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Volumn 10, Issue 13, 2014, Pages 2033-2044

Cancer stem cells: Are they responsible for treatment failure?

Author keywords

Apoptotic pathways; Cancer stem cells; Chemotherapy; Clonal evolution; CSC derived xenografts; Differentiation; Dna damage repair; Hierarchical model; Self renewal pathways; Survival pathways

Indexed keywords

ANTINEOPLASTIC AGENT;

EID: 84911164257     PISSN: 14796694     EISSN: 17448301     Source Type: Journal    
DOI: 10.2217/FON.14.126     Document Type: Review
Times cited : (12)

References (97)
  • 1
    • 69449096005 scopus 로고    scopus 로고
    • Heterogeneity in cancer: Cancer stem cells versus clonal evolution
    • Shackleton M, Quintana E, Fearon ER, Morrison SJ. Heterogeneity in cancer: cancer stem cells versus clonal evolution. Cell 138 (5), 822-829 (2009).
    • (2009) Cell , vol.138 , Issue.5 , pp. 822-829
    • Shackleton, M.1    Quintana, E.2    Fearon, E.R.3    Morrison, S.J.4
  • 2
    • 2042435768 scopus 로고
    • Totipotency and normal differentiation of single teratocarcinoma cells cloned by injection into blastocysts
    • Illmensee K, Mintz B. Totipotency and normal differentiation of single teratocarcinoma cells cloned by injection into blastocysts. Proc. Natl Acad. Sci. USA 73 (2), 549-553 (1976).
    • (1976) Proc. Natl Acad. Sci. USA , vol.73 , Issue.2 , pp. 549-553
    • Illmensee, K.1    Mintz, B.2
  • 3
    • 0022613519 scopus 로고
    • Differentiation of leukemia cells to polymorphonuclear leukocytes in patients with acute nonlymphocytic leukemia
    • Fearon ER, Burke PJ, Schiffer CA, Zehnbauer BA, Vogelstein B. Differentiation of leukemia cells to polymorphonuclear leukocytes in patients with acute nonlymphocytic leukemia. N. Engl. J. Med. 315 (1), 15-24 (1986).
    • (1986) N. Engl. J. Med. , vol.315 , Issue.1 , pp. 15-24
    • Fearon, E.R.1    Burke, P.J.2    Schiffer, C.A.3    Zehnbauer, B.A.4    Vogelstein, B.5
  • 4
    • 0030789242 scopus 로고    scopus 로고
    • Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
    • Bonnet D, Dick JE. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat. Med. 3 (7), 730-737 (1997).
    • (1997) Nat. Med. , vol.3 , Issue.7 , pp. 730-737
    • Bonnet, D.1    Dick, J.E.2
  • 6
    • 33846095137 scopus 로고    scopus 로고
    • Identification and expansion of human colon-cancer-initiating cells
    • Ricci-Vitiani L, Lombardi DG, Pilozzi E et al. Identification and expansion of human colon-cancer-initiating cells. Nature 445 (7123), 111-115 (2007).
    • (2007) Nature , vol.445 , Issue.7123 , pp. 111-115
    • Ricci-Vitiani, L.1    Lombardi, D.G.2    Pilozzi, E.3
  • 7
    • 39449088496 scopus 로고    scopus 로고
    • Identification and expansion of the tumorigenic lung cancer stem cell population
    • Eramo A, Lotti F, Sette G et al. Identification and expansion of the tumorigenic lung cancer stem cell population. Cell Death Differ. 15 (3), 504-514 (2008).
    • (2008) Cell Death Differ. , vol.15 , Issue.3 , pp. 504-514
    • Eramo, A.1    Lotti, F.2    Sette, G.3
  • 8
    • 9244241576 scopus 로고    scopus 로고
    • Identification of human brain tumour initiating cells
    • Singh SK, Hawkins C, Clarke ID et al. Identification of human brain tumour initiating cells. Nature 432 (7015), 396-401 (2004).
    • (2004) Nature , vol.432 , Issue.7015 , pp. 396-401
    • Singh, S.K.1    Hawkins, C.2    Clarke, I.D.3
  • 9
    • 78449281896 scopus 로고    scopus 로고
    • Tumorigenic and metastatic activity of human thyroid cancer stem cells
    • Todaro M, Iovino F, Eterno V. Tumorigenic and metastatic activity of human thyroid cancer stem cells. Cancer Res. 70 (21), 8874-8885 (2010).
    • (2010) Cancer Res. , vol.70 , Issue.21 , pp. 8874-8885
    • Todaro, M.1    Iovino, F.2    Eterno, V.3
  • 10
    • 33846512398 scopus 로고    scopus 로고
    • Identification of a subpopulation of cells with cancer stem cell properties inhead and neck squamous cell carcinoma
    • Prince ME, Sivanandan R, Kaczorowski A et al. Identification of a subpopulation of cells with cancer stem cell properties inhead and neck squamous cell carcinoma. Proc. Natl Acad. Sci. USA 104 (3), 973-978 (2007).
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , Issue.3 , pp. 973-978
    • Prince, M.E.1    Sivanandan, R.2    Kaczorowski, A.3
  • 11
    • 33847052127 scopus 로고    scopus 로고
    • Identification of pancreatic cancer stem cells
    • Li C, Heidt DG, Dalerba P et al. Identification of pancreatic cancer stem cells. Cancer Res. 67 (3), 1030-1037 (2007).
    • (2007) Cancer Res. , vol.67 , Issue.3 , pp. 1030-1037
    • Li, C.1    Heidt, D.G.2    Dalerba, P.3
  • 12
    • 28244472369 scopus 로고    scopus 로고
    • Prospective identification of tumorigenic prostate cancer stem cells
    • Collins AT, Berry PA, Hyde C, Stower MJ, Maitland NJ. Prospective identification of tumorigenic prostate cancer stem cells. Cancer Res. 65 (23), 10946-10951 (2005).
