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Volumn 57, Issue 3, 2012, Pages 161-169

Common genetic factors for hematological traits in humans

Author keywords

GWAS; hematological trait; quantitative trait

Indexed keywords

C REACTIVE PROTEIN; CXCL2 CHEMOKINE; LYMPHOCYTE ANTIGEN RECEPTOR; PLATELET DERIVED GROWTH FACTOR; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR; TRANSCRIPTION FACTOR ERG; TRANSFORMING GROWTH FACTOR BETA; VASCULOTROPIN;

EID: 84858980097     PISSN: 14345161     EISSN: 1435232X     Source Type: Journal    
DOI: 10.1038/jhg.2012.2     Document Type: Review
Times cited : (31)

References (109)
  • 2
    • 70350657093 scopus 로고    scopus 로고
    • Genes determining blood cell traits
    • Andrews, N. C. Genes determining blood cell traits. Nat. Genet. 41, 1161-1162 (2009).
    • (2009) Nat. Genet. , vol.41 , pp. 1161-1162
    • Andrews, N.C.1
  • 3
    • 0025720068 scopus 로고
    • Influence of platelet size on outcome after myocardial infarction
    • Martin, J. F., Bath, P. M. & Burr, M. L. Influence of platelet size on outcome after myocardial infarction. Lancet. 338, 1409-1411 (1991).
    • (1991) Lancet , vol.338 , pp. 1409-1411
    • Martin, J.F.1    Bath, P.M.2    Burr, M.L.3
  • 4
    • 0021821260 scopus 로고
    • Genetic and environmental influences on the size and number of cells in the blood
    • Whitfield, J. B. & Martin, N. G. Genetic and environmental influences on the size and number of cells in the blood. Genet. Epidemiol. 2, 133-144 (1985).
    • (1985) Genet. Epidemiol. , vol.2 , pp. 133-144
    • Whitfield, J.B.1    Martin, N.G.2
  • 5
    • 0033374163 scopus 로고    scopus 로고
    • Genetic and environmental causes of variation in basal levels of blood cells
    • Evans, D. M., Frazer, I. H. & Martin, N. G. Genetic and environmental causes of variation in basal levels of blood cells. Twin. Res. 2, 250-257 (1999).
    • (1999) Twin. Res. , vol.2 , pp. 250-257
    • Evans, D.M.1    Frazer, I.H.2    Martin, N.G.3
  • 7
    • 0016842252 scopus 로고
    • Smoking, oral contraceptives, and obesity. Effects on white blood cell count
    • Fisch, I. R. & Freedman, S. H. Smoking, oral contraceptives, and obesity. Effects on white blood cell count. JAMA. 234, 500-506 (1975).
    • (1975) JAMA , vol.234 , pp. 500-506
    • Fisch, I.R.1    Freedman, S.H.2
  • 8
    • 0027524618 scopus 로고
    • Apparent polycythaemia: Diagnosis, pathogenesis and management
    • Messinezy, M. & Pearson, T. C. Apparent polycythaemia: diagnosis, pathogenesis and management. Eur. J. Haematol. 51, 125-131 (1993).
    • (1993) Eur. J. Haematol. , vol.51 , pp. 125-131
    • Messinezy, M.1    Pearson, T.C.2
  • 9
    • 77949908008 scopus 로고    scopus 로고
    • A revised scheme for developmental pathways of hematopoietic cells: The myeloid-based model
    • Kawamoto, H., Wada, H. & Katsura, Y. A revised scheme for developmental pathways of hematopoietic cells: the myeloid-based model. Int. Immunol. 22, 65-70 (2010).
    • (2010) Int. Immunol. , vol.22 , pp. 65-70
    • Kawamoto, H.1    Wada, H.2    Katsura, Y.3
  • 10
    • 77049273556 scopus 로고
    • Correlation of absolute basophil and eosinophil counts in blood from institutionalized human subjects
    • Elveback, L., Gully, R. J., Halberg, F. & Hamerston, O. Correlation of absolute basophil and eosinophil counts in blood from institutionalized human subjects. J. Appl. Physiol. 9, 205-207 (1956).
    • (1956) J. Appl. Physiol. , vol.9 , pp. 205-207
    • Elveback, L.1    Gully, R.J.2    Halberg, F.3    Hamerston, O.4
  • 11
    • 0021330196 scopus 로고
    • Normal values for peripheral blood white cell counts in women of four different ethnic origins
    • Bain, B., Seed, M. & Godsland, I. Normal values for peripheral blood white cell counts in women of four different ethnic origins. J. Clin. Pathol. 37, 188-193 (1984).
    • (1984) J. Clin. Pathol. , vol.37 , pp. 188-193
    • Bain, B.1    Seed, M.2    Godsland, I.3
  • 12
    • 77952915346 scopus 로고    scopus 로고
    • 2008 Japanese Society for Dialysis Therapy: Guidelines for renal anemia in chronic kidney disease
    • Tsubakihara, Y., Nishi, S., Akiba, T., Hirakata, H., Iseki, K., Kubota, M. et al. 2008 Japanese Society for Dialysis Therapy: guidelines for renal anemia in chronic kidney disease. Ther. Apher. Dial. 14, 240-275 (2010).
    • (2010) Ther. Apher. Dial. , vol.14 , pp. 240-275
    • Tsubakihara, Y.1    Nishi, S.2    Akiba, T.3    Hirakata, H.4    Iseki, K.5    Kubota, M.6
  • 13
    • 67249117049 scopus 로고    scopus 로고
    • Potential etiologic and functional implications of genome-wide association loci for human diseases and traits
    • Hindorff, L. A., Sethupathy, P., Junkins, H. A., Ramos, E. M., Mehta, J. P., Collins, F. S. et al. Potential etiologic and functional implications of genome-wide association loci for human diseases and traits. Proc. Natl. Acad. Sci. U.S.A. 106, 9362-9367 (2009).
    • (2009) Proc. Natl. Acad. Sci. U.S.A. , vol.106 , pp. 9362-9367
    • Hindorff, L.A.1    Sethupathy, P.2    Junkins, H.A.3    Ramos, E.M.4    Mehta, J.P.5    Collins, F.S.6
  • 14
    • 18744407845 scopus 로고    scopus 로고
    • Functional SNPs in the lymphotoxin-alpha gene that are associated with susceptibility to myocardial infarction
    • Ozaki, K., Ohnishi, Y., Iida, A., Sekine, A., Yamada, R., Tsunoda, T. et al. Functional SNPs in the lymphotoxin-alpha gene that are associated with susceptibility to myocardial infarction. Nat. Genet. 32, 650-654 (2002).
