메뉴 건너뛰기




Volumn 102, Issue 2, 2008, Pages 155-161

Testicular dysgenesis syndrome and Leydig cell function

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN; DIMETHYLBENZ[A]ANTHRACENE; PHTHALIC ACID DIBUTYL ESTER; TESTOSTERONE;

EID: 38449100722     PISSN: 17427835     EISSN: 17427843     Source Type: Journal    
DOI: 10.1111/j.1742-7843.2007.00197.x     Document Type: Conference Paper
Times cited : (63)

References (52)
  • 1
    • 0037471163 scopus 로고    scopus 로고
    • Demographics. Europe's population at a turning point
    • Lutz W, O'Neill BC, Scherbov S. Demographics. Europe's population at a turning point. Science 2003 299 : 1991 2.
    • (2003) Science , vol.299 , pp. 1991-2
    • Lutz, W.1    O'Neill, B.C.2    Scherbov, S.3
  • 2
    • 0035988389 scopus 로고    scopus 로고
    • Poor semen quality may contribute to recent decline in fertility rates
    • Jensen TK, Carlsen E, Jørgensen N et al. Poor semen quality may contribute to recent decline in fertility rates. Hum Reprod 2002 17 : 1437 40.
    • (2002) Hum Reprod , vol.17 , pp. 1437-40
    • Jensen, T.K.1    Carlsen, E.2    Jørgensen, N.3
  • 3
    • 33645210318 scopus 로고    scopus 로고
    • Register data on assisted reproductive technology (ART) in Europe. Including a detailed description of ART in Denmark
    • Andersen AN, Erb K. Register data on assisted reproductive technology (ART) in Europe. Including a detailed description of ART in Denmark. Int J Androl 2006 29 : 12 6.
    • (2006) Int J Androl , vol.29 , pp. 12-6
    • Andersen, A.N.1    Erb, K.2
  • 4
    • 33645224455 scopus 로고    scopus 로고
    • Coordinated European investigations of semen quality: Results from studies of Scandinavian young men is a matter of concern
    • Jørgensen N, Asklund C, Carlsen E, Skakkebæk NE. Coordinated European investigations of semen quality: results from studies of Scandinavian young men is a matter of concern. Int J Androl 2006 29 : 54 61.
    • (2006) Int J Androl , vol.29 , pp. 54-61
    • Jørgensen, N.1    Asklund, C.2    Carlsen, E.3    Skakkebæk, N.E.4
  • 5
    • 33847379843 scopus 로고    scopus 로고
    • Fertility treatment and reproductive health of male offspring: A study of 1925 young men from the general population
    • Jensen TK, Jørgensen N, Asklund C, Carlsen E, Holm M, Skakkebæk NE. Fertility treatment and reproductive health of male offspring: a study of 1925 young men from the general population. Am J Epidemiol 2007 165 : 583 90.
    • (2007) Am J Epidemiol , vol.165 , pp. 583-90
    • Jensen, T.K.1    Jørgensen, N.2    Asklund, C.3    Carlsen, E.4    Holm, M.5    Skakkebæk, N.E.6
  • 6
    • 34447125106 scopus 로고    scopus 로고
    • Reduced serum testosterone levels in infant boys conceived by Intra-Cytoplasmic Sperm Injection (ICSI)
    • Mau KC, Main KM, Nyboe AA, Loft A, Skakkebæk NE, Juul A. Reduced serum testosterone levels in infant boys conceived by Intra-Cytoplasmic Sperm Injection (ICSI). J Clin Endocrinol Metab 2007 92 : 2598 603.
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 2598-603
    • Mau, K.C.1    Main, K.M.2    Nyboe, A.A.3    Loft, A.4    Skakkebæk, N.E.5    Juul, A.6
  • 7
    • 0035004535 scopus 로고    scopus 로고
    • Testicular dysgenesis syndrome: An increasingly common developmental disorder with environmental aspects
    • Skakkebæk NE, Rajpert-De Meyts E, Main KM. Testicular dysgenesis syndrome: an increasingly common developmental disorder with environmental aspects. Hum Reprod 2001 16 : 972 8.