    • (2005) Cancer Res. , vol.65 , Issue.23 , pp. 10946-10951
    • Collins, A.T.1    Berry, P.A.2    Hyde, C.3    Stower, M.J.4    Maitland, N.J.5
  • 13
    • 77952240931 scopus 로고    scopus 로고
    • + cells from hierarchically organized ovarian cancer are enriched in cancer stem cells
    • + cells from hierarchically organized ovarian cancer are enriched in cancer stem cells. Oncogene 29 (18), 2672-2680 (2010).
    • (2010) Oncogene , vol.29 , Issue.18 , pp. 2672-2680
    • Gao, M.Q.1    Choi, Y.P.2    Kang, S.3    Youn, J.H.4    Cho, N.H.5
  • 14
    • 84856013431 scopus 로고    scopus 로고
    • Clonal evolution in cancer
    • Greaves M, Maley CC. Clonal evolution in cancer. Nature 481(7381), 306-313 (2012).
    • (2012) Nature , vol.481 , Issue.7381 , pp. 306-313
    • Greaves, M.1    Maley, C.C.2
  • 15
    • 33747195353 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
    • Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126 (4), 663-676 (2006).
    • (2006) Cell , vol.126 , Issue.4 , pp. 663-676
    • Takahashi, K.1    Yamanaka, S.2
  • 16
    • 43049165453 scopus 로고    scopus 로고
    • The epithelial-mesenchymal transition generates cells with properties of stem cells
    • Mani SA, Guo W, Liao MJ et al. The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell 133 (4), 704-715 (2008).
    • (2008) Cell , vol.133 , Issue.4 , pp. 704-715
    • Mani, S.A.1    Guo, W.2    Liao, M.J.3
  • 17
    • 77951975325 scopus 로고    scopus 로고
    • Wnt activity defines colon cancer stem cells and is regulated by the microenvironment
    • Vermeulen L, De Sousa E Melo F, van der Heijden M et al. Wnt activity defines colon cancer stem cells and is regulated by the microenvironment. Nat. Cell Biol. 12 (5), 468-476 (2010).
    • (2010) Nat. Cell Biol. , vol.12 , Issue.5 , pp. 468-476
    • Vermeulen, L.1    De Sousa, E.2    Melo, F.3    Van Der Heijden, M.4
  • 18
    • 65749106405 scopus 로고    scopus 로고
    • Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells
    • Li Z, Bao S, Wu Q et al. Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells. Cancer Cell 15 (5), 501-513 (2009).
    • (2009) Cancer Cell , vol.15 , Issue.5 , pp. 501-513
    • Li, Z.1    Bao, S.2    Wu, Q.3
  • 19
    • 79954423356 scopus 로고    scopus 로고
    • Acidic stress promotes a glioma stem cell phenotype
    • Hjelmeland AB, Wu Q, Heddleston JM et al. Acidic stress promotes a glioma stem cell phenotype. Cell Death Differ. 18 (5), 829-840 (2011).
    • (2011) Cell Death Differ. , vol.18 , Issue.5 , pp. 829-840
    • Hjelmeland, A.B.1    Wu, Q.2    Heddleston, J.M.3
  • 20
    • 84896115102 scopus 로고    scopus 로고
    • CD44v6 is a marker of constitutive and reprogrammed cancer stem cells driving colon cancer metastasis
    • Todaro M, Gaggianesi M, Catalano V et al. CD44v6 is a marker of constitutive and reprogrammed cancer stem cells driving colon cancer metastasis. Cell Stem Cell 14(3), 342-356 (2014).
    • (2014) Cell Stem Cell , vol.14 , Issue.3 , pp. 342-356
    • Todaro, M.1    Gaggianesi, M.2    Catalano, V.3
  • 21
    • 77952330272 scopus 로고    scopus 로고
    • Intratumoral hypoxic gradient drives stem cells distribution and MGMT expression in glioblastoma
    • Pistollato F, Abbadi S, Rampazzo E et al. Intratumoral hypoxic gradient drives stem cells distribution and MGMT expression in glioblastoma. Stem Cells 28 (5), 851-862 (2010).
    • (2010) Stem Cells , vol.28 , Issue.5 , pp. 851-862
    • Pistollato, F.1    Abbadi, S.2    Rampazzo, E.3
  • 22
    • 33748051406 scopus 로고    scopus 로고
    • Stem cell-like glioma cells promote tumor angiogenesis through vascular endothelial growth factor
    • Bao S, Wu Q, Sathornsumetee S et al. Stem cell-like glioma cells promote tumor angiogenesis through vascular endothelial growth factor. Cancer Res. 66 (16), 7843-7848 (2006).
    • (2006) Cancer Res. , vol.66 , Issue.16 , pp. 7843-7848
    • Bao, S.1    Wu, Q.2    Sathornsumetee, S.3
  • 23
    • 78650098659 scopus 로고    scopus 로고
    • Glioblastoma stem-like cells give rise to tumour endothelium
    • Wang R, Chadalavada K, Wilshire J et al. Glioblastoma stem-like cells give rise to tumour endothelium. Nature 468 (7325), 829-833 (2010).
    • (2010) Nature , vol.468 , Issue.7325 , pp. 829-833
    • Wang, R.1    Chadalavada, K.2    Wilshire, J.3
  • 24
    • 78650153633 scopus 로고    scopus 로고
    • Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells
    • Ricci-Vitiani L, Pallini R, Biffoni M et al. Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells. Nature 468 (7325), 824-828 (2010).
