-
1
-
-
65649128580
-
Amino acid regulation of TOR complex 1
-
J. Avruch, X. Long, S. Ortiz-Vega, J. Rapley, A. Papageorgiou, and N. Dai Amino acid regulation of TOR complex 1 Am. J. Physiol. Endocrinol. Metab. 296 2009 E592 E602
-
(2009)
Am. J. Physiol. Endocrinol. Metab.
, vol.296
-
-
Avruch, J.1
Long, X.2
Ortiz-Vega, S.3
Rapley, J.4
Papageorgiou, A.5
Dai, N.6
-
2
-
-
56449115916
-
Mediobasal hypothalamic p70 S6 kinase 1 modulates the control of energy homeostasis
-
C. Blouet, H. Ono, and G.J. Schwartz Mediobasal hypothalamic p70 S6 kinase 1 modulates the control of energy homeostasis Cell Metab. 8 2008 459 467
-
(2008)
Cell Metab.
, vol.8
, pp. 459-467
-
-
Blouet, C.1
Ono, H.2
Schwartz, G.J.3
-
3
-
-
67649962153
-
Mediobasal hypothalamic leucine sensing regulates food intake through activation of a hypothalamus-brainstem circuit
-
C. Blouet, Y.H. Jo, X. Li, and G.J. Schwartz Mediobasal hypothalamic leucine sensing regulates food intake through activation of a hypothalamus-brainstem circuit J. Neurosci. 29 2009 8302 8311
-
(2009)
J. Neurosci.
, vol.29
, pp. 8302-8311
-
-
Blouet, C.1
Jo, Y.H.2
Li, X.3
Schwartz, G.J.4
-
4
-
-
79960635284
-
Fighting neurodegeneration with rapamycin: Mechanistic insights
-
J. Bové, M. Martínez-Vicente, and M. Vila Fighting neurodegeneration with rapamycin: mechanistic insights Nat. Rev. Neurosci. 12 2011 437 452
-
(2011)
Nat. Rev. Neurosci.
, vol.12
, pp. 437-452
-
-
Bové, J.1
Martínez-Vicente, M.2
Vila, M.3
-
5
-
-
33646582664
-
Hypothalamic mTOR signaling regulates food intake
-
D. Cota, K. Proulx, K.A. Smith, S.C. Kozma, G. Thomas, S.C. Woods, and R.J. Seeley Hypothalamic mTOR signaling regulates food intake Science 312 2006 927 930
-
(2006)
Science
, vol.312
, pp. 927-930
-
-
Cota, D.1
Proulx, K.2
Smith, K.A.3
Kozma, S.C.4
Thomas, G.5
Woods, S.C.6
Seeley, R.J.7
-
6
-
-
84863535512
-
P70S6 kinase phosphorylates AMPK on serine 491 to mediate leptin's effect on food intake
-
Y. Dagon, E. Hur, B. Zheng, K. Wellenstein, L.C. Cantley, and B.B. Kahn p70S6 kinase phosphorylates AMPK on serine 491 to mediate leptin's effect on food intake Cell Metab. 16 2012 104 112
-
(2012)
Cell Metab.
, vol.16
, pp. 104-112
-
-
Dagon, Y.1
Hur, E.2
Zheng, B.3
Wellenstein, K.4
Cantley, L.C.5
Kahn, B.B.6
-
7
-
-
20344365630
-
Long-term regulation of arterial blood pressure by hypothalamic nuclei: Some critical questions
-
R.A. Dampney, J. Horiuchi, S. Killinger, M.J. Sheriff, P.S. Tan, and L.M. McDowall Long-term regulation of arterial blood pressure by hypothalamic nuclei: some critical questions Clin. Exp. Pharmacol. Physiol. 32 2005 419 425
-
(2005)
Clin. Exp. Pharmacol. Physiol.