    • (2001) Hum Reprod , vol.16 , pp. 972-8
    • Skakkebæk, N.E.1    Rajpert-De Meyts, E.2    Main, K.M.3
  • 8
    • 0023176609 scopus 로고
    • Testicular cancer and fertility
    • Berthelsen JG. Testicular cancer and fertility. Int J Androl 1987 10 : 371 80.
    • (1987) Int J Androl , vol.10 , pp. 371-80
    • Berthelsen, J.G.1
  • 9
    • 0037770143 scopus 로고    scopus 로고
    • Risk of testicular cancer in subfertile men: Case-control study
    • Møller H, Skakkebæk NE. Risk of testicular cancer in subfertile men: case-control study. Br Med J 1999 318 : 559 62.
    • (1999) Br Med J , vol.318 , pp. 559-62
    • Møller, H.1    Skakkebæk, N.E.2
  • 11
    • 34347222881 scopus 로고    scopus 로고
    • High prevalence of testicular cancer in azoospermic men without spermatogenesis
    • Mancini M, Carmignani L, Gazzano G et al. High prevalence of testicular cancer in azoospermic men without spermatogenesis. Hum Reprod 2007 22 : 1042 6.
    • (2007) Hum Reprod , vol.22 , pp. 1042-6
    • Mancini, M.1    Carmignani, L.2    Gazzano, G.3
  • 12
    • 11144353583 scopus 로고    scopus 로고
    • Difference in prevalence of congenital cryptorchidism in infants between two Nordic countries
    • Boisen KA, Kaleva M, Main KM et al. Difference in prevalence of congenital cryptorchidism in infants between two Nordic countries. Lancet 2004 363 : 1264 9.
    • (2004) Lancet , vol.363 , pp. 1264-9
    • Boisen, K.A.1    Kaleva, M.2    Main, K.M.3
  • 13
    • 23044480789 scopus 로고    scopus 로고
    • Hypospadias in a cohort of 1072 Danish newborn boys: Prevalence and relationship to placental weight, anthropometrical measurements at birth, and reproductive hormone levels at 3 months of age
    • Boisen K, Chellakooty M, Schmidt I et al. Hypospadias in a cohort of 1072 Danish newborn boys: prevalence and relationship to placental weight, anthropometrical measurements at birth, and reproductive hormone levels at 3 months of age. J Clin Endocrinol Metab 2005 90 : 4041 6.
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 4041-6
    • Boisen, K.1    Chellakooty, M.2    Schmidt, I.3
  • 14
    • 34547889089 scopus 로고    scopus 로고
    • Testicular cancer trends as 'whistle blowers' of testicular developmental problems in populations
    • Skakkebæk NE, Rajpert-De Meyts E, Jørgensen N et al. Testicular cancer trends as 'whistle blowers' of testicular developmental problems in populations. Int J Androl 2007 30 : 198 205.
    • (2007) Int J Androl , vol.30 , pp. 198-205
    • Skakkebæk, N.E.1    Rajpert-De Meyts, E.2    Jørgensen, N.3
  • 15
    • 33644651006 scopus 로고    scopus 로고
    • Pathways of endocrine disruption during male sexual differentiation and masculinization
    • Sharpe RM. Pathways of endocrine disruption during male sexual differentiation and masculinization. Best Pract Res Clin Endocrinol Metab 2006 20 : 91 110.
    • (2006) Best Pract Res Clin Endocrinol Metab , vol.20 , pp. 91-110
    • Sharpe, R.M.1
  • 16
    • 0033693113 scopus 로고    scopus 로고
    • Levels of seven urinary phthalate metabolites in a human reference population
    • Blount BC, Silva MJ, Caudill SP et al. Levels of seven urinary phthalate metabolites in a human reference population. Environ Health Perspect 2000 108 : 979 82.
