메뉴 건너뛰기




Volumn 50, Issue 1, 2014, Pages 246-256

Post-Seizure α-Tocopherol Treatment Decreases Neuroinflammation and Neuronal Degeneration Induced by Status Epilepticus in Rat Hippocampus

Author keywords

Epilepsy; Neurodegeneration; Neuroglia; Neuroinflammation; Oxidative stress; Vitamin E

Indexed keywords

ALLOGRAFT INFLAMMATORY FACTOR 1; ALPHA TOCOPHEROL; GLIAL FIBRILLARY ACIDIC PROTEIN; GLUTAMATE AMMONIA LIGASE; INTERLEUKIN 1BETA; SYNAPTOPHYSIN; TUMOR NECROSIS FACTOR ALPHA; KAINIC ACID; NEUROPROTECTIVE AGENT;

EID: 84911003020     PISSN: 08937648     EISSN: 15591182     Source Type: Journal    
DOI: 10.1007/s12035-014-8648-2     Document Type: Article
Times cited : (53)

References (70)
  • 1
    • 0032921086 scopus 로고    scopus 로고
    • It’s time to revise the definition of status epilepticus
    • PID: 9924914, COI: 1:STN:280:DyaK1M7it1ejsA%3D%3D
    • Lowenstein DH, Bleck T, Macdonald RL (1999) It’s time to revise the definition of status epilepticus. Epilepsia 40:120–122
    • (1999) Epilepsia , vol.40 , pp. 120-122
    • Lowenstein, D.H.1    Bleck, T.2    Macdonald, R.L.3
  • 2
    • 2942555126 scopus 로고    scopus 로고
    • Innate immune reaction in response to seizures: implications for the neuropathology associated with epilepsy
    • PID: 15193289, COI: 1:CAS:528:DC%2BD2cXkvVegsbs%3D
    • Turrin NP, Rivest S (2004) Innate immune reaction in response to seizures: implications for the neuropathology associated with epilepsy. Neurobiol Dis 16:321–334
    • (2004) Neurobiol Dis , vol.16 , pp. 321-334
    • Turrin, N.P.1    Rivest, S.2
  • 3
    • 33644625777 scopus 로고    scopus 로고
    • Brain inflammation in epilepsy: experimental and clinical evidence
    • PID: 16302852, COI: 1:CAS:528:DC%2BD2MXhtlelsrzP
    • Vezzani A, Granata T (2005) Brain inflammation in epilepsy: experimental and clinical evidence. Epilepsia 46:1724–1743
    • (2005) Epilepsia , vol.46 , pp. 1724-1743
    • Vezzani, A.1    Granata, T.2
  • 4
    • 36549071601 scopus 로고    scopus 로고
    • Innate and adaptive immunity during epileptogenesis and spontaneous seizures: evidence from experimental models and human temporal lobe epilepsy
    • PID: 17931873, COI: 1:CAS:528:DC%2BD2sXhsVSnsL7I
    • Ravizza T, Gagliardi B, Noè F, Boer K, Aronica E, Vezzani A (2008) Innate and adaptive immunity during epileptogenesis and spontaneous seizures: evidence from experimental models and human temporal lobe epilepsy. Neurobiol Dis 29:142–160
    • (2008) Neurobiol Dis , vol.29 , pp. 142-160
    • Ravizza, T.1    Gagliardi, B.2    Noè, F.3    Boer, K.4    Aronica, E.5    Vezzani, A.6
  • 5
    • 38449102377 scopus 로고    scopus 로고
    • Rapid astrocyte and microglia activation following pilocarpine-induced seizures in rats
    • PID: 18226170, COI: 1:CAS:528:DC%2BD1cXisl2ktb8%3D
    • Shapiro LA, Wang L, Ribak CE (2008) Rapid astrocyte and microglia activation following pilocarpine-induced seizures in rats. Epilepsia 49:33–41
    • (2008) Epilepsia , vol.49 , pp. 33-41
    • Shapiro, L.A.1    Wang, L.2    Ribak, C.E.3
  • 6
    • 43049154803 scopus 로고    scopus 로고
    • Effect of cytokines on neuronal excitability
    • PID: 18420346
    • Schafers M, Sorkin L (2008) Effect of cytokines on neuronal excitability. Neurosci Lett 437:188–193
    • (2008) Neurosci Lett , vol.437 , pp. 188-193
    • Schafers, M.1    Sorkin, L.2
  • 7
    • 38449115258 scopus 로고    scopus 로고
    • Glia as a source of cytokines: implications for neuronal excitability and survival
    • PID: 18226169, COI: 1:CAS:528:DC%2BD1cXisl2ktb4%3D
    • Vezzani A, Ravizza T, Balosso S, Aronica E (2008) Glia as a source of cytokines: implications for neuronal excitability and survival. Epilepsia 49:24–32
    • (2008) Epilepsia , vol.49 , pp. 24-32
    • Vezzani, A.1    Ravizza, T.2    Balosso, S.3    Aronica, E.4
  • 8
    • 70450250305 scopus 로고    scopus 로고
    • Role of selenium on calcium signaling and oxidative stress-induced molecular pathways in epilepsy
    • PID: 19513830
    • Nazıroglu M (2009) Role of selenium on calcium signaling and oxidative stress-induced molecular pathways in epilepsy. Neurochem Res 34:2181–2191
