고    scopus 로고
    • Role for the Abi/wave protein complex in cell receptor-mediated proliferation and cytoskeletal remodeling
    • CrossRef PubMed
    • Zipfel, P.A., Bunnell, S.C., Witherow, D.S., Gu, J.J., Chislock, E.M., Ring, C. and Pendergast, A.M. (2006) Role for the Abi/wave protein complex in cell receptor-mediated proliferation and cytoskeletal remodeling. Curr. Biol. 16, 35-46 CrossRef PubMed
    • (2006) Curr. Biol. , vol.16 , pp. 35-46
    • Zipfel, P.A.1    Bunnell, S.C.2    Witherow, D.S.3    Gu, J.J.4    Chislock, E.M.5    Ring, C.6    Pendergast, A.M.7
  • 39
    • 27944479854 scopus 로고    scopus 로고
    • Rho GTPases: Biochemistry and biology
    • CrossRef PubMed
    • Jaffe, A.B. and Hall, A. (2005) Rho GTPases: biochemistry and biology. Annu. Rev. Cell Dev. Biol. 21, 247-269 CrossRef PubMed
    • (2005) Annu. Rev. Cell Dev. Biol. , vol.21 , pp. 247-269
    • Jaffe, A.B.1    Hall, A.2
  • 40
    • 84888095370 scopus 로고    scopus 로고
    • Annular PIP3 accumulation controls actin architecture and modulates cytotoxicity at the immunological synapse
    • CrossRef PubMed
    • Le Floc'h, A., Tanaka, Y., Bantilan, N.S., Voisinne, G., Altan-Bonnet, G., Fukui, Y. and Huse, M. (2013) Annular PIP3 accumulation controls actin architecture and modulates cytotoxicity at the immunological synapse. J. Exp. Med. 210, 2721-2737 CrossRef PubMed
    • (2013) J. Exp. Med. , vol.210 , pp. 2721-2737
    • Le Floc'h, A.1    Tanaka, Y.2    Bantilan, N.S.3    Voisinne, G.4    Altan-Bonnet, G.5    Fukui, Y.6    Huse, M.7
  • 41
    • 77950908560 scopus 로고    scopus 로고
    • Insights into function of the immunological synapse from studies with supported planar bilayers
    • PubMed
    • Dustin, M.L. (2010) Insights into function of the immunological synapse from studies with supported planar bilayers. Curr. Top. Microbiol. Immunol. 340, 1-24 PubMed
    • (2010) Curr. Top. Microbiol. Immunol. , vol.340 , pp. 1-24
    • Dustin, M.L.1
  • 42
    • 0038445857 scopus 로고    scopus 로고
    • DOCK2 is essential for antigen-induced translocation of TCR and lipid rafts, but not PKC-theta and LFA-1, in T cells
    • CrossRef PubMed
    • Sanui, T., Inayoshi, A., Noda, M., Iwata, E., Oike, M., Sasazuki, T. and Fukui, Y. (2003) DOCK2 is essential for antigen-induced translocation of TCR and lipid rafts, but not PKC-theta and LFA-1, in T cells. Immunity 19, 119-129 CrossRef PubMed
    • (2003) Immunity , vol.19 , pp. 119-129
    • Sanui, T.1    Inayoshi, A.2    Noda, M.3    Iwata, E.4    Oike, M.5    Sasazuki, T.6    Fukui, Y.7
  • 43
    • 34548472221 scopus 로고    scopus 로고
    • GEF what? Dock180 and related proteins help Rac to polarize cells in new ways
    • CrossRef PubMed
    • Cote, J.F. and Vuori, K. (2007) GEF what? Dock180 and related proteins help Rac to polarize cells in new ways. Trends Cell Biol. 17, 383-393 CrossRef PubMed
    • (2007) Trends Cell Biol. , vol.17 , pp. 383-393
    • Cote, J.F.1    Vuori, K.2
  • 44
    • 0036853106 scopus 로고    scopus 로고
    • Sustained and dynamic inositol lipid metabolism inside and outside the immunological synapse
    • CrossRef PubMed
    • Costello, P.S., Gallagher, M. and Cantrell, D.A. (2002) Sustained and dynamic inositol lipid metabolism inside and outside the immunological synapse. Nat. Immunol. 3, 1082-1089 CrossRef PubMed
    • (2002) Nat. Immunol. , vol.3 , pp. 1082-1089