, vol.32
, pp. 419-425
-
-
Dampney, R.A.1
Horiuchi, J.2
Killinger, S.3
Sheriff, M.J.4
Tan, P.S.5
McDowall, L.M.6
-
8
-
-
33744990592
-
Critical role for the p110alpha phosphoinositide-3-OH kinase in growth and metabolic regulation
-
L.C. Foukas, M. Claret, W. Pearce, K. Okkenhaug, S. Meek, E. Peskett, S. Sancho, A.J. Smith, D.J. Withers, and B. Vanhaesebroeck Critical role for the p110alpha phosphoinositide-3-OH kinase in growth and metabolic regulation Nature 441 2006 366 370
-
(2006)
Nature
, vol.441
, pp. 366-370
-
-
Foukas, L.C.1
Claret, M.2
Pearce, W.3
Okkenhaug, K.4
Meek, S.5
Peskett, E.6
Sancho, S.7
Smith, A.J.8
Withers, D.J.9
Vanhaesebroeck, B.10
-
9
-
-
33745712914
-
The sympathetic control of blood pressure
-
P.G. Guyenet The sympathetic control of blood pressure Nat. Rev. Neurosci. 7 2006 335 346
-
(2006)
Nat. Rev. Neurosci.
, vol.7
, pp. 335-346
-
-
Guyenet, P.G.1
-
10
-
-
77952893301
-
Obesity-induced hypertension: Role of sympathetic nervous system, leptin, and melanocortins
-
J.E. Hall, A.A. da Silva, J.M. do Carmo, J. Dubinion, S. Hamza, S. Munusamy, G. Smith, and D.E. Stec Obesity-induced hypertension: role of sympathetic nervous system, leptin, and melanocortins J. Biol. Chem. 285 2010 17271 17276
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 17271-17276
-
-
Hall, J.E.1
Da Silva, A.A.2
Do Carmo, J.M.3
Dubinion, J.4
Hamza, S.5
Munusamy, S.6
Smith, G.7
Stec, D.E.8
-
11
-
-
84862777407
-
Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway
-
J.M. Han, S.J. Jeong, M.C. Park, G. Kim, N.H. Kwon, H.K. Kim, S.H. Ha, S.H. Ryu, and S. Kim Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway Cell 149 2012 410 424
-
(2012)
Cell
, vol.149
, pp. 410-424
-
-
Han, J.M.1
Jeong, S.J.2
Park, M.C.3
Kim, G.4
Kwon, N.H.5
Kim, H.K.6
Ha, S.H.7
Ryu, S.H.8
Kim, S.9
-
12
-
-
79954701326
-
Ablation of the leptin receptor in the hypothalamic arcuate nucleus abrogates leptin-induced sympathetic activation
-
S.M. Harlan, D.A. Morgan, K. Agassandian, D.F. Guo, M.D. Cassell, C.D. Sigmund, A.L. Mark, and K. Rahmouni Ablation of the leptin receptor in the hypothalamic arcuate nucleus abrogates leptin-induced sympathetic activation Circ. Res. 108 2011 808 812
-
(2011)
Circ. Res.
, vol.108
, pp. 808-812
-
-
Harlan, S.M.1
Morgan, D.A.2
Agassandian, K.3
Guo, D.F.4
Cassell, M.D.5
Sigmund, C.D.6
Mark, A.L.7
Rahmouni, K.8
-
13
-
-
79953213613
-
Cardiovascular and sympathetic effects of disrupting tyrosine 985 of the leptin receptor
-
S.M. Harlan, D.A. Morgan, D.J. Dellsperger, M.G. Myers Jr., A.L. Mark, and K. Rahmouni Cardiovascular and sympathetic effects of disrupting tyrosine 985 of the leptin receptor Hypertension 57 2011 627 632
-
(2011)
Hypertension
, vol.57
, pp. 627-632
-
-
Harlan, S.M.1
Morgan, D.A.2
Dellsperger, D.J.3
Myers, Jr.M.G.4
Mark, A.L.5
Rahmouni, K.6
-
14
-
-
67650944993
-
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
-
D.E. Harrison, R. Strong, Z.D. Sharp, J.F. Nelson, C.M. Astle, K. Flurkey, N.L. Nadon, J.E. Wilkinson, K. Frenkel, and C.S. Carter Rapamycin fed late in life extends lifespan in genetically heterogeneous mice Nature 460 2009 392 395
-
(2009)
Nature
, vol.460
, pp. 392-395
-
-
Harrison, D.E.1
Strong, R.2
Sharp, Z.D.3
Nelson, J.F.4
Astle, C.M.5
Flurkey, K.6
Nadon, N.L.7
Wilkinson, J.E.8
Frenkel, K.9
Carter, C.S.10
-
15
-
-
4043171462
-
Upstream and downstream of mTOR
-
N. Hay, and N. Sonenberg Upstream and downstream of mTOR Genes Dev. 18 2004 1926 1945
-
(2004)
Genes Dev.