    • (2000) Environ Health Perspect , vol.108 , pp. 979-82
    • Blount, B.C.1    Silva, M.J.2    Caudill, S.P.3
  • 18
    • 0037899183 scopus 로고    scopus 로고
    • Histological evidence of testicular dysgenesis in contralateral biopsies from 218 patients with testicular germ cell cancer
    • Høi-Hansen CE, Holm M, Rajpert-De Meyts E, Skakkebæk NE. Histological evidence of testicular dysgenesis in contralateral biopsies from 218 patients with testicular germ cell cancer. J Pathol 2003 200 : 370 4.
    • (2003) J Pathol , vol.200 , pp. 370-4
    • Høi-Hansen, C.E.1    Holm, M.2    Rajpert-De Meyts, E.3    Skakkebæk, N.E.4
  • 19
    • 0001271885 scopus 로고
    • The association of testicular carcinoma in situ with intratubular microcalcifications
    • Kang JL, Rajpert-De Meyts E, Giwercman A, Skakkebæk NE. The association of testicular carcinoma in situ with intratubular microcalcifications. J Urol Pathol 1994 2 : 235 42.
    • (1994) J Urol Pathol , vol.2 , pp. 235-42
    • Kang, J.L.1    Rajpert-De Meyts, E.2    Giwercman, A.3    Skakkebæk, N.E.4
  • 20
    • 0043194051 scopus 로고    scopus 로고
    • Increased risk of carcinoma in situ in patients with testicular germ cell cancer with ultrasonic microlithiasis in the contralateral testicle
    • Holm M, Høi-Hansen CE, Rajpert-De Meyts E, Skakkebæk NE. Increased risk of carcinoma in situ in patients with testicular germ cell cancer with ultrasonic microlithiasis in the contralateral testicle. J Urol 2003 170 : 1163 7.
    • (2003) J Urol , vol.170 , pp. 1163-7
    • Holm, M.1    Høi-Hansen, C.E.2    Rajpert-De Meyts, E.3    Skakkebæk, N.E.4
  • 21
    • 0346995351 scopus 로고    scopus 로고
    • Bilateral testicular microlithiasis predicts the presence of the precursor of testicular germ cell tumors in subfertile men
    • De Gouveria Brazao CA, Pierik FH, Oosterhuis JW, Dohle GR, Looijenga LHJ, Weber RFA. Bilateral testicular microlithiasis predicts the presence of the precursor of testicular germ cell tumors in subfertile men. J Urol 2004 171 : 158 60.
    • (2004) J Urol , vol.171 , pp. 158-60
    • De Gouveria Brazao, C.A.1    Pierik, F.H.2    Oosterhuis, J.W.3    Dohle, G.R.4    Looijenga, L.H.J.5    Weber, R.F.A.6
  • 23
    • 0037370254 scopus 로고    scopus 로고
    • Leydig cell micronodules are a common finding in testicular biopsies from men with impaired spermatogenesis and are associated with decreases testosterone/LH ratio
    • Holm M, Rajpert-De Meyts E, Andersson A-M, Skakkebæk NE. Leydig cell micronodules are a common finding in testicular biopsies from men with impaired spermatogenesis and are associated with decreases testosterone/LH ratio. J Pathol 2003 199 : 378 86.
    • (2003) J Pathol , vol.199 , pp. 378-86
    • Holm, M.1    Rajpert-De Meyts, E.2    Andersson, A.-M.3    Skakkebæk, N.E.4
  • 24
    • 0032923928 scopus 로고    scopus 로고
    • Impaired testicular function in patients with carcinoma in situ of the testis
    • Petersen PM, Giwercman A, Hansen SW et al. Impaired testicular function in patients with carcinoma in situ of the testis. J Clin Oncol 1999 17 : 173 9.
    • (1999) J Clin Oncol , vol.17 , pp. 173-9
    • Petersen, P.M.1    Giwercman, A.2    Hansen, S.W.3
  • 25
  • 26
    • 27744583396 scopus 로고    scopus 로고
    • Low risk of impaired testicular Sertoli and Leydig cell functions in boys with isolated hypospadias
    • Rey RA, Codner E, Iniguez G et al. Low risk of impaired testicular Sertoli and Leydig cell functions in boys with isolated hypospadias. J Clin Endocrinol Metab 2005 90 : 6035 40.
