-
1
-
-
84855172814
-
The pathogenesis of rheumatoid arthritis
-
McInnes IB, Schett G. The pathogenesis of rheumatoid arthritis. N Engl J Med 2011: 365: 2205-2219.
-
(2011)
N Engl J Med
, vol.365
, pp. 2205-2219
-
-
McInnes, I.B.1
Schett, G.2
-
2
-
-
0033003164
-
The genetics revolution and the assault on rheumatoid arthritis
-
Seldin MF, Amos CI, Ward R et al. The genetics revolution and the assault on rheumatoid arthritis. Arthritis Rheum 1999: 42: 1071-1079.
-
(1999)
Arthritis Rheum
, vol.42
, pp. 1071-1079
-
-
Seldin, M.F.1
Amos, C.I.2
Ward, R.3
-
3
-
-
0042667153
-
Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritis
-
Suzuki A, Yamada R, Chang X et al. Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritis. Nat Genet 2003: 34: 395-402.
-
(2003)
Nat Genet
, vol.34
, pp. 395-402
-
-
Suzuki, A.1
Yamada, R.2
Chang, X.3
-
4
-
-
3242713277
-
A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis
-
Begovich AB, Carlton VE, Honigberg LA et al. A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis. Am J Hum Genet 2004: 75: 330-337.
-
(2004)
Am J Hum Genet
, vol.75
, pp. 330-337
-
-
Begovich, A.B.1
Carlton, V.E.2
Honigberg, L.A.3
-
5
-
-
84969213492
-
The WTCCC. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
-
The WTCCC. Genome-wide association study of 14, 000 cases of seven common diseases and 3, 000 shared controls. Nature 2007: 447: 661-678.
-
(2007)
Nature
, vol.447
, pp. 661-678
-
-
-
6
-
-
36549003138
-
Two independent alleles at 6q23 associated with risk of rheumatoid arthritis
-
Plenge RM, Cotsapas C, Davies L et al. Two independent alleles at 6q23 associated with risk of rheumatoid arthritis. Nat Genet 2007: 39: 1477-1482.
-
(2007)
Nat Genet
, vol.39
, pp. 1477-1482
-
-
Plenge, R.M.1
Cotsapas, C.2
Davies, L.3
-
7
-
-
52949111858
-
Common variants at CD40 and other loci confer risk of rheumatoid arthritis
-
Raychaudhuri S, Remmers EF, Lee AT et al. Common variants at CD40 and other loci confer risk of rheumatoid arthritis. Nat Genet 2008: 40: 1216-1223.
-
(2008)
Nat Genet
, vol.40
, pp. 1216-1223
-
-
Raychaudhuri, S.1
Remmers, E.F.2
Lee, A.T.3
-
8
-
-
67649880295
-
REL, encoding a member of the NF-kappaB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis
-
Gregersen PK, Amos CI, Lee AT et al. REL, encoding a member of the NF-kappaB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis. Nat Genet 2009: 41: 820-823.
-
(2009)
Nat Genet
, vol.41
, pp. 820-823
-
-
Gregersen, P.K.1
Amos, C.I.2
Lee, A.T.3
-
9
-
-
77952888454
-
Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci
-
Stahl EA, Raychaudhuri S, Remmers EF et al. Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci. Nat Genet 2010: 42: 508-514.
-
(2010)
Nat Genet
, vol.42
, pp. 508-514
-
-
Stahl, E.A.1
Raychaudhuri, S.2
Remmers, E.F.3
-
10
-
-
77952885768
-
A regulatory variant in CCR6 is associated with rheumatoid arthritis susceptibility
-
Kochi Y, Okada Y, Suzuki A et al. A regulatory variant in CCR6 is associated with rheumatoid arthritis susceptibility. Nat Genet 2010: 42: 515-519.
-
(2010)
Nat Genet
, vol.42
, pp. 515-519
-
-
Kochi, Y.1
Okada, Y.2
Suzuki, A.3
-
11
-
-
84862809846
-
Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population
-
Okada Y, Terao C, Ikari K et al. Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population. Nat Genet 2012: 44: 511-516.
-
(2012)
Nat Genet
, vol.44
, pp. 511-516
-
-
Okada, Y.1
Terao, C.2
Ikari, K.3
-
12
-
-
84870531924
-
High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis
-
Eyre S, Bowes J, Diogo D et al. High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis. Nat Genet 2012: 44: 1336-1340.
