Vitamin E suppression of microglial activation is neuroprotective

Journal of Neuroscience Research

Volumn 66, Issue 2, 2001, Pages 163-170

  Li, Yuekui ^a   Liu, Ling ^a   Barger, Steven W ^b   Mrak, Robert E ^b,c,d   Griffin, W Sue T ^a,b  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^b UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^c CENTRAL ARKANSAS VETERANS HEALTHCARE SYSTEM   (United States)

^d Medical Center   (United States)

Author keywords

Alzheimer's disease; Interleukin 1; NF B; Nitric oxide; p38 mitogen activated protein kinase; Tumor necrosis factor; Vitamin E

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ALPHA TOCOPHEROL; ANTIOXIDANT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1ALPHA; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; NITRIC OXIDE; OLIGONUCLEOTIDE; TUMOR NECROSIS FACTOR ALPHA;

ALZHEIMER DISEASE; ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; ENZYME ACTIVATION; GENE EXPRESSION; MICROGLIA; NERVE CELL STIMULATION; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTIOXIDANTS; CELLS, CULTURED; COCULTURE TECHNIQUES; CYTOKINES; ENZYME ACTIVATION; ENZYME INHIBITORS; IMIDAZOLES; INTERLEUKIN-1; LIPOPOLYSACCHARIDES; MAP KINASE SIGNALING SYSTEM; MICE; MICROGLIA; MITOGEN-ACTIVATED PROTEIN KINASES; NEUROPROTECTIVE AGENTS; NF-KAPPA B; NITRIC OXIDE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PC12 CELLS; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; PYRIDINES; RATS; THIONUCLEOTIDES; TUMOR NECROSIS FACTOR-ALPHA; VITAMIN E;

EID: 0035888177     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/jnr.1208     Document Type: Article

References (39)

1. Amyloid β-peptide stimulates nitric oxide production in astrocytes through an NFκB-dependent mechanism
2. Activation of microglia by secreted amyloid precursor protein evokes release of glutamate by cystine exchange and attenuates synaptic function
3. Microglial activation by Alzheimer amyloid precursor protein and modulation by apolipoprotein E
4. Vitamin E and other antioxidants in neuroprotection
5. A decomposition product of a contaminant implicated in L-tryptophan eosinophilla myalgia syndrome affects spinal cord neuronal cell death and survival through stereospecific, maturation and partly interleukin-1-dependent mechanisms
6. Vitamin E as an antioxidant/free radical scavenger against amyloid β-peptide-induced oxidative stress in neocortical synaptosomal membranes and hippocampal neurons in culture: Insights into Alzheimer's disease
7. The p38 mitogen-activated protein kinase is required for NF-κB-dependent gene expression. The role of TATA-binding protein (TBP)
8. Activated microglia mediate neuronal cell injury via a nitric oxide mechanism
9. Inducible nitric oxide synthase activity of cloned murine microglial cells
10. Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures
11. α-Tocopheryl succinate inhibits monocytic cell adhesion to endothelial cells by suppressing NF-κ B mobilization
12. Specific domains of β-amyloid from Alzheimer plaque elicit neuron killing in human microglia
13. Human tumor necrosis factor α gene regulation by virus and lipopolysaccharide
14. Secreted forms of β-amyloid precursor protein protect hippocampal neurons against amyloid β-peptide-induced oxidative injury
15. Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease
16. Glial-neuronal interactions in Alzheimer's disease: The potential role of a "cytokine cycle" in disease progression
17. The pervasiveness of interleukin-1 in alzheimer pathogenesis: A role for specific polymorphisms in disease risk
18. Vitamin E and Alzheimer disease: The basis for additional clinical trials
19. α-Tocopherol decreases lipid peroxidation, neuronal necrosis, and reactive gliosis in reaggregate cultures of fetal rat brain
20. Protective effect of α-tocopherol on ischemic neuronal damage in the gerbil hippocampus
21. A model for β-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: Relevance to Alzheimer disease
22. Characterization of a functional NF-κB site in the human interleukin 1 β promoter: Evidence for a positive autoregulatory loop
23. Synergistic neurotoxic effects of combined treatments with cytokines in murine primary mixed neuron/glia cultures
24. A protein kinase involved in the regulation of inflammatory cytokine biosynthesis
25. S100B increases levels of β-amyloid precursor protein and its encoding mRNA in rat neuronal cultures
26. S100B induction of the proinflammatory cytokine interleukin-6 in neurons
27. Neuronal-glial interactions mediated by interleukin-1 enhance neuronal acetylcholinesterase activity and mRNA expression
28. Activation of microglial cells by β-amyloid protein and interferon-gamma
29. Antioxidants and immune response in aged persons: Overview of present evidence
30. Interleukin-1 and the immunogenetics of Alzheimer disease
31. Inhibition of NF-κB transcriptional activity by α-tocopheryl succinate
32. Selective activation and functional significance of p38α mitogen-activated protein kinase in lipopolysaccharide-stimulated neutrophils
33. Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine
34. Inhibition of macrophage migration inhibitory factor secretion from macrophages by vitamin E
35. A controlled trial of selegiline, α-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's Disease Cooperative Study
36. β(1-40) amyloid peptide injection into the nucleus basalis of rats induces microglia reaction and enhances cortical gamma-aminobutyric acid release in vivo
37. Microglia in the pineal gland of the neonatal rat: Characterization and effects on pinealocyte neurite length and serotonin content
38. Promoter of the mouse gene encoding calcium-independent nitric oxide synthase confers inducibility by interferon gamma and bacterial lipopolysaccharide
39. Intracellular signaling in rat cultured vascular smooth muscle cells: Roles of nuclear factor-κB and p38 mitogen-activated protein kinase on tumor necrosis factor-α production