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 6035-40
    • Rey, R.A.1    Codner, E.2    Iniguez, G.3
  • 28
  • 31
    • 23744469802 scopus 로고    scopus 로고
    • Decrease in anogenital distance among male infants with prenatal phthalate exposure
    • Swan SH, Main KM, Liu F et al. Decrease in anogenital distance among male infants with prenatal phthalate exposure. Environ Health Perspect 2005 113 : 1056 1061.
    • (2005) Environ Health Perspect , vol.113 , pp. 1056-1061
    • Swan, S.H.1    Main, K.M.2    Liu, F.3
  • 32
    • 32044470078 scopus 로고    scopus 로고
    • Human breast milk contamination with phthalates and alterations of endogenous reproductive hormones in three months old infants
    • Main KM, Mortensen GK, Kaleva M et al. Human breast milk contamination with phthalates and alterations of endogenous reproductive hormones in three months old infants. Environ Health Perspect 2006 114 : 270 6.
    • (2006) Environ Health Perspect , vol.114 , pp. 270-6
    • Main, K.M.1    Mortensen, G.K.2    Kaleva, M.3
  • 33
    • 9144252565 scopus 로고    scopus 로고
    • Association of in utero exposure to maternal smoking with reduced semen quality and testis size in adulthood: A cross-sectional study of 1770 young men from the general population in five European countries
    • Jensen TK, Jørgensen N, Punab M et al. Association of in utero exposure to maternal smoking with reduced semen quality and testis size in adulthood: a cross-sectional study of 1770 young men from the general population in five European countries. Am J Epidemiol 2004 159 : 49 58.
    • (2004) Am J Epidemiol , vol.159 , pp. 49-58
    • Jensen, T.K.1    Jørgensen, N.2    Punab, M.3
  • 34
    • 85047691295 scopus 로고    scopus 로고
    • Does smoking during pregnancy affect sons' sperm counts?
    • Storgaard L, Bonde JP, Ernst E et al. Does smoking during pregnancy affect sons' sperm counts? Epidemiology 2003 14 : 278 86.
    • (2003) Epidemiology , vol.14 , pp. 278-86
    • Storgaard, L.1    Bonde, J.P.2    Ernst, E.3
  • 35
    • 5144232195 scopus 로고    scopus 로고
    • Body mass index in relation to semen quality and reproductive hormones among 1558 Danish men
    • Jensen TK, Andersson A-M, Jørgensen N et al. Body mass index in relation to semen quality and reproductive hormones among 1558 Danish men. Fertil Steril 2004 82 : 863 70.
    • (2004) Fertil Steril , vol.82 , pp. 863-70
    • Jensen, T.K.1    Andersson, A.-M.2    Jørgensen, N.3
  • 36
    • 0030740011 scopus 로고    scopus 로고
    • Breast-feeding exposure of infants to cadmium, lead, and mercury: A public health viewpoint
    • Abadin HG, Hibbs BF, Pohl HR. Breast-feeding exposure of infants to cadmium, lead, and mercury: a public health viewpoint. Toxicol Ind Health 1997 13 : 495 517.
    • (1997) Toxicol Ind Health , vol.13 , pp. 495-517
    • Abadin, H.G.1    Hibbs, B.F.2    Pohl, H.R.3
  • 37
    • 0021276849 scopus 로고
    • Sperm count results from 861 American chemical/agricultural workers from 14 separate studies
    • Whorton MD, Meyer CR. Sperm count results from 861 American chemical/agricultural workers from 14 separate studies. Fertil Steril 1984 42 : 82 86.
    • (1984) Fertil Steril , vol.42 , pp. 82-86
    • Whorton, M.D.1    Meyer, C.R.2
  • 38
    • 34247094802 scopus 로고    scopus 로고
    • Sequelae in male rabbits following developmental exposure to p,p'-DDT or a mixture of p,p'-DDT and vinclozolin: Cryptorchidism, germ cell atypia, and sexual dysfunction
    • Veeramachaneni DN, Palmer JS, Amann RP, Pau KY. Sequelae in male rabbits following developmental exposure to p,p'-DDT or a mixture of p,p'-DDT and vinclozolin: cryptorchidism, germ cell atypia, and sexual dysfunction. Reprod Toxicol 2007 23 : 353 65.
