Two peptidergic drugs increase the synaptophysin immunoreactivity in brains of 24-month-old rats

Histochemical Journal

Volumn 31, Issue 6, 1999, Pages 395-401

  Reinprecht, Ingrid ^a   Gschanes, Andrea ^a   Windisch, Manfred ^a   Fachbach, Günter ^b  

^a Research Initiative Ebewe   (Austria)

^b UNIVERSITY OF GRAZ   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

CEREBROLYSIN; E 021; PEPTIDE; SYNAPTOPHYSIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; DENTATE GYRUS; ENTORHINAL CORTEX; HIPPOCAMPUS; IMAGE ANALYSIS; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; INTRAPERITONEAL DRUG ADMINISTRATION; LEARNING; MEMORY; MICROSCOPY; NERVE CELL; NONHUMAN; PEPTIDERGIC NERVOUS SYSTEM; PRIORITY JOURNAL; RAT; SYNAPSE;

AMINO ACIDS; ANIMALS; BRAIN; IMAGE PROCESSING, COMPUTER-ASSISTED; IMMUNOHISTOCHEMISTRY; MICROSCOPY; NEUROPEPTIDES; NOOTROPIC AGENTS; PRESYNAPTIC TERMINALS; RATS; SYNAPTOPHYSIN;

ANIMALIA; HIPPOCAMPUS HIPPOCAMPUS;

EID: 0032774942     PISSN: 00182214     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1003752208971     Document Type: Article

References (56)

