Brainstem substrates of sympatho-motor circuitry identified using trans-synaptic tracing with pseudorabies virus recombinants

Journal of Neuroscience

Volumn 23, Issue 11, 2003, Pages 4657-4666

  Kerman, Ilan A ^a,b   Enquist, Lynn W ^c   Watson, Stanley J ^b   Yates, Bill J ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

^c PRINCETON UNIVERSITY   (United States)

Author keywords

Central command; Dual labeling immunofluorescence; Exercise; Motor pathway; Pontomedullary reticular formation; Pseudorabies virus; Raphe nuclei; Rats; Rostral ventromedial medulla; Stress; Sympathetic nervous system

Indexed keywords

GREEN FLUORESCENT PROTEIN;

ADRENAL GLAND; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN STEM; CONTROLLED STUDY; EFFERENT NERVE; GASTROCNEMIUS MUSCLE; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; MALE; MEDULLA OBLONGATA; MOTOR NERVE; NONHUMAN; PREGANGLIONIC NERVE; PRIORITY JOURNAL; PSEUDORABIES HERPETOVIRUS; RAT; RETICULAR FORMATION; RETROGRADE NERVE FIBER TRANSPORT; SYMPATHECTOMY; SYMPATHETIC INNERVATION; VIRUS RECOMBINANT;

EID: 0038456285     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.23-11-04657.2003     Document Type: Article

References (55)

