Erratum: Discovery of mer specific tyrosine kinase inhibitors for the treatment and prevention of thrombosis (Journal of Medicinal Chemistry (2013) 56:23 (9693-9700) DOI: 10.1021/jm4013888);Discovery of Mer specific tyrosine kinase inhibitors for the treatment and prevention of thrombosis

Journal of Medicinal Chemistry

Volumn 56, Issue 23, 2013, Pages 9693-9700

  Zhang, Weihe ^a,b   McIver, Andrew L ^a,b   Stashko, Michael A ^a,b   Deryckere, Deborah ^d   Branchford, Brian R ^d   Hunter, Debra ^c   Kireev, Dmitri ^a,b   Miley, Michael J ^c   Norris Drouin, Jacqueline ^a,b   Stewart, Wendy M ^a,b   Lee, Minjung ^d   Sather, Susan ^d   Zhou, Yingqiu ^b   Di Paola, Jorge A ^d   Machius, Mischa ^c   Janzen, William P ^a,b   Earp, H Shelton ^c   Graham, Douglas K ^d   Frye, Stephen V ^a,b,c   Wang, Xiaodong ^a,b  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b University of North Carolina   (United States)

^c UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^d Children's Hospital Colorado   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN; PROTEIN TYROSINE KINASE INHIBITOR; PYRIMIDINE DERIVATIVE; UNC 1062; UNC 2881; UNC 569; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CRYSTAL STRUCTURE; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; IC 50; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION; THROMBOCYTE AGGREGATION; THROMBOSIS;

EID: 84890459446     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm501217p     Document Type: Erratum

References (19)