1. Akai F, Hiruma S, Sato T, Iwamoto N, Fujimoto M, Ioku M, Hashimoto S (1992) Neurotrophic factor-like effect of FPF1070 on septal cholinergic neurons after transections of fimbria-fornix in the rat brain. Histol Histopathol 7: 213-221.
2. Allain H, Bentue-Ferrer D, Zekri O, Schück, S, Lebreton S, Reymann JM (1998) Experimental and clinical methods in the development of anti-Alzheimer drugs. Fundam Clin Pharm 12: 13-29.
3. Barolin GS, Koppi S, Kapeller E (1996) Old and new aspects of stroke treatment with emphasis on metabolically active medication and rehabilitative outcome. Euro Rehab 3: 135-143.
4. Bergmann M, Post A, Rittel I, Bechmann I, Nitsch R (1997) Expression of synaptophysin in sprouting neurons after entorhinal lesion in the rat. Exp Brain Res 117: 80-86.
5. Boado RJ (1995) Brain-derived peptides regulate the steady state levels and increase stability of blood-brain barrier GLUT1 glucose transporter mRNA. Neurosci Lett 197: 179-182.
6. Boado RJ (1996a) Molecular regulation of the blood-brain barrier GLUT1 glucose transporter by brain-derived peptides. J Neural Transm 47: 275.
7. Hondo RJ (1996b) Brain-derived peptides increase the expression of a blood-brain barrier GLUT1 glucose transporter gene. Neurosci Lett 220: 53-56.
8. Bondareff W, Geinisman Y (1976) Loss of synapses in the dentate gyrus of the senescent rat. Am J Anat 145: 129-136.
9. Chen KS, Masliah E, Mallory M, Gage FH (1995) Synaptic loss in cognitively impaired aged rats is ameliorated by chronic human nerve growth factor infusion. Neuroscience 68: 19-27.
10. Cowan D, Linial M, Scheller RH (1990) Torpedo synaptophysin: evolution of synaptic vesicle protein. Brain Res 509: 1-7.
11. De Toledo-Morrell L, Geinisman Y, Morrell F (1988) Age-dependent alterations in hippocampal synaptic plasticity: relation to memory disorders. Neurobiol Aging 9: 581-590.
12. Francis-Turner L, Valouskova V (1996) Nerve growth factor and nootropic drug Cerebrolysin but not fibroblast growth factor can reduce spatial memory impairment elicited by fimbria-fornix transection: short-term study. Neurosci Lett 202: 193-196.
13. Gaarskjaer FB (1986) The organization and development of the hippocampal mossy fiber system. Brain Res Rev 11: 335-357.
14. Gallagher M, Burwell R, Burchinal M (1993) Severity of spatial learning impairment in aging: development of a learning index for performance in the Morris water maze. Behav Neurosci 107: 618-626.
15. Gschanes A, Valouskova V, Windisch M (1997) Ameliorative influence of a nootropic drug on motor activity of rats after bilateral carotid artery occlusion. J Neural Transm 104: 1319-1327.
16. Gschanes A, Windisch M (1998a) The influence of Cerebrolysin and E021 on spatial navigation of 24-month-old rats. In: Jellinger K, Fazekas F, Windisch M eds. Ageing and Dementia. Wien: Springer-Verlag, pp. 313-321.
17. Gschanes A, Windisch M (1998b) Early postnatal treatment with peptide preparations influences spatial navigation of young and adult rats. Behav Brain Res (in press).
18. Hutter-Paier B, Eggenreich U, Windisch M (1996a) Effects of two protein-free peptide derivatives on passive avoidance behaviour of 24-month-old rats. Drug Res 46: 237-241.
19. Hutter-Paier B, Eggenreich U, Windisch M (1996b) Dose-dependent behavioural effects of two protein-free peptide derivatives on the passive avoidance reaction of rats. Drug Res 46: 242-246.
20. Hutter-Paier B, Grygar E, Windisch M (1996c) Death of cultured telencephalon neurons induced by glutamate is reduced by the peptide derivative Cerebrolysin. J Neural Transm 47: 267-273.
21. Hutter-Paier B, Frühwirth M, Grygar E, Windisch M (1996d) Cerebrolysin protects neurons from ischemia-induced loss of microtubule-associated protein. J Neural Transm 47: 276.
22. Hutter-Paier B, Frühwirth M, Windisch M (1996c) Ischemia induced loss of MAP2 is prevented by Cerebrolysin and THA. Mol Biol Cell 7: 1278.
23. Hutter-Paier B, Grygar E, Windisch M (1998) Iron-induced degeneration of isolated cortical neurons is prevented by Cerebrolysin. Neurobiol Aging Abstract 773: 184.
24. Johnston D, Amaral DG (1998) Hippocampus. In: Shepherd GM eds. The Synaptic Organisation Of The Brain, 4th edn, New York: Oxford University Press, pp. 417-458.
25. Johnston PA, Südhof TC (1990) The multisubunit structure of synaptophysin. J Biol Chem 265: 8869-8873.
26. Kadar T, Silbermann M, Brandeis R, Levy A (1990) Age-related structural changes in the rat hippocampus: correlation with working memory deficiency. Brain Res 512: 113-120.
27. Kadar T, Arbel I, Silbermann M, Levy A (1994) Morphological hippocampal changes during normal aging and their relation to cognitive deterioration. J Neural Transm 44: 133-143.
28. Masliah E, Terry RD, Alford M, De Teresa R (1990) Quantitative immunohistochemistry of synaptophysin in human neocortex: an alternative method to estimate density of presynaptic terminals in paraffin sections. J Histochem Cytochem 38: 837-844.
29. Masliah E, Mallory M, Hansen L, De Teresa R, Terry RD (1993) Quantitative synaptic alterations in the human neocortex during normal aging. Neurology 43: 192-197.