-
(2012)
Nat Genet
, vol.44
, pp. 1336-1340
-
-
Eyre, S.1
Bowes, J.2
Diogo, D.3
-
13
-
-
84894288992
-
Genetics of rheumatoid arthritis contributes to biology and drug discovery
-
Okada Y, Wu D, Trynka G et al. Genetics of rheumatoid arthritis contributes to biology and drug discovery. Nature 2014: 506: 376-381.
-
(2014)
Nature
, vol.506
, pp. 376-381
-
-
Okada, Y.1
Wu, D.2
Trynka, G.3
-
14
-
-
84860333083
-
Bayesian inference analyses of the polygenic architecture of rheumatoid arthritis
-
Stahl EA, Wegmann D, Trynka G et al. Bayesian inference analyses of the polygenic architecture of rheumatoid arthritis. Nat Genet 2012: 44: 483-489.
-
(2012)
Nat Genet
, vol.44
, pp. 483-489
-
-
Stahl, E.A.1
Wegmann, D.2
Trynka, G.3
-
16
-
-
0023500817
-
The shared epitope hypothesis. An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis
-
Gregersen PK, Silver J, Winchester RJ. The shared epitope hypothesis. An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis. Arthritis Rheum 1987: 30: 1205-1213.
-
(1987)
Arthritis Rheum
, vol.30
, pp. 1205-1213
-
-
Gregersen, P.K.1
Silver, J.2
Winchester, R.J.3
-
17
-
-
33846884241
-
Rheumatoid arthritis and genetic markers in Syrian and French populations: different effect of the shared epitope
-
Kazkaz L, Marotte H, Hamwi M et al. Rheumatoid arthritis and genetic markers in Syrian and French populations: different effect of the shared epitope. Ann Rheum Dis 2007: 66: 195-201.
-
(2007)
Ann Rheum Dis
, vol.66
, pp. 195-201
-
-
Kazkaz, L.1
Marotte, H.2
Hamwi, M.3
-
18
-
-
73249142153
-
Contribution of a haplotype in the HLA region to anti-cyclic citrullinated peptide antibody positivity in rheumatoid arthritis, independently of HLA-DRB1
-
Okada Y, Yamada R, Suzuki A et al. Contribution of a haplotype in the HLA region to anti-cyclic citrullinated peptide antibody positivity in rheumatoid arthritis, independently of HLA-DRB1. Arthritis Rheum 2009: 60: 3582-3590.
-
(2009)
Arthritis Rheum
, vol.60
, pp. 3582-3590
-
-
Okada, Y.1
Yamada, R.2
Suzuki, A.3
-
19
-
-
77955439698
-
HLA-DRB1*0901 lowers anti-cyclic citrullinated peptide antibody levels in Japanese patients with rheumatoid arthritis
-
Okada Y, Suzuki A, Yamada R et al. HLA-DRB1*0901 lowers anti-cyclic citrullinated peptide antibody levels in Japanese patients with rheumatoid arthritis. Ann Rheum Dis 2010: 69: 1569-1570.
-
(2010)
Ann Rheum Dis
, vol.69
, pp. 1569-1570
-
-
Okada, Y.1
Suzuki, A.2
Yamada, R.3
-
20
-
-
77956042213
-
The 2010 American College of Rheumatology/European League Against Rheumatism classification criteria for rheumatoid arthritis: phase 2 methodological report
-
Neogi T, Aletaha D, Silman AJ et al. The 2010 American College of Rheumatology/European League Against Rheumatism classification criteria for rheumatoid arthritis: phase 2 methodological report. Arthritis Rheum 2010: 62: 2582-2591.
-
(2010)
Arthritis Rheum
, vol.62
, pp. 2582-2591
-
-
Neogi, T.1
Aletaha, D.2
Silman, A.J.3
-
21
-
-
84878802935
-
Imputing amino acid polymorphisms in human leukocyte antigens
-
Jia X, Han B, Onengut-Gumuscu S et al. Imputing amino acid polymorphisms in human leukocyte antigens. PLoS One 2013: 8: e64683.
-
(2013)
PLoS One
, vol.8
, pp. e64683
-
-
Jia, X.1
Han, B.2
Onengut-Gumuscu, S.3
-
22
-
-
84862776511
-
Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis
-
Raychaudhuri S, Sandor C, Stahl EA et al. Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis. Nat Genet 2012: 44: 291-296.