    • (2009) Neurochem Res , vol.34 , pp. 2181-2191
    • Nazıroglu, M.1
  • 9
    • 79955832357 scopus 로고    scopus 로고
    • Decreased glutamine synthetase, increased citrulline-nitric oxide cycle activities, and oxidative stress in different regions of brain in epilepsy rat model
    • PID: 20960085, COI: 1:CAS:528:DC%2BC3MXhs1Ghsrk%3D
    • Swamy M, Yusof WR, Sirajudeen KN, Mustapha Z, Govindasamy C (2011) Decreased glutamine synthetase, increased citrulline-nitric oxide cycle activities, and oxidative stress in different regions of brain in epilepsy rat model. J Physiol Biochem 67:105–113
    • (2011) J Physiol Biochem , vol.67 , pp. 105-113
    • Swamy, M.1    Yusof, W.R.2    Sirajudeen, K.N.3    Mustapha, Z.4    Govindasamy, C.5
  • 10
    • 80054987695 scopus 로고    scopus 로고
    • The neuroprotective effect of curcumin and Nigella sativa oil against oxidative stress in the pilocarpine model of epilepsy: a comparison with valproate
    • PID: 21751034
    • Ezz HS, Khadrawy YA, Noor NA (2011) The neuroprotective effect of curcumin and Nigella sativa oil against oxidative stress in the pilocarpine model of epilepsy: a comparison with valproate. Neurochem Res 36:2195–2204
    • (2011) Neurochem Res , vol.36 , pp. 2195-2204
    • Ezz, H.S.1    Khadrawy, Y.A.2    Noor, N.A.3
  • 11
    • 82955247647 scopus 로고    scopus 로고
    • Evaluation of possible antioxidant and anticonvulsant effects of the ethyl acetate fraction from Platonia insignis Mart. (Bacuri) on epilepsy models
    • PID: 22056341
    • Júnior JS, de Almeida AA, Tomé Ada R, Citó AM, Saffi J, de Freitas RM (2011) Evaluation of possible antioxidant and anticonvulsant effects of the ethyl acetate fraction from Platonia insignis Mart. (Bacuri) on epilepsy models. Epilepsy Behav 22:678–684
    • (2011) Epilepsy Behav , vol.22 , pp. 678-684
    • Júnior, J.S.1    de Almeida, A.A.2    Tomé Ada, R.3    Citó, A.M.4    Saffi, J.5    de Freitas, R.M.6
  • 12
    • 25844464738 scopus 로고    scopus 로고
    • α-Tocopherol protects against pentylenetetrazol- and methylmalonate-induced convulsions
    • PID: 16162400, COI: 1:CAS:528:DC%2BD2MXhtVGrs7%2FI
    • Ribeiro MCP, de Avila DS, Schneider CYM, Hermesa FS, Furiana AF, Oliveira MS et al (2005) α-Tocopherol protects against pentylenetetrazol- and methylmalonate-induced convulsions. Epilepsy Res 66:185–190
    • (2005) Epilepsy Res , vol.66 , pp. 185-190
    • Ribeiro, M.C.P.1    de Avila, D.S.2    Schneider, C.Y.M.3    Hermesa, F.S.4    Furiana, A.F.5    Oliveira, M.S.6
  • 13
    • 77953490700 scopus 로고    scopus 로고
    • The effects of alpha-tocopherol on hippocampal oxidative stress prior to in pilocarpine-induced seizures
    • PID: 19941068
    • Tomè AR, Feng D, Freitas RM (2010) The effects of alpha-tocopherol on hippocampal oxidative stress prior to in pilocarpine-induced seizures. Neurochem Res 35:580–587
    • (2010) Neurochem Res , vol.35 , pp. 580-587
    • Tomè, A.R.1    Feng, D.2    Freitas, R.M.3
  • 14
    • 80052730502 scopus 로고    scopus 로고
    • Dietary supplementation with α-tocopherol reduces neuroinflammation and neuronal degeneration in the rat brain after kainic acid-induced status epilepticus
    • PID: 21749318, COI: 1:CAS:528:DC%2BC3MXhtFGnsb%2FN
    • Betti M, Minelli A, Ambrogini P, Ciuffoli S, Viola V, Galli F, Canonico B, Lattanzi D, Colombo E, Sestili P, Cuppini R (2011) Dietary supplementation with α-tocopherol reduces neuroinflammation and neuronal degeneration in the rat brain after kainic acid-induced status epilepticus. Free Radic Res 45:1136–1142
    • (2011) Free Radic Res , vol.45 , pp. 1136-1142
    • Betti, M.1    Minelli, A.2    Ambrogini, P.3    Ciuffoli, S.4    Viola, V.5    Galli, F.6    Canonico, B.7    Lattanzi, D.8    Colombo, E.9    Sestili, P.10    Cuppini, R.11
  • 15
    • 49049097966 scopus 로고    scopus 로고
    • Postnatal inflammation increases seizure susceptibility in adult rats
    • PID: 18596165, COI: 1:CAS:528:DC%2BD1cXot1OqtLw%3D