    • (2007) Reprod Toxicol , vol.23 , pp. 353-65
    • Veeramachaneni, D.N.1    Palmer, J.S.2    Amann, R.P.3    Pau, K.Y.4
  • 39
    • 0034523473 scopus 로고    scopus 로고
    • Perinatal exposure to the phthalates DEHP, BBP, and DINP, but not DEP, DMP, or DOTP, alters sexual differentiation of the male rat
    • Gray LE Jr., Ostby J, Furr J, Price M, Veeramachaneni DN, Parks L. Perinatal exposure to the phthalates DEHP, BBP, and DINP, but not DEP, DMP, or DOTP, alters sexual differentiation of the male rat. Toxicol Sci 2000 58 : 350 65.
    • (2000) Toxicol Sci , vol.58 , pp. 350-65
    • Gray Jr., L.E.1    Ostby, J.2    Furr, J.3    Price, M.4    Veeramachaneni, D.N.5    Parks, L.6
  • 40
    • 0035025368 scopus 로고    scopus 로고
    • Effects of phthalate esters on the developing reproductive tract of male rats
    • Foster PM, Mylchreest E, Gaido KW, Sar M. Effects of phthalate esters on the developing reproductive tract of male rats. Hum Reprod Update 2001 7 : 231 5.
    • (2001) Hum Reprod Update , vol.7 , pp. 231-5
    • Foster, P.M.1    Mylchreest, E.2    Gaido, K.W.3    Sar, M.4
  • 41
    • 0031793912 scopus 로고    scopus 로고
    • Abnormalities in functional development of the Sertoli cells in rats treated neonatally with diethylstilbestrol: A possible role for estrogens in Sertoli cell development
    • Sharpe RM, Atanassova N, McKinnell C et al. Abnormalities in functional development of the Sertoli cells in rats treated neonatally with diethylstilbestrol: a possible role for estrogens in Sertoli cell development. Biol Reprod 1998 59 : 1084 94.
    • (1998) Biol Reprod , vol.59 , pp. 1084-94
    • Sharpe, R.M.1    Atanassova, N.2    McKinnell, C.3
  • 42
    • 0027232797 scopus 로고
    • Are oestrogens involved in falling sperm counts and disorders of the male reproductive tract?
    • Sharpe RM, Skakkebæk NE. Are oestrogens involved in falling sperm counts and disorders of the male reproductive tract? Lancet 1993 341 : 1392 5.
    • (1993) Lancet , vol.341 , pp. 1392-5
    • Sharpe, R.M.1    Skakkebæk, N.E.2
  • 43
    • 0037238481 scopus 로고    scopus 로고
    • The 'oestrogen hypothesis' - Where do we stand now?
    • Sharpe RM. The 'oestrogen hypothesis' - where do we stand now? Int J Androl 2003 26 : 2 15.
    • (2003) Int J Androl , vol.26 , pp. 2-15
    • Sharpe, R.M.1
  • 44
    • 0031860360 scopus 로고    scopus 로고
    • Male reproductive tract malformations in rats following gestational and lactational exposure to Di(n-butyl) phthalate: An antiandrogenic mechanism?
    • Mylchreest E, Cattley RC, Foster PM. Male reproductive tract malformations in rats following gestational and lactational exposure to Di(n-butyl) phthalate: an antiandrogenic mechanism? Toxicol Sci 1998 43 : 47 60.
    • (1998) Toxicol Sci , vol.43 , pp. 47-60
    • Mylchreest, E.1    Cattley, R.C.2    Foster, P.M.3
  • 45
    • 0036010069 scopus 로고    scopus 로고
    • Fetal testosterone insufficiency and abnormal proliferation of Leydig cells and gonocytes in rats exposed to di(n-butyl) phthalate
    • Mylchreest E, Sar M, Wallace DG, Foster PM. Fetal testosterone insufficiency and abnormal proliferation of Leydig cells and gonocytes in rats exposed to di(n-butyl) phthalate. Reprod Toxicol 2002 16 : 19 28.
