Discovery of novel 2-aminopyridine-3-carboxamides as c-Met kinase inhibitors

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 17, 2012, Pages 5169-5180

  Zhang, Dengyou ^a   Ai, Jing ^a   Liang, Zhongjie ^a   Li, Chunpu ^a   Peng, Xia ^a   Ji, Yinchun ^a   Jiang, Hualiang ^a,b   Geng, Meiyu ^a   Luo, Cheng ^a   Liu, Hong ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^b EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

2 Aminopyridine 3 carboxamide; c Met; Receptor tyrosine kinase

Indexed keywords

2 AMINO 5 BROMO N [(2 CHLORO 3,6 DIFLUOROPHENYL)METHYL]PYRIDINE 3 CARBOXAMIDE; 2 AMINO 5 BROMO N [(2 CHLORO 6 FLUOROPHENYL)METHYL]PYRIDINE 3 CARBOXAMIDE; 2 AMINO 5 BROMO N [(2,3 DICHLORO 6 FLUOROPHENYL)METHYL]PYRIDINE 3 CARBOXAMIDE; 2 AMINO 5 BROMO N [(2,3 DIFLUOROPHENYL)METHYL]PYRIDINE 3 CARBOXAMIDE; 2 AMINO 5 BROMO N [(2,4 DIFLUOROPHENYL)METHYL]PYRIDINE 3 CARBOXAMIDE; 2 AMINO 5 BROMO N [(2,5 DIFLUOROPHENYL)METHYL]PYRIDINE 3 CARBOXAMIDE; 2 AMINO 5 BROMO N [(3 CHLORO 2,6 DIFLUOROPHENYL)METHYL]PYRIDINE 3 CARBOXAMIDE; 2 AMINO 5 BROMO N [(3,4 DIFLUOROPHENYL)METHYL]PYRIDINE 3 CARBOXAMIDE; 2 AMINO 5 BROMO N [(3,5 DIFLUOROPHENYL)METHYL]PYRIDINE 3 CARBOXAMIDE; 2 AMINO 5 BROMONICOTINIC ACID; 2 AMINO N [(2 CHLORO 3,6 DIFLUOROPHENYL)METHYL] 5 (1 METHYL 1H PYRAZOL 4 YL)PYRIDINE 3 CARBOXAMIDE; 2 AMINO N [(2 CHLORO 6 FLUOROPHENYL)METHYL] 5 (1 METHYL 1H PYRAZOL 4 YL)PYRIDINE 3 CARBOXAMIDE; 2 AMINO N [(2,3 DICHLORO 6 DIFLUOROPHENYL)METHYL] 5 (1 METHYL 1H PYRAZOL 4 YL)PYRIDINE 3 CARBOXAMIDE; 2 AMINO N [(2,3 DIFLUOROPHENYL)METHYL] 5 (1 METHYL 1H PYRAZOL 4 YL)PYRIDINE 3 CARBOXAMIDE; 2 AMINO N [(2,4 DIFLUOROPHENYL)METHYL] 5 (1 METHYL 1H PYRAZOL 4 YL)PYRIDINE 3 CARBOXAMIDE; 2 AMINO N [(2,5 DIFLUOROPHENYL)METHYL] 5 (1 METHYL 1H PYRAZOL 4 YL)PYRIDINE 3 CARBOXAMIDE; 2 AMINO N [(3 CHLORO 2,6 DIFLUOROPHENYL)METHYL] 5 (1 METHYL 1H PYRAZOL 4 YL)PYRIDINE 3 CARBOXAMIDE; 2 AMINO N [(3,4 DIFLUOROPHENYL)METHYL] 5 (1 METHYL 1H PYRAZOL 4 YL)PYRIDINE 3 CARBOXAMIDE; 2 AMINO N [(3,5 DIFLUOROPHENYL)METHYL] 5 (1 METHYL 1H PYRAZOL 4 YL)PYRIDINE 3 CARBOXAMIDE; 2 AMINOPYRIDINE 3 CARBOXAMIDE DERIVATIVE; 2 AMINOPYRIDINE DERIVATIVE; PROTEIN KINASE INHIBITOR; SCATTER FACTOR RECEPTOR; TERT BUTYL N [(2 CHLORO 3,6 DIFLUOROPHENYL)METHYL] N METHYLCARBAMATE; TERT BUTYL N [(2 CHLORO 3,6 DIFLUOROPHENYL)METHYL]CARBAMATE; TERT BUTYL N [(2,3 DICHLORO 6 FLUOROPHENYL)METHYL]CARBAMATE; TERT BUTYL N [(2,3 DICHLORO 6 FLUOROPHENYL)METHYL]N METHYLCARBAMATE; TERT BUTYL N [(3 CHLORO 2,6 DIFLUOROPHENYL)METHYL] N METHYLCARBAMATE; TERT BUTYL N [(3 CHLORO 2,6 DIFLUOROPHENYL)METHYL]CARBAMATE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; CHEMICAL ANALYSIS; CHEMICAL STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; INTRACELLULAR SIGNALING; MOLECULAR MODEL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SYNTHESIS;

AMINOPYRIDINES; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DISCOVERY; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NIACINAMIDE; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-MET; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84865003342     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.07.007     Document Type: Article

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