Evaluation of possible antioxidant and anticonvulsant effects of the ethyl acetate fraction from Platonia insignis Mart. (Bacuri) on epilepsy models

Epilepsy and Behavior

Volumn 22, Issue 4, 2011, Pages 678-684

  Da Costa, Joaquim Soares ^a   De Almeida, Antonia Amanda C ^b   Tomé, Adriana da Rocha ^c   Citó, Antonia Maria das Graças Lopes ^b   Saffi, Jenifer ^d   De Freitas, Rivelilson Mendes ^b  

^a UNIVERSIDADE LUTERANA DO BRASIL   (Brazil)

^b INSTITUTO FEDERAL DE EDUCAÇÃO   (Brazil)

^c STATE UNIVERSITY OF CEARÁ   (Brazil)

^d UNIVERSIDADE FEDERAL DE CIÊNCIAS DA SAÚDE DE PORTO ALEGRE   (Brazil)

Author keywords

Antioxidants; Botanicals; Ethyl acetate fraction; Neuroprotection; Pentylenetetrazole; Picrotoxin; Pilocarpine; Platonia insignis

Indexed keywords

ACETIC ACID ETHYL ESTER; CATALASE; NITRITE; PLANT EXTRACT; PLATONIA INSIGNIS EXTRACT; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; CORPUS STRIATUM; DRUG EFFECT; DRUG EFFICACY; ENZYME ACTIVITY; EPILEPSY; GUTTIFERAE; LIPID PEROXIDATION; MALE; NONHUMAN; PLATONIA INSIGNIS; RAT;

ACETATES; ANIMALS; ANTICONVULSANTS; ANTIOXIDANTS; CATALASE; CORPUS STRIATUM; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; DRUG COMPOUNDING; DRUG INTERACTIONS; EPILEPSY; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; LIPID PEROXIDATION; MALE; MANIHOT; MOTOR ACTIVITY; MUSCARINIC AGONISTS; PENTYLENETETRAZOLE; PHYTOTHERAPY; PICROTOXIN; PILOCARPINE; PLANT PREPARATIONS; RANDOM ALLOCATION; RATS; RATS, WISTAR; SEIZURES; SUPEROXIDE DISMUTASE;

EID: 82955247647     PISSN: 15255050     EISSN: 15255069     Source Type: Journal    
DOI: 10.1016/j.yebeh.2011.09.021     Document Type: Article

References (50)

