Neuroprotection by the soy isoflavone, genistein, via inhibition of mitochondria-dependent apoptosis pathways and reactive oxygen induced-NF-κB activation in a cerebral ischemia mouse model

Neurochemistry International

Volumn 60, Issue 8, 2012, Pages 759-767

  Qian, Yisong ^a   Guan, Teng ^b   Huang, Menghao ^b   Cao, Liangxun ^b   Li, Yunman ^a,b   Cheng, Hao ^a   Jin, Hangxia ^a   Yu, Deyue ^a  

^a NANJING AGRICULTURAL UNIVERSITY   (China)

^b CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Caspase 3 activation; Cytochrome C release; Genistein; Isoflavone; MCAO; Neuron apoptosis; NF B; Reactive oxygen species

Indexed keywords

CASPASE 3; CYTOCHROME C; GENISTEIN; GLUTATHIONE PEROXIDASE; I KAPPA B KINASE ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; ISOFLAVONE; MALONALDEHYDE; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTOR RELA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; CELL FUNCTION; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG STRUCTURE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME RELEASE; LIPID PEROXIDATION; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; MITOCHONDRION; MOUSE; NEUROPROTECTION; NONHUMAN; OUTCOME ASSESSMENT; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SOYBEAN;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; BRAIN ISCHEMIA; CASPASE 3; CYTOCHROMES C; DISEASE MODELS, ANIMAL; ENZYME ACTIVATION; GENISTEIN; GLUTATHIONE PEROXIDASE; IN SITU NICK-END LABELING; LIPID PEROXIDATION; MALE; MICE; MICE, INBRED C57BL; MITOCHONDRIA; NEUROPROTECTIVE AGENTS; NF-KAPPA B; REACTIVE OXYGEN SPECIES; SUPEROXIDE DISMUTASE;

GLYCINE MAX; MUS;

EID: 84861112895     PISSN: 01970186     EISSN: 18729754     Source Type: Journal    
DOI: 10.1016/j.neuint.2012.03.011     Document Type: Article

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