Experimental model for studying the effects of 2-ethylhexyl-phthalate and dialysate on connective tissue

International Journal of Artificial Organs

Volumn 23, Issue 5, 2000, Pages 305-311

  Stabellini, Giordano ^b   Berti, G ^c   Calastrini, C ^c   Mariani, G ^c   Scapoli, L ^c   Marcucci, A ^c   Bedani, P L ^a  

^a USL 31   (Italy)

^b UNIVERSITY OF FERRARA   (Italy)

^c NONE

Author keywords

2 Ethylhexyl phthalate; Air pouch; Dialysate; Fibrosis; Glycosaminoglycans

Indexed keywords

CELL CULTURE; CELL MEMBRANES; MUSCULOSKELETAL SYSTEM; OLIVE OIL; RATS; TISSUE;

2-ETHYLHEXYL-PHTHALATE; AIR POUCH; COLLAGEN FIBRES; CONNECTIVE TISSUES; DIALYSATES; EXPERIMENTAL MODELLING; FIBROSE; GLYCOSAMINOGLYCANS; PHTHALATES; STERILE AIR;

COLLAGEN;

COLLAGEN FIBER; GLYCOSAMINOGLYCAN; PHTHALIC ACID BIS(2 ETHYLHEXYL) ESTER;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL VACUOLE; CONNECTIVE TISSUE; DIALYSATE; ELECTRON MICROSCOPY; EXPERIMENTAL MODEL; FIBROSIS; NONHUMAN; RAT;

EID: 0034082514     PISSN: 03913988     EISSN: None     Source Type: Journal    
DOI: 10.1177/039139880002300504     Document Type: Article

References (25)

1. Jaeger RJ, Rubin RJ. Plasticizers from plastic devices: extraction, metabolism and accumulation by biological system. Science 1970; 170: 460-62.
2. Nässberger L, Arbin A, Östelius J. Exposure of patients to phtalates from polyvinyl chloride tubes and bags during dialysis. Nephron 1987; 45: 286-90.
3. Mettang T, Thomas S, Kiefer T, et al. Uraemic pruritus and exposure to di 2-ethylhexyl-phthalate (DEHP) in haemodialysis patients. Nephrol Dial Transplant 1996; 11: 2439-43.
4. Mettang T, Thomas S, Kiefer T, et al. The fate of leached di 2-ethylhexyl-phthalate in patients undergoing CAPD treatment. Perit Dial Int 1996; 16: 58-62.
5. Butterworth BE, Lovzy DJ, Smith-Oliver T, Cattley RC. The potential role of chemically induced hyperplasia in the carcinogenic activity of the hypolipidemic carcinogens. Toxitol Ind Health 1987; 3: 129-49.
6. Jacobson MS, Kevy SV, Parkman R, Wesolowskin JS. An in vitro evaluation of a new plasticizer for polyvinylchloride medical devices. Transfusion 1980; 20: 443-7.
7. Stabellini G, Fiocchi O, Pellati A, Caruso A. In vitro evaluation of plasticizer activity on the growth and metabolism of chick embryo fibroblasts and on the development of the chick embryo lung. J Int Medical Res 1992; 20: 475-82.
8. Fracasso A, Coli U, Landini S, et al. Plasticizer from plastic devices: effect on peritoneal membrane; In: La Greca G, Chiaramonte S, Fabris A, Feriani M, Ronco C, eds. Peritoneal Dialysis; Milano: Wichtig, 1988; 57-60.
9. Dobbie JW. Morphology of the peritoneum in CAPD. Blood Purif 1989; 2-4: 74-85.
10. Carozzi S, Nasini MG. Ca2+ concentration in the peritoneal dialysis solution regulates peritoneal fibroblast proliferation and peritoneal macrophage and lymphocyte cytokine release. Per Dial Int 1993; 13 suppl. 2: S41-4.
11. Davies M, Kastner S, Gareth TJ. Proteoglicans: Their role in renal fibrosis. Kidney Int 1996; 49: S55-S60.
12. Ruoslhati E, Yamaguchi Y. Proteoglycans as modulators of growth factors activities. Cell 1991; 64: 867-9.
13. Morita H, Shinzato T, David G, et al. Basic fibroblast growth factors-binding domain of heparan sulfate in the human glomerosclerosis and renal tubulointerstitial fibrosis. Lab Invest 1994; 71: 528-35.
14. Di Persio CM, Jackson DA, Zaret KS. The extracellular matrix coordinately modulates liver transcription factors and hepatocyte morphology. Mol Cell Biol 1991; 11: 4405-14.
15. Stabellini G, Bedani PL, Fiocchi O, et al. DEHP-induced alterations in the lining tissue of the rat air pouch. Int J Artif Organs 1998; 21: 87-94.
16. Stabellini G, Fiocchi O, Lunghi M, et al. Evaluation of plasticizer activity on connective tissue: histological, histochemical and biochemical variations. Med Sci Res 1994; 22: 395-7.
17. Molina S, Selgas R, Fernandez de Castro M, Vara F. Presence of different mitogenic activities in the nocturnal peritoneal effluent of patients treated with CARD. Adv Perit Dial 1993; 9: 190-4.
18. Edwards JCV, Sedgwich AD, Willoughby PA. The formation of a structure with the features of a synovial lining by subcutaneous infection of air: an in vivo tissue culture system. J Pathol 1981; 134: 147-56.
19. Bartold PM, Page RC. A microdetermination method for assaying glycosaminoglycans by two-dimensional electrophoresis on acetate strip. Anal Biochem 1985; 150: 320-4.
20. Patterson MKjr. Measurement of growth and vitality of cells in culture; In Jacob and Pastan IH eds. Methods in Enzymology. New York: Academic Press, 1979; 58: 141-5.
21. Fracasso A, Calo L, Landini S, et al. Peritoneal sclerosis: role of plasticizers in stimulating interleukin-1 production. Per Dial Int 13 (suppl) 1993; S517-9.
22. Skutches CL, Sigler MH, Teehan BP, Cooper JH, Reichard GA. Contribution of dialysate acetate to energy metabolism. Metabolic implication. Kidney Int 1983; 23: 57-9.
23. Krediet RT. Advances in peritoneal dialysis: towards improved efficacy and safety. Blood Pur 1998; 16: 1-14.
24. Bodo M, Carinci P, Venti G, et al. Glycosaminoglycan metabolism and cytokine release in normal and otosclerotic human bone cells interleukin-1 treated. Connective Tissue Res 1997; 36: 231-40.
25. Sato E, Tanaka T, Takeya T, Miyamoto H, Koide SS. Ovarian glycosaminoglycans potentiate angiogenic activity of epidermal growth factor in mice. Endocrinology 1991; 128: 2402-6.