, vol.18
, pp. 1926-1945
-
-
Hay, N.1
Sonenberg, N.2
-
16
-
-
33847038824
-
The growing role of mTOR in neuronal development and plasticity
-
J. Jaworski, and M. Sheng The growing role of mTOR in neuronal development and plasticity Mol. Neurobiol. 34 2006 205 219
-
(2006)
Mol. Neurobiol.
, vol.34
, pp. 205-219
-
-
Jaworski, J.1
Sheng, M.2
-
17
-
-
84859778293
-
MTOR signaling in growth control and disease
-
M. Laplante, and D.M. Sabatini mTOR signaling in growth control and disease Cell 149 2012 274 293
-
(2012)
Cell
, vol.149
, pp. 274-293
-
-
Laplante, M.1
Sabatini, D.M.2
-
18
-
-
33750068623
-
MTOR, translation initiation and cancer
-
Y. Mamane, E. Petroulakis, O. LeBacquer, and N. Sonenberg mTOR, translation initiation and cancer Oncogene 25 2006 6416 6422
-
(2006)
Oncogene
, vol.25
, pp. 6416-6422
-
-
Mamane, Y.1
Petroulakis, E.2
Lebacquer, O.3
Sonenberg, N.4
-
19
-
-
34547121196
-
Amino acids inhibit Agrp gene expression via an mTOR-dependent mechanism
-
C.D. Morrison, X. Xi, C.L. White, J. Ye, and R.J. Martin Amino acids inhibit Agrp gene expression via an mTOR-dependent mechanism Am. J. Physiol. Endocrinol. Metab. 293 2007 E165 E171
-
(2007)
Am. J. Physiol. Endocrinol. Metab.
, vol.293
-
-
Morrison, C.D.1
Xi, X.2
White, C.L.3
Ye, J.4
Martin, R.J.5
-
20
-
-
73349105928
-
Cardiovascular responses to hypothalamic arcuate nucleus stimulation in the rat: Role of sympathetic and vagal efferents
-
T. Nakamura, S. Bhatt, and H.N. Sapru Cardiovascular responses to hypothalamic arcuate nucleus stimulation in the rat: role of sympathetic and vagal efferents Hypertension 54 2009 1369 1375
-
(2009)
Hypertension
, vol.54
, pp. 1369-1375
-
-
Nakamura, T.1
Bhatt, S.2
Sapru, H.N.3
-
21
-
-
63449111894
-
A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance
-
C.B. Newgard, J. An, J.R. Bain, M.J. Muehlbauer, R.D. Stevens, L.F. Lien, A.M. Haqq, S.H. Shah, M. Arlotto, and C.A. Slentz A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance Cell Metab. 9 2009 311 326
-
(2009)
Cell Metab.
, vol.9
, pp. 311-326
-
-
Newgard, C.B.1
An, J.2
Bain, J.R.3
Muehlbauer, M.J.4
Stevens, R.D.5
Lien, L.F.6
Haqq, A.M.7
Shah, S.H.8
Arlotto, M.9
Slentz, C.A.10
-
22
-
-
0035950093
-
Intracellular signalling. Key enzyme in leptin-induced anorexia
-
K.D. Niswender, G.J. Morton, W.H. Stearns, C.J. Rhodes, M.G. Myers Jr., and M.W. Schwartz Intracellular signalling. Key enzyme in leptin-induced anorexia Nature 413 2001 794 795
-
(2001)
Nature
, vol.413
, pp. 794-795
-
-
Niswender, K.D.1
Morton, G.J.2
Stearns, W.H.3
Rhodes, C.J.4
Myers, Jr.M.G.5
Schwartz, M.W.6
-
23
-
-
84859882975
-
The intersection between aging and cardiovascular disease
-
B.J. North, and D.A. Sinclair The intersection between aging and cardiovascular disease Circ. Res. 110 2012 1097 1108
-
(2012)
Circ. Res.