1. De Berardis, G.; Lucisano, G.; D'Ettorre, A. Association of aspirin use with major bleeding in patients with and without diabetes JAMA, J. Am. Med. Assoc. 2012, 307 (21) 2286-2294
2. Diener, H.-C.; Bogousslavsky, J.; Brass, L. M.; Cimminiello, C.; Csiba, L.; Kaste, M.; Leys, D.; Matias-Guiu, J.; Rupprecht, H.-J. Aspirin and clopidogrel compared with clopidogrel alone after recent ischaemic stroke or transient ischaemic attack in high-risk patients (MATCH): randomised, double-blind, placebo-controlled trial Lancet 2004, 364 (9431) 331-337
3. Sanderson, S.; Emery, J.; Baglin, T.; Kinmonth, A.-L. Narrative Review: Aspirin Resistance and Its Clinical Implications Ann. Intern. Med. 2005, 142 (5) 370-380
4. Nguyen, T. A.; Diodati, J. G.; Pharand, C. Resistance to clopidogrel: a review of the evidence J. Am. Coll. Cardiol. 2005, 45 (8) 1157-1164
5. Laurance, S.; Lemarie, C. A.; Blostein, M. D. Growth Arrest-Specific Gene 6 (gas6) and Vascular Hemostasis Adv Nutr. 2012, 3 (2) 196-203
6. Linger, R. M. A.; Keating, A. K.; Earp, H. S.; Graham, D. K., TAM Receptor Tyrosine Kinases: Biologic Functions, Signaling, and Potential Therapeutic Targeting in Human Cancer. In Advances in Cancer Research, Academic Press: New York, 2008; Vol. 100, pp 35-83.
7. Chen, C. L.; Li, Q.; Darrow, A. L.; Wang, Y. P.; Derian, C. K.; Yang, J.; de Garavilla, L.; Andrade-Gordon, P.; Damiano, B. P. Mer receptor tyrosine kinase signaling participates in platelet function Arterioscl.. Thromb., Vasc. Biol. 2004, 24 (6) 1118-1123
8. Chen, J.; Carey, K.; Godowski, P. J. Identification of Gas6 as a ligand for Mer, a neural cell adhesion molecule related receptor tyrosine kinase implicated in cellular transformation Oncogene 1997, 14 (17) 2033-2039
9. Sather, S.; Kenyon, K. D.; Lefkowitz, J. B.; Liang, X.; Varnum, B. C.; Henson, P. M.; Graham, D. K. A soluble form of the Mer receptor tyrosine kinase inhibits macrophage clearance of apoptotic cells and platelet aggregation Blood 2007, 109 (3) 1026-1033
10. Angelillo-Scherrer, A.; Burnier, L.; Flores, N.; Savi, P.; DeMol, M.; Schaeffer, P.; Herbert, J. M.; Lemke, G.; Goff, S. P.; Matsushima, G. K.; Earp, H. S.; Vesin, C.; Hoylaerts, M. F.; Plaisance, S.; Collen, D.; Conway, E. M.; Wehrle-Haller, B.; Carmeliet, P. Role of Gas6 receptors in platelet signaling during thrombus stabilization and implications for antithrombotic therapy J. Clin. Invest. 2005, 115 (2) 237-246
11. Liu, J.; Yang, C.; Simpson, C.; DeRyckere, D.; Van, D. A.; Miley, M. J.; Kireev, D.; Norris-Drouin, J.; Sather, S.; Hunter, D.; Korboukh, V. K.; Patel, H. S.; Janzen, W. P.; Machius, M.; Johnson, G. L.; Earp, H. S.; Graham, D. K.; Frye, S. V.; Wang, X. Discovery of Small Molecule Mer Kinase Inhibitors for the Treatment of Pediatric Acute Lymphoblastic Leukemia ACS Med. Chem. Lett. 2012, 3, 129-134
12. Liu, J.; Zhang, W.; Stashko, M. A.; DeRyckere, D.; Cummings, C. T.; Hunter, D.; Yang, C.; Jayakody, C. N.; Cheng, N.; Simpson, C.; Norris-Drouin, J.; Sather, S.; Kireev, D.; Janzen, W. P.; Earp, H. S.; Graham, D. K.; Frye, S. V.; Wang, X. UNC1062, a new and potent Mer inhibitor Eur. J. Med. Chem. 2013, 65, 83-93
13. Schlegel, J.; Sambade, M. J.; Sather, S.; Moschos, S. J.; Tan, A. C.; Winges, A.; Deryckere, D.; Carson, C. C.; Trembath, D. G.; Tentler, J. J.; Eckhardt, S. G.; Kuan, P. F.; Hamilton, R. L.; Duncan, L. M.; Miller, C. R.; Nikolaishvili-Feinberg, N.; Midkiff, B. R.; Liu, J.; Zhang, W.; Yang, C.; Wang, X.; Frye, S. V.; Earp, H. S.; Shields, J. M.; Graham, D. K. MERTK receptor tyrosine kinase is a therapeutic target in melanoma J. Clin. Invest. 2013, 123 (5) 2257-2267
14. Mathieu, S.; Gradl, S. N.; Ren, L.; Wen, Z.; Aliagas, I.; Gunzner-Toste, J.; Lee, W.; Pulk, R.; Zhao, G.; Alicke, B.; Boggs, J. W.; Buckmelter, A. J.; Choo, E. F.; Dinkel, V.; Gloor, S. L.; Gould, S. E.; Hansen, J. D.; Hastings, G.; Hatzivassiliou, G.; Laird, E. R.; Moreno, D.; Ran, Y.; Voegtli, W. C.; Wenglowsky, S.; Grina, J.; Rudolph, J. Potent and Selective Aminopyrimidine- Based B-Raf Inhibitors with Favorable Physicochemical and Pharmacokinetic Properties J. Med. Chem. 2012, 55 (6) 2869-2881
15. Zhang, G.; Ren, P.; Gray, N. S.; Sim, T.; Liu, Y.; Wang, X.; Che, J.; Tian, S.-S.; Sandberg, M. L.; Spalding, T. A.; Romeo, R.; Iskandar, M.; Chow, D.; Martin Seidel, H.; Karanewsky, D. S.; He, Y. Discovery of pyrimidine benzimidazoles as Lck inhibitors: Part I Bioorg. Med. Chem. Lett. 2008, 18 (20) 5618-5621
16. Furet, P.; Caravatti, G.; Guagnano, V.; Lang, M.; Meyer, T.; Schoepfer, J. Entry into a new class of protein kinase inhibitors by pseudo ring design Bioorg. Med. Chem. Lett. 2008, 18 (3) 897-900
17. Pommereau, A.; Pap, E.; Kannt, A. Two simple and generic antibody-independent kinase assays: comparison of a bioluminescent and a microfluidic assay format J. Biomol. Screening 2004, 9 (5) 409-416
18. Dunne, J.; Reardon, H.; Trinh, V.; Li, E.; Farinas, J. Comparison of on-chip and off-chip microfluidic kinase assay formats Assay Drug Dev. Technol. 2004, 2 (2) 121-129
19. Bernasconi, P.; Chen, M.; Galasinski, S.; Popa-Burke, I.; Bobasheva, A.; Coudurier, L.; Birkos, S.; Hallam, R.; Janzen, W. P. A chemogenomic analysis of the human proteome: application to enzyme families J. Biomol. Screening 2007, 12 (7) 972-982