1. Souza V.A.B., Vasconcelos L.F.L., Araújo E.C.E., Alves R.E. Bacurizeiro: Platonia insignis Mart 2000, Jaboticabal, São Paulo.
2. Agra M.F., Freitas P.F., Barbosa-Filho J.M. Synopsis of the plants known as medicinal and poisonous in northeast of Brazil. Rev Bras Farmacogn 2007, 17:114-140.
3. Costa Júnior J.S., Freitas R.M., Citó A.M.G.L., Henriques J.A.P., Saffi J. Evaluation of effects of ethanolic extract (EE) from Platonia insignis Mart. on pilocarpine-induced seizures. J Biol Sci 2010, 10:747-753.
4. Ronen G.M., Streiner D.L., Verhey L.H., et al. Disease characteristics and psychosocial factors: explaining the expression of quality of life in childhood epilepsy. Epilepsy Behav 2010, 18:88-93.
5. Malawska B. New anticonvulsant agents. Curr Top Med Chem 2005, 5:69-85.
6. Quintans Júnior L.J., Almeida J., Lima J.T., et al. Plants with anticonvulsant properties: a review. Rev Bras Farmacogn 2008, 18:798-819.
7. Lopes J.J., Marx C., Ingrassia R., Picada J.N., Pereira P., Ferraz Ad.B.F. Neurobehavioral and toxicological activities of two potentially CNS-acting medicinal plants of Piper genus. Exp Toxicol Pathol 2010, EPub 23 June.
8. Ciochina R., Grossman R.B. Polycyclic polyprenylated acylphloroglucinols. Chem Rev 2006, 106:3963-3986.
9. Costa Júnior J.S., Ferraz A.B.F., Filho B.A.B., et al. Evaluation of antioxidant effects in vitro of Garcinielliptone FC (GFC) isolated from Platonia insignis Mart. J Med Plants Res 2011, 52:293-299.
10. Marona H., Pekala E., Filipek B., Maciag D., Szneler E. Pharmacological properties of some aminoalkanolic derivatives of xanthone. Pharmazie 2001, 56:567-572.
11. Marona H., Pekala E., Antkiewicz-Michaluk L., Walczak M., Szneler E. Anticonvulsant activity of some xanthone derivatives. Bioorg Med Chem 2008, 16:7234-7244.
12. Almeida R.N., Falcão A., Diniz R.S.T., et al. Metodologia para avaliação de plantas com atividade no sistema nervoso central e alguns dados experimentais. Rev Bras Farmacogn 1999, 80:72-76.
13. Asakura W., Matsumoto K., Ohta H., Watanabe H. Effect of [alpha] 2-adrenergic drugs on REM sleep deprivation-induced increase in swimming activity. Pharmacol Biochem Behav 1993, 46:111-115.
14. Draper H.H., Hadley M. Malondialdehyde determination as index of lipid peroxidation. Methods Enzymol 1990, 186:421-431.
15. Green L.C., Tannenbaum S.R., Goldman P. Nitrate synthesis in the germfree and conventional rat. Science 1981, 212:56-58.
16. Dos Santos I.M., Tome Ada R., Saldanha G.B., Ferreira P.M., Militao G.C., Freitas R.M. Oxidative stress in the hippocampus during experimental seizures can be ameliorated with the antioxidant ascorbic acid. Oxid Med Cell Longev 2009, 2:214-221.
17. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. Protein measurement with the Folin phenol reagent. J Biol Chem 1951, 193:265-275.
18. Flohe L., Otting F. Superoxide dismutase assays. Methods Enzymol 1984, 105:93-104.
19. Chance B., Maehly A.C. Assay of catalases and peroxidases. Methods Enzymol 1955, 2:764-775.
20. Smith M., Wilcox K.S., White H.S. Discovery of antiepileptic drugs. Neurotherapeutics 2007, 4:12-17.
21. Bum E.N., Schmutz M., Meyer C., et al. Anticonvulsant properties of the methanolic extract of Cyperus articulatus (Cyperaceae). J Ethnopharmacol 2001, 76:145-150.
22. Lehmann J., Hutchison A.J., McPherson S.E., et al. CGS 19755, a selective and competitive N-methyl-D-aspartate-type excitatory amino acid receptor antagonist. J Pharmacol Exp Ther 1988, 246:65-75.
23. File S.E., Pellow S. Intrinsic actions of the benzodiazepine receptor antagonist Ro 15-1788. Psychopharmacology 1986, 88:1-11.
24. Morais L., Quintans-Júnior L.J., Franco C.I.F., Almeida J., Almeida R.N. Antiparkinsonian-like effects of Plumbago scandens on tremorine-induced tremors methodology. Pharmacol Biochem Behav 2004, 79:745-749.
25. Netto S.M., Warela R.W.B., Fechine M.F., Queiroga M.N., Quintans-Júnior L.J. Anxiolytic-like effect of Rauvolfia ligustrina Willd. ex Roem. & Schult., Apocynaceae, in the elevated plus-maze and hole-board tests. Rev Bras Farmacogn 2009, 19:888-892.
26. Carlini E.A. Plants and the central nervous system. Pharmacol Biochem Behav 2003, 75:501-512.
27. Freire C.M.M., Marques M.O.M., Costa M. Effects of seasonal variation on the central nervous system activity of Ocimum gratissimum L. essential oil. J Ethnopharmacol 2006, 105:161-166.
