Orexin/hypocretin activates mTOR complex 1 (mTORC1) via an Erk/Akt-independent and calcium-stimulated lysosome v-ATPase pathway

Journal of Biological Chemistry

Volumn 289, Issue 46, 2014, Pages 31950-31959

  Wang, Zhiqiang ^a   Liu, Shimeng ^a,b   Kakizaki, Miyo ^c   Hirose, Yuuki ^c   Ishikawa, Yukiko ^c   Funato, Hiromasa ^c,d   Yanagisawa, Masashi ^c   Yu, Yonghao ^a   Liu, Qinghua ^a,d  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b WUHAN UNIVERSITY   (China)

^c UNIVERSITY OF TSUKUBA   (Japan)

^d TOHO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; CELL CULTURE; CHEMICAL ACTIVATION; EYE MOVEMENTS; METABOLISM; RECOMBINANT PROTEINS;

CALCIUM INFLUX; CALCIUM TRANSIENTS; G PROTEIN COUPLED RECEPTORS; METABOLIC PROCESS; NEUROPEPTIDES; RAPID EYE MOVEMENT; RECOMBINANT CELLS; SLEEP DISORDERS;

ANTIBIOTICS;

G PROTEIN COUPLED RECEPTOR; GUANOSINE TRIPHOSPHATASE; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MITOGEN ACTIVATED PROTEIN KINASE; OREXIN; OREXIN 1 RECEPTOR; OREXIN 2 RECEPTOR; PROTEIN KINASE B; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; RAG GUANOSINE TRIPHOSPHATASE; RAPAMYCIN; UNCLASSIFIED DRUG; AKT1 PROTEIN, HUMAN; AKT1 PROTEIN, MOUSE; CALCIUM; CD200R1 PROTEIN, MOUSE; HCRTR1 PROTEIN, HUMAN; HCRTR1 PROTEIN, MOUSE; HCRTR2 PROTEIN, HUMAN; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MULTIPROTEIN COMPLEX; NEUROPEPTIDE; OREXIN RECEPTOR; OREXINS; SIGNAL PEPTIDE; TARGET OF RAPAMYCIN KINASE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CALCIUM TRANSPORT; CONTROLLED STUDY; DOWNSTREAM PROCESSING; EXTRACELLULAR CALCIUM; HUMAN; HUMAN CELL; LYSOSOME; MOUSE; NARCOLEPSY; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; ANIMAL; BRAIN; C57BL MOUSE; CELL LINE; CYTOPLASM; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; HEK293 CELL LINE; METABOLISM; RNA INTERFERENCE; TRANSGENIC MOUSE;

ANIMALS; BRAIN; CALCIUM; CELL LINE; CYTOPLASM; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HEK293 CELLS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LYSOSOMES; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MULTIPROTEIN COMPLEXES; NEUROPEPTIDES; OREXIN RECEPTORS; PROTO-ONCOGENE PROTEINS C-AKT; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES; VACUOLAR PROTON-TRANSLOCATING ATPASES;

EID: 84911167135     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.600015     Document Type: Article

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