    • Costello, P.S.1    Gallagher, M.2    Cantrell, D.A.3
  • 45
    • 0036852243 scopus 로고    scopus 로고
    • Imaging antigen-induced PI3K activation in T cells
    • CrossRef PubMed
    • Harriague, J. and Bismuth, G. (2002) Imaging antigen-induced PI3K activation in T cells. Nat. Immunol. 3, 1090-1096 CrossRef PubMed
    • (2002) Nat. Immunol. , vol.3 , pp. 1090-1096
    • Harriague, J.1    Bismuth, G.2
  • 46
    • 0041695164 scopus 로고    scopus 로고
    • Continuous T cell receptor signaling required for synapse maintenance and full effector potential
    • CrossRef PubMed
    • Huppa, J.B., Gleimer, M., Sumen, C. and Davis, M.M. (2003) Continuous T cell receptor signaling required for synapse maintenance and full effector potential. Nat. Immunol. 4, 749-755 CrossRef PubMed
    • (2003) Nat. Immunol. , vol.4 , pp. 749-755
    • Huppa, J.B.1    Gleimer, M.2    Sumen, C.3    Davis, M.M.4
  • 47
    • 61849126233 scopus 로고    scopus 로고
    • Fine tuning the immune response with PI3K
    • CrossRef PubMed
    • Fruman, D.A. and Bismuth, G. (2009) Fine tuning the immune response with PI3K. Immunol. Rev. 228, 253-272 CrossRef PubMed
    • (2009) Immunol. Rev. , vol.228 , pp. 253-272
    • Fruman, D.A.1    Bismuth, G.2
  • 48
    • 38949150779 scopus 로고    scopus 로고
    • CD28 provides T-cell costimulation and enhances PI3K activity at the immune synapse independently of its capacity to interact with the p85/p110 heterodimer
    • CrossRef PubMed
    • Garcon, F., Patton, D.T., Emery, J.L., Hirsch, E., Rottapel, R., Sasaki, T. and Okkenhaug, K. (2008) CD28 provides T-cell costimulation and enhances PI3K activity at the immune synapse independently of its capacity to interact with the p85/p110 heterodimer. Blood 111, 1464-1471 CrossRef PubMed
    • (2008) Blood , vol.111 , pp. 1464-1471
    • Garcon, F.1    Patton, D.T.2    Emery, J.L.3    Hirsch, E.4    Rottapel, R.5    Sasaki, T.6    Okkenhaug, K.7
  • 51
    • 0029990003 scopus 로고    scopus 로고
    • Activation of phosphoinositide 3-kinase by interaction with Ras and by point mutation
    • PubMed
    • Rodriguez-Viciana, P., Warne, P.H., Vanhaesebroeck, B., Waterfield, M.D. and Downward, J. (1996) Activation of phosphoinositide 3-kinase by interaction with Ras and by point mutation. EMBO J. 15, 2442-2451 PubMed
    • (1996) EMBO J. , vol.15 , pp. 2442-2451
    • Rodriguez-Viciana, P.1    Warne, P.H.2    Vanhaesebroeck, B.3    Waterfield, M.D.4    Downward, J.5
  • 52
    • 34447579251 scopus 로고    scopus 로고
    • The lymphocyte function-associated antigen-1 receptor costimulates plasma membrane Ras via phospholipase D2
    • CrossRef PubMed
    • Mor, A., Campi, G., Du, G., Zheng, Y., Foster, D.A., Dustin, M.L. and Philips, M.R. (2007) The lymphocyte function-associated antigen-1 receptor costimulates plasma membrane Ras via phospholipase D2. Nat. Cell Biol. 9, 713-719 CrossRef PubMed
    • (2007) Nat. Cell Biol. , vol.9 , pp. 713-719
    • Mor, A.1    Campi, G.2    Du, G.3    Zheng, Y.4    Foster, D.A.5    Dustin, M.L.6    Philips, M.R.7
  • 53
    • 79952483287 scopus 로고    scopus 로고
    • Lipid signaling in T-cell development and function
    • PubMed
    • Huang, Y.H. and Sauer, K. (2010) Lipid signaling in T-cell development and function. Cold Spring Harb. Perspect. Biol. 2, a002428 PubMed
    • (2010) Cold Spring Harb. Perspect. Biol. , vol.2 , pp. a002428