    • (2002) Reprod Toxicol , vol.16 , pp. 19-28
    • Mylchreest, E.1    Sar, M.2    Wallace, D.G.3    Foster, P.M.4
  • 46
    • 0033010382 scopus 로고    scopus 로고
    • Disruption of androgen-regulated male reproductive development by di(n-butyl) phthalate during late gestation in rats is different from flutamide
    • Mylchreest E, Sar M, Cattley RC, Foster PM. Disruption of androgen-regulated male reproductive development by di(n-butyl) phthalate during late gestation in rats is different from flutamide. Toxicol Appl Pharmacol 1999 156 : 81 95.
    • (1999) Toxicol Appl Pharmacol , vol.156 , pp. 81-95
    • Mylchreest, E.1    Sar, M.2    Cattley, R.C.3    Foster, P.M.4
  • 47
    • 1642515878 scopus 로고    scopus 로고
    • Significance of experimental studies for assessing adverse effects of endocrine-disrupting chemicals
    • Gray LE Jr., Foster PMD. Significance of experimental studies for assessing adverse effects of endocrine-disrupting chemicals. Pure Appl Chem 2003 75 : 2125 41.
    • (2003) Pure Appl Chem , vol.75 , pp. 2125-41
    • Gray Jr., L.E.1    Foster, P.M.D.2
  • 48
    • 1342281540 scopus 로고    scopus 로고
    • Male reproductive tract lesions at 6, 12, and 18 months of age following in utero exposure to di(n-butyl) phthalate
    • Barlow NJ, McIntyre BS, Foster PM. Male reproductive tract lesions at 6, 12, and 18 months of age following in utero exposure to di(n-butyl) phthalate. Toxicol Pathol 2004 32 : 79 90.
    • (2004) Toxicol Pathol , vol.32 , pp. 79-90
    • Barlow, N.J.1    McIntyre, B.S.2    Foster, P.M.3
  • 49
    • 0035977842 scopus 로고    scopus 로고
    • Hormones and testis development and the possible adverse effects of environmental chemicals
    • Sharpe RM. Hormones and testis development and the possible adverse effects of environmental chemicals. Toxicol Lett 2001 120 : 221 32.
    • (2001) Toxicol Lett , vol.120 , pp. 221-32
    • Sharpe, R.M.1
  • 50
    • 0034521058 scopus 로고    scopus 로고
    • The plasticizer diethylhexyl phthalate induces malformations by decreasing fetal testosterone synthesis during sexual differentiation in the male rat
    • Parks LG, Ostby JS, Lambright CR et al. The plasticizer diethylhexyl phthalate induces malformations by decreasing fetal testosterone synthesis during sexual differentiation in the male rat. Toxicol Sci 2000 58 : 339 49.
    • (2000) Toxicol Sci , vol.58 , pp. 339-49
    • Parks, L.G.1    Ostby, J.S.2    Lambright, C.R.3
  • 51
    • 0035194978 scopus 로고    scopus 로고
    • Altered gene profiles in fetal rat testes after in utero exposure to di(n-butyl) phthalate
    • Shultz VD, Phillips S, Sar M, Foster PM, Gaido KW. Altered gene profiles in fetal rat testes after in utero exposure to di(n-butyl) phthalate. Toxicol Sci 2001 64 : 233 42.
    • (2001) Toxicol Sci , vol.64 , pp. 233-42
    • Shultz, V.D.1    Phillips, S.2    Sar, M.3    Foster, P.M.4    Gaido, K.W.5
  • 52
    • 34249826658 scopus 로고    scopus 로고
    • Role of androgens in fetal testis development and dysgenesis
    • Scott HM, Hutchison GR, Mahood IK et al. Role of androgens in fetal testis development and dysgenesis. Endocrinology 2007 148 : 2027 36.
    • (2007) Endocrinology , vol.148 , pp. 2027-36
    • Scott, H.M.1    Hutchison, G.R.2    Mahood, I.K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.