    • (2002) Nat. Genet. , vol.32 , pp. 650-654
    • Ozaki, K.1    Ohnishi, Y.2    Iida, A.3    Sekine, A.4    Yamada, R.5    Tsunoda, T.6
  • 15
    • 23944469845 scopus 로고    scopus 로고
    • Recent developments in genomewide association scans: A workshop summary and review
    • Thomas, D. C., Haile, R. W. & Duggan, D. Recent developments in genomewide association scans: a workshop summary and review. Am. J. Hum. Genet. 77, 337-345 (2005).
    • (2005) Am. J. Hum. Genet. , vol.77 , pp. 337-345
    • Thomas, D.C.1    Haile, R.W.2    Duggan, D.3
  • 17
    • 84969213492 scopus 로고    scopus 로고
    • Genome-wide association study of 14000 cases of seven common diseases and 3000 shared controls
    • The WTCCC. Genome-wide association study of 14000 cases of seven common diseases and 3000 shared controls. Nature 447, 661-678 (2007).
    • (2007) Nature , vol.447 , pp. 661-678
    • The, W.1
  • 18
    • 77957947562 scopus 로고    scopus 로고
    • Hundreds of variants clustered in genomic loci and biological pathways affect human height
    • Lango Allen, H., Estrada, K., Lettre, G., Berndt, S. I., Weedon, M. N., Rivadeneira, F. et al. Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature. 467, 832-838 (2010).
    • (2010) Nature , vol.467 , pp. 832-838
    • Lango Allen, H.1    Estrada, K.2    Lettre, G.3    Berndt, S.I.4    Weedon, M.N.5    Rivadeneira, F.6
  • 19
    • 77953507639 scopus 로고    scopus 로고
    • A genome-wide association study in 19633 Japanese subjects identified LHX3-QSOX2 and IGF1 as adult height loci
    • Okada, Y., Kamatani, Y., Takahashi, A., Matsuda, K., Hosono, N., Ohmiya, H. et al. A genome-wide association study in 19633 Japanese subjects identified LHX3-QSOX2 and IGF1 as adult height loci. Hum. Mol. Genet. 19, 2303-2312 (2010).
    • (2010) Hum. Mol. Genet. , vol.19 , pp. 2303-2312
    • Okada, Y.1    Kamatani, Y.2    Takahashi, A.3    Matsuda, K.4    Hosono, N.5    Ohmiya, H.6
  • 20
    • 34547450531 scopus 로고    scopus 로고
    • Intergenic variants of HBS1L-MYB are responsible for a major quantitative trait locus on chromosome 6q23 influencing fetal hemoglobin levels in adults
    • Thein, S. L., Menzel, S., Peng, X., Best, S., Jiang, J., Close, J. et al. Intergenic variants of HBS1L-MYB are responsible for a major quantitative trait locus on chromosome 6q23 influencing fetal hemoglobin levels in adults. Proc. Natl. Acad. Sci. U. S. A. 104, 11346-11351 (2007).
    • (2007) Proc. Natl. Acad. Sci. U. S. A. , vol.104 , pp. 11346-11351
    • Thein, S.L.1    Menzel, S.2    Peng, X.3    Best, S.4    Jiang, J.5    Close, J.6
  • 21
    • 38749132020 scopus 로고    scopus 로고
    • Admixture mapping of white cell count: Genetic locus responsible for lower white blood cell count in the Health ABC and Jackson Heart studies
    • Nalls, M. A., Wilson, J. G., Patterson, N. J., Tandon, A., Zmuda, J. M., Huntsman, S. et al. Admixture mapping of white cell count: genetic locus responsible for lower white blood cell count in the Health ABC and Jackson Heart studies. Am. J. Hum. Genet. 82, 81-87 (2008).
    • (2008) Am. J. Hum. Genet. , vol.82 , pp. 81-87
    • Nalls, M.A.1    Wilson, J.G.2    Patterson, N.J.3    Tandon, A.4    Zmuda, J.M.5    Huntsman, S.6
  • 22
    • 40349092939 scopus 로고    scopus 로고
    • Genomewide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia
    • Uda, M., Galanello, R., Sanna, S., Lettre, G., Sankaran, V. G., Chen, W. et al. Genomewide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia. Proc. Natl. Acad. Sci. U. S. A. 105, 1620-1625 (2008).
    • (2008) Proc. Natl. Acad. Sci. U. S. A. , vol.105 , pp. 1620-1625
    • Uda, M.1    Galanello, R.2    Sanna, S.3    Lettre, G.4    Sankaran, V.G.5    Chen, W.6
  • 23
    • 50149117726 scopus 로고    scopus 로고
    • DNA polymorphisms at the BCL11A, HBS1L-MYB, and beta-globin loci associate with fetal hemoglobin levels and pain crises in sickle cell disease
    • Lettre, G., Sankaran, V. G., Bezerra, M. A., Araujo, A. S., Uda,M., Sanna, S. et al. DNA polymorphisms at the BCL11A, HBS1L-MYB, and beta-globin loci associate with fetal hemoglobin levels and pain crises in sickle cell disease. Proc. Natl. Acad. Sci. U. S. A. 105, 11869-11874 (2008).
    • (2008) Proc. Natl. Acad. Sci. U. S. A. , vol.105 , pp. 11869-11874
    • Lettre, G.1    Sankaran, V.G.2    Bezerra, M.A.3    Araujo, A.S.4    Uda, M.5    Sanna, S.6
  • 24
    • 58049220179 scopus 로고    scopus 로고
    • A genome-wide association study identifies three loci associated with mean platelet volume
    • Meisinger, C., Prokisch, H., Gieger, C., Soranzo, N., Mehta, D., Rosskopf, D. et al. A genome-wide association study identifies three loci associated with mean platelet volume. Am. J. Hum. Genet. 84, 66-71 (2009).
    • (2009) Am. J. Hum. Genet. , vol.84 , pp. 66-71
    • Meisinger, C.1    Prokisch, H.2    Gieger, C.3    Soranzo, N.4    Mehta, D.5    Rosskopf, D.6
  • 25
    • 59249102648 scopus 로고    scopus 로고
    • Reduced neutrophil count in people of African descent is due to a regulatory variant in the Duffy antigen receptor for chemokines gene
    • Reich, D., Nalls, M. A., Kao, W. H., Akylbekova, E. L., Tandon, A., Patterson, N. et al. Reduced neutrophil count in people of African descent is due to a regulatory variant in the Duffy antigen receptor for chemokines gene. PLoS. Genet. 5, e1000360 (2009).
    • (2009) PLoS. Genet. , vol.5
    • Reich, D.1    Nalls, M.A.2    Kao, W.H.3    Akylbekova, E.L.4    Tandon, A.5    Patterson, N.6
  • 27
    • 65549162781 scopus 로고    scopus 로고
    • A novel variant on chromosome 7q22.3 associated with mean platelet volume, counts, and function
    • Soranzo, N., Rendon, A., Gieger, C., Jones, C. I., Watkins, N. A., Menzel, S. et al. A novel variant on chromosome 7q22.3 associated with mean platelet volume, counts, and function. Blood. 113, 3831-3837 (2009).