1. Allen GV, Cechetto DF (1994) Serotoninergic and nonserotoninergic neurons in the medullary raphe system have axon collateral projections to autonomic and somatic cell groups in the medulla and spinal cord. J Comp Neurol 350:357-366.
2. Benarroch EB (1993) The central atonomic network: functional organization, dysfunction, and perspective. Mayo Clin Proc 68:988-1001.
3. Billig I, Foris JM, Card JP, Yates BJ (1999) Transneuronal tracing of neural pathways controlling an abdominal muscle, rectus abdominis, in the ferret. Brain Res 820:31-44.
4. Billig I, Foris JM, Enquist LW, Card JP, Yates BJ (2000) Definition of neuronal circuitry controlling the activity of phrenic and abdominal motoneurons in the ferret using recombinant strains of pseudorabies virus. J Neurosci 20:7446-7454.
5. Billig I, Hartge K, Card JP, Yates BJ (2001) Transneuronal tracing of neural pathways controlling abdominal musculature in the ferret. Brain Res 912:24-32.
6. Byrum CE, Guyenet PG (1987) Afferent and efferent connections of the A5 noradrenergic cell group in the rat. J Comp Neurol 261:529-542.
7. Cannon WB (1963) The wisdom of the body. New York: W. W. Norton.
8. Cano G (2002) Characterization of the CNS control using viral transneuronal tracing. PhD thesis, University of Pittsburgh.
9. Cano G, Card JP, Rinaman L, Sved AF (2000) Connections of Barrington's nucleus to the sympathetic nervous system in rats. J Auton Nerv Syst 79:117-128.
10. Card JP, Rinaman L, Lynn RB, Lee BH, Meade RP, Miselis RR, Enquist LW (1993) Pseudorabies virus infection of the rat central nervous system: ultrastructural characterization of viral replication, transport, and pathogenesis. J Neurosci 13:2515-2539.
11. Card JP, Enquist LW (1994) The use of neurotropic herpes viruses for defining synaptically linked populations of neurons in the central nervous system. In: Methods in molecular genetics, molecular biology techniques (Adolph KW, ed), pp 363-382. San Diego: Academic.
12. Card JP, Enquist LW, Moore RY (1999) Neuroinvasiveness of pseudorabies virus injected intracerebrally is dependent on viral concentration and terminal field density. J Comp Neurol 407:438-452.
13. Edwards SL, Anderson CR, Southwell BR, McAllen RM (1996) Distinct preganglionic neurons innervate noradrenaline and adrenaline cells in the cat adrenal medulla. Neuroscience 70:825-832.
14. Enquist LW, Husak PJ, Banfield BW, Smith GA (1998) Infection and spread of alpha herpes viruses in the nervous system. Adv Virus Res 51:237-347.
15. Futuro-Neto HA, Coote JH (1982) Changes in sympathetic activity to heart and blood vessels during desynchronized sleep. Brain Res 252:259-268.
16. Gandevia SC, Killian K, McKenzie DK, Crawford M, Allen GM, Gorman RB, Hales JP (1993) Respiratory sensations, cardiovascular control, kinaesthesia and transcranial stimulation during paralysis in humans. J Physiol 470:85-107.
17. Greene EC (1963) Anatomy of the rat. New York: Hafner.
18. Gustafson DP, ed (1975) Pseudorabies. Ames, Iowa: Iowa State Press.
19. Hashizume K, Kanda K, Burke RE (1988) Medial gastrocnemius motor nucleus in the rat: age-related changes in the number and size of motoneurons. J Comp Neurol 269:425-430.
20. Holstege G, Kuypers HG, Boer RC (1979) Anatomical evidence for direct brain stem projections to the somatic motoneuronal cell groups and autonomic preganglionic cell groups in cat spinal cord. Brain Res 171:329-333.
21. Holstege JC, Kuypers HG (1987) Brainstem projections to spinal motoneurons: an update. Neuroscience 23:809-821.
22. Hsu SM, Raine L, Fanger H (1981) Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures. J Histochem Cytochem 29:577-580.
23. Jänig W, McLachlan EM (1992) Characteristics of function-specific pathways in the sympathetic nervous system. Trends Neurosci 15:475-481.
24. Jones BE, Yang TZ (1985) The efferent projections from the reticular formation and the locus coeruleus studied by anterograde and retrograde axonal transport in the rat. J Comp Neurol 242:56-92.
25. Joshi S, Levatte MA, Dekaban GA, Weaver LC (1995) Identification ofspinal interneurons antecedent to adrenal sympathetic preganglionic neurons using trans-synaptic transport of herpes simplex virus type 1. Neuroscience 65:893-903.
26. Kanda K, Sato H, Hashizume K, Yamada J (1989) The effects of blocking nerve conduction on retrograde HRP labeling of rat motoneuron. Neurosci Lett 99:153-156.
27. Kandel ER, Schwartz JH, Jessell TM (2000) Principles of neural science. New York: McGraw-Hill.
28. Kim JS, Enquist LW, Card JP (1999) Circuit-specific coinfection of neurons in the rat central nervous system with two pseudorabies virus recombinants. J Virol 73:9521-9531.
29. Langley JN (1921) The autonomic nervous system. Cambridge, UK: W. Heffer.
30. Li Y-W, Ding Z-Q, Wesselingh SL, Blessing WW (1992) Renal and adrenal sympathetic preganglionic neurons in rabbit spinal cord: tracing with Herpes simplex virus. Brain Res 573:147-152.