    • Galic MA, Riazi K, Heida JG, Mouihate A, Fournier NM, Spencer SJ et al (2008) Postnatal inflammation increases seizure susceptibility in adult rats. J Neurosci 28:6904–6913
    • (2008) J Neurosci , vol.28 , pp. 6904-6913
    • Galic, M.A.1    Riazi, K.2    Heida, J.G.3    Mouihate, A.4    Fournier, N.M.5    Spencer, S.J.6
  • 16
    • 67649804600 scopus 로고    scopus 로고
    • Enhanced microglial activation and proinflammatory cytokine upregulation are linked to increased susceptibility to seizures and neurologic injury in a ‘two-hit’seizure model
    • PID: 19501063, COI: 1:CAS:528:DC%2BD1MXotl2ltLk%3D
    • Somera-Molina KC, Nair S, van Eldik LJ, Watterson DM, Wainwright MS (2009) Enhanced microglial activation and proinflammatory cytokine upregulation are linked to increased susceptibility to seizures and neurologic injury in a ‘two-hit’seizure model. Brain Res 1282:162–172
    • (2009) Brain Res , vol.1282 , pp. 162-172
    • Somera-Molina, K.C.1    Nair, S.2    van Eldik, L.J.3    Watterson, D.M.4    Wainwright, M.S.5
  • 17
    • 0035888177 scopus 로고    scopus 로고
    • Vitamin E suppression of microglial activation is neuroprotective
    • PID: 11592111, COI: 1:CAS:528:DC%2BD3MXnsVyktLk%3D
    • Li Y, Liu L, Barger SW, Mrak RE, Griffin WST (2001) Vitamin E suppression of microglial activation is neuroprotective. J Neurosci Res 66:163–170
    • (2001) J Neurosci Res , vol.66 , pp. 163-170
    • Li, Y.1    Liu, L.2    Barger, S.W.3    Mrak, R.E.4    Griffin, W.S.T.5
  • 18
    • 0037087068 scopus 로고    scopus 로고
    • Beneficial effects of α-lipoic acid plus vitamin E on neurological deficit, reactive gliosis and neuronal remodeling in the penumbra of the ischemic rat brain
    • PID: 11872266, COI: 1:CAS:528:DC%2BD38XhsFWgurg%3D
    • Gonzalez-Perez O, Gonzales-Castaneda RE, Huerta M, Luquin S, Gomez-Pinedo U, Sanchez-Almaraz E et al (2002) Beneficial effects of α-lipoic acid plus vitamin E on neurological deficit, reactive gliosis and neuronal remodeling in the penumbra of the ischemic rat brain. Neurosci Lett 321:100–104
    • (2002) Neurosci Lett , vol.321 , pp. 100-104
    • Gonzalez-Perez, O.1    Gonzales-Castaneda, R.E.2    Huerta, M.3    Luquin, S.4    Gomez-Pinedo, U.5    Sanchez-Almaraz, E.6
  • 19
    • 1542710617 scopus 로고    scopus 로고
    • α-Tocopherol reduces lipopolysaccharide-induced peroxide radical formation and interleukin-6 secretion in primary murine microglia and in brain
    • PID: 15020070, COI: 1:CAS:528:DC%2BD2cXitFChtLs%3D
    • Godbout JP, Berg BM, Kelley KW, Johnson RW (2004) α-Tocopherol reduces lipopolysaccharide-induced peroxide radical formation and interleukin-6 secretion in primary murine microglia and in brain. J Neuroimmunol 149:101–109
    • (2004) J Neuroimmunol , vol.149 , pp. 101-109
    • Godbout, J.P.1    Berg, B.M.2    Kelley, K.W.3    Johnson, R.W.4
  • 20
    • 33745139199 scopus 로고    scopus 로고
    • Tocopherol-mediated modulation of age-related changes in microglial cells: turnover of extracellular oxidized protein material
    • PID: 16785026, COI: 1:CAS:528:DC%2BD28XlvF2htbc%3D
    • Stolzing A, Widmer R, Jung T, Voss P, Grune T (2006) Tocopherol-mediated modulation of age-related changes in microglial cells: turnover of extracellular oxidized protein material. Free Rad Biol Med 40:2126–2135
    • (2006) Free Rad Biol Med , vol.40 , pp. 2126-2135
    • Stolzing, A.1    Widmer, R.2    Jung, T.3    Voss, P.4    Grune, T.5
  • 21
    • 34548495793 scopus 로고    scopus 로고
    • Pre-treatment and post-treatment with alpha-tocopherol attenuates hippocampal neuronal damage in experimental cerebral hypoperfusion
    • Annahazi A, Mracsko E, Sule Z, Karg E, Penke B, Bari F, Farkas E (2007) Pre-treatment and post-treatment with alpha-tocopherol attenuates hippocampal neuronal damage in experimental cerebral hypoperfusion. Eur J Pharmacol 157:120–128
    • (2007) Eur J Pharmacol , vol.157 , pp. 120-128
    • Annahazi, A.1    Mracsko, E.2    Sule, Z.3    Karg, E.4    Penke, B.5    Bari, F.6    Farkas, E.7
  • 22
    • 0001490738 scopus 로고    scopus 로고
    • Is epilepsy a progressive disorder? Prospects for new therapeutic approaches in temporal-lobe epilepsy
