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Volumn 86, Issue 5, 2014, Pages 432-440

From the era of genome analysis to the era of genomic drug discovery: A pioneering example of rheumatoid arthritis

Author keywords

Genetics driven drug repositioning; Genetics driven genomic drug discovery; Genome wide association study; Pharmacogenomics; Rheumatoid arthritis

Indexed keywords

DRUG DEVELOPMENT; GENETIC ASSOCIATION; GENETIC PREDISPOSITION; GENETICS; GENOMICS; HUMAN; MAJOR HISTOCOMPATIBILITY COMPLEX; RHEUMATOID ARTHRITIS;

EID: 84911498917     PISSN: 00099163     EISSN: 13990004     Source Type: Journal    
DOI: 10.1111/cge.12465     Document Type: Review
Times cited : (16)

References (77)
  • 1
    • 84855172814 scopus 로고    scopus 로고
    • The pathogenesis of rheumatoid arthritis
    • McInnes IB, Schett G. The pathogenesis of rheumatoid arthritis. N Engl J Med 2011: 365: 2205-2219.
    • (2011) N Engl J Med , vol.365 , pp. 2205-2219
    • McInnes, I.B.1    Schett, G.2
  • 2
    • 0033003164 scopus 로고    scopus 로고
    • The genetics revolution and the assault on rheumatoid arthritis
    • Seldin MF, Amos CI, Ward R et al. The genetics revolution and the assault on rheumatoid arthritis. Arthritis Rheum 1999: 42: 1071-1079.
    • (1999) Arthritis Rheum , vol.42 , pp. 1071-1079
    • Seldin, M.F.1    Amos, C.I.2    Ward, R.3
  • 3
    • 0042667153 scopus 로고    scopus 로고
    • Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritis
    • Suzuki A, Yamada R, Chang X et al. Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritis. Nat Genet 2003: 34: 395-402.
    • (2003) Nat Genet , vol.34 , pp. 395-402
    • Suzuki, A.1    Yamada, R.2    Chang, X.3
  • 4
    • 3242713277 scopus 로고    scopus 로고
    • A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis
    • Begovich AB, Carlton VE, Honigberg LA et al. A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis. Am J Hum Genet 2004: 75: 330-337.
    • (2004) Am J Hum Genet , vol.75 , pp. 330-337
    • Begovich, A.B.1    Carlton, V.E.2    Honigberg, L.A.3
  • 5
    • 84969213492 scopus 로고    scopus 로고
    • The WTCCC. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
    • The WTCCC. Genome-wide association study of 14, 000 cases of seven common diseases and 3, 000 shared controls. Nature 2007: 447: 661-678.
    • (2007) Nature , vol.447 , pp. 661-678
  • 6
    • 36549003138 scopus 로고    scopus 로고
    • Two independent alleles at 6q23 associated with risk of rheumatoid arthritis
    • Plenge RM, Cotsapas C, Davies L et al. Two independent alleles at 6q23 associated with risk of rheumatoid arthritis. Nat Genet 2007: 39: 1477-1482.
    • (2007) Nat Genet , vol.39 , pp. 1477-1482
    • Plenge, R.M.1    Cotsapas, C.2    Davies, L.3
  • 7
    • 52949111858 scopus 로고    scopus 로고
    • Common variants at CD40 and other loci confer risk of rheumatoid arthritis
    • Raychaudhuri S, Remmers EF, Lee AT et al. Common variants at CD40 and other loci confer risk of rheumatoid arthritis. Nat Genet 2008: 40: 1216-1223.
    • (2008) Nat Genet , vol.40 , pp. 1216-1223
    • Raychaudhuri, S.1    Remmers, E.F.2    Lee, A.T.3
  • 8
    • 67649880295 scopus 로고    scopus 로고
    • REL, encoding a member of the NF-kappaB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis
    • Gregersen PK, Amos CI, Lee AT et al. REL, encoding a member of the NF-kappaB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis. Nat Genet 2009: 41: 820-823.
    • (2009) Nat Genet , vol.41 , pp. 820-823
    • Gregersen, P.K.1    Amos, C.I.2    Lee, A.T.3
  • 9
    • 77952888454 scopus 로고    scopus 로고
    • Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci
    • Stahl EA, Raychaudhuri S, Remmers EF et al. Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci. Nat Genet 2010: 42: 508-514.