-
(2012)
Nat Genet
, vol.44
, pp. 291-296
-
-
Raychaudhuri, S.1
Sandor, C.2
Stahl, E.A.3
-
23
-
-
84897992288
-
Fine mapping seronegative and seropositive rheumatoid arthritis to shared and distinct HLA alleles by adjusting for the effects of heterogeneity
-
Han B, Diogo D, Eyre S et al. Fine mapping seronegative and seropositive rheumatoid arthritis to shared and distinct HLA alleles by adjusting for the effects of heterogeneity. Am J Hum Genet 2014: 94: 522-532.
-
(2014)
Am J Hum Genet
, vol.94
, pp. 522-532
-
-
Han, B.1
Diogo, D.2
Eyre, S.3
-
24
-
-
84911495256
-
Risk for ACPA-positive rheumatoid arthritis is driven by shared HLA amino acid polymorphisms in Asian and European populations
-
Okada Y, Kim K, Han B et al. Risk for ACPA-positive rheumatoid arthritis is driven by shared HLA amino acid polymorphisms in Asian and European populations. Hum Mol Genet 2014: doi: 10.1093/hmg/ddu387.
-
(2014)
Hum Mol Genet
-
-
Okada, Y.1
Kim, K.2
Han, B.3
-
25
-
-
9144273357
-
Analysis of single-nucleotide polymorphisms in Japanese rheumatoid arthritis patients shows additional susceptibility markers besides the classic shared epitope susceptibility sequences
-
Kochi Y, Yamada R, Kobayashi K et al. Analysis of single-nucleotide polymorphisms in Japanese rheumatoid arthritis patients shows additional susceptibility markers besides the classic shared epitope susceptibility sequences. Arthritis Rheum 2004: 50: 63-71.
-
(2004)
Arthritis Rheum
, vol.50
, pp. 63-71
-
-
Kochi, Y.1
Yamada, R.2
Kobayashi, K.3
-
26
-
-
84904748039
-
Predicting HLA alleles from high-resolution SNP data in three Southeast Asian populations
-
Pillai NE, Okada Y, Ong RT et al. Predicting HLA alleles from high-resolution SNP data in three Southeast Asian populations. Hum Mol Genet 2014: 23: 4443-4451.
-
(2014)
Hum Mol Genet
, vol.23
, pp. 4443-4451
-
-
Pillai, N.E.1
Okada, Y.2
Ong, R.T.3
-
27
-
-
79959503826
-
The International HapMap Project
-
The International HapMap Consortium
-
The International HapMap Consortium. The International HapMap Project. Nature 2003: 426: 789-796.
-
(2003)
Nature
, vol.426
, pp. 789-796
-
-
-
28
-
-
67249117049
-
Potential etiologic and functional implications of genome-wide association loci for human diseases and traits
-
Hindorff LA, Sethupathy P, Junkins HA et al. Potential etiologic and functional implications of genome-wide association loci for human diseases and traits. Proc Natl Acad Sci U S A 2009: 106: 9362-9367.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 9362-9367
-
-
Hindorff, L.A.1
Sethupathy, P.2
Junkins, H.A.3
-
29
-
-
18744407845
-
Functional SNPs in the lymphotoxin-alpha gene that are associated with susceptibility to myocardial infarction
-
Ozaki K, Ohnishi Y, Iida A et al. Functional SNPs in the lymphotoxin-alpha gene that are associated with susceptibility to myocardial infarction. Nat Genet 2002: 32: 650-654.
-
(2002)
Nat Genet
, vol.32
, pp. 650-654
-
-
Ozaki, K.1
Ohnishi, Y.2
Iida, A.3
-
30
-
-
23944469845
-
Recent developments in genomewide association scans: a workshop summary and review
-
Thomas DC, Haile RW, Duggan D. Recent developments in genomewide association scans: a workshop summary and review. Am J Hum Genet 2005: 77: 337-345.
-
(2005)
Am J Hum Genet
, vol.77
, pp. 337-345
-
-
Thomas, D.C.1
Haile, R.W.2
Duggan, D.3
-
31
-
-
84889395646
-
-
Handbook of statistical genetics, 3rd edn. Wiley, NJ, USA
-
Balding DJ, Bishop M, Cannings C. Handbook of statistical genetics, 3rd edn. Wiley, NJ, USA, 2007.