, vol.110
, pp. 1097-1108
-
-
North, B.J.1
Sinclair, D.A.2
-
24
-
-
48749105887
-
Activation of hypothalamic S6 kinase mediates diet-induced hepatic insulin resistance in rats
-
H. Ono, A. Pocai, Y. Wang, H. Sakoda, T. Asano, J.M. Backer, G.J. Schwartz, and L. Rossetti Activation of hypothalamic S6 kinase mediates diet-induced hepatic insulin resistance in rats J. Clin. Invest. 118 2008 2959 2968
-
(2008)
J. Clin. Invest.
, vol.118
, pp. 2959-2968
-
-
Ono, H.1
Pocai, A.2
Wang, Y.3
Sakoda, H.4
Asano, T.5
Backer, J.M.6
Schwartz, G.J.7
Rossetti, L.8
-
25
-
-
36448941416
-
Enhanced leptin-stimulated Pi3k activation in the CNS promotes white adipose tissue transdifferentiation
-
L. Plum, E. Rother, H. Münzberg, F.T. Wunderlich, D.A. Morgan, B. Hampel, M. Shanabrough, R. Janoschek, A.C. Könner, and J. Alber Enhanced leptin-stimulated Pi3k activation in the CNS promotes white adipose tissue transdifferentiation Cell Metab. 6 2007 431 445
-
(2007)
Cell Metab.
, vol.6
, pp. 431-445
-
-
Plum, L.1
Rother, E.2
Münzberg, H.3
Wunderlich, F.T.4
Morgan, D.A.5
Hampel, B.6
Shanabrough, M.7
Janoschek, R.8
Könner, A.C.9
Alber, J.10
-
26
-
-
33847058514
-
Hypothalamic arcuate nucleus mediates the sympathetic and arterial pressure responses to leptin
-
K. Rahmouni, and D.A. Morgan Hypothalamic arcuate nucleus mediates the sympathetic and arterial pressure responses to leptin Hypertension 49 2007 647 652
-
(2007)
Hypertension
, vol.49
, pp. 647-652
-
-
Rahmouni, K.1
Morgan, D.A.2
-
27
-
-
0037338694
-
Intracellular mechanisms involved in leptin regulation of sympathetic outflow
-
K. Rahmouni, W.G. Haynes, D.A. Morgan, and A.L. Mark Intracellular mechanisms involved in leptin regulation of sympathetic outflow Hypertension 41 2003 763 767
-
(2003)
Hypertension
, vol.41
, pp. 763-767
-
-
Rahmouni, K.1
Haynes, W.G.2
Morgan, D.A.3
Mark, A.L.4
-
28
-
-
0038149085
-
Role of melanocortin-4 receptors in mediating renal sympathoactivation to leptin and insulin
-
K. Rahmouni, W.G. Haynes, D.A. Morgan, and A.L. Mark Role of melanocortin-4 receptors in mediating renal sympathoactivation to leptin and insulin J. Neurosci. 23 2003 5998 6004
-
(2003)
J. Neurosci.
, vol.23
, pp. 5998-6004
-
-
Rahmouni, K.1
Haynes, W.G.2
Morgan, D.A.3
Mark, A.L.4
-
29
-
-
62749109421
-
Hypothalamic ERK mediates the anorectic and thermogenic sympathetic effects of leptin
-
K. Rahmouni, C.D. Sigmund, W.G. Haynes, and A.L. Mark Hypothalamic ERK mediates the anorectic and thermogenic sympathetic effects of leptin Diabetes 58 2009 536 542
-
(2009)
Diabetes
, vol.58
, pp. 536-542
-
-
Rahmouni, K.1
Sigmund, C.D.2
Haynes, W.G.3
Mark, A.L.4
-
30
-
-
70350266820
-
The mammalian target of rapamycin as novel central regulator of puberty onset via modulation of hypothalamic Kiss1 system
-
J. Roa, D. Garcia-Galiano, L. Varela, M.A. Sánchez-Garrido, R. Pineda, J.M. Castellano, F. Ruiz-Pino, M. Romero, E. Aguilar, and M. López The mammalian target of rapamycin as novel central regulator of puberty onset via modulation of hypothalamic Kiss1 system Endocrinology 150 2009 5016 5026
-
(2009)
Endocrinology
, vol.150
, pp. 5016-5026
-
-
Roa, J.1
Garcia-Galiano, D.2
Varela, L.3
Sánchez-Garrido, M.A.4
Pineda, R.5
Castellano, J.M.6
Ruiz-Pino, F.7
Romero, M.8
Aguilar, E.9
López, M.10
-
31
-
-
7244247007
-
Collateral damage: Cardiovascular consequences of chronic sympathetic activation with human aging
-
D.R. Seals, and F.A. Dinenno Collateral damage: cardiovascular consequences of chronic sympathetic activation with human aging Am. J. Physiol. Heart Circ. Physiol. 287 2004 H1895 H1905
-
(2004)
Am. J. Physiol. Heart Circ. Physiol.