    • (2010) Nat Genet , vol.42 , pp. 508-514
    • Stahl, E.A.1    Raychaudhuri, S.2    Remmers, E.F.3
  • 10
    • 77952885768 scopus 로고    scopus 로고
    • A regulatory variant in CCR6 is associated with rheumatoid arthritis susceptibility
    • Kochi Y, Okada Y, Suzuki A et al. A regulatory variant in CCR6 is associated with rheumatoid arthritis susceptibility. Nat Genet 2010: 42: 515-519.
    • (2010) Nat Genet , vol.42 , pp. 515-519
    • Kochi, Y.1    Okada, Y.2    Suzuki, A.3
  • 11
    • 84862809846 scopus 로고    scopus 로고
    • Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population
    • Okada Y, Terao C, Ikari K et al. Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population. Nat Genet 2012: 44: 511-516.
    • (2012) Nat Genet , vol.44 , pp. 511-516
    • Okada, Y.1    Terao, C.2    Ikari, K.3
  • 12
    • 84870531924 scopus 로고    scopus 로고
    • High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis
    • Eyre S, Bowes J, Diogo D et al. High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis. Nat Genet 2012: 44: 1336-1340.
    • (2012) Nat Genet , vol.44 , pp. 1336-1340
    • Eyre, S.1    Bowes, J.2    Diogo, D.3
  • 13
    • 84894288992 scopus 로고    scopus 로고
    • Genetics of rheumatoid arthritis contributes to biology and drug discovery
    • Okada Y, Wu D, Trynka G et al. Genetics of rheumatoid arthritis contributes to biology and drug discovery. Nature 2014: 506: 376-381.
    • (2014) Nature , vol.506 , pp. 376-381
    • Okada, Y.1    Wu, D.2    Trynka, G.3
  • 14
    • 84860333083 scopus 로고    scopus 로고
    • Bayesian inference analyses of the polygenic architecture of rheumatoid arthritis
    • Stahl EA, Wegmann D, Trynka G et al. Bayesian inference analyses of the polygenic architecture of rheumatoid arthritis. Nat Genet 2012: 44: 483-489.
    • (2012) Nat Genet , vol.44 , pp. 483-489
    • Stahl, E.A.1    Wegmann, D.2    Trynka, G.3
  • 15
    • 0024431655 scopus 로고
    • The contribution of HLA to rheumatoid arthritis
    • Deighton CM, Walker DJ, Griffiths ID et al. The contribution of HLA to rheumatoid arthritis. Clin Genet 1989: 36: 178-182.
    • (1989) Clin Genet , vol.36 , pp. 178-182
    • Deighton, C.M.1    Walker, D.J.2    Griffiths, I.D.3
  • 16
    • 0023500817 scopus 로고
    • The shared epitope hypothesis. An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis
    • Gregersen PK, Silver J, Winchester RJ. The shared epitope hypothesis. An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis. Arthritis Rheum 1987: 30: 1205-1213.
    • (1987) Arthritis Rheum , vol.30 , pp. 1205-1213
    • Gregersen, P.K.1    Silver, J.2    Winchester, R.J.3
  • 17
    • 33846884241 scopus 로고    scopus 로고
    • Rheumatoid arthritis and genetic markers in Syrian and French populations: different effect of the shared epitope
    • Kazkaz L, Marotte H, Hamwi M et al. Rheumatoid arthritis and genetic markers in Syrian and French populations: different effect of the shared epitope. Ann Rheum Dis 2007: 66: 195-201.
    • (2007) Ann Rheum Dis , vol.66 , pp. 195-201
    • Kazkaz, L.1    Marotte, H.2    Hamwi, M.3
  • 18
    • 73249142153 scopus 로고    scopus 로고
    • Contribution of a haplotype in the HLA region to anti-cyclic citrullinated peptide antibody positivity in rheumatoid arthritis, independently of HLA-DRB1
    • Okada Y, Yamada R, Suzuki A et al. Contribution of a haplotype in the HLA region to anti-cyclic citrullinated peptide antibody positivity in rheumatoid arthritis, independently of HLA-DRB1. Arthritis Rheum 2009: 60: 3582-3590.