    • (2009) Blood , vol.113 , pp. 3831-3837
    • Soranzo, N.1    Rendon, A.2    Gieger, C.3    Jones, C.I.4    Watkins, N.A.5    Menzel, S.6
  • 28
    • 70350644759 scopus 로고    scopus 로고
    • A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium
    • Soranzo, N., Spector, T. D., Mangino, M., Kuhnel, B., Rendon, A., Teumer, A. et al. A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium. Nat. Genet. 41, 1182-1190 (2009).
    • (2009) Nat. Genet. , vol.41 , pp. 1182-1190
    • Soranzo, N.1    Spector, T.D.2    Mangino, M.3    Kuhnel, B.4    Rendon, A.5    Teumer, A.6
  • 30
    • 70350638919 scopus 로고    scopus 로고
    • Genomewide association study identifies variants in TMPRSS6 associated with hemoglobin levels
    • Chambers, J. C., Zhang, W., Li, Y., Sehmi, J., Wass, M. N., Zabaneh, D. et al. Genomewide association study identifies variants in TMPRSS6 associated with hemoglobin levels. Nat. Genet. 41, 1170-1172 (2009).
    • (2009) Nat. Genet. , vol.41 , pp. 1170-1172
    • Chambers, J.C.1    Zhang, W.2    Li, Y.3    Sehmi, J.4    Wass, M.N.5    Zabaneh, D.6
  • 33
    • 73149124061 scopus 로고    scopus 로고
    • Quantitative trait loci for CD4:CD8 lymphocyte ratio are associated with risk of type 1 diabetes and HIV-1 immune control
    • Ferreira, M. A., Mangino, M., Brumme, C. J., Zhao, Z. Z., Medland, S. E., Wright, M. J. et al. Quantitative trait loci for CD4:CD8 lymphocyte ratio are associated with risk of type 1 diabetes and HIV-1 immune control. Am. J. Hum. Genet. 86, 88-92 (2010).
    • (2010) Am. J. Hum. Genet. , vol.86 , pp. 88-92
    • Ferreira, M.A.1    Mangino, M.2    Brumme, C.J.3    Zhao, Z.Z.4    Medland, S.E.5    Wright, M.J.6
  • 34
    • 77649184039 scopus 로고    scopus 로고
    • Genomewide association study of hematological and biochemical traits in a Japanese population
    • Kamatani, Y., Matsuda, K., Okada, Y., Kubo, M., Hosono, N., Daigo, Y. et al. Genomewide association study of hematological and biochemical traits in a Japanese population. Nat. Genet. 42, 210-215 (2010).
    • (2010) Nat. Genet. , vol.42 , pp. 210-215
    • Kamatani, Y.1    Matsuda, K.2    Okada, Y.3    Kubo, M.4    Hosono, N.5    Daigo, Y.6
  • 35
    • 77952473808 scopus 로고    scopus 로고
    • Common variations in PSMD3-CSF3 and PLCB4 are associated with neutrophil count
    • Okada, Y., Kamatani, Y., Takahashi, A., Matsuda, K., Hosono, N., Ohmiya, H. et al. Common variations in PSMD3-CSF3 and PLCB4 are associated with neutrophil count. Hum. Mol. Genet. 19, 2079-2085 (2010).
    • (2010) Hum. Mol. Genet. , vol.19 , pp. 2079-2085
    • Okada, Y.1    Kamatani, Y.2    Takahashi, A.3    Matsuda, K.4    Hosono, N.5    Ohmiya, H.6
  • 36
    • 77954926596 scopus 로고    scopus 로고
    • Natural selection on EPAS1 (HIF2alpha) associated with low hemoglobin concentration in Tibetan highlanders
    • Beall, C. M., Cavalleri, G. L., Deng, L., Elston, R. C., Gao, Y., Knight, J. et al. Natural selection on EPAS1 (HIF2alpha) associated with low hemoglobin concentration in Tibetan highlanders. Proc. Natl. Acad. Sci. U. S. A. 107, 11459-11464 (2010).
    • (2010) Proc. Natl. Acad. Sci. U. S. A. , vol.107 , pp. 11459-11464
    • Beall, C.M.1    Cavalleri, G.L.2    Deng, L.3    Elston, R.C.4    Gao, Y.5    Knight, J.6
  • 37
    • 77958522275 scopus 로고    scopus 로고
    • A genome-wide association study of red blood cell traits using the electronic medical record
    • Kullo, I. J., Ding, K., Jouni, H., Smith, C. Y. & Chute, C. G. A genome-wide association study of red blood cell traits using the electronic medical record. PLoS. One. 5, e13011 (2010).
    • (2010) PLoS. One , vol.5
    • Kullo, I.J.1    Ding, K.2    Jouni, H.3    Smith, C.Y.4    Chute, C.G.5
  • 38
    • 79953756857 scopus 로고    scopus 로고
    • Genetic association analysis highlights new loci that modulate hematological trait variation in Caucasians and African Americans
    • Lo, K. S., Wilson, J. G., Lange, L. A., Folsom, A. R., Galarneau, G., Ganesh, S. K. et al. Genetic association analysis highlights new loci that modulate hematological trait variation in Caucasians and African Americans. Hum. Genet. 129, 307-317 (2011).
    • (2011) Hum. Genet. , vol.129 , pp. 307-317
    • Lo, K.S.1    Wilson, J.G.2    Lange, L.A.3    Folsom, A.R.4    Galarneau, G.5    Ganesh, S.K.6
  • 40
    • 79959812503 scopus 로고    scopus 로고
    • Genome-Wide Association Study of White Blood Cell Count in 16388 African Americans: The Continental Origins and Genetic Epidemiology Network (COGENT)
    • Reiner, A. P., Lettre, G., Nalls, M. A., Ganesh, S. K., Mathias, R., Austin, M. A. et al. Genome-Wide Association Study of White Blood Cell Count in 16388 African Americans: the Continental Origins and Genetic Epidemiology Network (COGENT). PLoS. Genet. 7, e1002108 (2011).
    • (2011) PLoS. Genet. , vol.7
    • Reiner, A.P.1    Lettre, G.2    Nalls, M.A.3    Ganesh, S.K.4    Mathias, R.5    Austin, M.A.6
  • 41
    • 79959859184 scopus 로고    scopus 로고
    • Identification of nine novel loci associated with white blood cell subtypes in a Japanese population
    • Okada, Y., Hirota, T., Kamatani, Y., Takahashi, A., Ohmiya, H., Kumasaka, N. et al. Identification of nine novel loci associated with white blood cell subtypes in a Japanese population. PLoS. Genet. 7, e1002067 (2011).