    • PID: 12849486
    • Pitkanen A, Sutula TP (2002) Is epilepsy a progressive disorder? Prospects for new therapeutic approaches in temporal-lobe epilepsy. Lancet Neurol 1:173–181
    • (2002) Lancet Neurol , vol.1 , pp. 173-181
    • Pitkanen, A.1    Sutula, T.P.2
  • 23
    • 0015309163 scopus 로고
    • Modification of seizure activity by electrical stimulation: II. Motor seizure
    • PID: 4110397, COI: 1:STN:280:DyaE387gvFCltg%3D%3D
    • Racine RJ (1972) Modification of seizure activity by electrical stimulation: II. Motor seizure. Electroencephalogr Clin Neurophysiol 32:281–294
    • (1972) Electroencephalogr Clin Neurophysiol , vol.32 , pp. 281-294
    • Racine, R.J.1
  • 24
    • 0037082352 scopus 로고    scopus 로고
    • Gas chromatography mass spectrometry analysis of carboxyethyl-hydroxychroman metabolites of alpha- and gamma-tocopherol in human plasma
    • PID: 11841923, COI: 1:CAS:528:DC%2BD38XhtF2jt7g%3D
    • Galli F, Lee R, Dunster C, Kelly FJ (2002) Gas chromatography mass spectrometry analysis of carboxyethyl-hydroxychroman metabolites of alpha- and gamma-tocopherol in human plasma. Free Radic Biol Med 32:333–340
    • (2002) Free Radic Biol Med , vol.32 , pp. 333-340
    • Galli, F.1    Lee, R.2    Dunster, C.3    Kelly, F.J.4
  • 25
    • 0018384650 scopus 로고
    • Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction
    • PID: 36810, COI: 1:CAS:528:DyaE1MXksFaisbk%3D
    • Ohkawa H, Ohishi N, Yagi K (1979) Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 95:351–358
    • (1979) Anal Biochem , vol.95 , pp. 351-358
    • Ohkawa, H.1    Ohishi, N.2    Yagi, K.3
  • 26
    • 78649962477 scopus 로고    scopus 로고
    • Maternal dietary loads of alpha-tocopherol depress protein kinase C signaling and synaptic plasticity in rat postnatal developing hippocampus and promote permanent deficits in adult offspring
    • PID: 20382010, COI: 1:CAS:528:DC%2BC3cXhsFGhtbjL
    • Betti M, Ambrogini P, Minelli A, Floridi A, Lattanzi D, Ciuffoli S et al (2011) Maternal dietary loads of alpha-tocopherol depress protein kinase C signaling and synaptic plasticity in rat postnatal developing hippocampus and promote permanent deficits in adult offspring. J Nutr Biochem 22:60–70
    • (2011) J Nutr Biochem , vol.22 , pp. 60-70
    • Betti, M.1    Ambrogini, P.2    Minelli, A.3    Floridi, A.4    Lattanzi, D.5    Ciuffoli, S.6
  • 27
    • 80052410549 scopus 로고    scopus 로고
    • High-throughput, detailed, cell-specific neuroanatomy of dendritic spines using microinjection and confocal microscopy
    • PID: 21886104, COI: 1:CAS:528:DC%2BC3MXhtFWku7fK
    • Dumitriu D, Rodriguez A, Morrison JH (2011) High-throughput, detailed, cell-specific neuroanatomy of dendritic spines using microinjection and confocal microscopy. Nat Protoc 6:1391–1411
    • (2011) Nat Protoc , vol.6 , pp. 1391-1411
    • Dumitriu, D.1    Rodriguez, A.2    Morrison, J.H.3
  • 28
    • 33748857971 scopus 로고    scopus 로고
    • Functional changes in astroglial cells in epilepsy
    • Binder DK, Steinhäuser C (2006) Functional changes in astroglial cells in epilepsy. Glia 4:358–368
    • (2006) Glia , vol.4 , pp. 358-368
    • Binder, D.K.1    Steinhäuser, C.2
  • 29
    • 9144228368 scopus 로고    scopus 로고
    • Loss of glutamine synthetase in the human epileptogenic hippocampus: possible mechanism for raised extracellular glutamate in mesial temporal lobe epilepsy
    • PID: 14723991, COI: 1:CAS:528:DC%2BD2cXos1aj
    • Eid T, Thomas MJ, Spencer DD, Rundén-Pran E, Lai JC, Malthankar GV, Kim JH, Danbolt NC, Ottersen OP, de Lanerolle NC (2004) Loss of glutamine synthetase in the human epileptogenic hippocampus: possible mechanism for raised extracellular glutamate in mesial temporal lobe epilepsy. Lancet 363:28–37
    • (2004) Lancet , vol.363 , pp. 28-37
    • Eid, T.1    Thomas, M.J.2    Spencer, D.D.3    Rundén-Pran, E.4    Lai, J.C.5    Malthankar, G.V.6    Kim, J.H.7    Danbolt, N.C.8    Ottersen, O.P.9    de Lanerolle, N.C.10
  • 30
    • 0027262604 scopus 로고