    • (2010) Nature , vol.468 , Issue.7325 , pp. 824-828
    • Ricci-Vitiani, L.1    Pallini, R.2    Biffoni, M.3
  • 25
    • 49949099841 scopus 로고    scopus 로고
    • Mesenchymal differentiation of glioblastoma stem cells
    • Ricci-Vitiani L, Pallini R, Larocca LM. Mesenchymal differentiation of glioblastoma stem cells. Cell Death Differ. 15 (9), 1491-1498 (2008).
    • (2008) Cell Death Differ. , vol.15 , Issue.9 , pp. 1491-1498
    • Ricci-Vitiani, L.1    Pallini, R.2    Larocca, L.M.3
  • 27
    • 73149110562 scopus 로고    scopus 로고
    • Biological and molecular heterogeneity of breast cancers correlates with their cancer stem cell content
    • Pece S, Tosoni D, Confalonieri S et al. Biological and molecular heterogeneity of breast cancers correlates with their cancer stem cell content. Cell 140 (1), 62-73 (2010).
    • (2010) Cell , vol.140 , Issue.1 , pp. 62-73
    • Pece, S.1    Tosoni, D.2    Confalonieri, S.3
  • 29
    • 80053904142 scopus 로고    scopus 로고
    • Distinct types of tumor-initiating cells form human colon cancer tumors and metastases
    • Dieter SM, Ball CR, Hoffmann CM et al. Distinct types of tumor-initiating cells form human colon cancer tumors and metastases. Cell Stem Cell 9 (4), 357-365 (2011).
    • (2011) Cell Stem Cell , vol.9 , Issue.4 , pp. 357-365
    • Dieter, S.M.1    Ball, C.R.2    Hoffmann, C.M.3
  • 30
    • 65049084510 scopus 로고    scopus 로고
    • Distinct pools of cancer stem-like cells coexist within human glioblastomas and display different tumorigenicity and independent genomic evolution
    • Piccirillo SG, Combi R, Cajola L et al. Distinct pools of cancer stem-like cells coexist within human glioblastomas and display different tumorigenicity and independent genomic evolution. Oncogene 28 (15), 1807-1811 (2009).
    • (2009) Oncogene , vol.28 , Issue.15 , pp. 1807-1811
    • Piccirillo, S.G.1    Combi, R.2    Cajola, L.3
  • 31
    • 78751644099 scopus 로고    scopus 로고
    • Genetic variegation of clonal architecture and propagating cells in leukaemia
    • Anderson K, Lutz C, van Delft FW et al. Genetic variegation of clonal architecture and propagating cells in leukaemia. Nature 469 (7330), 356-361 (2011).
    • (2011) Nature , vol.469 , Issue.7330 , pp. 356-361
    • Anderson, K.1    Lutz, C.2    Van Delft, F.W.3
  • 32
    • 78751661556 scopus 로고    scopus 로고
    • Evolution of human BCR-ABL1 lymphoblastic leukaemia-initiating cells
    • Notta F, Mullighan CG, Wang JC et al. Evolution of human BCR-ABL1 lymphoblastic leukaemia-initiating cells. Nature 469 (7330), 362-367 (2011).
    • (2011) Nature , vol.469 , Issue.7330 , pp. 362-367
    • Notta, F.1    Mullighan, C.G.2    Wang, J.C.3
  • 35
    • 33845317573 scopus 로고    scopus 로고
    • Glioma stem cells promote radioresistance by preferential activation of the DNA damage response
    • Bao S, Wu Q, McLendon RE et al. Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature 444 (7120), 756-760 (2006).
    • (2006) Nature , vol.444 , Issue.7120 , pp. 756-760
    • Bao, S.1    Wu, Q.2    McLendon, R.E.3
  • 36
    • 84859611140 scopus 로고    scopus 로고
    • Therapeutic targeting of Chk1 in NSCLC stem cells during chemotherapy
    • Bartucci M, Svensson S, Romania P et al. Therapeutic targeting of Chk1 in NSCLC stem cells during chemotherapy. Cell Death Differ. 19(5), 768-778 ( 2012).
    • (2012) Cell Death Differ. , vol.19 , Issue.5 , pp. 768-778
    • Bartucci, M.1    Svensson, S.2    Romania, P.3
  • 38
    • 84875131206 scopus 로고    scopus 로고
    • A pan-BCL2 inhibitor renders bone-marrowresident human leukemia stem cells sensitive to tyrosine kinase inhibition
    • Goff DJ, Recart AC, Sadarangani A et al. A pan-BCL2 inhibitor renders bone-marrowresident human leukemia stem cells sensitive to tyrosine kinase inhibition. Cell Stem Cell 12(3), 316-328 (2013).
    • (2013) Cell Stem Cell , vol.12 , Issue.3 , pp. 316-328
    • Goff, D.J.1    Recart, A.C.2    Sadarangani, A.3
  • 39
    • 34848866647 scopus 로고    scopus 로고
    • Colon cancer stem cells dictate tumor growth and resist cell death by production of interleukin-4
    • Todaro M, Alea MP, Di Stefano AB et al. Colon cancer stem cells dictate tumor growth and resist cell death by production of interleukin-4. Cell Stem Cell 1 (4), 389-402 (2007).
    • (2007) Cell Stem Cell , vol.1 , Issue.4 , pp. 389-402
    • Todaro, M.1    Alea, M.P.2    Di Stefano, A.B.3
  • 41
    • 84867306379 scopus 로고    scopus 로고
    • EGFR inhibition abrogates leiomyosarcoma cell chemoresistance through inactivation of survival pathways and impairment of CSC potential
    • Sette G, Salvati V, Memeo L et al. EGFR inhibition abrogates leiomyosarcoma cell chemoresistance through inactivation of survival pathways and impairment of CSC potential. PLoS ONE 7(10), e46891 (2012).