28. Leite M.P., Fassin J., Baziloni E.M.F., Almeida R.N., Mattei R., Leite J.R. Behavioral effects of essential oil of Citrus aurantium L. inhalation in rats. Rev Bras Farmacogn 2008, 18:661-666.
29. Quintans Júnior L.J., Souza T.T., Leite B.S., et al. Phythochemical screening and anticonvulsant activity of Cymbopogon winterianus Jowitt (Poaceae) leaf essential oil in rodents. Phytomedicine 2008, 15:619-624.
30. Dos Santos R.N., Silva M.G.V., de Freitas R.M. Crysophanol effects on lipid peroxidation levels and catalase activity in mice hippocampus after pilocarpine-induced seizures. J Cell Sci Ther 2011, 2:104.
31. Hosni K., Msaâda K., Taârit M.B., Hammami M., Marzouk B. Bioactive components of three Hypericum species from Tunisia: a comparative study. Ind Crop Prod 2010, 31:158-163.
32. Lenta B.N., Vonthron-Sénécheau C., Weniger B., et al. Leishmanicidal and cholinesterase inhibiting activities of phenolic compounds from Allanblackia monticola and Symphonia globulifera. Molecules 2007, 12:1548-1557.
33. Wu C.C., Weng J.R., Won S.J., Lin C.N. Constituents of the pericarp of Garcinia subelliptica. J Nat Prod 2005, 68:1125-1127.
34. Wu C.C., Lu Y.H., Wei B.L., Yang S.C., Won S.J., Lin C.N. Phloroglucinols with prooxidant activity from Garcinia subelliptica. J Nat Prod 2008, 71:246-250.
35. Iinuma M., Tosa H., Tanaka T., et al. Antibacterial activity of some Garcinia benzophenone derivatives against methicillin-resistant Staphylococcus aureus. Biol Pharm Bull 1996, 19:311-314.
36. Gustafson K.R., Blunt J.W., Munro M.H.G., Fuller R.W., McKee T.C., Cardellina J.H. The guttiferones, HIV-inhibitory benzophenones from from Symphonia globulifera, Garcinia livingstonei, Garcinia ovalifolia, and Clusia rosea. Tetrahedron 1992, 48:10093-10102.
37. Rauca C., Wiswedel I., Zerbe R., Keilhoff G., Krug M. The role of superoxide dismutase and alpha-tocopherol in the development of seizures and kindling induced by pentylenetetrazol: influence of the radical scavenger alpha-phenyl-N-tert-butyl nitrone. Brain Res 2004, 1009:203-212.
38. Castagne V., Gautschi M., Lefevre K., Posada A., Clarke P.G.H. Relationships between neuronal death and the cellular redox status: focus on the developing nervous system. Prog Neurobiol 1999, 59:397-423.
39. Halliwell B., Gutteridge J.M.C. Free radicals in biology and medicine 1999, London, Oxford.
40. Gottlieb M., Leal-Campanario R., Campos-Esparza M.R., et al. Neuroprotection by two polyphenols following excitotoxicity and experimental ischemia. Neurobiol Dis 2006, 23:374-386.
41. Halliwell B., Gutteridge J.M.C. Lipid peroxidation: a radical chain reaction. Free radicals in biology and medicine 1989, 188-276. Clarendon Press, Oxford.
42. Maczurek A., Hager K., Kenklies M., et al. Lipoic acid as an anti-inflammatory and neuroprotective treatment for Alzheimer's disease. Adv Drug Deliv Rev 2008, 60:1463-1470.
43. Michiels C., Raes M., Toussaint O., Remacle J. Importance of Se-glutathione peroxidase, catalase, and Cu/Zn-SOD for cell survival against oxidative stress. Free Radic Biol Med 1994, 17:235-248.
44. Tejada S., Roca C., Sureda A., Rial R.V., Gamundí A., Esteban S. Antioxidant response analysis in the brain after pilocarpine treatments. Brain Res Bull 2006, 69:587-592.
45. Freitas R.M., Souza F.C.F., Vasconcelos S.M.M., Viana G.S.B., Fonteles M.M.F. Oxidative stress in the hippocampus after status epilepticus in rats. FEBS J 2005, 272:1307-1312.
46. Freitas R.M., Nascimento K.G., Ferreira P.M., Jordan J. Neurochemical changes on oxidative stress in rat hippocampus during acute phase of pilocarpine-induced seizures. Pharmacol Biochem Behav 2010, 94:341-345.
47. De Sarro A., Cecchetti V., Fravolini V., Naccari F., Tabarrini O., De Sarro G. Effects of novel 6-desfluoroquinolones and classic quinolones on pentylenetetrazole-induced seizures in mice. Antimicrob Agents Chemother 1999, 43:1729-1736.
48. Westmoreland B.F., Benarroch E.E., Dube J.R., Regan T.J., Sandok B.A. Medical neurosciences 1994, Mayo Foundation, Rochester, MN.
49. Pedersen M.E., Vestergaard H.T., Hansen S.L., Bah S., Diallo D., Jäger A.K. Pharmacological screening of Malian medicinal plants used against epilepsy and convulsions. J Ethnopharmacol 2009, 121:472-475.
50. Nicoll R.A. Introduction to the pharmacology of the central nervous system (CNS). Basic and clinical pharmacology 2001, 351-363. McGraw-Hill, New York. B.G. Katzung (Ed.).