-
(2007)
-
-
Balding, D.J.1
Bishop, M.2
Cannings, C.3
-
32
-
-
84890162458
-
Genome-wide association studies to advance our understanding of critical cell types and pathways in rheumatoid arthritis: recent findings and challenges
-
Diogo D, Okada Y, Plenge RM. Genome-wide association studies to advance our understanding of critical cell types and pathways in rheumatoid arthritis: recent findings and challenges. Curr Opin Rheumatol 2014: 26: 85-92.
-
(2014)
Curr Opin Rheumatol
, vol.26
, pp. 85-92
-
-
Diogo, D.1
Okada, Y.2
Plenge, R.M.3
-
33
-
-
84856405512
-
The mystery of missing heritability: genetic interactions create phantom heritability
-
Zuk O, Hechter E, Sunyaev SR et al. The mystery of missing heritability: genetic interactions create phantom heritability. Proc Natl Acad Sci U S A 2012: 109: 1193-1198.
-
(2012)
Proc Natl Acad Sci U S A
, vol.109
, pp. 1193-1198
-
-
Zuk, O.1
Hechter, E.2
Sunyaev, S.R.3
-
34
-
-
84872323563
-
Rare, low-frequency, and common variants in the protein-coding sequence of biological candidate genes from GWASs contribute to risk of rheumatoid arthritis
-
Diogo D, Kurreeman F, Stahl EA et al. Rare, low-frequency, and common variants in the protein-coding sequence of biological candidate genes from GWASs contribute to risk of rheumatoid arthritis. Am J Hum Genet 2013: 92: 15-27.
-
(2013)
Am J Hum Genet
, vol.92
, pp. 15-27
-
-
Diogo, D.1
Kurreeman, F.2
Stahl, E.A.3
-
35
-
-
84881336633
-
Entering the age of whole-exome sequencing in rheumatic diseases: novel insights into disease pathogenicity
-
Okada Y, Plenge RM. Entering the age of whole-exome sequencing in rheumatic diseases: novel insights into disease pathogenicity. Arthritis Rheum 2013: 65: 1975-1979.
-
(2013)
Arthritis Rheum
, vol.65
, pp. 1975-1979
-
-
Okada, Y.1
Plenge, R.M.2
-
36
-
-
84895770158
-
Integration of sequence data from a consanguineous family with genetic data from an outbred population identifies PLB1 as a candidate rheumatoid arthritis risk gene
-
Okada Y, Diogo D, Greenberg JD et al. Integration of sequence data from a consanguineous family with genetic data from an outbred population identifies PLB1 as a candidate rheumatoid arthritis risk gene. PLoS One 2014: 9: e87645.
-
(2014)
PLoS One
, vol.9
, pp. e87645
-
-
Okada, Y.1
Diogo, D.2
Greenberg, J.D.3
-
37
-
-
84893378179
-
Searching for missing heritability: designing rare variant association studies
-
Zuk O, Schaffner SF, Samocha K et al. Searching for missing heritability: designing rare variant association studies. Proc Natl Acad Sci U S A 2014: 111: E455-E464.
-
(2014)
Proc Natl Acad Sci U S A
, vol.111
, pp. E455-E464
-
-
Zuk, O.1
Schaffner, S.F.2
Samocha, K.3
-
38
-
-
77956534324
-
ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data
-
Wang K, Li M, Hakonarson H. ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data. Nucleic Acids Res 2010: 38: e164.
-
(2010)
Nucleic Acids Res
, vol.38
, pp. e164
-
-
Wang, K.1
Li, M.2
Hakonarson, H.3
-
39
-
-
84885018609
-
Systematic identification of trans eQTLs as putative drivers of known disease associations
-
Westra HJ, Peters MJ, Esko T et al. Systematic identification of trans eQTLs as putative drivers of known disease associations. Nat Genet 2013: 45: 1238-1243.
-
(2013)
Nat Genet
, vol.45
, pp. 1238-1243
-
-
Westra, H.J.1
Peters, M.J.2
Esko, T.3
-
40
-
-
84900338300
-
Polarization of the effects of autoimmune and neurodegenerative risk alleles in leukocytes
-
Raj T, Rothamel K, Mostafavi S et al. Polarization of the effects of autoimmune and neurodegenerative risk alleles in leukocytes. Science 2014: 344: 519-523.