    • Extracellular hippocampal glutamate and spontaneous seizure in the conscious human brain
    • PID: 8099987, COI: 1:STN:280:DyaK3s3psFWmsg%3D%3D
    • During MJ, Spencer DD (1993) Extracellular hippocampal glutamate and spontaneous seizure in the conscious human brain. Lancet 341:1607–1610
    • (1993) Lancet , vol.341 , pp. 1607-1610
    • During, M.J.1    Spencer, D.D.2
  • 31
    • 0032102358 scopus 로고    scopus 로고
    • Microglia-specific localisation of a novel calcium binding protein, Iba1
    • PID: 9630473, COI: 1:CAS:528:DyaK1cXjs1alsrs%3D
    • Ito D, Imai Y, Ohsawa K, Nakajima K, Fukuuchi Y, Kohsaka S (1998) Microglia-specific localisation of a novel calcium binding protein, Iba1. Brain Res Mol Brain Res 57:1–9
    • (1998) Brain Res Mol Brain Res , vol.57 , pp. 1-9
    • Ito, D.1    Imai, Y.2    Ohsawa, K.3    Nakajima, K.4    Fukuuchi, Y.5    Kohsaka, S.6
  • 32
    • 0019531573 scopus 로고
    • The dynamic ordering of neuronal cytoskeletons
    • PID: 6163111, COI: 1:CAS:528:DyaL3MXhs12nt7c%3D
    • Lasek RJ (1981) The dynamic ordering of neuronal cytoskeletons. Neurosci Res Program Bull 19:7–32
    • (1981) Neurosci Res Program Bull , vol.19 , pp. 7-32
    • Lasek, R.J.1
  • 33
    • 15944409728 scopus 로고    scopus 로고
    • Neurofilament phosphoforms: surrogate markers for axonal injury, degeneration and loss
    • PID: 15896809, COI: 1:CAS:528:DC%2BD2MXltVejurY%3D
    • Petzold A (2005) Neurofilament phosphoforms: surrogate markers for axonal injury, degeneration and loss. J Neurol Sci 233:183–198
    • (2005) J Neurol Sci , vol.233 , pp. 183-198
    • Petzold, A.1
  • 35
    • 0028057395 scopus 로고
    • Changes in neurofilament protein NF-L and NF-H immunoreactivity following kainic acid-induced seizures
    • PID: 8294936, COI: 1:CAS:528:DyaK2cXhs1Sltrc%3D
    • Wang S, Hamberger A, Yang Q, Haglid KG (1994) Changes in neurofilament protein NF-L and NF-H immunoreactivity following kainic acid-induced seizures. J Neurochem 62:739–748
    • (1994) J Neurochem , vol.62 , pp. 739-748
    • Wang, S.1    Hamberger, A.2    Yang, Q.3    Haglid, K.G.4
  • 37
    • 84882781778 scopus 로고    scopus 로고
    • Effects of carnosine plus vitamin E and betaine treatments on oxidative stress in some tissues of aged rats
    • PID: 23701646, COI: 1:CAS:528:DC%2BC3sXhsV2gur%2FP
    • Coban J, Bingül I, Yesil-Mizrak K, Dogru-Abbasoglu S, Oztezcan S, Uysal M (2013) Effects of carnosine plus vitamin E and betaine treatments on oxidative stress in some tissues of aged rats. Curr Aging Sci 6:199–205
    • (2013) Curr Aging Sci , vol.6 , pp. 199-205
    • Coban, J.1    Bingül, I.2    Yesil-Mizrak, K.3    Dogru-Abbasoglu, S.4    Oztezcan, S.5    Uysal, M.6
  • 38
    • 84892825282 scopus 로고    scopus 로고
    • Alpha-tocopherol ameliorates oxidative renal insult associated with spinal cord reperfusion injury
    • PID: 23345003, COI: 1:CAS:528:DC%2BC3sXht1ent7rM
    • Morsy MD, Bashir SO (2013) Alpha-tocopherol ameliorates oxidative renal insult associated with spinal cord reperfusion injury. J Physiol Biochem 69:487–496
    • (2013) J Physiol Biochem , vol.69 , pp. 487-496
    • Morsy, M.D.1    Bashir, S.O.2
  • 39
    • 84893162715 scopus 로고    scopus 로고
    • Study of antioxidative effects and anti-inflammatory effects in mice due to low-dose X-irradiation or radon inhalation
    • COI: 1:CAS:528:DC%2BC3sXhtlCrtr3J
    • Kataoka T (2013) Study of antioxidative effects and anti-inflammatory effects in mice due to low-dose X-irradiation or radon inhalation. J Rad Res 54:587–596
    • (2013) J Rad Res , vol.54 , pp. 587-596
    • Kataoka, T.1
  • 40
    • 84877716163 scopus 로고    scopus 로고
    • Alpha tocopherol treatment reduces the expression of Nogo-A and NgR in rat brain after traumatic brain injury
    • PID: 23207171, COI: 1:CAS:528:DC%2BC38Xhslyms7fI
    • Yang J, Han Y, Ye W, Liu F, Zhuang K, Wu G (2013) Alpha tocopherol treatment reduces the expression of Nogo-A and NgR in rat brain after traumatic brain injury. J Surg Res 182:e69–e77
    • (2013) J Surg Res , vol.182 , pp. e69-e77
    • Yang, J.1    Han, Y.2    Ye, W.3    Liu, F.4    Zhuang, K.5    Wu, G.6