    • Huang, Y.H.1    Sauer, K.2
  • 54
    • 49249109489 scopus 로고    scopus 로고
    • Diacylglycerol kinases in immune cell function and self-tolerance
    • CrossRef PubMed
    • Zhong, X.P., Guo, R., Zhou, H., Liu, C. and Wan, C.K. (2008) Diacylglycerol kinases in immune cell function and self-tolerance. Immunol. Rev. 224, 249-264 CrossRef PubMed
    • (2008) Immunol. Rev. , vol.224 , pp. 249-264
    • Zhong, X.P.1    Guo, R.2    Zhou, H.3    Liu, C.4    Wan, C.K.5
  • 55
    • 0037452071 scopus 로고    scopus 로고
    • Adaptation of core mechanisms to generate cell polarity
    • CrossRef PubMed
    • Nelson, W.J. (2003) Adaptation of core mechanisms to generate cell polarity. Nature 422, 766-774 CrossRef PubMed
    • (2003) Nature , vol.422 , pp. 766-774
    • Nelson, W.J.1
  • 56
    • 14844364701 scopus 로고    scopus 로고
    • Regulation of the polarity protein Par6 by TGFβ receptors controls epithelial cell plasticity
    • CrossRef PubMed
    • Ozdamar, B., Bose, R., Barrios-Rodiles, M., Wang, H.R., Zhang, Y. and Wrana, J.L. (2005) Regulation of the polarity protein Par6 by TGFβ receptors controls epithelial cell plasticity. Science 307, 1603-1609 CrossRef PubMed
    • (2005) Science , vol.307 , pp. 1603-1609
    • Ozdamar, B.1    Bose, R.2    Barrios-Rodiles, M.3    Wang, H.R.4    Zhang, Y.5    Wrana, J.L.6
  • 57
    • 39149135251 scopus 로고    scopus 로고
    • Downregulation of Par-3 expression and disruption of Par complex integrity by TGF-β during the process of epithelial to mesenchymal transition in rat proximal epithelial cells
    • CrossRef PubMed
    • Wang, X., Nie, J., Zhou, Q., Liu, W., Zhu, F., Chen, W., Mao, H., Luo, N., Dong, X. and Yu, X. (2008) Downregulation of Par-3 expression and disruption of Par complex integrity by TGF-β during the process of epithelial to mesenchymal transition in rat proximal epithelial cells. Biochim. Biophys. Acta 1782, 51-59 CrossRef PubMed
    • (2008) Biochim. Biophys. Acta , vol.1782 , pp. 51-59
    • Wang, X.1    Nie, J.2    Zhou, Q.3    Liu, W.4    Zhu, F.5    Chen, W.6    Mao, H.7    Luo, N.8    Dong, X.9    Yu, X.10
  • 58
    • 0347717903 scopus 로고    scopus 로고
    • T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases
    • CrossRef PubMed
    • Mempel, T.R., Henrickson, S.E. and Von Andrian, U.H. (2004) T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases. Nature 427, 154-159 CrossRef PubMed
    • (2004) Nature , vol.427 , pp. 154-159
    • Mempel, T.R.1    Henrickson, S.E.2    Von Andrian, U.H.3
  • 59
    • 79954906546 scopus 로고    scopus 로고
    • Asymmetric proteasome segregation as a mechanism for unequal partitioning of the transcription factor T-bet during T lymphocyte division
    • CrossRef PubMed
    • Chang, J.T., Ciocca, M.L., Kinjyo, I., Palanivel, V.R., McClurkin, C.E., Dejong, C.S., Mooney, E.C., Kim, J.S., Steinel, N.C., Oliaro, J. et al. (2011) Asymmetric proteasome segregation as a mechanism for unequal partitioning of the transcription factor T-bet during T lymphocyte division. Immunity 34, 492-504 CrossRef PubMed
    • (2011) Immunity , vol.34 , pp. 492-504
    • Chang, J.T.1    Ciocca, M.L.2    Kinjyo, I.3    Palanivel, V.R.4    McClurkin, C.E.5    Dejong, C.S.6    Mooney, E.C.7    Kim, J.S.8    Steinel, N.C.9    Oliaro, J.10


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