-
(2014)
Science
, vol.344
, pp. 519-523
-
-
Raj, T.1
Rothamel, K.2
Mostafavi, S.3
-
41
-
-
84858980097
-
Common genetic factors for hematological traits in humans
-
Okada Y, Kamatani Y. Common genetic factors for hematological traits in humans. J Hum Genet 2012: 57: 161-169.
-
(2012)
J Hum Genet
, vol.57
, pp. 161-169
-
-
Okada, Y.1
Kamatani, Y.2
-
42
-
-
67651205715
-
Identifying relationships among genomic disease regions: predicting genes at pathogenic SNP associations and rare deletions
-
Raychaudhuri S, Plenge RM, Rossin EJ et al. Identifying relationships among genomic disease regions: predicting genes at pathogenic SNP associations and rare deletions. PLoS Genet 2009: 5: e1000534.
-
(2009)
PLoS Genet
, vol.5
, pp. e1000534
-
-
Raychaudhuri, S.1
Plenge, R.M.2
Rossin, E.J.3
-
43
-
-
79851502150
-
Proteins encoded in genomic regions associated with immune-mediated disease physically interact and suggest underlying biology
-
Rossin EJ, Lage K, Raychaudhuri S et al. Proteins encoded in genomic regions associated with immune-mediated disease physically interact and suggest underlying biology. PLoS Genet 2011: 7: e1001273.
-
(2011)
PLoS Genet
, vol.7
, pp. e1001273
-
-
Rossin, E.J.1
Lage, K.2
Raychaudhuri, S.3
-
44
-
-
84873086126
-
Chromatin marks identify critical cell types for fine mapping complex trait variants
-
Trynka G, Sandor C, Han B et al. Chromatin marks identify critical cell types for fine mapping complex trait variants. Nat Genet 2013: 45: 124-130.
-
(2013)
Nat Genet
, vol.45
, pp. 124-130
-
-
Trynka, G.1
Sandor, C.2
Han, B.3
-
45
-
-
78651330430
-
COSMIC: mining complete cancer genomes in the catalogue of somatic mutations in cancer
-
Forbes SA, Bindal N, Bamford S et al. COSMIC: mining complete cancer genomes in the catalogue of somatic mutations in cancer. Nucleic Acids Res 2011: 39: D945-D950.
-
(2011)
Nucleic Acids Res
, vol.39
, pp. D945-D950
-
-
Forbes, S.A.1
Bindal, N.2
Bamford, S.3
-
46
-
-
84859727275
-
The Mouse Genome Database (MGD): comprehensive resource for genetics and genomics of the laboratory mouse
-
Eppig JT, Blake JA, Bult CJ et al. The Mouse Genome Database (MGD): comprehensive resource for genetics and genomics of the laboratory mouse. Nucleic Acids Res 2012: 40: D881-D886.
-
(2012)
Nucleic Acids Res
, vol.40
, pp. D881-D886
-
-
Eppig, J.T.1
Blake, J.A.2
Bult, C.J.3
-
47
-
-
77957342306
-
Common inherited variation in mitochondrial genes is not enriched for associations with type 2 diabetes or related glycemic traits
-
Segre AV, Groop L, Mootha VK et al. Common inherited variation in mitochondrial genes is not enriched for associations with type 2 diabetes or related glycemic traits. PLoS Genet 2010: 6: e1001058.
-
(2010)
PLoS Genet
, vol.6
, pp. e1001058
-
-
Segre, A.V.1
Groop, L.2
Mootha, V.K.3
-
49
-
-
84859638338
-
Use of genome-wide association studies for drug repositioning
-
Sanseau P, Agarwal P, Barnes MR et al. Use of genome-wide association studies for drug repositioning. Nat Biotechnol 2012: 30: 317-320.
-
(2012)
Nat Biotechnol
, vol.30
, pp. 317-320
-
-
Sanseau, P.1
Agarwal, P.2
Barnes, M.R.3
-
50
-
-
77649234756
-
How to improve R&D productivity: the pharmaceutical industry's grand challenge
-
Paul SM, Mytelka DS, Dunwiddie CT et al. How to improve R&D productivity: the pharmaceutical industry's grand challenge. Nat Rev Drug Discov 2010: 9: 203-214.
-
(2010)
Nat Rev Drug Discov
, vol.9
, pp. 203-214
-
-
Paul, S.M.1
Mytelka, D.S.2
Dunwiddie, C.T.3
-
53
-
-
40749124955
-
Successful treatment of animal models of rheumatoid arthritis with small-molecule cyclin-dependent kinase inhibitors
-
Sekine C, Sugihara T, Miyake S et al. Successful treatment of animal models of rheumatoid arthritis with small-molecule cyclin-dependent kinase inhibitors. J Immunol 2008: 180: 1954-1961.
