CanSAR: Updated cancer research and drug discovery knowledgebase

Nucleic Acids Research

Volumn 42, Issue D1, 2014, Pages

  Bulusu, Krishna C ^a   Tym, Joseph E ^a   Coker, Elizabeth A ^a   Schierz, Amanda C ^a   Al Lazikani, Bissan ^a  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CANCER CELL CULTURE; CANCER RESEARCH; CANSAR DATABASE; CELLULAR DISTRIBUTION; DATA ANALYSIS; DRUG RESEARCH; GENE MUTATION; INTERNET; KNOWLEDGE BASE; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN DATA BANK; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN STRUCTURE; PROTEOMICS; SYSTEMS BIOLOGY; THREE DIMENSIONAL IMAGING; TRANSLATIONAL RESEARCH; WEB BROWSER; CHEMISTRY; CLASSIFICATION; DRUG DEVELOPMENT; GENETIC DATABASE; GENETICS; HUMAN; METABOLISM; MUTATION; NEOPLASM; PROTEIN ANALYSIS; PROTEIN CONFORMATION; TUMOR CELL LINE; AMINO ACID SEQUENCE; CANCER CELL LINE; CANSAR; CHEMICAL STRUCTURE; COPY NUMBER VARIATION; GENE EXPRESSION; ONLINE SYSTEM; PROTEIN INTERACTION; RNA INTERFERENCE;

ANTINEOPLASTIC AGENT; PROTEIN;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; DATABASES, GENETIC; DRUG DISCOVERY; HUMANS; INTERNET; KNOWLEDGE BASES; MUTATION; NEOPLASMS; PROTEIN CONFORMATION; PROTEIN INTERACTION MAPPING; PROTEINS; TRANSLATIONAL MEDICAL RESEARCH;

EID: 84891785390     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkt1182     Document Type: Article

References (16)

1. International Cancer Genome Consortium, Hudson, T.J., Anderson, W., Artez, A., Barker, A.D., Bell, C., Bernabe, R.R., Bhan, M.K., Calvo, F., Eerola, I. et al. (2010) International network of cancer genome projects. Nature, 464, 993-998.
2. Orchard, S., Kerrien, S., Abbani, S., Aranda, B., Bhate, J., Bidwell, S., Bridge, A., Briganti, L., Brinklan, F.S., Casareni, G. et al. (2012) Protein interaction data curation: the International Molecular Exchange (IMEx) consortium. Nat. Methods, 9, 345-350.
3. Barretina, J., Caponigro, G., Stransky, N., Venkatesan, K., Margolin, A.A., Kim, S., Wilson, C.J., Lehar, J., Sonkin, D., Reddy, A. et al. (2012) The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity. Nature, 483, 603-607.
4. Garnett, M.J., Edelman, E.J., Heidorn, S.J., Greenman, C.D., Dastur, A., Lau, K.W., Greninger, P., Thompson, I.R., Luo, X., Soares, J. et al. (2012) Systematic identification of genomic markers of drug sensitivity in cancer cells. Nature, 483, 570-575.
5. 1000 Genomes Project Consortium, Abecasis, G.R., Altshuler, D., Auton, A., Brooks, L.D., Durbin, R.M., Gibbs, R.A., Hurles, M.E. and McVean, G.A. (2010) A map of human genome variation from population-scale sequencing. Nature, 467, 1061-1073.
6. Vogelstein, B., Papadopoulos, N., Velculescu, V.E., Zhou, S., Diaz, L.A. and Kinzler, K.W. (2013) Cancer genome landscapes. Science, 339, 1546-1558.
7. Rose, P.W., Bi, C., Bluhm, W.F., Christie, C.H., Dimitropoulos, D., Dutta, S., Green, R.K., Goodsell, D.S., Prlic, A., Quesada, M. et al. (2013) The RCSB Protein Data Bank: new resources for research and education. Nucleic Acids Res., 41, D475-D482.
8. Cerami, E., Gao, J., Dogrusoz, U., Gross, B.E., Sumer, S.O., Aksoy, B.A., Jacobsen, A., Byrne, C.J., Heuer, M.L., Larsson, E. et al. (2012) The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data. Cancer Discov., 2, 401-404.
9. Yang, W., Soares, J., Greninger, P., Edelman, E.J., Lightfoot, H., Forbes, S., Bindal, N., Beare, D., Smith, J.A., Thompson, I.R. et al. (2013) Genomics of Drug Sensitivity in Cancer (GDSC): a resource for therapeutic biomarker discovery in cancer cells. Nucleic Acids Res., 41, D955-D961.
10. Ahmed, J., Meinel, T., Dunkel, M., Murgueitio, M.S., Adams, R., Blasse, C, Eckert, A., Preissner, S. and Preissner, R. (2011) CancerResource: a comprehensive database of cancer-relevant proteins and compound interactions supported by experimental knowledge. Nucleic Acids Res., 39, D960-D967.
11. Lamb, J. (2007) The Connectivity Map: a new tool for biomedical research. Nat. Rev. Cancer, 7, 54-60.
12. Gaulton, A., Bellis, L.J., Bento, A.P., Chambers, J., Davies, M., Hersey, A., Light, Y., McGlinchey, S., Michalovich, D., Al-Lazikani, B. et al. (2012) ChEMBL: a large-scale bioactivity database for drug discovery. Nucleic Acids Res., 40, D1100-D1107.
13. Halling-Brown, M.D., Bulusu, K.C, Patel, M., Tym, J.E. and Al-Lazikani, B. (2011) canSAR: an integrated cancer public translational research and drug discovery resource. Nucleic Acids Res., 40, D947-D956.
14. UniProt Consortium. (2013) Update on activities at the Universal Protein Resource (UniProt) in 2013. Nucleic Acids Res., 41, D43-D47.
15. Punta, M., Coggill, P.C, Eberhardt, R.Y., Mistry, J., Tate, J., Boursnell, C, Pang, N., Forslund, K., Ceric, G, Clements, J. et al. (2012) The Pfam protein families database. Nucleic Acids Res., 40, D290-D301.
16. Patel, M.N., Halling-Brown, M.D., Tym, J.E., Workman, P. and Al-Lazikani, B. (2012) Objective assessment of cancer genes for drug discovery. Nat. Rev. Drug Discov., 12, 35-50.