    • (2009) Arthritis Rheum , vol.60 , pp. 3582-3590
    • Okada, Y.1    Yamada, R.2    Suzuki, A.3
  • 19
    • 77955439698 scopus 로고    scopus 로고
    • HLA-DRB1*0901 lowers anti-cyclic citrullinated peptide antibody levels in Japanese patients with rheumatoid arthritis
    • Okada Y, Suzuki A, Yamada R et al. HLA-DRB1*0901 lowers anti-cyclic citrullinated peptide antibody levels in Japanese patients with rheumatoid arthritis. Ann Rheum Dis 2010: 69: 1569-1570.
    • (2010) Ann Rheum Dis , vol.69 , pp. 1569-1570
    • Okada, Y.1    Suzuki, A.2    Yamada, R.3
  • 20
    • 77956042213 scopus 로고    scopus 로고
    • The 2010 American College of Rheumatology/European League Against Rheumatism classification criteria for rheumatoid arthritis: phase 2 methodological report
    • Neogi T, Aletaha D, Silman AJ et al. The 2010 American College of Rheumatology/European League Against Rheumatism classification criteria for rheumatoid arthritis: phase 2 methodological report. Arthritis Rheum 2010: 62: 2582-2591.
    • (2010) Arthritis Rheum , vol.62 , pp. 2582-2591
    • Neogi, T.1    Aletaha, D.2    Silman, A.J.3
  • 21
    • 84878802935 scopus 로고    scopus 로고
    • Imputing amino acid polymorphisms in human leukocyte antigens
    • Jia X, Han B, Onengut-Gumuscu S et al. Imputing amino acid polymorphisms in human leukocyte antigens. PLoS One 2013: 8: e64683.
    • (2013) PLoS One , vol.8 , pp. e64683
    • Jia, X.1    Han, B.2    Onengut-Gumuscu, S.3
  • 22
    • 84862776511 scopus 로고    scopus 로고
    • Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis
    • Raychaudhuri S, Sandor C, Stahl EA et al. Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis. Nat Genet 2012: 44: 291-296.
    • (2012) Nat Genet , vol.44 , pp. 291-296
    • Raychaudhuri, S.1    Sandor, C.2    Stahl, E.A.3
  • 23
    • 84897992288 scopus 로고    scopus 로고
    • Fine mapping seronegative and seropositive rheumatoid arthritis to shared and distinct HLA alleles by adjusting for the effects of heterogeneity
    • Han B, Diogo D, Eyre S et al. Fine mapping seronegative and seropositive rheumatoid arthritis to shared and distinct HLA alleles by adjusting for the effects of heterogeneity. Am J Hum Genet 2014: 94: 522-532.
    • (2014) Am J Hum Genet , vol.94 , pp. 522-532
    • Han, B.1    Diogo, D.2    Eyre, S.3
  • 24
    • 84911495256 scopus 로고    scopus 로고
    • Risk for ACPA-positive rheumatoid arthritis is driven by shared HLA amino acid polymorphisms in Asian and European populations
    • Okada Y, Kim K, Han B et al. Risk for ACPA-positive rheumatoid arthritis is driven by shared HLA amino acid polymorphisms in Asian and European populations. Hum Mol Genet 2014: doi: 10.1093/hmg/ddu387.
    • (2014) Hum Mol Genet
    • Okada, Y.1    Kim, K.2    Han, B.3
  • 25
    • 9144273357 scopus 로고    scopus 로고
    • Analysis of single-nucleotide polymorphisms in Japanese rheumatoid arthritis patients shows additional susceptibility markers besides the classic shared epitope susceptibility sequences
    • Kochi Y, Yamada R, Kobayashi K et al. Analysis of single-nucleotide polymorphisms in Japanese rheumatoid arthritis patients shows additional susceptibility markers besides the classic shared epitope susceptibility sequences. Arthritis Rheum 2004: 50: 63-71.
    • (2004) Arthritis Rheum , vol.50 , pp. 63-71
    • Kochi, Y.1    Yamada, R.2    Kobayashi, K.3
  • 26
    • 84904748039 scopus 로고    scopus 로고
    • Predicting HLA alleles from high-resolution SNP data in three Southeast Asian populations
    • Pillai NE, Okada Y, Ong RT et al. Predicting HLA alleles from high-resolution SNP data in three Southeast Asian populations. Hum Mol Genet 2014: 23: 4443-4451.