  • 41
    • 0037073570 scopus 로고    scopus 로고
    • Involvement of nitric oxide in kainic acid-induced excitotoxicity in rat brain
    • PID: 12445975, COI: 1:CAS:528:DC%2BD38XoslamtLk%3D
    • Milatovic D, Gupta RC, Dettbarn WD (2002) Involvement of nitric oxide in kainic acid-induced excitotoxicity in rat brain. Brain Res 957:330–337
    • (2002) Brain Res , vol.957 , pp. 330-337
    • Milatovic, D.1    Gupta, R.C.2    Dettbarn, W.D.3
  • 42
    • 72249087964 scopus 로고    scopus 로고
    • Mitochondria, oxidative stress, and temporal lobe epilepsy
    • PID: 19850449, COI: 1:CAS:528:DC%2BD1MXhs1Wjtr%2FJ
    • Waldbaum S, Patel M (2010) Mitochondria, oxidative stress, and temporal lobe epilepsy. Epilepsy Res 88:23–45
    • (2010) Epilepsy Res , vol.88 , pp. 23-45
    • Waldbaum, S.1    Patel, M.2
  • 43
    • 70449678738 scopus 로고    scopus 로고
    • Molecular dissection of reactive astrogliosis and glial scar formation
    • PID: 19782411, COI: 1:CAS:528:DC%2BD1MXhsVKgs7bP
    • Sofroniew MV (2009) Molecular dissection of reactive astrogliosis and glial scar formation. Trends Neurosci 32:638–647
    • (2009) Trends Neurosci , vol.32 , pp. 638-647
    • Sofroniew, M.V.1
  • 44
    • 78651369895 scopus 로고    scopus 로고
    • The role of inflammation in epilepsy
    • PID: 21135885, COI: 1:CAS:528:DC%2BC3MXjs1OmtA%3D%3D
    • Vezzani A, French J, Bartfai T, Baram TZ (2011) The role of inflammation in epilepsy. Nat Rev Neurol 7:31–40
    • (2011) Nat Rev Neurol , vol.7 , pp. 31-40
    • Vezzani, A.1    French, J.2    Bartfai, T.3    Baram, T.Z.4
  • 45
    • 0036849018 scopus 로고    scopus 로고
    • Microglia as a source and target of cytokines
    • PID: 12379902
    • Hanisch UK (2002) Microglia as a source and target of cytokines. Glia 40:140–155
    • (2002) Glia , vol.40 , pp. 140-155
    • Hanisch, U.K.1
  • 46
    • 33846621575 scopus 로고    scopus 로고
    • The tripartite synapse: roles for gliotransmission in health and disease
    • PID: 17207662, COI: 1:CAS:528:DC%2BD2sXhtlSnsr8%3D
    • Halassa MM, Fellin T, Haydon PG (2007) The tripartite synapse: roles for gliotransmission in health and disease. Trends Mol Med 13:54–63
    • (2007) Trends Mol Med , vol.13 , pp. 54-63
    • Halassa, M.M.1    Fellin, T.2    Haydon, P.G.3
  • 47
    • 77952427037 scopus 로고    scopus 로고
    • Glia modulates synaptic transmission
    • PID: 19896978, COI: 1:CAS:528:DC%2BC3cXlsFahtrw%3D
    • Perea G, Araque A (2010) Glia modulates synaptic transmission. Brain Res Rev 63:93–102
    • (2010) Brain Res Rev , vol.63 , pp. 93-102
    • Perea, G.1    Araque, A.2
  • 48
    • 0017579832 scopus 로고
    • Glutamine synthetase: glial localization in brain
    • PID: 14400, COI: 1:CAS:528:DyaE2sXhsFejsbg%3D
    • Martinez-Hernandez A, Bell KP, Norenberg MD (1977) Glutamine synthetase: glial localization in brain. Science 195:1356–1358
    • (1977) Science , vol.195 , pp. 1356-1358
    • Martinez-Hernandez, A.1    Bell, K.P.2    Norenberg, M.D.3
  • 49
    • 0002835597 scopus 로고    scopus 로고
    • Biochemistry and anatomy of transmitter glutamate
    • Ottersen OP, Storm-Mathgisen J, (eds), Elsevier Science, Amsterdam:
    • Broman J, Hassel B, Rinvik E, Ottersen OP (2000) Biochemistry and anatomy of transmitter glutamate. In: Ottersen OP, Storm-Mathgisen J (eds) Glutamate. Elsevier Science, Amsterdam
    • (2000) Glutamate
    • Broman, J.1    Hassel, B.2    Rinvik, E.3    Ottersen, O.P.4
  • 50
    • 0036062186 scopus 로고    scopus 로고
    • Glutamate-glutamine cycling in the epileptic human hippocampus
    • PID: 12102672, COI: 1:CAS:528:DC%2BD38Xmt1Ohsrw%3D
    • Petroff OA, Errante LD, Rothman DL, Kim JH, Spencer DD (2002) Glutamate-glutamine cycling in the epileptic human hippocampus. Epilepsia 43:703–710
    • (2002) Epilepsia , vol.43 , pp. 703-710
    • Petroff, O.A.1    Errante, L.D.2    Rothman, D.L.3    Kim, J.H.4    Spencer, D.D.5
  • 51
    • 0018086338 scopus 로고
    • Enzyme histochemical studies in the rat hippocampus, cerebellar cortex and brainstem motor nuclei during methionine sulphoximine convulsions
