Hippocampal extracellular matrix levels and stochasticity in synaptic protein expression increase with age and are associated with age-dependent cognitive decline

Molecular and Cellular Proteomics

Volumn 13, Issue 11, 2014, Pages 2975-2985

  Végh, Marlene J ^a   Rausell, Antonio ^b   Loos, Maarten ^a,c   Heldring, Céline M ^a   Jurkowski, Wiktor ^b   Van Nierop, Pim ^a   Paliukhovich, Iryna ^a   Li, Ka Wan ^a   Del Sol, Antonio ^b   Smit, August B ^a   Spijker, Sabine ^a   Van Kesteren, Ronald E ^a  

^a VU UNIVERSITY AMSTERDAM   (Netherlands)

^b UNIVERSITY OF LUXEMBOURG   (Luxembourg)

^c Sylics (Synaptologics BV)   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEOME; SCLEROPROTEIN;

AGED; AGING; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COGNITION; COGNITIVE DEFECT; CONTROLLED STUDY; DISEASE ASSOCIATION; EXPERIMENTAL AMNESIA; EXTRACELLULAR MATRIX; HIPPOCAMPUS; HISTOCHEMISTRY; IMMUNOBLOTTING; MALE; MOUSE; NERVE CELL PLASTICITY; NEUROPATHOLOGY; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEOMICS; SENESCENCE; SPATIAL MEMORY; SYNAPTIC TRANSMISSION; UPREGULATION; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; CYTOLOGY; DEGENERATIVE DISEASE; MASS SPECTROMETRY; MAZE TEST; MEMORY DISORDER; METABOLISM; MILD COGNITIVE IMPAIRMENT; PATHOPHYSIOLOGY; PHYSIOLOGY; STATISTICS; TANDEM MASS SPECTROMETRY;

AGING; ANIMALS; COGNITION; EXTRACELLULAR MATRIX; EXTRACELLULAR MATRIX PROTEINS; HIPPOCAMPUS; MALE; MAZE LEARNING; MEMORY DISORDERS; MICE; MICE, INBRED C57BL; MILD COGNITIVE IMPAIRMENT; NEURODEGENERATIVE DISEASES; NEURONAL PLASTICITY; PROTEOME; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; STOCHASTIC PROCESSES; TANDEM MASS SPECTROMETRY;

EID: 84910673986     PISSN: 15359476     EISSN: 15359484     Source Type: Journal    
DOI: 10.1074/mcp.M113.032086     Document Type: Article

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