    • (2014) Hum Mol Genet , vol.23 , pp. 4443-4451
    • Pillai, N.E.1    Okada, Y.2    Ong, R.T.3
  • 27
    • 79959503826 scopus 로고    scopus 로고
    • The International HapMap Project
    • The International HapMap Consortium
    • The International HapMap Consortium. The International HapMap Project. Nature 2003: 426: 789-796.
    • (2003) Nature , vol.426 , pp. 789-796
  • 28
    • 67249117049 scopus 로고    scopus 로고
    • Potential etiologic and functional implications of genome-wide association loci for human diseases and traits
    • Hindorff LA, Sethupathy P, Junkins HA et al. Potential etiologic and functional implications of genome-wide association loci for human diseases and traits. Proc Natl Acad Sci U S A 2009: 106: 9362-9367.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 9362-9367
    • Hindorff, L.A.1    Sethupathy, P.2    Junkins, H.A.3
  • 29
    • 18744407845 scopus 로고    scopus 로고
    • Functional SNPs in the lymphotoxin-alpha gene that are associated with susceptibility to myocardial infarction
    • Ozaki K, Ohnishi Y, Iida A et al. Functional SNPs in the lymphotoxin-alpha gene that are associated with susceptibility to myocardial infarction. Nat Genet 2002: 32: 650-654.
    • (2002) Nat Genet , vol.32 , pp. 650-654
    • Ozaki, K.1    Ohnishi, Y.2    Iida, A.3
  • 30
    • 23944469845 scopus 로고    scopus 로고
    • Recent developments in genomewide association scans: a workshop summary and review
    • Thomas DC, Haile RW, Duggan D. Recent developments in genomewide association scans: a workshop summary and review. Am J Hum Genet 2005: 77: 337-345.
    • (2005) Am J Hum Genet , vol.77 , pp. 337-345
    • Thomas, D.C.1    Haile, R.W.2    Duggan, D.3
  • 31
    • 84889395646 scopus 로고    scopus 로고
    • Handbook of statistical genetics, 3rd edn. Wiley, NJ, USA
    • Balding DJ, Bishop M, Cannings C. Handbook of statistical genetics, 3rd edn. Wiley, NJ, USA, 2007.
    • (2007)
    • Balding, D.J.1    Bishop, M.2    Cannings, C.3
  • 32
    • 84890162458 scopus 로고    scopus 로고
    • Genome-wide association studies to advance our understanding of critical cell types and pathways in rheumatoid arthritis: recent findings and challenges
    • Diogo D, Okada Y, Plenge RM. Genome-wide association studies to advance our understanding of critical cell types and pathways in rheumatoid arthritis: recent findings and challenges. Curr Opin Rheumatol 2014: 26: 85-92.
    • (2014) Curr Opin Rheumatol , vol.26 , pp. 85-92
    • Diogo, D.1    Okada, Y.2    Plenge, R.M.3
  • 33
    • 84856405512 scopus 로고    scopus 로고
    • The mystery of missing heritability: genetic interactions create phantom heritability
    • Zuk O, Hechter E, Sunyaev SR et al. The mystery of missing heritability: genetic interactions create phantom heritability. Proc Natl Acad Sci U S A 2012: 109: 1193-1198.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 1193-1198
    • Zuk, O.1    Hechter, E.2    Sunyaev, S.R.3
  • 34
    • 84872323563 scopus 로고    scopus 로고
    • Rare, low-frequency, and common variants in the protein-coding sequence of biological candidate genes from GWASs contribute to risk of rheumatoid arthritis
    • Diogo D, Kurreeman F, Stahl EA et al. Rare, low-frequency, and common variants in the protein-coding sequence of biological candidate genes from GWASs contribute to risk of rheumatoid arthritis. Am J Hum Genet 2013: 92: 15-27.
    • (2013) Am J Hum Genet , vol.92 , pp. 15-27
    • Diogo, D.1    Kurreeman, F.2    Stahl, E.A.3
  • 35
    • 84881336633 scopus 로고    scopus 로고
    • Entering the age of whole-exome sequencing in rheumatic diseases: novel insights into disease pathogenicity
    • Okada Y, Plenge RM. Entering the age of whole-exome sequencing in rheumatic diseases: novel insights into disease pathogenicity. Arthritis Rheum 2013: 65: 1975-1979.