    • (2012) PLoS ONE , vol.7 , Issue.10 , pp. e46891
    • Sette, G.1    Salvati, V.2    Memeo, L.3
  • 42
    • 33846237601 scopus 로고    scopus 로고
    • HEDGEHOG-GLI1 signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicity
    • Clement V, Sanchez P, de Tribolet N, Radovanovic I, Ruiz i Altaba A. HEDGEHOG-GLI1 signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicity. Curr. Biol. 17 (2), 165-172 (2007).
    • (2007) Curr. Biol. , vol.17 , Issue.2 , pp. 165-172
    • Clement, V.1    Sanchez, P.2    De Tribolet, N.3    Radovanovic, I.4    Ruiz I Altaba, A.5
  • 43
    • 84869176553 scopus 로고    scopus 로고
    • Cyclopamine cooperates with EGFR inhibition to deplete stem-like cancer cells in glioblastoma-derived spheroid cultures
    • Eimer S, Dugay F, Airiau K et al. Cyclopamine cooperates with EGFR inhibition to deplete stem-like cancer cells in glioblastoma-derived spheroid cultures. Neuro Oncol. 14(12), 1441-1451 (2012).
    • (2012) Neuro Oncol. , vol.14 , Issue.12 , pp. 1441-1451
    • Eimer, S.1    Dugay, F.2    Airiau, K.3
  • 44
    • 84866021276 scopus 로고    scopus 로고
    • Suppression of acquired docetaxel resistance in prostate cancer through depletion of Notch- and Hedgehogdependent tumor-initiating cells
    • Domingo-Domenech J, Vidal SJ, Rodriguez-Bravo V et al. Suppression of acquired docetaxel resistance in prostate cancer through depletion of Notch- and Hedgehogdependent tumor-initiating cells. Cancer Cell 22(3), 373-388 (2012).
    • (2012) Cancer Cell , vol.22 , Issue.3 , pp. 373-388
    • Domingo-Domenech, J.1    Vidal, S.J.2    Rodriguez-Bravo, V.3
  • 45
    • 80755141299 scopus 로고    scopus 로고
    • Nodal/Activin signaling drives self-renewal and tumorigenicity of pancreatic cancer stem cells and provides a target for combined drug therapy
    • Lonardo E, Hermann PC, Mueller MT et al. Nodal/Activin signaling drives self-renewal and tumorigenicity of pancreatic cancer stem cells and provides a target for combined drug therapy. Cell Stem Cell 9 (5), 433-446 (2011).
    • (2011) Cell Stem Cell , vol.9 , Issue.5 , pp. 433-446
    • Lonardo, E.1    Hermann, P.C.2    Mueller, M.T.3
  • 47
    • 62549096930 scopus 로고    scopus 로고
    • Tumor-initiating cells of HER2-positive carcinoma cell lines express the highest oncoprotein levels and are sensitive to trastuzumab
    • Magnifico A, Albano L, Campaner S et al. Tumor-initiating cells of HER2-positive carcinoma cell lines express the highest oncoprotein levels and are sensitive to trastuzumab. Clin. Cancer Res. 15 (6), 2010-2021 (2009).
    • (2009) Clin. Cancer Res. , vol.15 , Issue.6 , pp. 2010-2021
    • Magnifico, A.1    Albano, L.2    Campaner, S.3
  • 48
    • 79952240423 scopus 로고    scopus 로고
    • Anti-DLL4 inhibits growth and reduces tumor-initiating cell frequency in colorectal tumors with oncogenic KRAS mutations
    • Fischer M, Yen WC, Kapoun AM et al. Anti-DLL4 inhibits growth and reduces tumor-initiating cell frequency in colorectal tumors with oncogenic KRAS mutations. Cancer Res. 71(5), 1520-1525 (2011).
    • (2011) Cancer Res. , vol.71 , Issue.5 , pp. 1520-1525
    • Fischer, M.1    Yen, W.C.2    Kapoun, A.M.3
  • 49
    • 79961170670 scopus 로고    scopus 로고
    • Regulation of glioblastoma stem cells by retinoic acid: Role for Notch pathway inhibition
    • Ying M, Wang S, Sang Y et al. Regulation of glioblastoma stem cells by retinoic acid: role for Notch pathway inhibition. Oncogene 30 (31), 3454-3467 (2011).
    • (2011) Oncogene , vol.30 , Issue.31 , pp. 3454-3467
    • Ying, M.1    Wang, S.2    Sang, Y.3
  • 51
    • 33845610993 scopus 로고    scopus 로고
    • Bone morphogenetic proteins inhibit the tumorigenic potential of human brain tumourinitiating cells
    • Piccirillo SG, Reynolds BA, Zanetti N et al. Bone morphogenetic proteins inhibit the tumorigenic potential of human brain tumourinitiating cells. Nature 444 (7120), 761-765 (2006).
    • (2006) Nature , vol.444 , Issue.7120 , pp. 761-765
    • Piccirillo, S.G.1    Reynolds, B.A.2    Zanetti, N.3
  • 52
    • 84866116474 scopus 로고    scopus 로고
    • A BMP7 variant inhibits the tumorigenic potential of glioblastoma stem-like cells
    • Tate CM, Pallini R, Ricci-Vitiani L et al. A BMP7 variant inhibits the tumorigenic potential of glioblastoma stem-like cells. Cell Death Differ. 19(10), 1644-1654 (2012).
    • (2012) Cell Death Differ. , vol.19 , Issue.10 , pp. 1644-1654
    • Tate, C.M.1    Pallini, R.2    Ricci-Vitiani, L.3
  • 53
    • 84870481111 scopus 로고    scopus 로고
    • BMP2 sensitizes glioblastoma stem-like cells to temozolomide by affecting HIF-1α stability and MGMT expression
    • Persano L, Pistollato F, Rampazzo E et al. BMP2 sensitizes glioblastoma stem-like cells to temozolomide by affecting HIF-1α stability and MGMT expression. Cell Death Dis. 3, e412 (2012).