    • (2011) PLoS. Genet. , vol.7
    • Okada, Y.1    Hirota, T.2    Kamatani, Y.3    Takahashi, A.4    Ohmiya, H.5    Kumasaka, N.6
  • 43
    • 83055161438 scopus 로고    scopus 로고
    • New gene functions in megakaryopoiesis and platelet formation
    • Gieger, C., Radhakrishnan, A., Cvejic, A., Tang, W., Porcu, E., Pistis, G. et al. New gene functions in megakaryopoiesis and platelet formation. Nature. 480, 201-208 (2011).
    • (2011) Nature. , vol.480 , pp. 201-208
    • Gieger, C.1    Radhakrishnan, A.2    Cvejic, A.3    Tang, W.4    Porcu, E.5    Pistis, G.6
  • 46
    • 67049144615 scopus 로고    scopus 로고
    • Eosinophilic and neutrophilic inflammation in asthma: Insights from clinical studies
    • Fahy, J. V. Eosinophilic and neutrophilic inflammation in asthma: insights from clinical studies. Proc. Am. Thorac. Soc. 6, 256-259 (2009).
    • (2009) Proc. Am. Thorac. Soc. , vol.6 , pp. 256-259
    • Fahy, J.V.1
  • 48
    • 58149218230 scopus 로고    scopus 로고
    • Basophils: A nonredundant contributor to host immunity
    • Sullivan, B. M. & Locksley, R. M. Basophils: a nonredundant contributor to host immunity. Immunity. 30, 12-20 (2009).
    • (2009) Immunity. , vol.30 , pp. 12-20
    • Sullivan, B.M.1    Locksley, R.M.2
  • 49
    • 68349130434 scopus 로고    scopus 로고
    • Haemopoietic processes in allergic disease: Eosinophil/basophil development
    • Gauvreau, G. M., Ellis, A. K. & Denburg, J. A. Haemopoietic processes in allergic disease: eosinophil/basophil development. Clin. Exp. Allergy. 39, 1297-1306 (2009).
    • (2009) Clin. Exp. Allergy , vol.39 , pp. 1297-1306
    • Gauvreau, G.M.1    Ellis, A.K.2    Denburg, J.A.3
  • 50
    • 67649227119 scopus 로고    scopus 로고
    • Basophils contribute to T(H)2-IgE responses in vivo via IL-4 production and presentation of peptide-MHC class II complexes to CD4+ T cells
    • Yoshimoto, T., Yasuda, K., Tanaka, H., Nakahira, M., Imai, Y., Fujimori, Y. et al. Basophils contribute to T(H)2-IgE responses in vivo via IL-4 production and presentation of peptide-MHC class II complexes to CD4+ T cells. Nat. Immunol. 10, 706-712 (2009).
    • (2009) Nat. Immunol. , vol.10 , pp. 706-712
    • Yoshimoto, T.1    Yasuda, K.2    Tanaka, H.3    Nakahira, M.4    Imai, Y.5    Fujimori, Y.6
  • 51
    • 70349756907 scopus 로고    scopus 로고
    • Genetic control of resistance to human malaria
    • Allison, A. C. Genetic control of resistance to human malaria. Curr. Opin. Immunol. 21, 499-505 (2009).
    • (2009) Curr. Opin. Immunol. , vol.21 , pp. 499-505
    • Allison, A.C.1
  • 52
    • 0022621191 scopus 로고
    • Molecular cloning and expression of cDNA for human granulocyte colony-stimulating factor
    • Nagata, S., Tsuchiya, M., Asano, S., Kaziro, Y., Yamazaki, T., Yamamoto, O. et al. Molecular cloning and expression of cDNA for human granulocyte colony-stimulating factor. Nature. 319, 415-418 (1986).
    • (1986) Nature , vol.319 , pp. 415-418
    • Nagata, S.1    Tsuchiya, M.2    Asano, S.3    Kaziro, Y.4    Yamazaki, T.5    Yamamoto, O.6
  • 53
    • 33646490285 scopus 로고    scopus 로고
    • Lineage-specific hematopoietic growth factors
    • Kaushansky, K. Lineage-specific hematopoietic growth factors. N. Engl. J. Med. 354, 2034-2045 (2006).
    • (2006) N. Engl. J. Med. , vol.354 , pp. 2034-2045
    • Kaushansky, K.1
  • 54
    • 0036696904 scopus 로고    scopus 로고
    • Alpha4 integrins and the immune response
    • Rose, D. M., Han, J. & Ginsberg, M. H. Alpha4 integrins and the immune response. Immunol. Rev. 186, 118-124 (2002).
    • (2002) Immunol. Rev. , vol.186 , pp. 118-124
    • Rose, D.M.1    Han, J.2    Ginsberg, M.H.3
  • 55
    • 77956637896 scopus 로고    scopus 로고
    • Genetics and beyond-the transcriptome of human monocytes and disease susceptibility
    • Zeller, T., Wild, P., Szymczak, S., Rotival, M., Schillert, A., Castagne, R. et al. Genetics and beyond-the transcriptome of human monocytes and disease susceptibility. PLoS. One. 5, e10693 (2010).
    • (2010) PLoS. One , vol.5
    • Zeller, T.1    Wild, P.2    Szymczak, S.3    Rotival, M.4    Schillert, A.5    Castagne, R.6
  • 56
    • 0037413240 scopus 로고    scopus 로고
    • Alpha4 integrins as therapeutic targets in autoimmune disease
    • von Andrian, U. H. & Engelhardt, B. Alpha4 integrins as therapeutic targets in autoimmune disease. N. Engl. J. Med. 348, 68-72 (2003).
    • (2003) N. Engl. J. Med. , vol.348 , pp. 68-72
    • Von Andrian, U.H.1    Engelhardt, B.2
  • 57
    • 63449100039 scopus 로고    scopus 로고
    • Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium: Design of prospective meta-analyses of genome-wide association studies from 5 cohorts
    • Psaty, B. M., O'Donnell, C. J., Gudnason, V., Lunetta, K. L., Folsom, A. R., Rotter, J. I. et al. Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium: Design of prospective meta-analyses of genome-wide association studies from 5 cohorts. Circ. Cardiovasc. Genet. 2, 73-80 (2009).
    • (2009) Circ. Cardiovasc. Genet. , vol.2 , pp. 73-80
    • Psaty, B.M.1    O'Donnell, C.J.2    Gudnason, V.3    Lunetta, K.L.4    Folsom, A.R.5    Rotter, J.I.6
  • 60
    • 77952888454 scopus 로고    scopus 로고
    • Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci
    • Stahl, E. A., Raychaudhuri, S., Remmers, E. F., Xie, G., Eyre, S., Thomson, B. P. et al. Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci. Nat. Genet. 42, 508-514 (2010).