    • PID: 688292, COI: 1:CAS:528:DyaE1cXlvFGjurc%3D
    • Szegedy L (1978) Enzyme histochemical studies in the rat hippocampus, cerebellar cortex and brainstem motor nuclei during methionine sulphoximine convulsions. Cell Mol Biol Incl Cyto Enzymol 23:43–53
    • (1978) Cell Mol Biol Incl Cyto Enzymol , vol.23 , pp. 43-53
    • Szegedy, L.1
  • 52
    • 0024918177 scopus 로고
    • Seizures in the Mongolian gerbil are related to a deficiency in cerebral glutamine synthetase
    • PID: 2576778, COI: 1:STN:280:DyaK3c3jsFGkug%3D%3D
    • Laming PR, Cosby SL, O’Neill JK (1989) Seizures in the Mongolian gerbil are related to a deficiency in cerebral glutamine synthetase. Comp Biochem Physiol C 94:399–404
    • (1989) Comp Biochem Physiol C , vol.94 , pp. 399-404
    • Laming, P.R.1    Cosby, S.L.2    O’Neill, J.K.3
  • 54
  • 55
    • 34547435817 scopus 로고    scopus 로고
    • Neuroinflammation and regulation of glial glutamate uptake in neurological disorders
    • PID: 17497670, COI: 1:CAS:528:DC%2BD2sXovFanurc%3D
    • Tilleux S, Hermans E (2007) Neuroinflammation and regulation of glial glutamate uptake in neurological disorders. J Neurosci Res 85:2059–2070
    • (2007) J Neurosci Res , vol.85 , pp. 2059-2070
    • Tilleux, S.1    Hermans, E.2
  • 56
    • 41249084362 scopus 로고    scopus 로고
    • Seizures in the developing brain: cellular and molecular mechanisms of neuronal damage, neurogenesis and cellular reorganization
    • PID: 18093696, COI: 1:CAS:528:DC%2BD1cXktVKltb0%3D
    • Holopainen IE (2008) Seizures in the developing brain: cellular and molecular mechanisms of neuronal damage, neurogenesis and cellular reorganization. Neurochem Int 52:935–947
    • (2008) Neurochem Int , vol.52 , pp. 935-947
    • Holopainen, I.E.1
  • 57
    • 84891590133 scopus 로고    scopus 로고
    • Loss of hippocampal interneurons and epileptogenesis: a comparison of two animal models of acquired epilepsy
    • Huusko N, Römer C, Ndode-Ekane XE, Lukasiuk K, Pitkänen A (2013) Loss of hippocampal interneurons and epileptogenesis: a comparison of two animal models of acquired epilepsy. Brain Struct Funct doi:. doi:10.1007/s00429-013-0644-1
    • (2013) Brain Struct Funct doi:
    • Huusko, N.1    Römer, C.2    Ndode-Ekane, X.E.3    Lukasiuk, K.4    Pitkänen, A.5
  • 59
    • 77955925285 scopus 로고    scopus 로고
    • Neuronal vulnerability of stroke-prone spontaneously hypertensive rats to ischemia and its prevention with antioxidants such as vitamin E
    • PID: 20633610, COI: 1:CAS:528:DC%2BC3cXhtVKhu7vP
    • Yamagata K, Tagami M, Yamori Y (2010) Neuronal vulnerability of stroke-prone spontaneously hypertensive rats to ischemia and its prevention with antioxidants such as vitamin E. Neuroscience 170:1–7
    • (2010) Neuroscience , vol.170 , pp. 1-7
    • Yamagata, K.1    Tagami, M.2    Yamori, Y.3
  • 60
    • 7444250188 scopus 로고    scopus 로고
    • Alpha-tocotrienol provides the most potent neuroprotection among vitamin E analogs on cultured striatal neurons
    • PID: 15527824, COI: 1:CAS:528:DC%2BD2cXpsVOmurY%3D
    • Osakada F, Hashino A, Kume T, Katsuki H, Kaneko S, Akaike A (2004) Alpha-tocotrienol provides the most potent neuroprotection among vitamin E analogs on cultured striatal neurons. Neuropharmacology 47:904–915
    • (2004) Neuropharmacology , vol.47 , pp. 904-915
    • Osakada, F.1    Hashino, A.2    Kume, T.3    Katsuki, H.4    Kaneko, S.5    Akaike, A.6
  • 61
    • 0037121663 scopus 로고    scopus 로고
    • Activity-dependent changes in synaptophysin immunoreactivity in hippocampus, piriform cortex, and entorhinal cortex of the rat
    • PID: 12453493, COI: 1:CAS:528:DC%2BD38XovFehs7o%3D
    • Li S, Reinprecht I, Fahnestock M, Racine RJ (2002) Activity-dependent changes in synaptophysin immunoreactivity in hippocampus, piriform cortex, and entorhinal cortex of the rat. Neuroscience 115:1221–1229
    • (2002) Neuroscience , vol.115 , pp. 1221-1229
    • Li, S.1    Reinprecht, I.2    Fahnestock, M.3    Racine, R.J.4
  • 62
    • 0027511905 scopus 로고
    • The role of synaptic proteins in the pathogenesis of disorders of the central nervous system