    • (2012) Cell Death Dis. , vol.3 , pp. e412
    • Persano, L.1    Pistollato, F.2    Rampazzo, E.3
  • 54
    • 84896725037 scopus 로고    scopus 로고
    • BMP signaling induces astrocytic differentiation of clinically derived oligodendroglioma propagating cells
    • Srikanth M, Kim J, Das S, Kessler JA. BMP signaling induces astrocytic differentiation of clinically derived oligodendroglioma propagating cells. Mol. Cancer Res. 12(2), 283-294 (2014).
    • (2014) Mol. Cancer Res. , vol.12 , Issue.2 , pp. 283-294
    • Srikanth, M.1    Kim, J.2    Das, S.3    Kessler, J.A.4
  • 55
    • 78650448449 scopus 로고    scopus 로고
    • Bone morphogenetic protein 4 induces differentiation of colorectal cancer stem cells and increases their response to chemotherapy in mice
    • Lombardo Y, Scopelliti A, Cammareri P et al. Bone morphogenetic protein 4 induces differentiation of colorectal cancer stem cells and increases their response to chemotherapy in mice. Gastroenterology 140 (1), 297-309 (2011).
    • (2011) Gastroenterology , vol.140 , Issue.1 , pp. 297-309
    • Lombardo, Y.1    Scopelliti, A.2    Cammareri, P.3
  • 56
    • 80053557393 scopus 로고    scopus 로고
    • Statins augment the chemosensitivity of colorectal cancer cells inducing epigenetic reprogramming and reducing colorectal cancer cell 'stemness' via the bone morphogenetic protein pathway
    • Kodach LL, Jacobs RJ, Voorneveld PW et al. Statins augment the chemosensitivity of colorectal cancer cells inducing epigenetic reprogramming and reducing colorectal cancer cell 'stemness' via the bone morphogenetic protein pathway. Gut 60 (11), 1544-1553 (2011).
    • (2011) Gut , vol.60 , Issue.11 , pp. 1544-1553
    • Kodach, L.L.1    Jacobs, R.J.2    Voorneveld, P.W.3
  • 57
    • 0035902108 scopus 로고    scopus 로고
    • Genome maintenance mechanisms for preventing cancer
    • Hoeijmakers JH. Genome maintenance mechanisms for preventing cancer. Nature 411 (6835), 366-374 (2001).
    • (2001) Nature , vol.411 , Issue.6835 , pp. 366-374
    • Hoeijmakers, J.H.1
  • 58
  • 59
    • 84876961320 scopus 로고    scopus 로고
    • Checkpoint kinase 1 inhibitors for potentiating systemic anticancer therapy
    • Maugeri-Saccà M, Bartucci M, De Maria R. Checkpoint kinase 1 inhibitors for potentiating systemic anticancer therapy. Cancer Treat. Rev. 39(5), 525-533 (2013).
    • (2013) Cancer Treat. Rev. , vol.39 , Issue.5 , pp. 525-533
    • Maugeri-Saccà, M.1    Bartucci, M.2    De Maria, R.3
  • 60
    • 49649085001 scopus 로고    scopus 로고
    • Identification of tumor-initiating cells in a p53-null mouse model of breast cancer
    • Zhang M, Behbod F, Atkinson RL et al. Identification of tumor-initiating cells in a p53-null mouse model of breast cancer. Cancer Res. 68 (12), 4674-4682 (2008).
    • (2008) Cancer Res. , vol.68 , Issue.12 , pp. 4674-4682
    • Zhang, M.1    Behbod, F.2    Atkinson, R.L.3
  • 61
    • 84890723104 scopus 로고    scopus 로고
    • Biological and clinical implications of cancer stem cells in primary brain tumors
    • Maugeri-Saccà M, Di Martino S, De Maria R. Biological and clinical implications of cancer stem cells in primary brain tumors. Front. Oncol. 3, 6 (2013).
    • (2013) Front. Oncol. , vol.3 , pp. 6
    • Maugeri-Saccà, M.1    Di Martino, S.2    De Maria, R.3
  • 62
  • 63
    • 79251519687 scopus 로고    scopus 로고
    • Extent and patterns of MGMT promoter methylation in glioblastoma- and respective glioblastoma-derived spheres
    • Sciuscio D, Diserens AC, van Dommelen K et al. Extent and patterns of MGMT promoter methylation in glioblastoma- and respective glioblastoma-derived spheres. Clin. Cancer Res. 17 (2), 255-266 (2011).
    • (2011) Clin. Cancer Res. , vol.17 , Issue.2 , pp. 255-266
    • Sciuscio, D.1    Diserens, A.C.2    Van Dommelen, K.3
  • 64
    • 84876094075 scopus 로고    scopus 로고
    • Targeting apoptosis pathways in cancer stem cells
    • Signore M, Ricci-Vitiani L, De Maria R. Targeting apoptosis pathways in cancer stem cells. Cancer Lett. 332(2), 374-382 (2013).
    • (2013) Cancer Lett. , vol.332 , Issue.2 , pp. 374-382
    • Signore, M.1    Ricci-Vitiani, L.2    De Maria, R.3
  • 65
    • 79960230433 scopus 로고    scopus 로고
    • Mitochondria in apoptosis: Bcl-2 family members and mitochondrial dynamics
    • Martinou JC, Youle RJ. Mitochondria in apoptosis: Bcl-2 family members and mitochondrial dynamics. Dev. Cell 21 (1), 92-101 (2011).
