Disruption of rat testis development following combined in utero exposure to the phytoestrogen genistein and antiandrogenic plasticizer di-(2-ethylhexyl) phthalate

Biology of Reproduction

Volumn 91, Issue 3, 2014, Pages

  Jones, Steven ^a,b   Boisvert, Annie ^a,b   Duong, Tam B ^a,c   Francois, Sade ^a,c   Thrane, Peter ^a   Culty, Martine ^a,b,c  

^a RESEARCH INSTITUTE OF THE MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c MCGILL UNIVERSITY   (Canada)

Author keywords

Endocrine disruptor; Genistein; Germ cells; Leydig; Phthalate; Sertoli; Testis; Toxicology

Indexed keywords

ANTIANDROGEN; CD163 ANTIGEN; CD33 ANTIGEN; CD38 ANTIGEN; CHLORDANE; ENDOCRINE DISRUPTOR; FOLLITROPIN; GENISTEIN; LUTEINIZING HORMONE; LUTEINIZING HORMONE BETA SUBUNIT; MESSENGER RNA; MICROSOMAL AMINOPEPTIDASE; PHTHALIC ACID 2 ETHYLHEXYL MONOESTER; PHYTOESTROGEN; PLASTICIZER; TESTOSTERONE; TRANSCRIPTION FACTOR SOX17; WT1 PROTEIN; BIOLOGICAL MARKER; PHTHALIC ACID BIS(2 ETHYLHEXYL) ESTER;

ADULT; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL DISRUPTION; CONTROLLED STUDY; DISORDER OF SEX DEVELOPMENT; FEMALE; FOLLITROPIN BLOOD LEVEL; GENE EXPRESSION; GERM CELL; IMMUNOHISTOCHEMISTRY; LEYDIG CELL; MALE; MAST CELL; NONHUMAN; PRENATAL EXPOSURE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; REAL TIME POLYMERASE CHAIN REACTION; REPRODUCTIVE TOXICITY; SERTOLI CELL; SOMATIC CELL; SPRAGUE DAWLEY RAT; TESTIS; TESTIS FUNCTION; TESTIS WEIGHT; TESTOSTERONE BLOOD LEVEL; ANIMAL; BLOOD; CHEMICALLY INDUCED; COMPARATIVE STUDY; DRUG EFFECTS; DRUG POTENTIATION; GENE EXPRESSION REGULATION; IMMUNOLOGY; MALE INFERTILITY; METABOLISM; ORGAN SIZE; PATHOLOGY; PREGNANCY; SPERMATOGENESIS;

RATTUS; ZEA MAYS;

ANIMALS; BIOLOGICAL MARKERS; DIETHYLHEXYL PHTHALATE; DRUG SYNERGISM; ENDOCRINE DISRUPTORS; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENISTEIN; INFERTILITY, MALE; LEYDIG CELLS; MALE; MAST CELLS; NONSTEROIDAL ANTI-ANDROGENS; ORGAN SIZE; PHYTOESTROGENS; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; RATS, SPRAGUE-DAWLEY; SERTOLI CELLS; SPERMATOGENESIS; TESTIS; TESTOSTERONE;

EID: 84911389148     PISSN: 00063363     EISSN: 15297268     Source Type: Journal    
DOI: 10.1095/biolreprod.114.120907     Document Type: Article

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