    • (2013) Arthritis Rheum , vol.65 , pp. 1975-1979
    • Okada, Y.1    Plenge, R.M.2
  • 36
    • 84895770158 scopus 로고    scopus 로고
    • Integration of sequence data from a consanguineous family with genetic data from an outbred population identifies PLB1 as a candidate rheumatoid arthritis risk gene
    • Okada Y, Diogo D, Greenberg JD et al. Integration of sequence data from a consanguineous family with genetic data from an outbred population identifies PLB1 as a candidate rheumatoid arthritis risk gene. PLoS One 2014: 9: e87645.
    • (2014) PLoS One , vol.9 , pp. e87645
    • Okada, Y.1    Diogo, D.2    Greenberg, J.D.3
  • 37
    • 84893378179 scopus 로고    scopus 로고
    • Searching for missing heritability: designing rare variant association studies
    • Zuk O, Schaffner SF, Samocha K et al. Searching for missing heritability: designing rare variant association studies. Proc Natl Acad Sci U S A 2014: 111: E455-E464.
    • (2014) Proc Natl Acad Sci U S A , vol.111 , pp. E455-E464
    • Zuk, O.1    Schaffner, S.F.2    Samocha, K.3
  • 38
    • 77956534324 scopus 로고    scopus 로고
    • ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data
    • Wang K, Li M, Hakonarson H. ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data. Nucleic Acids Res 2010: 38: e164.
    • (2010) Nucleic Acids Res , vol.38 , pp. e164
    • Wang, K.1    Li, M.2    Hakonarson, H.3
  • 39
    • 84885018609 scopus 로고    scopus 로고
    • Systematic identification of trans eQTLs as putative drivers of known disease associations
    • Westra HJ, Peters MJ, Esko T et al. Systematic identification of trans eQTLs as putative drivers of known disease associations. Nat Genet 2013: 45: 1238-1243.
    • (2013) Nat Genet , vol.45 , pp. 1238-1243
    • Westra, H.J.1    Peters, M.J.2    Esko, T.3
  • 40
    • 84900338300 scopus 로고    scopus 로고
    • Polarization of the effects of autoimmune and neurodegenerative risk alleles in leukocytes
    • Raj T, Rothamel K, Mostafavi S et al. Polarization of the effects of autoimmune and neurodegenerative risk alleles in leukocytes. Science 2014: 344: 519-523.
    • (2014) Science , vol.344 , pp. 519-523
    • Raj, T.1    Rothamel, K.2    Mostafavi, S.3
  • 41
    • 84858980097 scopus 로고    scopus 로고
    • Common genetic factors for hematological traits in humans
    • Okada Y, Kamatani Y. Common genetic factors for hematological traits in humans. J Hum Genet 2012: 57: 161-169.
    • (2012) J Hum Genet , vol.57 , pp. 161-169
    • Okada, Y.1    Kamatani, Y.2
  • 42
    • 67651205715 scopus 로고    scopus 로고
    • Identifying relationships among genomic disease regions: predicting genes at pathogenic SNP associations and rare deletions
    • Raychaudhuri S, Plenge RM, Rossin EJ et al. Identifying relationships among genomic disease regions: predicting genes at pathogenic SNP associations and rare deletions. PLoS Genet 2009: 5: e1000534.
    • (2009) PLoS Genet , vol.5 , pp. e1000534
    • Raychaudhuri, S.1    Plenge, R.M.2    Rossin, E.J.3
  • 43
    • 79851502150 scopus 로고    scopus 로고
    • Proteins encoded in genomic regions associated with immune-mediated disease physically interact and suggest underlying biology
    • Rossin EJ, Lage K, Raychaudhuri S et al. Proteins encoded in genomic regions associated with immune-mediated disease physically interact and suggest underlying biology. PLoS Genet 2011: 7: e1001273.
    • (2011) PLoS Genet , vol.7 , pp. e1001273
    • Rossin, E.J.1    Lage, K.2    Raychaudhuri, S.3
  • 44
    • 84873086126 scopus 로고    scopus 로고
    • Chromatin marks identify critical cell types for fine mapping complex trait variants
    • Trynka G, Sandor C, Han B et al. Chromatin marks identify critical cell types for fine mapping complex trait variants. Nat Genet 2013: 45: 124-130.