    • (2011) Dev. Cell , vol.21 , Issue.1 , pp. 92-101
    • Martinou, J.C.1    Youle, R.J.2
  • 66
    • 80052594392 scopus 로고    scopus 로고
    • BikDD eliminates breast cancer initiating cells and synergizes with lapatinib for breast cancer treatment
    • Lang JY, Hsu JL, Meric-Bernstam F et al. BikDD eliminates breast cancer initiating cells and synergizes with lapatinib for breast cancer treatment. Cancer Cell 20 (3), 341-356 (2011).
    • (2011) Cancer Cell , vol.20 , Issue.3 , pp. 341-356
    • Lang, J.Y.1    Hsu, J.L.2    Meric-Bernstam, F.3
  • 67
    • 40949107635 scopus 로고    scopus 로고
    • Apoptosis resistance in epithelial tumors is mediated by tumor-cell-derived interleukin-4
    • Todaro M, Lombardo Y, Francipane MG et al. Apoptosis resistance in epithelial tumors is mediated by tumor-cell-derived interleukin-4. Cell Death Differ. 15 (4), 762-772 (2008).
    • (2008) Cell Death Differ. , vol.15 , Issue.4 , pp. 762-772
    • Todaro, M.1    Lombardo, Y.2    Francipane, M.G.3
  • 68
    • 84865401715 scopus 로고    scopus 로고
    • + breast cancer by expanding the cancer stem cell population
    • + breast cancer by expanding the cancer stem cell population. Mol. Cell 47(4), 570-584 (2012).
    • (2012) Mol. Cell , vol.47 , Issue.4 , pp. 570-584
    • Korkaya, H.1    Kim, G.I.2    Davis, A.3
  • 69
    • 84874650275 scopus 로고    scopus 로고
    • Development of PI3K inhibitors: Lessons learned from early clinical trials
    • Rodon J, Dienstmann R, Serra V, Tabernero J. Development of PI3K inhibitors: lessons learned from early clinical trials. Nat. Rev. Clin. Oncol. 10(3), 143-153 (2013).
    • (2013) Nat. Rev. Clin. Oncol. , vol.10 , Issue.3 , pp. 143-153
    • Rodon, J.1    Dienstmann, R.2    Serra, V.3    Tabernero, J.4
  • 70
    • 84887148630 scopus 로고    scopus 로고
    • Erythropoietin activates cell survival pathways in breast cancer stem-like cells to protect them from chemotherapy
    • Todaro M, Turdo A, Bartucci M et al. Erythropoietin activates cell survival pathways in breast cancer stem-like cells to protect them from chemotherapy. Cancer Res. 73(21), 6393-6400 (2013).
    • (2013) Cancer Res. , vol.73 , Issue.21 , pp. 6393-6400
    • Todaro, M.1    Turdo, A.2    Bartucci, M.3
  • 71
    • 65449117261 scopus 로고    scopus 로고
    • Recombinant human erythropoiesisstimulating agents and mortality in patients with cancer: A meta-analysis of randomised trials
    • Bohlius J, Schmidlin K, Brillant C et al. Recombinant human erythropoiesisstimulating agents and mortality in patients with cancer: a meta-analysis of randomised trials. Lancet 373 (9674), 1532-1542 (2009).
    • (2009) Lancet , vol.373 , Issue.9674 , pp. 1532-1542
    • Bohlius, J.1    Schmidlin, K.2    Brillant, C.3
  • 72
    • 84865341013 scopus 로고    scopus 로고
    • Proliferation state and polo-like kinase1 dependence of tumorigenic colon cancer cells
    • Francescangeli F, Patrizii M, Signore M et al. Proliferation state and polo-like kinase1 dependence of tumorigenic colon cancer cells. Stem Cells 30 (9), 1819-1830 (2012).
    • (2012) Stem Cells , vol.30 , Issue.9 , pp. 1819-1830
    • Francescangeli, F.1    Patrizii, M.2    Signore, M.3
  • 73
    • 70349238733 scopus 로고    scopus 로고
    • Inhibition of the Hedgehog pathway in advanced basal-cell carcinoma
    • Von Hoff DD, LoRusso PM, Rudin CM et al. Inhibition of the Hedgehog pathway in advanced basal-cell carcinoma. N. Engl. J. Med. 361 (12), 1164-1172 (2009).
    • (2009) N. Engl. J. Med. , vol.361 , Issue.12 , pp. 1164-1172
    • Von Hoff, D.D.1    LoRusso, P.M.2    Rudin, C.M.3
  • 74
    • 70349244812 scopus 로고    scopus 로고
    • Treatment of medulloblastoma with Hedgehog pathway inhibitor GDC-0449
    • Rudin CM, Hann CL, Laterra J et al. Treatment of medulloblastoma with Hedgehog pathway inhibitor GDC-0449. N. Engl. J. Med. 361 (12), 1173-1178 (2009).
    • (2009) N. Engl. J. Med. , vol.361 , Issue.12 , pp. 1173-1178
    • Rudin, C.M.1    Hann, C.L.2    Laterra, J.3
  • 75
    • 84870366661 scopus 로고    scopus 로고
    • A Phase II, randomized, placebo-controlled study of vismodegib as maintenance therapy in patients with ovarian cancer in second or third complete remission
    • Kaye SB, Fehrenbacher L, Holloway R et al. A Phase II, randomized, placebo-controlled study of vismodegib as maintenance therapy in patients with ovarian cancer in second or third complete remission. Clin. Cancer Res. 18(23), 6509-6518 (2012).
    • (2012) Clin. Cancer Res. , vol.18 , Issue.23 , pp. 6509-6518
    • Kaye, S.B.1    Fehrenbacher, L.2    Holloway, R.3
  • 76
    • 84887512714 scopus 로고    scopus 로고
    • Unraveling the therapeutic potential of the Hedgehog pathway in cancer
    • Amakye D, Jagani Z, Dorsch M. Unraveling the therapeutic potential of the Hedgehog pathway in cancer. Nat. Med. 19(11), 1410-1422 (2013).