    • (2010) Nat. Genet. , vol.42 , pp. 508-514
    • Stahl, E.A.1    Raychaudhuri, S.2    Remmers, E.F.3    Xie, G.4    Eyre, S.5    Thomson, B.P.6
  • 61
    • 73249142153 scopus 로고    scopus 로고
    • Contribution of a haplotype in the HLA region to anti-cyclic citrullinated peptide antibody positivity in rheumatoid arthritis, independently of HLA-DRB1
    • Okada, Y., Yamada, R., Suzuki, A., Kochi, Y., Shimane, K., Myouzen, K. et al. Contribution of a haplotype in the HLA region to anti-cyclic citrullinated peptide antibody positivity in rheumatoid arthritis, independently of HLA-DRB1. Arthritis. Rheum. 60, 3582-3590 (2009).
    • (2009) Arthritis. Rheum. , vol.60 , pp. 3582-3590
    • Okada, Y.1    Yamada, R.2    Suzuki, A.3    Kochi, Y.4    Shimane, K.5    Myouzen, K.6
  • 62
    • 77955439698 scopus 로고    scopus 로고
    • HLADRB1*0901 lowers anti-cyclic citrullinated peptide antibody levels in Japanese patients with rheumatoid arthritis
    • Okada, Y., Suzuki, A., Yamada, R., Kochi, Y., Shimane, K., Myouzen, K. et al. HLADRB1*0901 lowers anti-cyclic citrullinated peptide antibody levels in Japanese patients with rheumatoid arthritis. Ann. Rheum. Dis. 69, 1569-1570 (2010).
    • (2010) Ann. Rheum. Dis. , vol.69 , pp. 1569-1570
    • Okada, Y.1    Suzuki, A.2    Yamada, R.3    Kochi, Y.4    Shimane, K.5    Myouzen, K.6
  • 63
    • 34547216747 scopus 로고    scopus 로고
    • Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma
    • Moffatt, M. F., Kabesch, M., Liang, L., Dixon, A. L., Strachan, D., Heath, S. et al. Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma. Nature. 448, 470-473 (2007).
    • (2007) Nature. , vol.448 , pp. 470-473
    • Moffatt, M.F.1    Kabesch, M.2    Liang, L.3    Dixon, A.L.4    Strachan, D.5    Heath, S.6
  • 64
    • 45549102935 scopus 로고    scopus 로고
    • The transcription factor Erg is essential for definitive hematopoiesis and the function of adult hematopoietic stem cells
    • Loughran, S. J., Kruse, E. A., Hacking, D. F., de Graaf, C. A., Hyland, C. D., Willson, T. A. et al. The transcription factor Erg is essential for definitive hematopoiesis and the function of adult hematopoietic stem cells. Nat. Immunol. 9, 810-819 (2008).
    • (2008) Nat. Immunol. , vol.9 , pp. 810-819
    • Loughran, S.J.1    Kruse, E.A.2    Hacking, D.F.3    De Graaf, C.A.4    Hyland, C.D.5    Willson, T.A.6
  • 65
    • 0025069873 scopus 로고
    • The prognostic value of cellular and serologic markers in infection with human immunodeficiency virus type 1
    • Fahey, J. L., Taylor, J. M., Detels, R., Hofmann, B., Melmed, R., Nishanian, P. et al. The prognostic value of cellular and serologic markers in infection with human immunodeficiency virus type 1. N. Engl. J. Med. 322, 166-172 (1990).
    • (1990) N. Engl. J. Med. , vol.322 , pp. 166-172
    • Fahey, J.L.1    Taylor, J.M.2    Detels, R.3    Hofmann, B.4    Melmed, R.5    Nishanian, P.6
  • 66
    • 27644504938 scopus 로고    scopus 로고
    • A prospective study of anemia status, hemoglobin concentration, and mortality in an elderly cohort: The Cardiovascular Health Study
    • Zakai, N. A., Katz, R., Hirsch, C., Shlipak, M. G., Chaves, P. H., Newman, A. B. et al. A prospective study of anemia status, hemoglobin concentration, and mortality in an elderly cohort: the Cardiovascular Health Study. Arch. Intern. Med. 165, 2214-2220 (2005).
    • (2005) Arch. Intern. Med. , vol.165 , pp. 2214-2220
    • Zakai, N.A.1    Katz, R.2    Hirsch, C.3    Shlipak, M.G.4    Chaves, P.H.5    Newman, A.B.6
  • 67
    • 0031712378 scopus 로고    scopus 로고
    • The therapeutic reactivation of fetal haemoglobin
    • Olivieri, N. F. & Weatherall, D. J. The therapeutic reactivation of fetal haemoglobin. Hum. Mol. Genet. 7, 1655-1658 (1998).
    • (1998) Hum. Mol. Genet. , vol.7 , pp. 1655-1658
    • Olivieri, N.F.1    Weatherall, D.J.2
  • 68
    • 44449177930 scopus 로고    scopus 로고
    • The serine protease TMPRSS6 is required to sense iron deficiency
    • Du, X., She, E., Gelbart, T., Truksa, J., Lee, P., Xia, Y. et al. The serine protease TMPRSS6 is required to sense iron deficiency. Science. 320, 1088-1092 (2008).
    • (2008) Science. , vol.320 , pp. 1088-1092
    • Du, X.1    She, E.2    Gelbart, T.3    Truksa, J.4    Lee, P.5    Xia, Y.6
  • 69
    • 58049202750 scopus 로고    scopus 로고
    • Variants in TF and HFE explain approximately 40% of genetic variation in serumtransferrin levels
    • Benyamin, B., McRae, A. F., Zhu, G., Gordon, S., Henders, A. K., Palotie, A. et al. Variants in TF and HFE explain approximately 40% of genetic variation in serumtransferrin levels. Am. J. Hum. Genet. 84, 60-65 (2009).
    • (2009) Am. J. Hum. Genet. , vol.84 , pp. 60-65
    • Benyamin, B.1    McRae, A.F.2    Zhu, G.3    Gordon, S.4    Henders, A.K.5    Palotie, A.6
  • 70
    • 74949090955 scopus 로고    scopus 로고
    • A genome-wide association analysis of serum iron concentrations
    • Tanaka, T., Roy, C. N., Yao, W., Matteini, A., Semba, R. D., Arking, D. et al. A genome-wide association analysis of serum iron concentrations. Blood. 115, 94-96 (2010).
    • (2010) Blood , vol.115 , pp. 94-96
    • Tanaka, T.1    Roy, C.N.2    Yao, W.3    Matteini, A.4    Semba, R.D.5    Arking, D.6
  • 71
    • 79551586854 scopus 로고    scopus 로고
    • Novel association to the proprotein convertase PCSK7 gene locus revealed by analysing soluble transferrin receptor (sTfR) levels
    • Oexle, K., Ried, J. S., Hicks, A. A., Tanaka, T., Hayward, C., Bruegel, M. et al. Novel association to the proprotein convertase PCSK7 gene locus revealed by analysing soluble transferrin receptor (sTfR) levels. Hum. Mol. Genet. 20, 1042-1047 (2011).