    • (2013) Nat Genet , vol.45 , pp. 124-130
    • Trynka, G.1    Sandor, C.2    Han, B.3
  • 45
    • 78651330430 scopus 로고    scopus 로고
    • COSMIC: mining complete cancer genomes in the catalogue of somatic mutations in cancer
    • Forbes SA, Bindal N, Bamford S et al. COSMIC: mining complete cancer genomes in the catalogue of somatic mutations in cancer. Nucleic Acids Res 2011: 39: D945-D950.
    • (2011) Nucleic Acids Res , vol.39 , pp. D945-D950
    • Forbes, S.A.1    Bindal, N.2    Bamford, S.3
  • 46
    • 84859727275 scopus 로고    scopus 로고
    • The Mouse Genome Database (MGD): comprehensive resource for genetics and genomics of the laboratory mouse
    • Eppig JT, Blake JA, Bult CJ et al. The Mouse Genome Database (MGD): comprehensive resource for genetics and genomics of the laboratory mouse. Nucleic Acids Res 2012: 40: D881-D886.
    • (2012) Nucleic Acids Res , vol.40 , pp. D881-D886
    • Eppig, J.T.1    Blake, J.A.2    Bult, C.J.3
  • 47
    • 77957342306 scopus 로고    scopus 로고
    • Common inherited variation in mitochondrial genes is not enriched for associations with type 2 diabetes or related glycemic traits
    • Segre AV, Groop L, Mootha VK et al. Common inherited variation in mitochondrial genes is not enriched for associations with type 2 diabetes or related glycemic traits. PLoS Genet 2010: 6: e1001058.
    • (2010) PLoS Genet , vol.6 , pp. e1001058
    • Segre, A.V.1    Groop, L.2    Mootha, V.K.3
  • 49
    • 84859638338 scopus 로고    scopus 로고
    • Use of genome-wide association studies for drug repositioning
    • Sanseau P, Agarwal P, Barnes MR et al. Use of genome-wide association studies for drug repositioning. Nat Biotechnol 2012: 30: 317-320.
    • (2012) Nat Biotechnol , vol.30 , pp. 317-320
    • Sanseau, P.1    Agarwal, P.2    Barnes, M.R.3
  • 50
    • 77649234756 scopus 로고    scopus 로고
    • How to improve R&D productivity: the pharmaceutical industry's grand challenge
    • Paul SM, Mytelka DS, Dunwiddie CT et al. How to improve R&D productivity: the pharmaceutical industry's grand challenge. Nat Rev Drug Discov 2010: 9: 203-214.
    • (2010) Nat Rev Drug Discov , vol.9 , pp. 203-214
    • Paul, S.M.1    Mytelka, D.S.2    Dunwiddie, C.T.3
  • 53
    • 40749124955 scopus 로고    scopus 로고
    • Successful treatment of animal models of rheumatoid arthritis with small-molecule cyclin-dependent kinase inhibitors
    • Sekine C, Sugihara T, Miyake S et al. Successful treatment of animal models of rheumatoid arthritis with small-molecule cyclin-dependent kinase inhibitors. J Immunol 2008: 180: 1954-1961.
    • (2008) J Immunol , vol.180 , pp. 1954-1961
    • Sekine, C.1    Sugihara, T.2    Miyake, S.3
  • 54
    • 77951115122 scopus 로고    scopus 로고
    • International network of cancer genome projects
    • Hudson TJ, Anderson W, Artez A et al. International network of cancer genome projects. Nature 2010: 464: 993-998.
    • (2010) Nature , vol.464 , pp. 993-998
    • Hudson, T.J.1    Anderson, W.2    Artez, A.3
  • 55
    • 54549108740 scopus 로고    scopus 로고
    • Comprehensive genomic characterization defines human glioblastoma genes and core pathways
    • Cancer Genome Atlas Research Network
    • Cancer Genome Atlas Research Network. Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature 2008: 455: 1061-1068.