    • (2013) Nat. Med. , vol.19 , Issue.11 , pp. 1410-1422
    • Amakye, D.1    Jagani, Z.2    Dorsch, M.3
  • 77
    • 84875168492 scopus 로고    scopus 로고
    • Preclinical and clinical studies of gamma secretase inhibitors with docetaxel on human breast tumors
    • Schott AF, Landis MD, Dontu G et al. Preclinical and clinical studies of gamma secretase inhibitors with docetaxel on human breast tumors. Clin. Cancer Res. 19(6), 1512-1524 (2013).
    • (2013) Clin. Cancer Res. , vol.19 , Issue.6 , pp. 1512-1524
    • Schott, A.F.1    Landis, M.D.2    Dontu, G.3
  • 78
    • 75349105363 scopus 로고    scopus 로고
    • NOTCH pathway blockade depletes CD133-positive glioblastoma cells and inhibits growth of tumor neurospheres and xenografts
    • Fan X, Khaki L, Zhu TS et al. NOTCH pathway blockade depletes CD133-positive glioblastoma cells and inhibits growth of tumor neurospheres and xenografts. Stem Cells 28 (1), 5-16 (2010).
    • (2010) Stem Cells , vol.28 , Issue.1 , pp. 5-16
    • Fan, X.1    Khaki, L.2    Zhu, T.S.3
  • 79
    • 80052795862 scopus 로고    scopus 로고
    • Endothelial cells create a stem cell niche in glioblastoma by providing NOTCH ligands that nurture self-renewal of cancer stem-like cells
    • Zhu TS, Costello MA, Talsma CE et al. Endothelial cells create a stem cell niche in glioblastoma by providing NOTCH ligands that nurture self-renewal of cancer stem-like cells. Cancer Res. 71 (18), 6061-6072 (2011).
    • (2011) Cancer Res. , vol.71 , Issue.18 , pp. 6061-6072
    • Zhu, T.S.1    Costello, M.A.2    Talsma, C.E.3
  • 80
    • 76749157186 scopus 로고    scopus 로고
    • Chronic DLL4 blockade induces vascular neoplasms
    • Yan M, Callahan CA, Beyer JC et al. Chronic DLL4 blockade induces vascular neoplasms. Nature 463 (7282), E6-E7 (2010).
    • (2010) Nature , vol.463 , Issue.7282 , pp. E6-E7
    • Yan, M.1    Callahan, C.A.2    Beyer, J.C.3
  • 81
    • 84864005118 scopus 로고    scopus 로고
    • Phase I pharmacologic and pharmacodynamic study of the gamma secretase (Notch) inhibitor MK-0752 in adult patients with advanced solid tumors
    • Krop I, Demuth T, Guthrie T et al. Phase I pharmacologic and pharmacodynamic study of the gamma secretase (Notch) inhibitor MK-0752 in adult patients with advanced solid tumors. J. Clin. Oncol. 30(19), 2307-2313 (2012).
    • (2012) J. Clin. Oncol. , vol.30 , Issue.19 , pp. 2307-2313
    • Krop, I.1    Demuth, T.2    Guthrie, T.3
  • 82
    • 81055140859 scopus 로고    scopus 로고
    • The Hippo transducer TAZ confers cancer stem cell-related traits on breast cancer cells
    • Cordenonsi M, Zanconato F, Azzolin L et al. The Hippo transducer TAZ confers cancer stem cell-related traits on breast cancer cells. Cell 147 (4), 759-772 (2011).
    • (2011) Cell , vol.147 , Issue.4 , pp. 759-772
    • Cordenonsi, M.1    Zanconato, F.2    Azzolin, L.3
  • 83
    • 84893721816 scopus 로고    scopus 로고
    • TAZ is required for metastatic activity and chemoresistance of breast cancer stem cells
    • (Epub ahead of print)
    • Bartucci M, Dattilo R, Moriconi C et al. TAZ is required for metastatic activity and chemoresistance of breast cancer stem cells. Oncogene doi:10.1038/onc.2014.5 (2014) (Epub ahead of print).
    • (2014) Oncogene
    • Bartucci, M.1    Dattilo, R.2    Moriconi, C.3
  • 84
    • 54049087434 scopus 로고    scopus 로고
    • Risk-adapted treatment of acute promyelocytic leukemia with all-trans retinoic acid and anthracycline monochemotherapy: Long-term outcome of the LPA 99 multicenter study by the PETHEMA group
    • Sanz MA, Montesinos P, Vellenga E et al. Risk-adapted treatment of acute promyelocytic leukemia with all-trans retinoic acid and anthracycline monochemotherapy: long-term outcome of the LPA 99 multicenter study by the PETHEMA group. Blood 112 (8), 3130-3134 (2008).
    • (2008) Blood , vol.112 , Issue.8 , pp. 3130-3134
    • Sanz, M.A.1    Montesinos, P.2    Vellenga, E.3
  • 85
    • 0038149438 scopus 로고    scopus 로고
    • Phase II evaluation of temozolomide and 13- cis -retinoic acid for the treatment of recurrent and progressive malignant glioma: A North American Brain Tumor Consortium study
    • Jaeckle KA, Hess KR, Yung WK et al. Phase II evaluation of temozolomide and 13- cis -retinoic acid for the treatment of recurrent and progressive malignant glioma: a North American Brain Tumor Consortium study. J. Clin. Oncol. 21 (12), 2305-2311 (2003).
