Structural elucidation of the DFG-Asp in and DFG-Asp out states of TAM kinases and insight into the selectivity of their inhibitors

Molecules

Volumn 19, Issue 10, 2014, Pages 16223-16239

  Messoussi, Abdellah ^a,b   Peyronnet, Lucile ^a   Feneyrolles, Clémence ^a   Chevé, Gwénaël ^a   Bougrin, Khalid ^b   Yasri, Aziz ^a  

^a OriBase Pharma   (France)

^b FACULTÉ DES SCIENCES   (Morocco)

Author keywords

Homology model; Kinase selectivity; TAM kinase family; Tyrosine kinase

Indexed keywords

PHOSPHOTRANSFERASE; PROTEIN BINDING; PROTEIN KINASE INHIBITOR; PROTEIN TYROSINE KINASE;

AMINO ACID SEQUENCE; ANTAGONISTS AND INHIBITORS; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; DRUG DESIGN; DRUG DEVELOPMENT; ENZYME ACTIVE SITE; HUMAN; MOLECULAR GENETICS; PROTEIN DOMAIN; SEQUENCE ALIGNMENT;

AMINO ACID SEQUENCE; BINDING SITES; CATALYTIC DOMAIN; DRUG DESIGN; DRUG DISCOVERY; HUMANS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR SEQUENCE DATA; PHOSPHOTRANSFERASES; PROTEIN BINDING; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN KINASE INHIBITORS; RECEPTOR PROTEIN-TYROSINE KINASES; SEQUENCE ALIGNMENT;

EID: 84911896085     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules191016223     Document Type: Article

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