    • (2011) Hum. Mol. Genet. , vol.20 , pp. 1042-1047
    • Oexle, K.1    Ried, J.S.2    Hicks, A.A.3    Tanaka, T.4    Hayward, C.5    Bruegel, M.6
  • 72
    • 79952016793 scopus 로고    scopus 로고
    • Identification of a common variant in the TFR2 gene implicated in the physiological regulation of serum iron levels
    • Pichler, I., Minelli, C., Sanna, S., Tanaka, T., Schwienbacher, C., Naitza, S. et al. Identification of a common variant in the TFR2 gene implicated in the physiological regulation of serum iron levels. Hum. Mol. Genet. 20, 1232-1240 (2011).
    • (2011) Hum. Mol. Genet. , vol.20 , pp. 1232-1240
    • Pichler, I.1    Minelli, C.2    Sanna, S.3    Tanaka, T.4    Schwienbacher, C.5    Naitza, S.6
  • 74
    • 0036380553 scopus 로고    scopus 로고
    • Sequence variation at the human ABO locus
    • Yip, S. P. Sequence variation at the human ABO locus. Ann. Hum. Genet. 66, 1-27 (2002).
    • (2002) Ann. Hum. Genet. , vol.66 , pp. 1-27
    • Yip, S.P.1
  • 75
    • 37249068975 scopus 로고    scopus 로고
    • A new method for ABO genotyping to avoid discrepancy between genetic and serological determinations
    • Shintani-Ishida, K., Zhu, B. L., Maeda, H., Uemura, K. & Yoshida, K. A new method for ABO genotyping to avoid discrepancy between genetic and serological determinations. Int. J. Legal. Med. 122, 7-9 (2008).
    • (2008) Int. J. Legal. Med. , vol.122 , pp. 7-9
    • Shintani-Ishida, K.1    Zhu, B.L.2    Maeda, H.3    Uemura, K.4    Yoshida, K.5
  • 76
    • 44149090296 scopus 로고    scopus 로고
    • Role of platelet-derived growth factors in physiology and medicine
    • Andrae, J., Gallini, R. & Betsholtz, C. Role of platelet-derived growth factors in physiology and medicine. Genes. Dev. 22, 1276-1312 (2008).
    • (2008) Genes. Dev. , vol.22 , pp. 1276-1312
    • Andrae, J.1    Gallini, R.2    Betsholtz, C.3
  • 77
    • 61849095255 scopus 로고    scopus 로고
    • Shear activates platelet-derived latent TGF-beta
    • Miyazono, K. Shear activates platelet-derived latent TGF-beta. Blood. 112, 3533-3534 (2008).
    • (2008) Blood. , vol.112 , pp. 3533-3534
    • Miyazono, K.1
  • 78
    • 0031975482 scopus 로고    scopus 로고
    • An activating splice donor mutation in the thrombopoietin gene causes hereditary thrombocythaemia
    • Wiestner, A., Schlemper, R. J., van der Maas, A. P. & Skoda, R. C. An activating splice donor mutation in the thrombopoietin gene causes hereditary thrombocythaemia. Nat. Genet. 18, 49-52 (1998).
    • (1998) Nat. Genet. , vol.18 , pp. 49-52
    • Wiestner, A.1    Schlemper, R.J.2    Van Der Maas, A.P.3    Skoda, R.C.4
  • 79
    • 29644444727 scopus 로고    scopus 로고
    • Two candidate genes for low platelet count identified in an Asian Indian kindred by genome-wide linkage analysis: Glycoprotein IX and thrombopoietin
    • Garner, C., Best, S., Menzel, S., Rooks, H., Spector, T. D. & Thein, S. L. Two candidate genes for low platelet count identified in an Asian Indian kindred by genome-wide linkage analysis: glycoprotein IX and thrombopoietin. Eur. J. Hum. Genet. 14, 101-108 (2006).
    • (2006) Eur. J. Hum. Genet. , vol.14 , pp. 101-108
    • Garner, C.1    Best, S.2    Menzel, S.3    Rooks, H.4    Spector, T.D.5    Thein, S.L.6
  • 81
    • 77950217693 scopus 로고    scopus 로고
    • Novel associations of multiple genetic loci with plasma levels of factor VII, factor VIII, and von Willebrand factor: The CHARGE (Cohorts for Heart and Aging Research in Genome Epidemiology) Consortium
    • Smith, N. L., Chen, M. H., Dehghan, A., Strachan, D. P., Basu, S., Soranzo, N. et al. Novel associations of multiple genetic loci with plasma levels of factor VII, factor VIII, and von Willebrand factor: The CHARGE (Cohorts for Heart and Aging Research in Genome Epidemiology) Consortium. Circulation. 121, 1382-1392 (2010).
    • (2010) Circulation. , vol.121 , pp. 1382-1392
    • Smith, N.L.1    Chen, M.H.2    Dehghan, A.3    Strachan, D.P.4    Basu, S.5    Soranzo, N.6
  • 82
    • 78649735165 scopus 로고    scopus 로고
    • Genome-wide association study identifies novel loci for plasma levels of protein C: The ARIC study
    • Tang, W., Basu, S., Kong, X., Pankow, J. S., Aleksic, N., Tan, A. et al. Genome-wide association study identifies novel loci for plasma levels of protein C: the ARIC study. Blood. 116, 5032-5036 (2010).
    • (2010) Blood. , vol.116 , pp. 5032-5036
    • Tang, W.1    Basu, S.2    Kong, X.3    Pankow, J.S.4    Aleksic, N.5    Tan, A.6
  • 83
    • 77649222029 scopus 로고    scopus 로고
    • Novel loci, including those related to Crohn disease, psoriasis, and inflammation, identified in a genome-wide association study of fibrinogen in 17686 women: The Women's Genome Health Study
    • Danik, J. S., Pare, G., Chasman, D. I., Zee, R. Y., Kwiatkowski, D. J., Parker, A. et al. Novel loci, including those related to Crohn disease, psoriasis, and inflammation, identified in a genome-wide association study of fibrinogen in 17686 women: the Women's Genome Health Study. Circ. Cardiovasc. Genet. 2, 134-141 (2009).
    • (2009) Circ. Cardiovasc. Genet. , vol.2 , pp. 134-141
    • Danik, J.S.1    Pare, G.2    Chasman, D.I.3    Zee, R.Y.4    Kwiatkowski, D.J.5    Parker, A.6
  • 84
    • 67849121952 scopus 로고    scopus 로고
    • Association of novel genetic Loci with circulating fibrinogen levels: A genome-wide association study in 6 population-based cohorts
    • Dehghan, A., Yang, Q., Peters, A., Basu, S., Bis, J. C., Rudnicka, A. R. et al. Association of novel genetic Loci with circulating fibrinogen levels: a genome-wide association study in 6 population-based cohorts. Circ. Cardiovasc. Genet. 2, 125-133 (2009).