    • (2003) J. Clin. Oncol. , vol.21 , Issue.12 , pp. 2305-2311
    • Jaeckle, K.A.1    Hess, K.R.2    Yung, W.K.3
  • 86
    • 20144388196 scopus 로고    scopus 로고
    • A Phase II study of concurrent temozolomide and cis-retinoic acid with radiation for adult patients with newly diagnosed supratentorial glioblastoma
    • Butowski N, Prados MD, Lamborn KR et al. A Phase II study of concurrent temozolomide and cis-retinoic acid with radiation for adult patients with newly diagnosed supratentorial glioblastoma. Int. J. Radiat. Oncol. Biol. Phys. 61 (5), 1454-1459 (2005).
    • (2005) Int. J. Radiat. Oncol. Biol. Phys. , vol.61 , Issue.5 , pp. 1454-1459
    • Butowski, N.1    Prados, M.D.2    Lamborn, K.R.3
  • 87
    • 37349067098 scopus 로고    scopus 로고
    • Epigenetic-mediated dysfunction of the bone morphogenetic protein pathway inhibits differentiation of glioblastoma-initiating cells
    • Lee J, Son MJ, Woolard K et al. Epigenetic-mediated dysfunction of the bone morphogenetic protein pathway inhibits differentiation of glioblastoma-initiating cells. Cancer Cell 13 (1), 69-80 (2008).
    • (2008) Cancer Cell , vol.13 , Issue.1 , pp. 69-80
    • Lee, J.1    Son, M.J.2    Woolard, K.3
  • 90
    • 33846425793 scopus 로고    scopus 로고
    • The prognostic role of a gene signature from tumorigenic breast-cancer cells
    • Liu R, Wang X, Chen GY et al. The prognostic role of a gene signature from tumorigenic breast-cancer cells. N. Engl. J. Med. 356 (3), 217-226 (2007).
    • (2007) N. Engl. J. Med. , vol.356 , Issue.3 , pp. 217-226
    • Liu, R.1    Wang, X.2    Chen, G.Y.3
  • 91
    • 80455127294 scopus 로고    scopus 로고
    • Common cancer stem cell gene variants predict colon cancer recurrence
    • Gerger A, Zhang W, Yang D et al. Common cancer stem cell gene variants predict colon cancer recurrence. Clin. Cancer Res. 17 (21), 6934-6943 (2011).
    • (2011) Clin. Cancer Res. , vol.17 , Issue.21 , pp. 6934-6943
    • Gerger, A.1    Zhang, W.2    Yang, D.3
  • 92
    • 44049100934 scopus 로고    scopus 로고
    • Intrinsic resistance of tumorigenic breast cancer cells to chemotherapy
    • Li X, Lewis MT, Huang J et al. Intrinsic resistance of tumorigenic breast cancer cells to chemotherapy. J. Natl Cancer Inst. 100 (9), 672-679 (2008).
    • (2008) J. Natl Cancer Inst. , vol.100 , Issue.9 , pp. 672-679
    • Li, X.1    Lewis, M.T.2    Huang, J.3
  • 93
    • 58149340463 scopus 로고    scopus 로고
    • Cancer stem cell analysis and clinical outcome in patients with glioblastoma multiforme
    • Pallini R, Ricci-Vitiani L, Banna GL et al. Cancer stem cell analysis and clinical outcome in patients with glioblastoma multiforme. Clin. Cancer Res. 14 (24), 8205-8212 (2008).
    • (2008) Clin. Cancer Res. , vol.14 , Issue.24 , pp. 8205-8212
    • Pallini, R.1    Ricci-Vitiani, L.2    Banna, G.L.3
  • 94
    • 46449115281 scopus 로고    scopus 로고
    • Stem cell-related 'self-renewal' signature and high epidermal growth factor receptor expression associated with resistance to concomitant chemoradiotherapy in glioblastoma
    • Murat A, Migliavacca E, Gorlia T et al. Stem cell-related 'self-renewal' signature and high epidermal growth factor receptor expression associated with resistance to concomitant chemoradiotherapy in glioblastoma. J. Clin. Oncol. 26 (18), 3015-3024 (2008).
    • (2008) J. Clin. Oncol. , vol.26 , Issue.18 , pp. 3015-3024
    • Murat, A.1    Migliavacca, E.2    Gorlia, T.3
  • 95
    • 75449106680 scopus 로고    scopus 로고
    • Stem cell and epithelial-mesenchymal transition markers are frequently overexpressed in circulating tumor cells of metastatic breast cancer patients
    • Aktas B, Tewes M, Fehm T, Hauch S, Kimmig R, Kasimir-Bauer S. Stem cell and epithelial-mesenchymal transition markers are frequently overexpressed in circulating tumor cells of metastatic breast cancer patients. Breast Cancer Res. 11 (4), R46 (2009).
    • (2009) Breast Cancer Res. , vol.11 , Issue.4 , pp. R46
    • Aktas, B.1    Tewes, M.2    Fehm, T.3    Hauch, S.4    Kimmig, R.5    Kasimir-Bauer, S.6
  • 96
    • 82955187028 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition and stemness features in circulating tumor cells from breast cancer patients
    • Raimondi C, Gradilone A, Naso G et al. Epithelial-mesenchymal transition and stemness features in circulating tumor cells from breast cancer patients. Breast Cancer Res. Treat. 130 (2), 449-455 (2011).
    • (2011) Breast Cancer Res. Treat. , vol.130 , Issue.2 , pp. 449-455
    • Raimondi, C.1    Gradilone, A.2    Naso, G.3
  • 97
    • 84883746175 scopus 로고    scopus 로고
    • CD133 expression in circulating tumor cells from breast cancer patients: Potential role in resistance to chemotherapy
    • Nadal R, Ortega FG, Salido M et al. CD133 expression in circulating tumor cells from breast cancer patients: potential role in resistance to chemotherapy. Int. J. Cancer 133(10), 2398-2407 (2013).
    • (2013) Int. J. Cancer , vol.133 , Issue.10 , pp. 2398-2407
    • Nadal, R.1    Ortega, F.G.2    Salido, M.3


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