-
(2008)
J Immunol
, vol.180
, pp. 1954-1961
-
-
Sekine, C.1
Sugihara, T.2
Miyake, S.3
-
54
-
-
77951115122
-
International network of cancer genome projects
-
Hudson TJ, Anderson W, Artez A et al. International network of cancer genome projects. Nature 2010: 464: 993-998.
-
(2010)
Nature
, vol.464
, pp. 993-998
-
-
Hudson, T.J.1
Anderson, W.2
Artez, A.3
-
55
-
-
54549108740
-
Comprehensive genomic characterization defines human glioblastoma genes and core pathways
-
Cancer Genome Atlas Research Network
-
Cancer Genome Atlas Research Network. Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature 2008: 455: 1061-1068.
-
(2008)
Nature
, vol.455
, pp. 1061-1068
-
-
-
56
-
-
84892833777
-
Discovery and saturation analysis of cancer genes across 21 tumour types
-
Lawrence MS, Stojanov P, Mermel CH et al. Discovery and saturation analysis of cancer genes across 21 tumour types. Nature 2014: 505: 495-501.
-
(2014)
Nature
, vol.505
, pp. 495-501
-
-
Lawrence, M.S.1
Stojanov, P.2
Mermel, C.H.3
-
58
-
-
77951640946
-
A method and server for predicting damaging missense mutations
-
Adzhubei IA, Schmidt S, Peshkin L et al. A method and server for predicting damaging missense mutations. Nat Methods 2010: 7: 248-249.
-
(2010)
Nat Methods
, vol.7
, pp. 248-249
-
-
Adzhubei, I.A.1
Schmidt, S.2
Peshkin, L.3
-
59
-
-
68149165614
-
Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm
-
Kumar P, Henikoff S, Ng PC. Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm. Nat Protoc 2009: 4: 1073-1081.
-
(2009)
Nat Protoc
, vol.4
, pp. 1073-1081
-
-
Kumar, P.1
Henikoff, S.2
Ng, P.C.3
-
60
-
-
78651237647
-
Identifying a high fraction of the human genome to be under selective constraint using GERP++
-
Davydov EV, Goode DL, Sirota M et al. Identifying a high fraction of the human genome to be under selective constraint using GERP++. PLoS Comput Biol 2010: 6: e1001025.
-
(2010)
PLoS Comput Biol
, vol.6
, pp. e1001025
-
-
Davydov, E.V.1
Goode, D.L.2
Sirota, M.3
-
61
-
-
84878682420
-
The genotype-tissue expression (GTEx) project
-
GTEx Consortium
-
GTEx Consortium. The genotype-tissue expression (GTEx) project. Nat Genet 2013: 45: 580-585.
-
(2013)
Nat Genet
, vol.45
, pp. 580-585
-
-
-
62
-
-
84865790047
-
An integrated encyclopedia of DNA elements in the human genome
-
Bernstein BE, Birney E, Dunham I et al. An integrated encyclopedia of DNA elements in the human genome. Nature 2012: 489: 57-74.
-
(2012)
Nature
, vol.489
, pp. 57-74
-
-
Bernstein, B.E.1
Birney, E.2
Dunham, I.3
-
64
-
-
84858779229
-
HaploReg: a resource for exploring chromatin states, conservation, and regulatory motif alterations within sets of genetically linked variants
-
Ward LD, Kellis M. HaploReg: a resource for exploring chromatin states, conservation, and regulatory motif alterations within sets of genetically linked variants. Nucleic Acids Res 2012: 40: D930-D934.
-
(2012)
Nucleic Acids Res
, vol.40
, pp. D930-D934
-
-
Ward, L.D.1
Kellis, M.2
-
66
-
-
84891760956
-
Data, information, knowledge and principle: back to metabolism in KEGG
-
Kanehisa M, Goto S, Sato Y et al. Data, information, knowledge and principle: back to metabolism in KEGG. Nucleic Acids Res 2014: 42: D199-D205.
-
(2014)
Nucleic Acids Res
, vol.42
, pp. D199-D205
-
-
Kanehisa, M.1
Goto, S.2
Sato, Y.3
-
67
-
-
84891753483
-
The Reactome pathway knowledgebase
-
Croft D, Mundo AF, Haw R et al. The Reactome pathway knowledgebase. Nucleic Acids Res 2014: 42: D472-D477.