    • (2009) Circ. Cardiovasc. Genet. , vol.2 , pp. 125-133
    • Dehghan, A.1    Yang, Q.2    Peters, A.3    Basu, S.4    Bis, J.C.5    Rudnicka, A.R.6
  • 85
    • 77954145555 scopus 로고    scopus 로고
    • Genome-wide meta-analyses identifies seven loci associated with platelet aggregation in response to agonists
    • Johnson, A. D., Yanek, L. R., Chen, M. H., Faraday, N., Larson, M. G., Tofler, G. et al. Genome-wide meta-analyses identifies seven loci associated with platelet aggregation in response to agonists. Nat. Genet. 42, 608-613 (2010).
    • (2010) Nat. Genet. , vol.42 , pp. 608-613
    • Johnson, A.D.1    Yanek, L.R.2    Chen, M.H.3    Faraday, N.4    Larson, M.G.5    Tofler, G.6
  • 86
    • 61349108698 scopus 로고    scopus 로고
    • SNPs in BRAP associated with risk of myocardial infarction in Asian populations
    • Ozaki, K., Sato, H., Inoue, K., Tsunoda, T., Sakata, Y., Mizuno, H. et al. SNPs in BRAP associated with risk of myocardial infarction in Asian populations. Nat. Genet. 41, 329-333 (2009).
    • (2009) Nat. Genet. , vol.41 , pp. 329-333
    • Ozaki, K.1    Sato, H.2    Inoue, K.3    Tsunoda, T.4    Sakata, Y.5    Mizuno, H.6
  • 87
    • 79957585975 scopus 로고    scopus 로고
    • Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians
    • Kato, N., Takeuchi, F., Tabara, Y., Kelly, T. N., Go, M. J., Sim, X. et al. Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians. Nat. Genet. 43, 531-538 (2011).
    • (2011) Nat. Genet. , vol.43 , pp. 531-538
    • Kato, N.1    Takeuchi, F.2    Tabara, Y.3    Kelly, T.N.4    Go, M.J.5    Sim, X.6
  • 88
    • 79951521421 scopus 로고    scopus 로고
    • Progress and promise of genome-wide association studies for human complex trait genetics
    • Stranger, B. E., Stahl, E. A. & Raj, T. Progress and promise of genome-wide association studies for human complex trait genetics. Genetics. 187, 367-383 (2011).
    • (2011) Genetics , vol.187 , pp. 367-383
    • Stranger, B.E.1    Stahl, E.A.2    Raj, T.3
  • 89
    • 78650860672 scopus 로고    scopus 로고
    • Genetic basis of autoantibody positive and negative rheumatoid arthritis risk in a multi-ethnic cohort derived from electronic health records
    • Kurreeman, F., Liao, K., Chibnik, L., Hickey, B., Stahl, E., Gainer, V. et al. Genetic basis of autoantibody positive and negative rheumatoid arthritis risk in a multi-ethnic cohort derived from electronic health records. Am. J. Hum. Genet. 88, 57-69 (2011).
    • (2011) Am. J. Hum. Genet. , vol.88 , pp. 57-69
    • Kurreeman, F.1    Liao, K.2    Chibnik, L.3    Hickey, B.4    Stahl, E.5    Gainer, V.6
  • 90
    • 77952885768 scopus 로고    scopus 로고
    • A regulatory variant in CCR6 is associated with rheumatoid arthritis susceptibility
    • Kochi, Y., Okada, Y., Suzuki, A., Ikari, K., Terao, C., Takahashi, A. et al. A regulatory variant in CCR6 is associated with rheumatoid arthritis susceptibility. Nat. Genet. 42, 515-519 (2010).
    • (2010) Nat. Genet. , vol.42 , pp. 515-519
    • Kochi, Y.1    Okada, Y.2    Suzuki, A.3    Ikari, K.4    Terao, C.5    Takahashi, A.6
  • 91
    • 54049083105 scopus 로고    scopus 로고
    • SLC22A4 polymorphism and rheumatoid arthritis susceptibility: A replication study in a Japanese population and a metaanalysis
    • Okada, Y., Mori, M., Yamada, R., Suzuki, A., Kobayashi, K., Kubo, M. et al. SLC22A4 polymorphism and rheumatoid arthritis susceptibility: a replication study in a Japanese population and a metaanalysis. J. Rheumatol. 35, 1723-1728 (2008).
    • (2008) J. Rheumatol. , vol.35 , pp. 1723-1728
    • Okada, Y.1    Mori, M.2    Yamada, R.3    Suzuki, A.4    Kobayashi, K.5    Kubo, M.6
  • 92
    • 79955860273 scopus 로고    scopus 로고
    • Random-effects model aimed at discovering associations in metaanalysis of genome-wide association studies
    • Han, B. & Eskin, E. Random-effects model aimed at discovering associations in metaanalysis of genome-wide association studies. Am. J. Hum. Genet. 88, 586-598 (2011).
    • (2011) Am. J. Hum. Genet. , vol.88 , pp. 586-598
    • Han, B.1    Eskin, E.2
  • 93
    • 73149103718 scopus 로고    scopus 로고
    • Prioritizing GWAS results: A review of statistical methods and recommendations for their application
    • Cantor, R. M., Lange, K. & Sinsheimer, J. S. Prioritizing GWAS results: a review of statistical methods and recommendations for their application. Am. J. Hum. Genet. 86, 6-22 (2010).
    • (2010) Am. J. Hum. Genet. , vol.86 , pp. 6-22
    • Cantor, R.M.1    Lange, K.2    Sinsheimer, J.S.3
  • 94
    • 84857487791 scopus 로고    scopus 로고
    • A genomewide association study identified AFF1 as a susceptibility locus for systemic lupus eyrthematosus in Japanese
    • doi:10.1371/journal.pgen.1002455.
    • Okada, Y., Shimane, K., Kochi, Y., Tahira, T., Suzuki, A., Higasa, K. et al. A genomewide association study identified AFF1 as a susceptibility locus for systemic lupus eyrthematosus in Japanese. PLoS. Genet doi:10.1371/journal.pgen. 1002455.
    • PLoS. Genet
    • Okada, Y.1    Shimane, K.2    Kochi, Y.3    Tahira, T.4    Suzuki, A.5    Higasa, K.6
  • 95
    • 78549251736 scopus 로고    scopus 로고
    • Analysing biological pathways in genome-wide association studies
    • Wang, K., Li, M. & Hakonarson, H. Analysing biological pathways in genome-wide association studies. Nat. Rev. Genet. 11, 843-854 (2010).
    • (2010) Nat. Rev. Genet. , vol.11 , pp. 843-854
    • Wang, K.1    Li, M.2    Hakonarson, H.3
  • 96
    • 67651205715 scopus 로고    scopus 로고
    • Identifying relationships among genomic disease regions: Predicting genes at pathogenic SNP associations and rare deletions
    • Raychaudhuri, S., Plenge, R. M., Rossin, E. J., Ng, A. C., Purcell, S. M., Sklar, P. et al. Identifying relationships among genomic disease regions: predicting genes at pathogenic SNP associations and rare deletions. PLoS. Genet. 5, e1000534 (2009).