30. Masliah E, Armasolo F, Veinbergs I, Mallory M, Samuel W (1999) Cerebrolysin ameliorates performance deficits, and neuronal damage in apolipoprotein E-deficient mice. Pharmacol Biochem Behav 62: 239-245.
31. Miwa C, Ueki A (1996) Effects of entorhinal cortex lesion on learning behavior and on hippocampus in the rat. Psychiat Clin Neuros 50: 223-230.
32. Mullany P, Lynch MA (1997) Changes in protein synthesis and synthesis of the synaptic vesicle protein, synaptophysin, in entorhinal cortex following induction of long-term potentiation in dentate gyrus: an age-related study in the rat. Neuropharmacology 36: 973-980.
33. Ordy JM, Thomas GJ, Volpe BT, Dunlap WP, Colombo PM (1988) An animal model of human-type memory loss based on aging, lesion, forebrain ischemia, and drug studies with the rat. Neurobiol Aging 9: 667-683.
34. Paier B, Windisch M, Eggenreich U (1992) Postnatal administration of two peptide solutions affects passive avoidance behaviour of young rats. Behav Brain Res 51: 23-28.
35. Rainer M, Windisch M, Moessler H (1998) Open-label study of Cerebrolysin in the treatment of dementia under conditions of daily clinical practice. Neurobiol Aging Abstract 772: 184.
36. Rapp PR, Rosenberg RA, Gallagher M (1987) An evaluation of spatial information processing in aged rats. Behav Neurosci 101: 3-12.
37. Roch JM, Masliah E, Roch-Levecq AC, Sundsmo MP, Otero DA, Veinbergs I, Saitoh T (1994) Increase of synaptic density and memory retention by a peptide representing the trophic domain of the amyloid beta/A4 protein precursor. Proc Natl Acad Sci 91: 7450-7454.
38. Rubenstein JL, Greengard P, Czernik AJ (1993) Calcium-dependent serine phosphorilation of synaptophysin. Synapse 13: 161-172.
39. Rüther E, Ritter R, Apecechea M, Freytag S, Windisch M (1994) Efficacy of the peptidergic nootropic drug Cerebrolysin in patients with senile dementia of the Alzheimer type (SDAT). Pharmacopsychiatry 27: 32-40.
40. Schwab M, Bauer R, Zwicner U (1993) Effects of Cere on ECoG during moderate forebrain ischemia under normothermic and hypothermic conditions. In: Eiselt M, Zwiener U, Witte H eds. Quantitative and Topological EEG and MEG Analysis. Jena: Universitätsverlag Jena, pp. 243-347.
41. Schwab M, Bauer R, Zwiener U (1997) Physiological effects and brain protection by hypothermia and Cerebrolysin after moderate forebrain ischemia in rats. Exp Toxicol Pathol 49: 105-116.
42. Shen J, Barnes CA (1996) Age-related decrease in cholinergic synaptic transmission in three hippocampal subfields. Neurobiol Aging 17: 439-451.
43. Sugita Y, Kondo T, Kanazawa A, Itou T, Mizuno Y (1993) Protective effect of FPF 1070 (Cerebrolysin) on delayed neuronal death in the gerbil - detection of hydroxyl radicals wilh salicylic acid. Brain Nerve 45: 330-331.
44. Swanson LW (1996) Brain Maps: Structure of the Rat Brain. Amsterdam: Elsevier Science Publisher B.V.
45. Sze C, Troncoso JC, Kawas C, Mouton P, Price DL, Martin IJ (1997) Loss of the presynaptic vesicle protein synaptophysin in hippocampus correlates with cognitive decline in Alzheimer disease. J Neuropath Exp New 56: 933-944.
46. Ucki A, Miwa C, Shinjo H, Kokai M, Morita Y (1997) Synapse alteration in hippocampal CA3 field following entorhinal cortex lesion. J Neurol Sci 151: 1-5.
47. Valouskova V, Francis-Turner L (1998) Can Cercbrolysin influence chronic deterioration of spatial learning and memory? In: Jellinger K, Fazekas F, Windisch Meds. Aging and Dementia Wien: Springer-Verlag, pp. 343-349.
48. Valouskova V, Gschanes A (1998) Effects of NGF, b-FGF, and Cerebrolysin on water maze performance and on motor activity of rats: short-and long-term study. Neurobiol Learn Mem 71: 132-149.
49. Vereschagin NV, Nekrasova YM, Lebedova NV, Suslina ZA, Soloviev OI, Priadov MA, Altunina M (1991) Mild forms of multi-infact dementia: Efficacy of Cerebrolysin. Sov Med 11: 1-6.
50. Wallace JE, Krauter EE, Campbell RA (1980) Animal models of declining memory in the aged: short-term and spatial memory in the aged rat. J Gerontol 35: 355-363.
51. Windisch M, Gschanes A, Valouskova V (1993a) The effects of different growth factors in rats after lesions of the somato sensory cortex. Eur Neurosci Abstract 542: 140.
52. Windisch M, Albrecht E, Eggenreich U, Paier B (1993b) Neurotrophic effects of the nootropic drug Cerebrolysin - A summary. In: Nicolini M, Zatta PF, Corain B eds. Alzheimers's Disease and Related Disorders. Vol 87. Oxford: Pergamon Press, pp. 355-357.
53. Windisch M, Paier B, Eggenreich U (1994) Neuronal growth factors and their role in degenerative brain diseases: a mini-review. Neural Croat 43: 9-20.
54. Windisch M, Gschanes A, Hutter-Paier B (1998) Neurotrophic activities and therapeutic experience with a brain-derived peptide preparation. In: Jellinger K, Fazekas F, Windisch M eds. Aging and Dementia. Wien: Springer-Verlag, pp. 289-298.
55. Wong TP, Campbell PM, Ribeiro-da-Silva A, Cuello AC (1998) Synaptic numbers across cortical laminae and cognitive performance of the rat during ageing. Neuroscienee 84: 403-412.
56. Wronski R, Hutter-Paier B, Crailsheim K, Windisch M (1998) The peptide derivative Cerebrolysin inhibits the calcium dependent protease Calpain II. Neurobiol Aging Abstract 774: 185.