    • (2008) Nature , vol.455 , pp. 1061-1068
  • 56
    • 84892833777 scopus 로고    scopus 로고
    • Discovery and saturation analysis of cancer genes across 21 tumour types
    • Lawrence MS, Stojanov P, Mermel CH et al. Discovery and saturation analysis of cancer genes across 21 tumour types. Nature 2014: 505: 495-501.
    • (2014) Nature , vol.505 , pp. 495-501
    • Lawrence, M.S.1    Stojanov, P.2    Mermel, C.H.3
  • 58
    • 77951640946 scopus 로고    scopus 로고
    • A method and server for predicting damaging missense mutations
    • Adzhubei IA, Schmidt S, Peshkin L et al. A method and server for predicting damaging missense mutations. Nat Methods 2010: 7: 248-249.
    • (2010) Nat Methods , vol.7 , pp. 248-249
    • Adzhubei, I.A.1    Schmidt, S.2    Peshkin, L.3
  • 59
    • 68149165614 scopus 로고    scopus 로고
    • Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm
    • Kumar P, Henikoff S, Ng PC. Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm. Nat Protoc 2009: 4: 1073-1081.
    • (2009) Nat Protoc , vol.4 , pp. 1073-1081
    • Kumar, P.1    Henikoff, S.2    Ng, P.C.3
  • 60
    • 78651237647 scopus 로고    scopus 로고
    • Identifying a high fraction of the human genome to be under selective constraint using GERP++
    • Davydov EV, Goode DL, Sirota M et al. Identifying a high fraction of the human genome to be under selective constraint using GERP++. PLoS Comput Biol 2010: 6: e1001025.
    • (2010) PLoS Comput Biol , vol.6 , pp. e1001025
    • Davydov, E.V.1    Goode, D.L.2    Sirota, M.3
  • 61
    • 84878682420 scopus 로고    scopus 로고
    • The genotype-tissue expression (GTEx) project
    • GTEx Consortium
    • GTEx Consortium. The genotype-tissue expression (GTEx) project. Nat Genet 2013: 45: 580-585.
    • (2013) Nat Genet , vol.45 , pp. 580-585
  • 62
    • 84865790047 scopus 로고    scopus 로고
    • An integrated encyclopedia of DNA elements in the human genome
    • Bernstein BE, Birney E, Dunham I et al. An integrated encyclopedia of DNA elements in the human genome. Nature 2012: 489: 57-74.
    • (2012) Nature , vol.489 , pp. 57-74
    • Bernstein, B.E.1    Birney, E.2    Dunham, I.3
  • 64
    • 84858779229 scopus 로고    scopus 로고
    • HaploReg: a resource for exploring chromatin states, conservation, and regulatory motif alterations within sets of genetically linked variants
    • Ward LD, Kellis M. HaploReg: a resource for exploring chromatin states, conservation, and regulatory motif alterations within sets of genetically linked variants. Nucleic Acids Res 2012: 40: D930-D934.
    • (2012) Nucleic Acids Res , vol.40 , pp. D930-D934
    • Ward, L.D.1    Kellis, M.2
  • 66
    • 84891760956 scopus 로고    scopus 로고
    • Data, information, knowledge and principle: back to metabolism in KEGG
    • Kanehisa M, Goto S, Sato Y et al. Data, information, knowledge and principle: back to metabolism in KEGG. Nucleic Acids Res 2014: 42: D199-D205.
    • (2014) Nucleic Acids Res , vol.42 , pp. D199-D205
    • Kanehisa, M.1    Goto, S.2    Sato, Y.3
  • 67
    • 84891753483 scopus 로고    scopus 로고
    • The Reactome pathway knowledgebase
    • Croft D, Mundo AF, Haw R et al. The Reactome pathway knowledgebase. Nucleic Acids Res 2014: 42: D472-D477.
    • (2014) Nucleic Acids Res , vol.42 , pp. D472-D477
    • Croft, D.1    Mundo, A.F.2    Haw, R.3
  • 68
    • 0034069495 scopus 로고    scopus 로고
    • Gene ontology: tool for the unification of biology. The Gene Ontology Consortium
    • Ashburner M, Ball CA, Blake JA et al. Gene ontology: tool for the unification of biology. The Gene Ontology Consortium. Nat Genet 2000: 25: 25-29.