    • PID: 8269086, COI: 1:STN:280:DyaK2c%2Fptlynsw%3D%3D
    • Masliah E, Terry R (1993) The role of synaptic proteins in the pathogenesis of disorders of the central nervous system. Brain Pathol 3:77–85
    • (1993) Brain Pathol , vol.3 , pp. 77-85
    • Masliah, E.1    Terry, R.2
  • 63
    • 0028853825 scopus 로고
    • Decreased synaptophysin in the medial temporal lobe in schizophrenia demonstrated using immunoautoradiography
    • PID: 8552231, COI: 1:CAS:528:DyaK2MXptVOjsbk%3D
    • Eastwood SL, Harrison PJ (1995) Decreased synaptophysin in the medial temporal lobe in schizophrenia demonstrated using immunoautoradiography. Neuroscience 69:339–343
    • (1995) Neuroscience , vol.69 , pp. 339-343
    • Eastwood, S.L.1    Harrison, P.J.2
  • 64
    • 0032774942 scopus 로고    scopus 로고
    • Two peptidergic drugs increase the synaptophysin immunoreactivity in brains of 24-month-old rats
    • PID: 10462225, COI: 1:CAS:528:DyaK1MXlslehsb4%3D
    • Reinprecht I, Gschanes A, Windisch M, Fachbach G (1999) Two peptidergic drugs increase the synaptophysin immunoreactivity in brains of 24-month-old rats. Histochem J 31:395–401
    • (1999) Histochem J , vol.31 , pp. 395-401
    • Reinprecht, I.1    Gschanes, A.2    Windisch, M.3    Fachbach, G.4
  • 65
    • 0033541509 scopus 로고    scopus 로고
    • Reduced synaptophysin immunoreactivity in the dentate gyrus of prepulse inhibition-impaired isolation-reared rats
    • PID: 10196449, COI: 1:CAS:528:DyaK1MXitFWrsbk%3D
    • Varty GB, Marsden CA, Higgins GA (1999) Reduced synaptophysin immunoreactivity in the dentate gyrus of prepulse inhibition-impaired isolation-reared rats. Brain Res 824:197–203
    • (1999) Brain Res , vol.824 , pp. 197-203
    • Varty, G.B.1    Marsden, C.A.2    Higgins, G.A.3
  • 66
    • 0037474059 scopus 로고    scopus 로고
    • Differences in lesion-induced hippocampal plasticity between mice and rats
    • PID: 12559105, COI: 1:CAS:528:DC%2BD3sXmsVertg%3D%3D
    • Kadish I, Van Groen T (2003) Differences in lesion-induced hippocampal plasticity between mice and rats. Neuroscience 116:499–509
    • (2003) Neuroscience , vol.116 , pp. 499-509
    • Kadish, I.1    Van Groen, T.2
  • 67
    • 33745800033 scopus 로고    scopus 로고
    • Alpha-Tocopherol affects neuronal plasticity in adult rat dentate gyrus: the possible role of PKCdelta
    • PID: 16673395, COI: 1:CAS:528:DC%2BD28Xnsl2msbo%3D
    • Ferri P, Cecchini T, Ambrogini P, Betti M, Cuppini R, Del Grande P, Ciaroni S (2006) Alpha-Tocopherol affects neuronal plasticity in adult rat dentate gyrus: the possible role of PKCdelta. J Neurobiol 66:793–810
    • (2006) J Neurobiol , vol.66 , pp. 793-810
    • Ferri, P.1    Cecchini, T.2    Ambrogini, P.3    Betti, M.4    Cuppini, R.5    Del Grande, P.6    Ciaroni, S.7
  • 68
    • 77951133554 scopus 로고    scopus 로고
    • Present trends in vitamin E research
    • PID: 20108329, COI: 1:CAS:528:DC%2BC3cXitlCju70%3D
    • Galli F, Azzi A (2010) Present trends in vitamin E research. Biofactors 36:33–42
    • (2010) Biofactors , vol.36 , pp. 33-42
    • Galli, F.1    Azzi, A.2
  • 69
    • 77950355906 scopus 로고    scopus 로고
    • Gene-regulatory activity of alpha-tocopherol
    • PID: 20336011, COI: 1:CAS:528:DC%2BC3cXjs1ygu74%3D
    • Rimbach G, Moehring J, Huebbe P, Lodge JK (2010) Gene-regulatory activity of alpha-tocopherol. Molecules 15:1746–1761
    • (2010) Molecules , vol.15 , pp. 1746-1761
    • Rimbach, G.1    Moehring, J.2    Huebbe, P.3    Lodge, J.K.4
  • 70
    • 77952745811 scopus 로고    scopus 로고
    • Micro RNA-125b (miRNA-125b) function in astrogliosis and glial cell proliferation
    • PID: 20347935, COI: 1:CAS:528:DC%2BC3cXlvVejsLo%3D
    • Pogue AI, Cui JG, Li YY, Zhao Y, Culicchia F, Lukiw WJ (2010) Micro RNA-125b (miRNA-125b) function in astrogliosis and glial cell proliferation. Neurosci Lett 476:18–22
    • (2010) Neurosci Lett , vol.476 , pp. 18-22
    • Pogue, A.I.1    Cui, J.G.2    Li, Y.Y.3    Zhao, Y.4    Culicchia, F.5    Lukiw, W.J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.