    • (2009) PLoS. Genet. , vol.5
    • Raychaudhuri, S.1    Plenge, R.M.2    Rossin, E.J.3    Ng, A.C.4    Purcell, S.M.5    Sklar, P.6
  • 97
    • 80052111188 scopus 로고    scopus 로고
    • HLA-Cw*1202-B*5201-DRB1*1502 haplotype increases risk for ulcerative colitis but reduces risk for Crohn's disease
    • Okada, Y., Yamazaki, K., Umeno, J., Takahashi, A., Kumasaka, N., Ashikawa, K. et al. HLA-Cw*1202-B*5201-DRB1*1502 haplotype increases risk for ulcerative colitis but reduces risk for Crohn's disease. Gastroenterology. 141, 864-871 (2011).
    • (2011) Gastroenterology. , vol.141 , pp. 864-871
    • Okada, Y.1    Yamazaki, K.2    Umeno, J.3    Takahashi, A.4    Kumasaka, N.5    Ashikawa, K.6
  • 98
    • 79952019307 scopus 로고    scopus 로고
    • Genome-wide association study for C-reactive protein levels identified pleiotropic associations in the IL6 locus
    • Okada, Y., Takahashi, A., Ohmiya, H., Kumasaka, N., Kamatani, Y., Hosono, N. et al. Genome-wide association study for C-reactive protein levels identified pleiotropic associations in the IL6 locus. Hum. Mol. Genet. 20, 1224-1231 (2011).
    • (2011) Hum. Mol. Genet. , vol.20 , pp. 1224-1231
    • Okada, Y.1    Takahashi, A.2    Ohmiya, H.3    Kumasaka, N.4    Kamatani, Y.5    Hosono, N.6
  • 99
    • 77950405093 scopus 로고    scopus 로고
    • Genome-wide association study of CNVs in 16000 cases of eight common diseases and 3000 shared controls
    • The WTCCC. Genome-wide association study of CNVs in 16000 cases of eight common diseases and 3000 shared controls. Nature 464, 713-720 (2010).
    • (2010) Nature , vol.464 , pp. 713-720
    • The, W.1
  • 100
    • 82455203887 scopus 로고    scopus 로고
    • PlatinumCNV: A Bayesian Gaussian mixture model for genotyping copy number polymorphisms using SNP array signal intensity data
    • Kumasaka, N., Fujisawa, H., Hosono, N., Okada, Y., Takahashi, A., Nakamura, Y. et al. PlatinumCNV: a Bayesian Gaussian mixture model for genotyping copy number polymorphisms using SNP array signal intensity data. Genet. Epidemiol. 35, 831-844 (2011).
    • (2011) Genet. Epidemiol. , vol.35 , pp. 831-844
    • Kumasaka, N.1    Fujisawa, H.2    Hosono, N.3    Okada, Y.4    Takahashi, A.5    Nakamura, Y.6
  • 101
    • 79960556965 scopus 로고    scopus 로고
    • Epigenome-wide association studies for common human diseases
    • Rakyan, V. K., Down, T. A., Balding, D. J. & Beck, S. Epigenome-wide association studies for common human diseases. Nat. Rev. Genet. 12, 529-541 (2011).
    • (2011) Nat. Rev. Genet. , vol.12 , pp. 529-541
    • Rakyan, V.K.1    Down, T.A.2    Balding, D.J.3    Beck, S.4
  • 102
    • 67349166946 scopus 로고    scopus 로고
    • Detecting gene-gene interactions that underlie human diseases
    • Cordell, H. J. Detecting gene-gene interactions that underlie human diseases. Nat. Rev. Genet. 10, 392-404 (2009).
    • (2009) Nat. Rev. Genet. , vol.10 , pp. 392-404
    • Cordell, H.J.1
  • 103
    • 78049321495 scopus 로고    scopus 로고
    • Whole-genome sequencing and comprehensive variant analysis of a Japanese individual using massively parallel sequencing
    • Fujimoto, A., Nakagawa, H., Hosono, N., Nakano, K., Abe, T., Boroevich, K. A. et al. Whole-genome sequencing and comprehensive variant analysis of a Japanese individual using massively parallel sequencing. Nat. Genet. 42, 931-936 (2010).
    • (2010) Nat. Genet. , vol.42 , pp. 931-936
    • Fujimoto, A.1    Nakagawa, H.2    Hosono, N.3    Nakano, K.4    Abe, T.5    Boroevich, K.A.6
  • 104
    • 77956838065 scopus 로고    scopus 로고
    • Advances in understanding cancer genomes through second-generation sequencing
    • Meyerson, M., Gabriel, S. & Getz, G. Advances in understanding cancer genomes through second-generation sequencing. Nat. Rev. Genet. 11, 685-696 (2010).
    • (2010) Nat. Rev. Genet. , vol.11 , pp. 685-696
    • Meyerson, M.1    Gabriel, S.2    Getz, G.3
  • 105
    • 84975742565 scopus 로고    scopus 로고
    • Consortium A map of human genome variation from population-scale sequencing
    • 1000 Genomes Project
    • 1000 Genomes Project, Consortium A map of human genome variation from population-scale sequencing. Nature 467, 1061-1073 (2010).
    • (2010) Nature , vol.467 , pp. 1061-1073
  • 107
    • 80054975975 scopus 로고    scopus 로고
    • Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease
    • Rivas, M. A., Beaudoin, M., Gardet, A., Stevens, C., Sharma, Y., Zhang, C. K. et al. Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease. Nat. Genet. 43, 1066-1073 (2011).
    • (2011) Nat. Genet. , vol.43 , pp. 1066-1073
    • Rivas, M.A.1    Beaudoin, M.2    Gardet, A.3    Stevens, C.4    Sharma, Y.5    Zhang, C.K.6
  • 108
    • 79959378465 scopus 로고    scopus 로고
    • Family-based designs for genome-wide association studies
    • Ott, J., Kamatani, Y. & Lathrop, M. Family-based designs for genome-wide association studies. Nat. Rev. Genet. 12, 465-474 (2011).
    • (2011) Nat. Rev. Genet. , vol.12 , pp. 465-474
    • Ott, J.1    Kamatani, Y.2    Lathrop, M.3
  • 109
    • 80052398214 scopus 로고    scopus 로고
    • Human metabolic individuality in biomedical and pharmaceutical research
    • Suhre, K., Shin, S. Y., Petersen, A. K., Mohney, R. P., Meredith, D., Wagele, B. et al. Human metabolic individuality in biomedical and pharmaceutical research. Nature. 477, 54-60 (2011).
    • (2011) Nature. , vol.477 , pp. 54-60
    • Suhre, K.1    Shin, S.Y.2    Petersen, A.K.3    Mohney, R.P.4    Meredith, D.5    Wagele, B.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.