    • (2000) Nat Genet , vol.25 , pp. 25-29
    • Ashburner, M.1    Ball, C.A.2    Blake, J.A.3
  • 69
    • 84875216538 scopus 로고    scopus 로고
    • PrePPI: a structure-informed database of protein-protein interactions
    • Zhang QC, Petrey D, Garzon JI et al. PrePPI: a structure-informed database of protein-protein interactions. Nucleic Acids Res 2013: 41: D828-D833.
    • (2013) Nucleic Acids Res , vol.41 , pp. D828-D833
    • Zhang, Q.C.1    Petrey, D.2    Garzon, J.I.3
  • 70
    • 33947095027 scopus 로고    scopus 로고
    • A human phenome-interactome network of protein complexes implicated in genetic disorders
    • Lage K, Karlberg EO, Storling ZM et al. A human phenome-interactome network of protein complexes implicated in genetic disorders. Nat Biotechnol 2007: 25: 309-316.
    • (2007) Nat Biotechnol , vol.25 , pp. 309-316
    • Lage, K.1    Karlberg, E.O.2    Storling, Z.M.3
  • 71
    • 84876515907 scopus 로고    scopus 로고
    • STRING v9.1: protein-protein interaction networks, with increased coverage and integration
    • Franceschini A, Szklarczyk D, Frankild S et al. STRING v9.1: protein-protein interaction networks, with increased coverage and integration. Nucleic Acids Res 2013: 41: D808-D815.
    • (2013) Nucleic Acids Res , vol.41 , pp. D808-D815
    • Franceschini, A.1    Szklarczyk, D.2    Frankild, S.3
  • 72
    • 38049148026 scopus 로고    scopus 로고
    • DAVID knowledgebase: a gene-centered database integrating heterogeneous gene annotation resources to facilitate high-throughput gene functional analysis
    • Sherman BT, Huang W da, Tan Q et al. DAVID knowledgebase: a gene-centered database integrating heterogeneous gene annotation resources to facilitate high-throughput gene functional analysis. BMC Bioinformatics 2007: 8: 426.
    • (2007) BMC Bioinformatics , vol.8 , pp. 426
    • Sherman, B.T.1    Huang da, W.2    Tan, Q.3
  • 73
    • 84863987483 scopus 로고    scopus 로고
    • INRICH: interval-based enrichment analysis for genome-wide association studies
    • Lee PH, O'Dushlaine C, Thomas B et al. INRICH: interval-based enrichment analysis for genome-wide association studies. Bioinformatics 2012: 28: 1797-1799.
    • (2012) Bioinformatics , vol.28 , pp. 1797-1799
    • Lee, P.H.1    O'Dushlaine, C.2    Thomas, B.3
  • 74
    • 78651287426 scopus 로고    scopus 로고
    • DrugBank 3.0: a comprehensive resource for 'omics' research on drugs
    • Knox C, Law V, Jewison T et al. DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res 2011: 39: D1035-D1041.
    • (2011) Nucleic Acids Res , vol.39 , pp. D1035-D1041
    • Knox, C.1    Law, V.2    Jewison, T.3
  • 75
    • 84859267371 scopus 로고    scopus 로고
    • Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery
    • Zhu F, Shi Z, Qin C et al. Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery. Nucleic Acids Res 2012: 40: D1128-D1136.
    • (2012) Nucleic Acids Res , vol.40 , pp. D1128-D1136
    • Zhu, F.1    Shi, Z.2    Qin, C.3
  • 76
    • 84861508376 scopus 로고    scopus 로고
    • STITCH 3: zooming in on protein-chemical interactions
    • Kuhn M, Szklarczyk D, Franceschini A et al. STITCH 3: zooming in on protein-chemical interactions. Nucleic Acids Res 2012: 40: D876-D880.
    • (2012) Nucleic Acids Res , vol.40 , pp. D876-D880
    • Kuhn, M.1    Szklarczyk, D.2    Franceschini, A.3
  • 77
    • 84880383420 scopus 로고    scopus 로고
    • PharmGKB: the pharmacogenomics knowledge base
    • Thorn CF, Klein TE, Altman RB. PharmGKB: the pharmacogenomics knowledge base. Methods Mol Biol 2013: 1015: 311-320.
    • (2013) Methods Mol Biol , vol.1015 , pp. 311-320
    • Thorn, C.F.1    Klein, T.E.2    Altman, R.B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.