31. Loewy AD (1990) Central autonomic pathways. In: Central regulation of autonomic functions (Loewy AD, Spyer KM, eds), pp 89-103. New York: Oxford UP.
32. Loewy AD, McKellar S, Saper CB (1979) Direct projections from the A5 catecholamine cell group to the intermediolateral cell column. Brain Res 174:309-314.
33. Loewy AD, Wallach JH, McKellar S (1981) Efferent connections of the ventral medulla oblongata in the rat. Brain Res 228:63-80.
34. Lyons WE, Grzanna R (1988) Noradrenergic neurons with divergent projections to the motor trigeminal nucleus and the spinal cord: a double retrograde neuronal labeling study. Neuroscience 26:681-693.
35. Martin GF, Humbertson AO, Laxson C, Panneton WM (1979a) Evidence for direct bulbospinal projections to laminae IX, X and the intermediolateral cell column. Studies using axonal transport techniques in the North American opossum. Brain Res 170:165-171.
36. Martin GF, Humbertson Jr AO, Laxson LC, Panneton WM, Tschismadia I (1979b) Spinal projections from the mesencephalic and pontine reticular formation in the North American opossum: a study using axonal transport techniques. J Comp Neurol 187:373-399.
37. Martin GF, Vertes RP, Waltzer R (1985) Spinal projections of the gigantocellular reticular formation in the rat. Evidence for projections from different areas to laminae I and II and lamina IX. Exp Brain Res 58:154-162.
38. Matsukawa K, Mitchell JH, Wall PT, Wilson LB (1991) The effect of static exercise on renal sympathetic nerve activity in conscious cats. J Physiol 434:453-467.
39. McLean IW, Nakane PK (1974) Periodate-lysine-paraformaldehyde fixative. A new fixation for immunoelectron microscopy. J Histochem Cytochem 22:1077-1083.
40. Molander C, Xu Q, Grant G (1984) The cytoarchitectonic organization of the spinal cord in the rat. I. The lower thoracic and lumbosacral cord. J Comp Neurol 230:133-141.
41. Nygren LG, Olson L (1977) A new major projection from locus coeruleus: the main source of noradrenergic nerve terminals in the ventral and dorsal columns of the spinal cord. Brain Res 132:85-93.
42. Papka RE, McCurdy JR, Williams SJ, Mayer B, Marson L, Platt KB (1995) Parasympathetic preganglionic neurons in the spinal cord involved in uterine innervation are cholinergic and nitric oxide-containing. Anat Rec 241:554-562.
43. Paxinos G, Watson C (1986) The rat brain in stereotaxic coordinates, Ed 2. San Diego: Academic.
44. Rowell LB (1993) Human cardiovascular control. New York: Oxford UP.
45. Smith BN, Banfield BW, Smeraski CA, Wilcox CL, Dudek FE, Enquist LW, Pickard GE (2000) Pseudorabies virus expressing enhanced green fluorescent protein: a tool for in vitro electrophysiological analysis of transsynaptically labeled neurons in identified central nervous system circuits. Proc Natl Acad Sci USA 97:9264-9269.
46. Standish A, Enquist LW, Miselis RR, Schwaber JS (1995) Dendritic morphology of cardiac related medullary neurons defined by circuit-specific infection by a recombinant pseudorabies virus expressing betagalactosidase. J Neurovirol 1:359-368.
47. Strack AM, Sawyer WB, Platt KB, Loewy AD (1989) CNS cell groups regulating the sympathetic outflow to adrenal gland as revealed by transneuronal cell body labeling with pseudorabies virus. Brain Res 491:274-296.
48. Vahlne A, Nystrom B, Sandberg M, Hamberger A, Lycke E (1978) Attachment of herpes simplex virus to neurons and glial cells. J Gen Virol 40:359-371.
49. Vahlne A, Svennerholm B, Sandberg M, Hamberger A, Lycke E (1980) Differences in attachment between herpes simplex type 1 and type 2 viruses to neurons and glial cells. Infect Immun 28:675-680.
50. Verberne AJ, Lam W, Owens NC, Sartor D (1997) Supramedullary modulation of sympathetic vasomotor function. Clin Exp Pharmacol Physiol 24:748-754.
51. Victor RG, Secher NH, Lyson T, Mitchell JH (1995) Central command increases muscle sympathetic nerve activity during intense intermittent isometric exercise in humans. Circ Res 76:127-131.
52. Vissing J, Wilson LB, Mitchell JH, Victor RG (1991) Static muscle contraction reflexly increases adrenal sympathetic nerve activity in rats. Am J Physiol 261:R1307-1312.
53. Waldrop TG, Eldridge FL, Iwamoto GA, Mitchell JH (1996) Central neural control of respiration and circulation during exercise. In: Handbook of physiology, Sect 12: Exercise: regulation and integration of multiple systems (Rowell LB, Shepherd JT, eds), pp 333-380. New York: Oxford UP.
54. Zemlan FP, Kow LM, Pfaff DW (1983) Effect of interruption of bulbospinal pathways on lordosis, posture, and locomotion. Exp Neurol 81:177-194.
55. Zemlan FP, Behbehani MM, Beckstead RM (1984) Ascending and descending projections from nucleus reticularis magnocellularis and nucleus reticularis gigantocellularis: an autoradiographic and horseradish peroxidase study in the rat. Brain Res 292:207-220.