-
(2014)
Nucleic Acids Res
, vol.42
, pp. D472-D477
-
-
Croft, D.1
Mundo, A.F.2
Haw, R.3
-
68
-
-
0034069495
-
Gene ontology: tool for the unification of biology. The Gene Ontology Consortium
-
Ashburner M, Ball CA, Blake JA et al. Gene ontology: tool for the unification of biology. The Gene Ontology Consortium. Nat Genet 2000: 25: 25-29.
-
(2000)
Nat Genet
, vol.25
, pp. 25-29
-
-
Ashburner, M.1
Ball, C.A.2
Blake, J.A.3
-
69
-
-
84875216538
-
PrePPI: a structure-informed database of protein-protein interactions
-
Zhang QC, Petrey D, Garzon JI et al. PrePPI: a structure-informed database of protein-protein interactions. Nucleic Acids Res 2013: 41: D828-D833.
-
(2013)
Nucleic Acids Res
, vol.41
, pp. D828-D833
-
-
Zhang, Q.C.1
Petrey, D.2
Garzon, J.I.3
-
70
-
-
33947095027
-
A human phenome-interactome network of protein complexes implicated in genetic disorders
-
Lage K, Karlberg EO, Storling ZM et al. A human phenome-interactome network of protein complexes implicated in genetic disorders. Nat Biotechnol 2007: 25: 309-316.
-
(2007)
Nat Biotechnol
, vol.25
, pp. 309-316
-
-
Lage, K.1
Karlberg, E.O.2
Storling, Z.M.3
-
71
-
-
84876515907
-
STRING v9.1: protein-protein interaction networks, with increased coverage and integration
-
Franceschini A, Szklarczyk D, Frankild S et al. STRING v9.1: protein-protein interaction networks, with increased coverage and integration. Nucleic Acids Res 2013: 41: D808-D815.
-
(2013)
Nucleic Acids Res
, vol.41
, pp. D808-D815
-
-
Franceschini, A.1
Szklarczyk, D.2
Frankild, S.3
-
72
-
-
38049148026
-
DAVID knowledgebase: a gene-centered database integrating heterogeneous gene annotation resources to facilitate high-throughput gene functional analysis
-
Sherman BT, Huang W da, Tan Q et al. DAVID knowledgebase: a gene-centered database integrating heterogeneous gene annotation resources to facilitate high-throughput gene functional analysis. BMC Bioinformatics 2007: 8: 426.
-
(2007)
BMC Bioinformatics
, vol.8
, pp. 426
-
-
Sherman, B.T.1
Huang da, W.2
Tan, Q.3
-
73
-
-
84863987483
-
INRICH: interval-based enrichment analysis for genome-wide association studies
-
Lee PH, O'Dushlaine C, Thomas B et al. INRICH: interval-based enrichment analysis for genome-wide association studies. Bioinformatics 2012: 28: 1797-1799.
-
(2012)
Bioinformatics
, vol.28
, pp. 1797-1799
-
-
Lee, P.H.1
O'Dushlaine, C.2
Thomas, B.3
-
74
-
-
78651287426
-
DrugBank 3.0: a comprehensive resource for 'omics' research on drugs
-
Knox C, Law V, Jewison T et al. DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res 2011: 39: D1035-D1041.
-
(2011)
Nucleic Acids Res
, vol.39
, pp. D1035-D1041
-
-
Knox, C.1
Law, V.2
Jewison, T.3
-
75
-
-
84859267371
-
Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery
-
Zhu F, Shi Z, Qin C et al. Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery. Nucleic Acids Res 2012: 40: D1128-D1136.
-
(2012)
Nucleic Acids Res
, vol.40
, pp. D1128-D1136
-
-
Zhu, F.1
Shi, Z.2
Qin, C.3
-
76
-
-
84861508376
-
STITCH 3: zooming in on protein-chemical interactions
-
Kuhn M, Szklarczyk D, Franceschini A et al. STITCH 3: zooming in on protein-chemical interactions. Nucleic Acids Res 2012: 40: D876-D880.
-
(2012)
Nucleic Acids Res
, vol.40
, pp. D876-D880
-
-
Kuhn, M.1
Szklarczyk, D.2
Franceschini, A.3
|