, vol.287
-
-
Seals, D.R.1
Dinenno, F.A.2
-
32
-
-
70349669095
-
Ribosomal protein S6 kinase 1 signaling regulates mammalian life span
-
C. Selman, J.M. Tullet, D. Wieser, E. Irvine, S.J. Lingard, A.I. Choudhury, M. Claret, H. Al-Qassab, D. Carmignac, and F. Ramadani Ribosomal protein S6 kinase 1 signaling regulates mammalian life span Science 326 2009 140 144
-
(2009)
Science
, vol.326
, pp. 140-144
-
-
Selman, C.1
Tullet, J.M.2
Wieser, D.3
Irvine, E.4
Lingard, S.J.5
Choudhury, A.I.6
Claret, M.7
Al-Qassab, H.8
Carmignac, D.9
Ramadani, F.10
-
33
-
-
77953667219
-
Association of a peripheral blood metabolic profile with coronary artery disease and risk of subsequent cardiovascular events
-
S.H. Shah, J.R. Bain, M.J. Muehlbauer, R.D. Stevens, D.R. Crosslin, C. Haynes, J. Dungan, L.K. Newby, E.R. Hauser, and G.S. Ginsburg Association of a peripheral blood metabolic profile with coronary artery disease and risk of subsequent cardiovascular events Circ. Cardiovasc. Genet. 3 2010 207 214
-
(2010)
Circ. Cardiovasc. Genet.
, vol.3
, pp. 207-214
-
-
Shah, S.H.1
Bain, J.R.2
Muehlbauer, M.J.3
Stevens, R.D.4
Crosslin, D.R.5
Haynes, C.6
Dungan, J.7
Newby, L.K.8
Hauser, E.R.9
Ginsburg, G.S.10
-
34
-
-
84861304175
-
Baseline metabolomic profiles predict cardiovascular events in patients at risk for coronary artery disease
-
e1
-
S.H. Shah, J.L. Sun, R.D. Stevens, J.R. Bain, M.J. Muehlbauer, K.S. Pieper, C. Haynes, E.R. Hauser, W.E. Kraus, and C.B. Granger Baseline metabolomic profiles predict cardiovascular events in patients at risk for coronary artery disease Am. Heart J. 163 2012 844 850 e1
-
(2012)
Am. Heart J.
, vol.163
, pp. 844-850
-
-
Shah, S.H.1
Sun, J.L.2
Stevens, R.D.3
Bain, J.R.4
Muehlbauer, M.J.5
Pieper, K.S.6
Haynes, C.7
Hauser, E.R.8
Kraus, W.E.9
Granger, C.B.10
-
36
-
-
33747690458
-
Activation of mammalian target of rapamycin (mTOR) by insulin is associated with stimulation of 4EBP1 binding to dimeric mTOR complex 1
-
L. Wang, C.J. Rhodes, and J.C. Lawrence Jr. Activation of mammalian target of rapamycin (mTOR) by insulin is associated with stimulation of 4EBP1 binding to dimeric mTOR complex 1 J. Biol. Chem. 281 2006 24293 24303
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 24293-24303
-
-
Wang, L.1
Rhodes, C.J.2
Lawrence, Jr.J.C.3
-
37
-
-
32044465506
-
TOR signaling in growth and metabolism
-
S. Wullschleger, R. Loewith, and M.N. Hall TOR signaling in growth and metabolism Cell 124 2006 471 484
-
(2006)
Cell
, vol.124
, pp. 471-484
-
-
Wullschleger, S.1
Loewith, R.2
Hall, M.N.3
-
38
-
-
84864927001
-
Rapamycin ameliorates age-dependent obesity associated with increased mTOR signaling in hypothalamic POMC neurons
-
S.B. Yang, A.C. Tien, G. Boddupalli, A.W. Xu, Y.N. Jan, and L.Y. Jan Rapamycin ameliorates age-dependent obesity associated with increased mTOR signaling in hypothalamic POMC neurons Neuron 75 2012 425 436
-
(2012)
Neuron
, vol.75
, pp. 425-436
-
-
Yang, S.B.1
Tien, A.C.2
Boddupalli, G.3
Xu, A.W.4
Jan, Y.N.5
Jan, L.Y.6
|